Mutations in Protocadherin 15 and Cadherin 23 Affect Tip Links and Mechanotransduction in Mammalian Sensory Hair Cells

Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids

(2010) Amel Bahloul et al.   HUMAN MOLECULAR GENETICS

Development and Regeneration of Sensory Transduction in Auditory Hair Cells Requires Functional Interaction Between Cadherin-23 and Protocadherin-15

(2010) A. Lelli et al.   JOURNAL OF NEUROSCIENCE

Structural Determinants of Cadherin-23 Function in Hearing and Deafness

(2010) Marcos Sotomayor et al.   NEURON

Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members

(2010) H. M. Elledge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hearing Loss: Mechanisms Revealed by Genetics and Cell Biology

(2009) Amiel A. Dror et al.   Annual Review of Genetics

Mechanotransduction by Hair Cells: Models, Molecules, and Mechanisms

(2009) Peter G. Gillespie et al.   CELL

Fast Adaptation and Ca2+ Sensitivity of the Mechanotransducer Require Myosin-XVa in Inner But Not Outer Cochlear Hair Cells

(2009) R. Stepanyan et al.   JOURNAL OF NEUROSCIENCE

Linking genes underlying deafness to hair-bundle development and function

(2009) Christine Petit et al.   NATURE NEUROSCIENCE

Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging

(2009) Maryline Beurg et al.   NATURE NEUROSCIENCE

A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells

(2009) M. Schwander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The dimensions and structural attachments of tip links in mammalian cochlear hair cells and the effects of exposure to different levels of extracellular calcium

(2008) D.N. Furness et al.   NEUROSCIENCE

Presence of interstereocilial links in waltzer mutants suggests Cdh23 is not essential for tip Link formation

(2008) A.K. Rzadzinska et al.   NEUROSCIENCE