Multiplexed visualization of dynamic signaling networks using genetically encoded fluorescent protein-based biosensors

Parallel tracking of cAMP and PKA signaling dynamics in living cells with FRET-based fluorescent biosensors

(2012) Nwe-Nwe Aye-Han et al.   Molecular BioSystems

Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP

(2012) Vedangi Sample et al.   Nature Chemical Biology

pHTomato, a red, genetically encoded indicator that enables multiplex interrogation of synaptic activity

(2012) Yulong Li et al.   NATURE NEUROSCIENCE

Förster Resonance Energy Transfer-Based Biosensors for Multiparameter Ratiometric Imaging of Ca2+Dynamics and Caspase-3 Activity in Single Cells

(2011) Yidan Ding et al.   ANALYTICAL CHEMISTRY

Reporting from the Field: Genetically Encoded Fluorescent Reporters Uncover Signaling Dynamics in Living Biological Systems

(2011) Sohum Mehta et al.   Annual Review of Biochemistry

Intracellular Protein Target Detection by Quantum Dots Optimized for Live Cell Imaging

(2011) Youngseon Choi et al.   BIOCONJUGATE CHEMISTRY

A Fluorescent Reporter of AMPK Activity and Cellular Energy Stress

(2011) Peiling Tsou et al.   Cell Metabolism

Genetically Encodable Fluorescent Biosensors for Tracking Signaling Dynamics in Living Cells

(2011) Robert H. Newman et al.   CHEMICAL REVIEWS

Development of an optimized backbone of FRET biosensors for kinases and GTPases

(2011) Naoki Komatsu et al.   MOLECULAR BIOLOGY OF THE CELL

Imaging the coordination of multiple signalling activities in living cells

(2011) Christopher M. Welch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Simultaneous Visualization of Protumorigenic Src and MT1-MMP Activities with Fluorescence Resonance Energy Transfer

(2010) M. Ouyang et al.   CANCER RESEARCH

Visualization of PKA activity in plasma membrane microdomains

(2010) Charlene Depry et al.   Molecular BioSystems

Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit

(2010) Qiang Ni et al.   Nature Chemical Biology

Blue Fluorescent cGMP Sensor for Multiparameter Fluorescence Imaging

(2010) Yusuke Niino et al.   PLoS One

Local and Long-Range Reciprocal Regulation of cAMP and cGMP in Axon/Dendrite Formation

(2010) M. Shelly et al.   SCIENCE

Genetically encoded biosensors based on engineered fluorescent proteins

(2009) Wolf B. Frommer et al.   CHEMICAL SOCIETY REVIEWS

The role of membrane microdomains in shaping β2-adrenergic receptor-mediated cAMP dynamics

(2009) Lisa M. DiPilato et al.   Molecular BioSystems

Coordination of Rho GTPase activities during cell protrusion

(2009) Matthias Machacek et al.   NATURE

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

(2009) Lin Tian et al.   NATURE METHODS

Simultaneous Live Cell Imaging Using Dual FRET Sensors with a Single Excitation Light

(2009) Yusuke Niino et al.   PLoS One

Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators

(2009) H. Imamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein kinase inhibitors: contributions from structure to clinical compounds

(2009) Louise N. Johnson   QUARTERLY REVIEWS OF BIOPHYSICS

Simultaneous Recording of Multiple Cellular Events by FRET

(2008) Alen Piljic et al.   ACS Chemical Biology

Therapeutic Protein Kinase Inhibitors

(2008) S. K. Grant   CELLULAR AND MOLECULAR LIFE SCIENCES

Genetically Encoded Calcium Indicators

(2008) Marco Mank et al.   CHEMICAL REVIEWS

Crystal Structures of the GCaMP Calcium Sensor Reveal the Mechanism of Fluorescence Signal Change and Aid Rational Design

(2008) Jasper Akerboom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid Turnover Rate of Phosphoinositides at the Front of Migrating MDCK Cells

(2008) Teruko Nishioka et al.   MOLECULAR BIOLOGY OF THE CELL

Visualization of phosphatase activity in living cells with a FRET-based calcineurin activity sensor

(2008) Robert H. Newman et al.   Molecular BioSystems

Fluorescent protein FRET pairs for ratiometric imaging of dual biosensors

(2008) Hui-wang Ai et al.   NATURE METHODS

A genetically encoded fluorescent sensor of ERK activity

(2008) C. D. Harvey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA