Drug-metabolizing enzymes CYP3A as a link between tacrolimus and vitamin D in renal transplant recipients: is it relevant in clinical practice?

Was 4β-hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?

(2018) Sibylle Neuhoff et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Clinical aspects of tacrolimus use in paediatric renal transplant recipients

(2018) Agnieszka Prytuła et al.   PEDIATRIC NEPHROLOGY

Long-Term Influence of CYP3A5, CYP3A4, ABCB1, and NR1I2 Polymorphisms on Tacrolimus Concentration in Chinese Renal Transplant Recipients

(2017) Fei Liu et al.   Genetic Testing and Molecular Biomarkers

CYP3A4 Induction by Rifampin: An Alternative Pathway for Vitamin D Inactivation in Patients With CYP24A1 Mutations

(2017) Colin Patrick Hawkes et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

1,25(OH) 2 D 3 induces regulatory T cell differentiation by influencing the VDR/PLC-γ1/TGF-β1/pathway

(2017) Qiang Zhou et al.   MOLECULAR IMMUNOLOGY

CYP3A4 is a crosslink between vitamin D and calcineurin inhibitors in solid organ transplant recipients: implications for bone health

(2017) A Prytuła et al.   PHARMACOGENOMICS JOURNAL

Effects of Cyclosporine, Tacrolimus, and Rapamycin on Osteoblasts

(2017) M. Martín-Fernández et al.   TRANSPLANTATION PROCEEDINGS

A Randomized Controlled Trial Comparing the Efficacy of Cyp3a5 Genotype-Based With Body-Weight-Based Tacrolimus Dosing After Living Donor Kidney Transplantation

(2016) N. Shuker et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Effect of Weight and CYP3A5 Genotype on the Population Pharmacokinetics of Tacrolimus in Stable Paediatric Renal Transplant Recipients

(2016) Agnieszka A. Prytuła et al.   CLINICAL PHARMACOKINETICS

CYP3Apharmacogenetics and tacrolimus disposition in adult heart transplant recipients

(2016) Kimberly M. Deininger et al.   CLINICAL TRANSPLANTATION

The renal microenvironment modifies dendritic cell phenotype

(2016) Federica Chessa et al.   KIDNEY INTERNATIONAL

Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies MultipleCYP3A5Alleles

(2015) W. S. Oetting et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Calcium and bone homeostasis in heterozygous carriers of CYP24A1 mutations: A cross-sectional study

(2015) M. Cools et al.   BONE

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines forCYP3A5Genotype and Tacrolimus Dosing

(2015) KA Birdwell et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Genotype-guided tacrolimus dosing in African-American kidney transplant recipients

(2015) K Sanghavi et al.   PHARMACOGENOMICS JOURNAL

Which Genetic Determinants Should be Considered for Tacrolimus Dose Optimization in Kidney Transplantation? A Combined Analysis of Genes Affecting the CYP3A Locus

(2015) Henrike Bruckmueller et al.   THERAPEUTIC DRUG MONITORING

Vitamin D in Renal Transplantation - from Biological Mechanisms to Clinical Benefits

(2014) R. McGregor et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Metabolic bone disease after renal transplantation

(2014) Dieter Haffner et al.   CURRENT OPINION IN PEDIATRICS

Comparison of two endogenous biomarkers of CYP3A4 activity in a drug–drug interaction study between midostaurin and rifampicin

(2014) Catherine Dutreix et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Combined effects of CYP3A5*1, POR*28, and CYP3A4*22 single nucleotide polymorphisms on early concentration-controlled tacrolimus exposure in de-novo renal recipients

(2014) Dirk R.J. Kuypers et al.   Pharmacogenetics and Genomics

The CYP3A4*22 C>T single nucleotide polymorphism is associated with reduced midazolam and tacrolimus clearance in stable renal allograft recipients

(2014) H de Jonge et al.   PHARMACOGENOMICS JOURNAL

Developmental Changes in the Expression and Function of Cytochrome P450 3A Isoforms: Evidence from In Vitro and In Vivo Investigations

(2013) Ibrahim Ince et al.   CLINICAL PHARMACOKINETICS

The Role of Pharmacogenetics in the Disposition of and Response to Tacrolimus in Solid Organ Transplantation

(2013) Dennis A. Hesselink et al.   CLINICAL PHARMACOKINETICS

FGF23 and mineral metabolism in the early post-renal transplantation period

(2013) Katherine Wesseling-Perry et al.   PEDIATRIC NEPHROLOGY

Effects of Oral Paricalcitol on Secondary Hyperparathyroidism and Proteinuria of Kidney Transplant Patients

(2013) Esther Gonzalez et al.   TRANSPLANTATION

Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation

(2012) Ranjit K. Thirumaran et al.   BIOCHEMICAL PHARMACOLOGY

Impact of tacrolimus on bone metabolism after kidney transplantation

(2012) Limei Luo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D3through CYP3A4 induction in vitro and in vivo: Implications for drug-induced osteomalacia

(2012) Zhican Wang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Phosphate is a vascular toxin

(2012) Rukshana Shroff   PEDIATRIC NEPHROLOGY

Effects of Cyclosporine, Tacrolimus and Rapamycin on Renal Calcium Transport and Vitamin D Metabolism

(2011) Chien-Te Lee et al.   AMERICAN JOURNAL OF NEPHROLOGY

Gender- and dose-related effects of cyclosporin A on hepatic and bone metabolism

(2011) Walter Jäger et al.   BONE

A New Functional CYP3A4 Intron 6 Polymorphism Significantly Affects Tacrolimus Pharmacokinetics in Kidney Transplant Recipients

(2011) L. Elens et al.   CLINICAL CHEMISTRY

Seasonal Variation in Blood Drug Concentrations and a Potential Relationship to Vitamin D

(2011) J. D. Lindh et al.   DRUG METABOLISM AND DISPOSITION

Changes in vitamin D binding protein and vitamin D concentrations associated with liver transplantation

(2011) Peter P. Reese et al.   LIVER INTERNATIONAL

Mutations inCYP24A1and Idiopathic Infantile Hypercalcemia

(2011) Karl P. Schlingmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

4β-hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans

(2010) Ulf Diczfalusy et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The virtues of vitamin D—but how much is too much?

(2010) Rukshana Shroff et al.   PEDIATRIC NEPHROLOGY

Regulation of VDR expression in rat and human intestine and liver – Consequences for CYP3A expression

(2009) Ansar A. Khan et al.   TOXICOLOGY IN VITRO

The CYP3A4*18 Genotype in the Cytochrome P450 3A4 Gene, a Rapid Metabolizer of Sex Steroids, Is Associated With Low Bone Mineral Density

(2008) YS Kang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Xenobiotic-Induced Transcriptional Regulation of Xenobiotic Metabolizing Enzymes of the Cytochrome P450 Superfamily in Human Extrahepatic Tissues

(2008) Petr Pavek et al.   CURRENT DRUG METABOLISM

The ontogeny of drug metabolism enzymes and implications for adverse drug events

(2008) Ronald N. Hines   PHARMACOLOGY & THERAPEUTICS