A Carbon Nanotube Toxicity Paradigm Driven by Mast Cells and the IL-33/ST2 Axis

Multi-walled carbon nanotubes induce cytotoxicity and genotoxicity in human lung epithelial cells

(2012) Delia Cavallo et al.   JOURNAL OF APPLIED TOXICOLOGY

Endogenous IL-33 Is Highly Expressed in Mouse Epithelial Barrier Tissues, Lymphoid Organs, Brain, Embryos, and Inflamed Tissues: In Situ Analysis Using a Novel Il-33-LacZ Gene Trap Reporter Strain

(2012) M. Pichery et al.   JOURNAL OF IMMUNOLOGY

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

(2012) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dispersal State of Multiwalled Carbon Nanotubes Elicits Profibrogenic Cellular Responses That Correlate with Fibrogenesis Biomarkers and Fibrosis in the Murine Lung

(2011) Xiang Wang et al.   ACS Nano

Novel Murine Model of Chronic Granulomatous Lung Inflammation Elicited by Carbon Nanotubes

(2011) Isham Huizar et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Multiwalled Carbon Nanotubes Induce a Fibrogenic Response by Stimulating Reactive Oxygen Species Production, Activating NF-κB Signaling, and Promoting Fibroblast-to-Myofibroblast Transformation

(2011) Xiaoqing He et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Serum IL-33 levels are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis

(2011) Koichi Yanaba et al.   CLINICAL RHEUMATOLOGY

Neutrophil Proteinase 3 Induces Diabetes in a Mouse Model of Glucose Tolerance

(2011) Suyoung Bae et al.   ENDOCRINE RESEARCH

Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice

(2011) Mitsuteru Akahoshi et al.   JOURNAL OF CLINICAL INVESTIGATION

Mast Cells as Sensors of Cell Injury through IL-33 Recognition

(2011) M. Enoksson et al.   JOURNAL OF IMMUNOLOGY

The mouse interleukin (Il)33 gene is expressed in a cell type- and stimulus-dependent manner from two alternative promoters

(2011) Dominique Talabot-Ayer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Effects of single and multi walled carbon nanotubes on macrophages: Cyto and genotoxicity and electron microscopy

(2011) Maria Laura Di Giorgio et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes

(2011) Robert R Mercer et al.   Particle and Fibre Toxicology

Multi-Walled Carbon Nanotube Instillation Impairs Pulmonary Function in C57BL/6 Mice

(2011) Xiaojia Wang et al.   Particle and Fibre Toxicology

Parasitic Infection Improves Survival from Septic Peritonitis by Enhancing Mast Cell Responses to Bacteria in Mice

(2011) Rachel E. Sutherland et al.   PLoS One

Unique populations of lung mast cells are required for antigen-mediated bronchoconstriction

(2010) J. M. Cyphert et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Over-expression of IL-33 leads to spontaneous pulmonary inflammation in mIL-33 transgenic mice

(2010) Xiang Zhiguang et al.   IMMUNOLOGY LETTERS

Pulmonary Toxicity of Intratracheally Instilled Multiwall Carbon Nanotubes in Male Fischer 344 Rats

(2010) Shigetoshi AISO et al.   INDUSTRIAL HEALTH

IL-33 Mediates Inflammatory Responses in Human Lung Tissue Cells

(2010) A. Yagami et al.   JOURNAL OF IMMUNOLOGY

Serum Soluble ST2

(2010) Robin A.P. Weir et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mast cells contribute to altered vascular reactivity and ischemia-reperfusion injury following cerium oxide nanoparticle instillation

(2010) Christopher J. Wingard et al.   Nanotoxicology

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

(2009) Alexander U. Lüthi et al.   IMMUNITY

Interleukin-33 overexpression is associated with liver fibrosis in mice and humans

(2009) Pierrick Marvie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

IL-33 Induces IL-13-Dependent Cutaneous Fibrosis

(2009) A. L. Rankin et al.   JOURNAL OF IMMUNOLOGY

Carbon nanotubes in biology and medicine: In vitro and in vivo detection, imaging and drug delivery

(2009) Zhuang Liu et al.   Nano Research

Effects of multi-walled carbon nanotubes on a murine allergic airway inflammation model

(2009) Ken-ichiro Inoue et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Interleukin-33 – cytokine of dual function or novel alarmin?

(2009) Guttorm Haraldsen et al.   TRENDS IN IMMUNOLOGY

Inhaled Multiwalled Carbon Nanotubes Potentiate Airway Fibrosis in Murine Allergic Asthma

(2008) Jessica P. Ryman-Rasmussen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

(2008) Craig A. Poland et al.   Nature Nanotechnology

The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’?

(2008) Christine Moussion et al.   PLoS One

Relaxin induces mast cell inhibition and reduces ventricular arrhythmias in a swine model of acute myocardial infarction

(2007) Silvia Nistri et al.   PHARMACOLOGICAL RESEARCH