Article
Medicine, General & Internal
Agnieszka Bartczak-Rutkowska, Lidia Tomkiewicz-Pajak, Katarzyna Kawka-Paciorkowska, Natalia Bajorek, Aleksandra Cieplucha, Mariola Ropacka-Lesiak, Olga Trojnarska
Summary: A study investigated the maternal and fetal outcomes of women who had undergone the Fontan procedure in two Polish medical centers. Among 26 pregnancies, 11 ended in miscarriages and 15 resulted in 16 live births. Fetal complications were observed in 9 live births, with prematurity being the most common. Obstetrical complications occurred in 6 pregnancies, including placental abruption, premature rupture of membranes, and antepartum hemorrhage. Specialized care from experienced cardiologists and obstetricians is necessary for these women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Hematology
Silje Johansen, Ingvild Jenssen Laegreid, Siw Leiknes Ernstsen, Nessar Ahmad Azrakhsh, Astrid Olsnes Kittang, Roald Lindas, Bjorn Tore Gjertsen, Nils Vetti, Trude Victoria Mortberg, Ingvild Hausberg Sorvoll, Pal Andre Holme, Maria Therese Ahlen, Hakon Reikvam
Summary: This study reported a case of VITT following HPV vaccination, suggesting the possibility of VITT occurring after other vaccines, not limited to adenoviral vector-based SARS-CoV-2 vaccines.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Multidisciplinary Sciences
Malika Aid, Kathryn E. Stephenson, Ai-ris Y. Collier, Joseph P. Nkolola, James V. Michael, Steven E. Mckenzie, Dan H. Barouch
Summary: Thrombosis with thrombocytopenia syndrome (TTS) is a rare but potentially severe adverse event following immunization with adenovirus vector-based COVID-19 vaccines. Transcriptomic and proteomic profiling reveals that TTS patients show robust upregulation of platelet, coagulation, and immune pathways after receiving the initial dose of Ad26.COV2.S. A second immunization or a reduced initial dose of Ad26.COV2.S induces lower activation of these pathways.
NATURE COMMUNICATIONS
(2023)
Review
Gastroenterology & Hepatology
Alberto Zanetto, Patrick Northup, Lara Roberts, Marco Senzolo
Summary: Hospitalised patients with decompensated cirrhosis experience a rebalanced haemostasis, but this balance can easily be disrupted, leading to bleeding. Acute kidney injury, bacterial infections/sepsis, and progression to acute-on-chronic liver failure further increase the risk of bleeding. Unfortunately, there is no single laboratory method to accurately assess bleeding risk and guide preventive measures. Understanding the haemostatic alterations during acute illness could improve the management of these patients.
JOURNAL OF HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Magdalena Okolska, Grzegorz Karkowski, Marcin Kuniewicz, Jacek Bednarek, Jacek Pajak, Beata Rog, Jacek Lach, Jacek Legutko, Lidia Tomkiewicz-Pajak
Summary: Structural, hemodynamic, and morphological changes in the heart after Fontan operation can lead to the development of arrhythmias and conduction disorders. In this study, 44% of patients were diagnosed with bradyarrhythmia, 28% with supraventricular tachyarrhythmias, and 12% with ventricular arrhythmias.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Emma Payne, Frances Garden, Yves D'Udekem, Zoe McCallum, Helen Wightman, Diana Zannino, Dominica Zentner, Rachael Cordina, Robert Weintraub, Thomas G. Wilson, Julian Ayer
Summary: Poor infant growth in patients with a single ventricle is associated with increased long-term Fontan failure. Establishing BMI trajectory models in these patients helps determine optimal BMI targets for patient outcomes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Pharmacology & Pharmacy
Natalia Marcinczyk, Anna Gromotowicz-Poplawska, Michal Tomczyk, Ewa Chabielska
Summary: This paper describes the hemostasis-modifying ability of tannins, compounds of plant origin and plant extracts, and their influence on the thrombotic process. It highlights the effects of tannins on platelets, coagulation system, fibrinolysis system, and endothelium, as well as their pathophysiology-dependent action. The low bioavailability of tannins suggests the need for further in vivo studies to understand their actual activity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Nurul Syafiqah Mohd Ariff, Izzati Abdul Halim Zaki, Zakiah Mohd Noordin, Nur Sabiha Md Hussin, Khang Wen Goh, Long Chiau Ming, Hanis Hanum Zulkifly
Summary: Thromboembolic complications are relatively low in pregnant women infected with COVID-19, with disseminated intravascular coagulation being the most common form and placental thrombosis being the least common form. Anticoagulation, particularly low molecular weight heparin (variable dose), is frequently used to prevent thromboembolic complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Majd B. B. Protty, P. Vince Jenkins, Peter W. W. Collins, Valerie B. B. O'Donnell
Summary: Phospholipids are vital for cell structure and cell activation signalling pathways. They play a key role in supporting blood clotting by rapidly externalizing upon platelet activation. Enzymatically oxidized phospholipids have also been found to facilitate blood clotting. However, the exact role of phospholipids in thrombo-inflammatory conditions is not fully understood.
Article
Cardiac & Cardiovascular Systems
Masamichi Ono, Melchior Burri, Benedikt Mayr, Lisa Anderl, Martina Strbad, Julie Cleuziou, Alfred Hager, Juergen Hoerer, Rudiger Lange
Summary: This study evaluated the outcomes of BCPS and identified risk factors for failed Fontan completion. The study found that hypoplastic left heart syndrome, unbalanced atrioventricular septal defect, high pulmonary artery pressure, and reduced ventricular function were risk factors for failure to successfully complete the Fontan procedure.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Makoto Miyake, Jiro Sakamoto, Hirokazu Kondo, Atsushi Iwakura, Hiraku Doi, Toshihiro Tamura
Summary: This study aimed to investigate the long-term outcomes of patients with single-ventricle physiology after the Glenn procedure without the subsequent Fontan procedure. The study found that the 40-year overall survival after the Glenn procedure in patients with single-ventricle physiology was 40.3%. Dominant left ventricular morphology may be associated with better long-term overall survival than dominant right ventricular morphology.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Varun J. Sharma, Ajay J. Iyengar, Diana Zannino, Thomas Gentles, Robert Justo, David S. Celermajer, Andrew Bullock, David Winlaw, Gavin Wheaton, Luke Burchill, Rachael Cordina, Yves D'Udekem
Summary: Protein losing enteropathy and plastic bronchitis are severe complications in Fontan circulation, mainly affecting patients with dominant right single ventricle, with older age being a predictor of developing these diseases and having a poorer prognosis. Heart transplantation remains the ultimate treatment option, with 30% of patients either dying or requiring transplantation within 5 years.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Maciej Skubera, Aleksandra Golab, Tomasz Sternalski, Olga Trojnarska, Dariusz Plicner, Monika Smas-Suska, Anna Mazurek-Kula, Agnieszka Bartczak-Rutkowska, Jacek Pajak, Piotr Podolec, Lidia Tomkiewicz-Pajak
Summary: This multicenter study investigated the incidence of thromboembolic complications (TECs) in adult patients after Fontan (FO) surgery. The study found that 23.1% of FO patients had a history of TECs, with pulmonary embolism being the most common complication. The results suggest that TECs occur at a higher rate in FO patients than expected.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Shahryar M. Chowdhury, Eric M. Graham, Carolyn L. Taylor, Andrew Savage, Kimberly E. McHugh, Stephanie Gaydos, Arni C. Nutting, Michael R. Zile, Andrew M. Atz
Summary: This study aimed to identify high-risk Fontan patients with abnormal diastolic function and preserved ejection fraction and analyze their cardiac mechanics, exercise function, and functional health status.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, General & Internal
Ivo M. B. Francischetti, Kevin Toomer, Yifan Zhang, Jayesh Jani, Zishan Siddiqui, Daniel J. Brotman, Jody E. Hooper, Thomas S. Kickler
Summary: This study found that COVID-19 patients have thrombotic and microvascular complications, and the coagulation abnormalities have a multifactorial etiology. Biomarkers of endothelial cell, neutrophil activation, and fibrinolysis were elevated in severe disease group, correlating with severity. Postmortem specimens demonstrated potential links to immunothrombosis with upregulation of pulmonary TF and loss of thrombomodulin staining.
Article
Hematology
Camous Moslemi, Susanne Saekmose, Rune Larsen, Thorsten Brodersen, Maria Didriksen, Henrik Hjalgrim, Karina Banasik, Kaspar R. Nielsen, Mie T. Bruun, Joseph Dowsett, Kathrine A. Kasperen, Susan Mikkelsen, Thomas F. Hansen, Henrik Ullum, Christian Erikstrup, Martin L. Olsson, Sisse R. Ostrowski, Ole B. Pedersen
Summary: This study reveals a new association between the Lewis blood group antigen Le(a) and reduced susceptibility to SARS-CoV-2, confirming the previous link to blood type O. However, no associations were found between other blood groups or secretor status and infection, COVID-19 hospitalization, or long COVID-19.
Article
Medicine, General & Internal
Tanja Schlaikjaer Hartwig, Louise Ambye, Jennifer R. Gruhn, Jesper Friis Petersen, Tine Wronding, Letizia Amato, Andrew Chi-Ho Chan, Boyang Ji, Maiken Hemme Bro-Jorgensen, Lene Werge, Mette Marie Babiel Schmidt Petersen, Clara Brinkmann, Julie Birch Petersen, Morten Duno, Iben Bache, Markus J. Herrgard, Finn Stener Jorgensen, Eva R. Hoffmann, Henriette Svarre Nielsen
Summary: This study validates the feasibility of using cell-free fetal DNA (cffDNA) from maternal blood for the detection of fetal aneuploidy in cases of pregnancy loss. The results show that this method has a high sensitivity and specificity in distinguishing between euploid and aneuploid pregnancy loss, providing valuable information for clinical management.
Article
Genetics & Heredity
Jonas Ghouse, Vinicius Tragante, Gustav Ahlberg, Soren A. Rand, Jakob B. B. Jespersen, Eva Birgitte Leinoe, Christoffer Rasmus Vissing, Linea Trudso, Ingileif Jonsdottir, Karina Banasik, Soren Brunak, Sisse R. R. Ostrowski, Ole B. B. Pedersen, Erik Sorensen, Christian Erikstrup, Mie Topholm Bruun, Kaspar Rene Nielsen, Lars Kober, Alex H. H. Christensen, Kasper Iversen, David Jones, Kirk U. U. Knowlton, Lincoln Nadauld, Gisli H. H. Halldorsson, Egil Ferkingstad, Isleifur Olafsson, Solveig Gretarsdottir, Pall T. T. Onundarson, Patrick Sulem, Unnur Thorsteinsdottir, Gudmundur Thorgeirsson, Daniel F. F. Gudbjartsson, Kari Stefansson, Hilma Holm, Morten Salling Olesen, Henning Bundgaard
Summary: This study conducts a genome-wide association analysis of venous thromboembolism (VTE) using a large cohort of cases and controls. They identify 93 risk loci, with 62 loci being newly discovered. The study also demonstrates the effectiveness of a VTE polygenic risk score in identifying individuals at high or low risk for VTE. Additionally, they investigate the shared clinical risk factors between venous and arterial thrombosis.
Article
Anesthesiology
Theis S. Itenov, Maria E. Kromann, Sisse R. Ostrowski, Morten H. Bestle, Thomas Mohr, Louise Gyldensted, Anne Lindhardt, Katrin Thormar, Daniel I. Sessler, Nicole P. Juffermans, Jens D. Lundgren, Jens-Ulrik Jensen
Summary: This study found that mild induced hypothermia has a slight impact on coagulation and platelet aggregation in patients with septic shock, but does not change clot strength. It does, however, significantly reduce fibrinolysis.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Environmental Sciences
Bertram Kjerulff, Henriette Thisted Horsdal, Kathrine Kaspersen, Susan Mikkelsen, Khoa Manh Dinh, Margit Horup Larsen, Sisse Rye Ostrowski, Henrik Ullum, Erik Sorensen, Ole Birger Pedersen, Mie Topholm Bruun, Kaspar Rene Nielsen, Jorgen Brandt, Camilla Geels, Lise M. Frohn, Jesper H. Christensen, Torben Sigsgaard, Clive Eric Sabel, Carsten Bocker Pedersen, Christian Erikstrup
Summary: Air pollution is a significant contributor to the global burden of disease, leading to inflammation and various health issues. However, studies on the impact of air pollution exposure on CRP levels in low to moderate pollution settings have yielded inconsistent results.
ENVIRONMENTAL RESEARCH
(2023)
Article
Genetics & Heredity
Pol Sole-Navais, Christopher Flatley, Valgerdur L. Steinthorsdottir, Marc Vaudel, Julius Juodakis, Jing Chen, Triin Laisk, Abigail C. LaBella, David Westergaard, Jonas Bacelis, Ben Brumpton, Line Skotte, Maria Borges, Oyvind A. Helgeland, Anubha Mahajan, Matthias N. Wielscher, Frederick P. Lin, Catherine Briggs, Carol Wang, Gunn-Helen E. Moen, Robin R. Beaumont, Jonathan Bradfield, Abin A. Abraham, Gudmar Thorleifsson, Maiken Gabrielsen, Sisse Ostrowski, Dominika Modzelewska, Ellen M. Nohr, Elina Hypponen, Amit M. Srivastava, Octavious Talbot, Catherine Allard, Scott Williams, Ramkumar Menon, Beverley Shields, Gardar Sveinbjornsson, Huan B. Xu, Mads F. Melbye, William Lowe, Luigi Bouchard, Emily I. Oken, Ole I. Pedersen, Daniel T. Gudbjartsson, Christian Erikstrup, Erik Sorensen, Rolv Lie, Kari Teramo, Mikko T. Hallman, Thorhildur Juliusdottir, Hakon Hakonarson, Henrik L. Ullum, Andrew Hattersley, Line Sletner, Mario Merialdi, Sheryl Rifas-Shiman, Thora Steingrimsdottir, Denise A. Scholtens, Christine H. Power, Jane West, Mette A. Nyegaard, John Capra, Anne Skogholt, Per Magnus, Ole E. Andreassen, Unnur Thorsteinsdottir, Struan F. A. M. Grant, Elisabeth Qvigstad, Craig I. Pennell, Marie-France A. Hivert, Geoffrey M. Hayes, Marjo-Riitta Jarvelin, Mark I. McCarthy, Deborah Lawlor, Henriette Nielsen, Reedik Maegi, Antonis Rokas, Kristian Hveem, Kari J. Stefansson, Bjarke M. Feenstra, Pal Njolstad, Louis Muglia, Rachel Freathy, Stefan Johanson, Ge Zhang, Bo Jacobsson
Summary: The study conducted a meta-analysis and identified genetic variants associated with gestational duration and preterm delivery. It revealed the importance of maternal alleles in influencing gestational duration and the complex relationship between gestational duration and birth weight. The study also identified antagonistic pleiotropy, where maternal alleles that increase gestational duration have negative effects on birth weight.
Correction
Genetics & Heredity
Pol Sole-Navais, Christopher Flatley, Valgerdur L. Steinthorsdottir, Marc Vaudel, Julius Juodakis, Jing Chen, Triin Laisk, Abigail C. LaBella, David Westergaard, Jonas Bacelis, Ben Brumpton, Line Skotte, Maria Borges, Oyvind A. Helgeland, Anubha Mahajan, Matthias N. Wielscher, Frederick P. Lin, Catherine Briggs, Carol Wang, Gunn-Helen E. Moen, Robin R. Beaumont, Jonathan Bradfield, Abin A. Abraham, Gudmar Thorleifsson, Maiken Gabrielsen, Sisse Ostrowski, Dominika Modzelewska, Ellen M. Nohr, Elina Hypponen, Amit M. Srivastava, Octavious Talbot, Catherine Allard, Scott Williams, Ramkumar Menon, Beverley Shields, Gardar Sveinbjornsson, Huan B. Xu, Mads F. Melbye, William Lowe Jr, Luigi Bouchard, Emily I. Oken, Ole I. Pedersen, Daniel T. Gudbjartsson, Christian Erikstrup, Erik Sorensen, Rolv Lie, Kari Teramo, Mikko T. Hallman, Thorhildur Juliusdottir, Hakon Hakonarson, Henrik L. Ullum, Andrew Hattersley, Line Sletner, Mario Merialdi, Sheryl Rifas-Shiman, Thora Steingrimsdottir, Denise A. Scholtens, Christine H. Power, Jane West, Mette A. Nyegaard, John Capra, Anne Skogholt, Per Magnus, Ole E. Andreassen, Unnur Thorsteinsdottir, Struan F. A. M. Grant, Elisabeth Qvigstad, Craig I. Pennell, Marie-France A. Hivert, Geoffrey S. Hayes, Marjo-Riitta Jarvelin, Mark I. McCarthy, Deborah Lawlor, Henriette Nielsen, Reedik Magi, Antonis Rokas, Kristian Hveem, Kari J. Stefansson, Bjarke M. Feenstra, Pal Njolstad, Louis Muglia, Rachel Freathy, Stefan Johansson, Ge Zhang, Bo Jacobsson
Article
Critical Care Medicine
Rasmus Paulin Beske, Laust Emil Roelsgaard Obling, John Bro-Jeppesen, Niklas Nielsen, Martin Abild Steengaard Meyer, Jesper Kjaergaard, Par Ingemar Johansson, Christian Hassager
Summary: Targeted temperature management (TTM) may reduce injury from out-of-hospital cardiac arrest by slowing metabolism. However, studies have found higher lactate levels in patients cooled to 33 degrees C compared with 36 degrees C even days after TTM cessation. Larger studies on the effect of TTM on the metabolome have not been conducted.
THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT
(2023)
Review
Environmental Sciences
Sidsel Dan Hull, Laura Deen, Kajsa Ugelvig Petersen, Tina Kold Jensen, Paula Hammer, Regitze Solling Wils, Hannah N. o rtoft Frankel, Sisse Rye Ostrowski, Sandra Sogaard Tottenberg
Summary: The study aimed to investigate the temporal trends of PFAS concentrations in the Danish population. The results showed a significant decline in blood concentrations of PFOS and PFOA from the late 1990s until 2021, reflecting a decrease in the use of these substances. The time trends for other PFAS were less evident but also displayed a tendency towards a decrease.
ENVIRONMENTAL RESEARCH
(2023)
Article
Genetics & Heredity
Maria Nethander, Sofia Moverare-Skrtic, Anders Kampe, Eivind Coward, Ene Reimann, Louise Grahnemo, Eva Borbely, Zsuzsanna Helyes, Thomas Funck-Brentano, Martine Cohen-Solal, Juha Tuukkanen, Antti Koskela, Jianyao Wu, Lei Li, Tianyuan Lu, Maiken E. Gabrielsen, Reedik Estonian Biobank Res Team, Reedik Magi, Mari Hoff, Ulf H. Lerner, Petra Henning, Henrik Ullum, Christian Erikstrup, Soren Brunak, Tiinamaija DBDS Genomic Consortium, Arnulf Langhammer, Tiinamaija Tuomi, Asmundur Oddsson, Kari Stefansson, Ulrika Pettersson-Kymmer, Sisse Rye Ostrowski, Ole Birger Vesterager Pedersen, Unnur Styrkarsdottir, Outi Makitie, Kristian Hveem, J. Brent Richards, Claes Ohlsson
Summary: This study identified 43 loci associated with forearm fracture through genome-wide association analysis, including some influencing bone quality parameters. Functional studies of one of these loci revealed that Tac4 knockout mice exhibit reduced mechanical bone strength without affecting bone mineral density.
Article
Genetics & Heredity
Gyda Bjornsdottir, Mona A. Chalmer, Lilja Stefansdottir, Astros Th. Skuladottir, Gudmundur Einarsson, Margret Andresdottir, Doruk Beyter, Egil Ferkingstad, Solveig Gretarsdottir, Bjarni V. Halldorsson, Gisli H. Halldorsson, Anna Helgadottir, Hannes Helgason, Grimur Hjorleifsson Eldjarn, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Ingileif Jonsdottir, Kirk U. Knowlton, Lincoln D. Nadauld, Sigrun H. Lund, Olafur Th. Magnusson, Pall Melsted, Kristjan H. S. Moore, Asmundur Oddsson, Pall I. Olason, Asgeir Sigurdsson, Olafur A. Stefansson, Jona Saemundsdottir, Gardar Sveinbjornsson, Vinicius Tragante, Unnur Unnsteinsdottir, G. Bragi Walters, Florian Zink, Linn Rodevand, Ole A. Andreassen, Jannicke Igland, Rolv T. Lie, Jan Haavik, Karina Banasik, Soren Brunak, Maria Didriksen, Mie T. Bruun, Christian Erikstrup, Lisette J. A. Kogelman, Kaspar R. Nielsen, Erik Sorensen, Ole B. Pedersen, Henrik Ullum, Gisli Masson, Unnur Thorsteinsdottir, Jes Olesen, Petur Ludvigsson, Olafur Thorarensen, Anna Bjornsdottir, Gudrun R. Sigurdardottir, Olafur A. Sveinsson, Sisse R. Ostrowski, Hilma Holm, Daniel F. Gudbjartsson, Gudmar Thorleifsson, Patrick Sulem, Hreinn Stefansson, Thorgeir E. Thorgeirsson, Thomas F. Hansen, Kari Stefansson
Summary: This study combines large GWAS datasets from six European populations to investigate the main subtypes of migraine and identifies new susceptibility loci associated with migraine and its subtypes. Rare variants with large effects on PRRT2, SCN11A, and KCNK5 genes are found to be related to migraine. These findings provide new insights into the complex biology of migraine and its subtypes, offering potential for therapeutic interventions.
Article
Immunology
Dina Leth Moller, Soren Schwartz Sorensen, Omid Rezahosseini, Daniel Brauner Rasmussen, Nicoline Stender Arentoft, Josefine Amalie Loft, Michael Perch, Finn Gustafsson, Jens Lundgren, Thomas Scheike, Jenny Dahl Knudsen, Sisse Rye Ostrowski, Allan Rasmussen, Susanne Dam Nielsen
Summary: This study aimed to determine the incidence of positive herpes virus PCR tests during the first year post-transplantation and assess whether a model including immune function could predict subsequent positive tests. The cumulative incidence of positive tests was 36.6%, and the prediction model had an AUC of 77%. Risk scores based on the model allowed for identification of recipients with higher risk.
FRONTIERS IN IMMUNOLOGY
(2023)
Correction
Cardiac & Cardiovascular Systems
Hildur M. Aegisdottir, Rosa B. Thorolfsdottir, Gardar Sveinbjornsson, Olafur A. Stefansson, Bjarni Gunnarsson, Vinicius Tragante, Gudmar Thorleifsson, Lilja Stefansdottir, Thorgeir E. Thorgeirsson, Egil Ferkingstad, Patrick Sulem, Gudmundur Norddahl, Gudrun Rutsdottir, Karina Banasik, Alex Hoerby Christensen, Ole Birger Pedersen, Christina Mikkelsen, Soren Brunak, Mie Topholm Bruun, Christian Erikstrup, Rikke Louise Jacobsen, Kaspar Rene Nielsen, Erik Sorensen, Michael L. Frigge, Kristjan E. Hjorleifsson, Erna Ivarsdottir, Anna Helgadottir, Solveig Gretarsdottir, Valgerdur Steinthorsdottir, Asmundur Oddsson, Hannes P. Eggertsson, Gisli H. Halldorsson, David A. Jones, Jeffrey L. Anderson, Kirk U. Knowlton, Lincoln D. Nadauld, DBDS Genomic Consortium, Magnus Haraldsson, Gudmundur Thorgeirsson, Henning Bundgaard, David O. Arnar, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Sisse R. Ostrowski, Hilma Holm, Kari Stefansson
EUROPEAN HEART JOURNAL
(2023)
Article
Hematology
Lars Klingen Gjaerde, Sisse Rye Ostrowski, Frederikke Schierbeck, Niels Smedegaard Andersen, Lone Smidstrup Friis, Brian Kornblit, Soren Lykke Petersen, Ida Schjodt, Henrik Sengelov
Summary: This study found that plasma ST2 levels measured before allogeneic hematopoietic cell transplantation (HCT) were associated with 1-year nonrelapse mortality (NRM) and provided additional prognostic value. The study also confirmed the associations between post-transplantation ST2 levels and outcomes of HCT. Pretransplantation ST2 levels were correlated with patient characteristics and other plasma biomarkers. ST2 levels at different time points were prognostic of 1-year NRM, all-cause mortality, relapse, and acute GVHD.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Correction
Medicine, Research & Experimental
Rebecka Svanberg, Cameron MacPherson, Adrian Zucco, Rudi Agius, Tereza Faitova, Michael Asger Andersen, Caspar da Cunha-Bang, Lars Klingen Gjaerde, Maria Elizabeth Engel Moller, Patrick Terrence Brooks, Birgitte Lindegaard, Adin Sejdic, Zitta Barrella Harboe, Anne Ortved Gang, Ditte Stampe Hersby, Christian Brieghel, Susanne Dam Nielsen, Daria Podlekareva, Annemette Hald, Jakob Thaning Bay, Hanne Marquart, Jens Lundgren, Anne-Mette Lebech, Marie Helleberg, Carsten Utoft Niemann, Sisse Rye Ostrowski
COMMUNICATIONS MEDICINE
(2023)