Article
Surgery
Niels Riemersma, Daan J. Kremer, Tim Knobbe, C. Tji Gan, Svea Nolte, Antonio W. Gomes-Neto, Hans E. Blokzijl, Vincent de Meijer, Kevin F. Damman, Michele Eisenga, Gea Drost, Jan Willem J. J. Elting, Daan P. Touw, Stefan Berger, Stephan J. L. Bakker, A. M. Madelein van der Stouwe, Transplantlines Invest
Summary: Solid organ transplant recipients frequently experience tremor, and this study investigates the impact of tremor on activities of daily living and health-related quality of life (HRQoL). Results show that whole blood tacrolimus trough concentration is an independent determinant of mild tremor among these recipients. Severe tremor is strongly associated with lower physical and mental HRQoL. These findings emphasize the need for further research on the effects of tacrolimus on tremor.
TRANSPLANT INTERNATIONAL
(2023)
Review
Virology
Roni Bitterman, Deepali Kumar
Summary: Solid organ transplantation comes with an increased risk of respiratory viral infections, especially problematic for lung transplant recipients. While influenza has treatment options, other respiratory viruses present treatment challenges. Novel antivirals, immunologic treatments, and vaccines are hoped for in the coming years to address this evolving area of concern.
Article
Surgery
Molly Hayes, Craig L. K. Boge, Anna Sharova, Daniel Vader, Marina Mitrou, Despoina M. Galetaki, Yun Li, Kevin J. Downes
Summary: Toxicities are common with VGCV prophylaxis in pediatric SOT recipients, including kidney injury and neutropenia.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Microbiology
Tirdad T. T. Zangeneh, Mohanad M. M. Al-Obaidi
Summary: Coccidioidomycosis is a fungal infection that is prevalent in certain regions of the United States, Mexico, and Central and South America. It can cause severe infections in immunocompromised patients, such as solid organ transplant recipients. The timely and accurate diagnosis of coccidioidomycosis in these patients is challenging due to limitations of diagnostic methods, making it important to explore alternative approaches. This review discusses available diagnostic modalities and the role of early diagnosis in guiding antifungal therapy for reducing complications in SOT recipients with coccidioidomycosis.
Article
Medicine, General & Internal
Elisabetta Bussalino, Laura Panaro, Luigina Marsano, Diego Bellino, Maura Ravera, Ernesto Paoletti
Summary: The prevalence of hyperkalemia in stable kidney transplant recipients is about 9%, and it is mainly associated with metabolic acidosis, arterial hypertension, and the use of RAAS inhibitors.
INTERNAL AND EMERGENCY MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Lauryn A. Benninger, Cesar Trillo, Jorge Lascano
Summary: CFTR modulator therapy may improve extrapulmonary manifestations of cystic fibrosis in post-lung transplant recipients without affecting graft function or immunosuppressive drug levels.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Surgery
Zachary A. Yetmar, Supavit Chesdachai, Dustin Duffy, Byron H. Smith, Douglas W. Challener, Maria Teresa Seville, Wendelyn Bosch, Elena Beam
Summary: Nocardia infection is associated with immunosuppression, while trimethoprim-sulfamethoxazole prophylaxis may provide protection for SOT recipients. The effectiveness of prophylaxis may depend on the dose or frequency of trimethoprim-sulfamethoxazole.
CLINICAL TRANSPLANTATION
(2023)
Review
Immunology
Mauro Vigano, Marta Beretta, Marta Lepore, Raffaele Abete, Simone Vasilij Benatti, Maria Vittoria Grassini, Stefania Camagni, Greta Chiodini, Simone Vargiu, Claudia Vittori, Marco Iachini, Amedeo Terzi, Flavia Neri, Domenico Pinelli, Valeria Casotti, Fabiano Di Marco, Piero Ruggenenti, Marco Rizzi, Michele Colledan, Stefano Fagiuoli
Summary: Prevention of infections is crucial in solid organ transplant candidates and recipients. Vaccination is an important measure, however, the vaccine response is reduced, especially in the early post-transplant period or after rejection treatment.
Review
Virology
S. Reshwan K. Malahe, Jeroen J. A. van Kampen, Olivier C. C. Manintveld, Rogier A. S. Hoek, Caroline M. M. den Hoed, Carla C. C. Baan, Marcia M. L. Kho, Georges M. G. M. Verjans
Summary: Solid organ transplant recipients (SOTRs) face a high risk of human herpesvirus (HHV)-related morbidity and mortality due to immunosuppressive therapy. We aim to increase awareness of the HHV disease burden in SOTRs by providing an overview of current prevention and management strategies from the literature and guidelines. We discuss challenges in prevention, treatment, and future perspectives.
Article
Oncology
Tomohiro Tanaka, Charles F. Lynch, Kelly J. Yu, Bozena M. Morawski, Mei-Chin Hsieh, Georgetta Alverson, April A. Austin, Yun Zeng, Eric A. Engels
Summary: The incidence of pancreatic cancer is higher in solid organ transplant recipients, particularly in liver transplant recipients. Compared with the general population, pancreatic cancer is more commonly diagnosed in transplant recipients, especially in cases arising in the head of the pancreas and those diagnosed at localized stage. Risk factors for pancreatic cancer in transplant recipients are consistent with those in the general population, including male sex, older age, non-O blood type, and history of diabetes.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Letter
Medicine, General & Internal
Teresa Po-Yu Chiang, Aura T. Abedon, Jennifer L. Alejo, Dorry L. Segev, Allan B. Massie, William A. Werbel
Summary: This cohort study examines the occurrence of COVID-19 and hospitalizations among solid organ transplant (SOT) recipients who have been vaccinated, during different variant eras in 2021 and 2022.
Article
Medicine, General & Internal
Seyed M. Hosseini-Moghaddam, Bin Luo, Sarah E. Bota, Shahid Husain, Michael S. Silverman, Nick Daneman, Kevin A. Brown, J. Michael Paterson
Summary: This study reveals an increasing trend of CDI in annual cohorts of SOT recipients. Posttransplant CDI is associated with mortality, and late-onset CDI poses a greater risk of death compared to early-onset CDI.
Review
Surgery
Lara Danziger-Isakov, Emily A. Blumberg, Oriol Manuel, Martina Sester
Summary: The COVID-19 pandemic in 2020 had a significant impact on organ transplantation globally, leading to decreased donations and increased pressure due to limited medical resources.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Peripheral Vascular Disease
Gilad Hamdani, Mark M. Mitsnefes
Summary: The current literature on hypertension (HTN) following pediatric solid organ transplant (SOTx) was reviewed, including definition, prevalence, risk factors, outcomes, and treatment. Several new guidelines for pediatric HTN have been published, but no specific recommendations for SOTx recipients. HTN is highly prevalent, yet underdiagnosed and undertreated in kidney transplant recipients, especially with ambulatory blood pressure monitoring. Little data is available regarding its prevalence in other SOTx recipients. HTN in this population is multifactorial and associated with pre-transplant HTN, demographic factors, weight status, and immunosuppression protocol. HTN is associated with subclinical cardiovascular (CV) end-organ damage, but no recent data on long-term outcomes are available. There are no updated recommendations for the optimal management of HTN in this population.
CURRENT HYPERTENSION REPORTS
(2023)
Article
Immunology
Omid Rezahosseini, Christina Ekenberg, Dina Leth Moller, Soren Schwartz Sorensen, Neval Ete Wareham, Michael Perch, Finn Gustafsson, Allan Rasmussen, Nikolai Kirkby, Joanne Reekie, Jens Lundgren, Susanne Dam Nielsen
Summary: Routine monitoring of parvovirus B19 in seronegative solid organ transplant recipients may not be necessary, as targeted screening 1 month posttransplantation and screening upon clinical suspicion could be alternative strategies.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Gilles Tourlamain, Mandy Keijzer-Veen, Antonia Bouts, Karlien Cransberg, Huib de Jong, Rani De Pauw, Karen Vanderstraeten, Amina El Amouri, Ann Raes, Noel Knops, Agnieszka Prytula
Summary: The study analyzed the effects of pre-transplant recombinant human growth hormone (rhGH) and corticosteroid withdrawal on linear growth in pediatric kidney transplantation patients. It also identified factors associated with final height (FH).
PEDIATRIC NEPHROLOGY
(2023)
Article
Pediatrics
Sevasti Karamaria, Lien Dossche, Vincent Delens, Eva Degraeuwe, Ann Raes, Reiner Mauel, Caroline Vande Walle, Karel Everaert, Johan Vande Walle
Summary: This study investigates the factors associated with nocturnal polyuria in treatment-naive patients with enuresis, and finds that nocturnal polyuria is associated with urine production and solute excretion.
PEDIATRIC NEPHROLOGY
(2023)
Article
Pediatrics
Christian Patry, Lukas D. Sauer, Anja Sander, Kai Krupka, Alexander Fichtner, Jolanda Brezinski, Yvonne Geissbuehler, Elodie Aubrun, Anna Grinienko, Luca Dello Strologo, Dieter Haffner, Jun Oh, Ryszard Grenda, Lars Pape, Rezan Topaloglu, Lutz T. Weber, Antonia Bouts, Jon Jin Kim, Agnieszka Prytula, Jens Koenig, Mohan Shenoy, Britta Hoecker, Burkhard Toenshoff
Summary: This study investigated whether patient registries could be used to emulate control cohorts in randomized controlled trials (RCTs) for pediatric kidney transplantation. The results showed that there were no significant differences in various outcome measures between the emulated control cohort and the actual control cohort of the RCT. Therefore, the usage of Real-World Data from patient registries could facilitate the conduct of clinical trials in pediatric kidney transplantation.
PEDIATRIC NEPHROLOGY
(2023)
Article
Urology & Nephrology
Jaap W. Groothoff, Ella Metry, Lisa Deesker, Sander Garrelfs, Cecile Acquaviva, Reham Almardini, Bodo B. Beck, Olivia Boyer, Rimante Cerkauskiene, Pietro Manuel Ferraro, Luitzen A. Groen, Asheeta Gupta, Bertrand Knebelmann, Giorgia Mandrile, Shabbir S. Moochhala, Agnieszka Prytula, Jovana Putnik, Gill Rumsby, Neveen A. Soliman, Bhaskar Somani, Justine Bacchetta
Summary: Primary hyperoxaluria (PH) is an inherited disorder that causes overproduction of oxalate, resulting in kidney stones, nephrocalcinosis, and kidney failure. Diagnosis and management of PH are challenging due to its rarity and variable clinical expression. However, recent developments in outcome data and therapies, including RNA interference, have led to the need for updated guidelines on PH. A consensus group formulated and graded practical statements on the diagnosis and management of PH based on existing evidence.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Pediatrics
Justine Bacchetta, Claus Peter Schmitt, Sevcan A. Bakkaloglu, Shelley Cleghorn, Maren Leifheit-Nestler, Agnieszka Prytula, Bruno Ranchin, Anne Schoen, Stella Stabouli, Johan van de Walle, Enrico Vidal, Dieter Haffner, Rukshana Shroff
Summary: Infants with CKD are highly susceptible to mineral and bone disorders, and this position paper provides guidelines for diagnosing and managing CKD-MBD in infants. The paper includes 34 clinical practice points, such as dietary control of calcium and phosphate, and medication recommendations. The strength of the statements in the paper may vary and should be tailored to individual patient needs by the treating physician.
PEDIATRIC NEPHROLOGY
(2023)
Article
Pediatrics
Annelies Matthys, Jo Dehoorne, Amelie Dendooven, Petra Schelstraete, Agnieszka Prytula
Summary: This study reports two cases of acute tubulointerstitial nephritis (ATIN) in children, one caused by leptospirosis in a 12-year-old boy and the other caused by hantavirus in a 10-year-old girl. Both patients presented with jaundice, elevated serum creatinine, and thrombocytopenia, with urine analysis revealing tubular proteinuria. Kidney biopsy confirmed tubulointerstitial inflammation. Both children showed excellent clinical and biochemical response to glucocorticoid treatment.
PEDIATRIC NEPHROLOGY
(2023)
Editorial Material
Pediatrics
Agnieszka Prytula, Ryszard Grenda
PEDIATRIC NEPHROLOGY
(2023)
Review
Pediatrics
Eline Braekman, Ruth De Bruyne, Kristof Vandekerckhove, Agnieszka Prytula
Summary: Post-transplant hypertension is one of the significant factors leading to cardiovascular diseases in pediatric liver transplant recipients. The chronic use of immunosuppressants is one of the main causes of post-transplant hypertension. Blood pressure monitoring and hypertension treatment are crucial for the quality of life and life expectancy of pediatric liver transplant patients. However, there is a lack of guidelines for monitoring and managing post-transplant hypertension.
PEDIATRIC TRANSPLANTATION
(2023)
Meeting Abstract
Pediatrics
Eline Hermans, Johan Vande Walle, Agnieszka Prytula, Joke Dehoorne, Evelyn Dhont, Evelien Snauwaert, Lien Dossche, Ann Raes
PEDIATRIC NEPHROLOGY
(2022)
Meeting Abstract
Pediatrics
Lien Dossche, Evelien Snauwaert, Agnieszka Prytula, Joke Dehoorne, Ann Raes, Noortje Van Oostrum, Caroline Jamaer, Erik Van Laecke, Anne-franCoise Spinoit, Johan Vande Walle
PEDIATRIC NEPHROLOGY
(2022)
Meeting Abstract
Pediatrics
Eline Hermans, Johan Vande Walle, Agnieszka Prytula, Joke Dehoorne, Evelien Snauwaert, Lien Dossche, Ann Raes
PEDIATRIC NEPHROLOGY
(2022)
Meeting Abstract
Pediatrics
Lieselot Peremans, Johan Vande Walle, Lien Dossche, Evelien Snauwaert, Agnieszka Prytula, Joke Dehoorne, Caroline Jamaer, Mieke Waterschoot, Anne-francoise Spinoit, Eric Van Laecke, Ann Raes
PEDIATRIC NEPHROLOGY
(2022)
Meeting Abstract
Pediatrics
Raphael Schild, Karla Carvajal Abreu, Kai Krupka, Anja Buescher, Marcus Weitz, Agnieszka Prytula, Nikoleta Printza, Nele Kanzelmeyer, Laszlo Berta, Seha Kamil Saygili, Anne-Laure Sellier-Leclerc, Stephen D. Marks, Sabine Koenig, Rezan Topaloglu, Dominik Mueller, Gunter Klaus, Stefanie Weber, Jun Oh, Uta Herden, Luisa Murer, Luca Dello Strologo, Gema Ariceta, Peter Hoyer, Burkhard Toenshoff, Lars Pape
PEDIATRIC TRANSPLANTATION
(2022)
Meeting Abstract
Pediatrics
Gilles Tourlamain, Mandy Keijzer--Veen, Antonia Bouts, Karlien Cransberg, Huib de Jong, Rani De Pauw, Karen Vanderstraeten, Amina El Amouri, Ann Raes, Noel Knops, Agnieszka Prytula
PEDIATRIC TRANSPLANTATION
(2022)
