Article
Immunology
Spencer E. E. Brightman, Angelica Becker, Rukman R. R. Thota, Martin S. S. Naradikian, Leila Chihab, Karla Soria Zavala, Ryan Q. Q. Griswold, Joseph S. S. Dolina, Ezra E. W. Cohen, Aaron M. M. Miller, Bjoern Peters, Stephen P. P. Schoenberger
Summary: CD4(+) T cells have important roles in immune responses, either directly or through accessory cells such as CD8(+) T lymphocytes. While the role of NeoAg-specific CD8(+) T cells in cancer has been extensively studied, the role of NeoAg-specific CD4(+) T cells is less well understood.
Article
Oncology
Nana Dang, Yuan Lin, Mark Waer, Ben Sprangers
Summary: Alloantibodies, particularly immunoglobulin G (allo-IgG), enhance rejection of tumors sharing the same major histocompatibility complex (MHC) in mice. In this study, high titer allo-IgG generated through immunization increased tumor immunogenicity, leading to a systemic antitumor response when combined with 5-fluorouracil. The tumor-specific response relied on the lymph nodes, suggesting a potential use of allo-IgG in cancer treatment.
Review
Chemistry, Multidisciplinary
Jeffrey Y. W. Mak, Ligong Liu, David P. Fairlie
Summary: Researchers have made significant contributions in the field of microbial natural products and synthetic ligands over the past decade, particularly focusing on compounds related to riboflavin and uracils that modulate immune cells. Through collaboration, they discovered a naturally occurring compound synthesized by bacteria that activates MAIT cells, leading to its use in detecting and characterizing MAIT cells in tissues.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Oncology
Tim B. Fessenden, Lauren E. Stopfer, Fiona Chatterjee, Julian Zulueta, Josh Mesfin, Therese Cordero Dumit, Irene Reijers, Esmee P. Hoefsmit, Christian Blank, Forest White, Stefani Spranger
Summary: Cytotoxic CD8(+) T cells must recognize tumor-derived antigens to achieve effective tumor elimination. Our study shows that dendritic cells induce cytotoxic CD8(+) T-cell responses by cross-presenting tumor-derived peptides, and the proportion of membrane-derived neoantigens is associated with reduced survival and treatment response.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Francis R. R. Carbone, Laura K. K. Mackay
Summary: The steps leading to immune-related adverse effects suggest that suppression of autoreactive T cells by checkpoint occurs in peripheral target tissues rather than at the point of lymph node activation.
Article
Multidisciplinary Sciences
Kana Fujimoto, Akira Nakajima, Shohei Hori, Yumiko Tanaka, Yoshitaka Shirasaki, Sotaro Uemura, Naoki Irie
Summary: Although the mother and fetus of placental mammals are immunologically distinct from each other, small numbers of cells are known to be exchanged between them. These maternal cells, known as maternal microchimeric cells (MMc cells), have been found to play roles in various physiological phenomena. By isolating MMc cells from whole mouse embryos and using single-cell RNA sequencing, we have successfully determined the variability in MMc cell types among different embryos. The majority of MMc cells are immune-related cells, and there are significant inter-individual variations in the proportion of immune-related cells among different embryos, which may be one of the potential mechanisms underlying the differing MMc-related physiological phenomena in offspring.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Andrea Sabatini, Gisella Guerrera, Marta Corsetti, Gabriella Ruocco, Marco De Bardi, Sonia Renzi, Duccio Cavalieri, Luca Battistini, Daniela Francesca Angelini, Elisabetta Volpe
Summary: Saccharomyces cerevisiae is a commensal yeast colonizer of mucosal surfaces and can become an opportunistic pathogen in the mucosa and bloodstream. It has been found that human dendritic cells (DCs) can sense S. cerevisiae and produce inflammatory cytokines and interferon-alpha in response. This finding highlights the role of DCs in regulating the host microbiota-immune system balance and the anti-fungal immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Valeria Ukrainskaya, Yuri Rubtsov, Dmitry Pershin, Nadezhda Podoplelova, Stanislav Terekhov, Igor Yaroshevich, Anstasiia Sokolova, Dmitry Bagrov, Elena Kulakovskaya, Victoria Shipunova, Sergey Deyev, Rustam Ziganshin, Aleksandr Chernov, Georgii Telegin, Eugene Maksimov, Oleg Markov, Anastasiya Oshchepkova, Marina Zenkova, Jia Xie, Hongkai Zhang, Alexander Gabibov, Michael Maschan, Alexey Stepanov, Richard Lerner
Summary: The development of CAR-T therapy has achieved success in the treatment of B cell leukemia, but the expansion of CAR-T cells remains challenging with current protocols. A novel approach using cell-derived membrane vesicles has been proposed, showing greater potential in stimulating, proliferating, and enhancing the functional activity of CAR-T cells.
Review
Oncology
Aarushi Audhut Caro, Sofie Deschoemaeker, Lize Allonsius, An Coosemans, Damya Laoui
Summary: This review provides an overview of current therapies for ovarian cancer, focusing on immunotherapies and the potential of dendritic cell vaccines. By highlighting different subsets of dendritic cells and their functions in ovarian cancer, we summarize the advancements and pitfalls of current dendritic cell vaccine strategies and discuss future perspectives for improving patient outcomes.
Article
Endocrinology & Metabolism
Yong Lin, Jelena Perovanovic, Yuelin Kong, Botond Z. Igyarto, Sandra Zurawski, Dean Tantin, Gerard Zurawski, Maria Bettini, Matthew L. Bettini
Summary: Thymic presentation of self-antigens is crucial for the development of a functional and self-tolerant T-cell population. This study investigates the role of hybrid insulin peptides (HIPs) in type 1 diabetes and explores the potential of antibody-mediated delivery of autoimmune neoantigens in preventing autoimmune diseases. The findings suggest that targeting HIPs to thymic dendritic cells enhances T-cell central tolerance and delays the onset of diabetes.
Article
Immunology
Lukas Page, Julia Wallstabe, Jasmin Lother, Maximilian Bauser, Olaf Kniemeyer, Lea Strobel, Vera Voltersen, Janka Teutschbein, Peter Hortschansky, Charles Oliver Morton, Axel A. Brakhage, Max Topp, Hermann Einsele, Sebastian Wurster, Juergen Loeffler
Summary: Dendritic cells play a crucial role in anti-Aspergillus defense, with proteins CcpA and Shm2 triggering significant upregulation of maturation markers and release of pro-inflammatory cytokines. These proteins also enhance MHC class II expression, proliferation, and IFN-gamma secretion from T cells, as well as oxidative burst in neutrophils, suggesting their potential as a therapeutic approach for invasive aspergillosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Johnathan Canton, Hanna Blees, Conor M. Henry, Michael D. Buck, Oliver Schulz, Neil C. Rogers, Eleanor Childs, Santiago Zelenay, Hefin Rhys, Marie-Charlotte Domart, Lucy Collinson, Andres Alloatti, Cara J. Ellison, Sebastian Amigorena, Venizelos Papayannopoulos, David C. Thomas, Felix Randow, Caetano Reis e Sousa
Summary: DNGR-1 is a dedicated cross-presentation receptor that promotes phagosomal rupture, allowing corpse-associated antigens to access the major histocompatibility complex class I antigen processing pathway. This mechanism reveals the existence of innate immune receptors that couple ligand binding and endocytic vesicle damage to regulate adaptive immunity.
Review
Immunology
Sara Ness, Shiming Lin, John R. Gordon
Summary: Dendritic cells are antigen-presenting cells that interact with T cells to regulate adaptive immune responses. Under certain conditions, dendritic cells can develop into anti-inflammatory cells, inducing immunologic tolerance. Studies have shown that regulatory dendritic cells induce T cell tolerance by suppressing effector T cells and inducing regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Seokhyeong Go, Mungyo Jung, Suyoung Lee, Sangjun Moon, Jihye Hong, Cheesue Kim, Yeonseok Chung, Byung-Soo Kim
Summary: A therapeutic cancer nanovaccine has been developed that enhances T cell responses by interacting with both dendritic cells (DCs) and T cells. This nanovaccine, named CCM-MPLA-aCD28, activates tumor-specific CD8+ T cells and exhibits a higher antitumor efficacy compared to nanovaccines that interact with either DCs or T cells.
ADVANCED MATERIALS
(2023)
Article
Toxicology
Yaqian Qu, Lei Bao, Youliang Zhao, Yiping Li, Mingcui Ding, Changfu Hao, Wu Yao
Summary: Cimetidine enhances the maturity and T cell priming capacity of dendritic cells (DCs). It also interferes with DC-mediated T cell polarization, leading to enhanced pro-inflammatory T cell response and weakened immunosuppressive T cell response.
TOXICOLOGY IN VITRO
(2022)
Article
Immunology
Sergej Tomic, Jelena Dokic, Dejan Stevanovic, Natasa Ilic, Alisa Gruden-Movsesijan, Miroslav Dinic, Dusan Radojevic, Marina Bekic, Nebojsa Mitrovic, Ratko Tomasevic, Dragan Mikic, Dragos Stojanovic, Miodrag Colic
Summary: Severe COVID-19 is characterized by dysregulated immune response, lymphocytopenia, impaired T cell activation, and increased inflammation. Factors such as down-regulated IRF-8 and autophagy-related genes expression, and expansion of MDSC subsets play critical roles in dysregulating T cell response in COVID-19. The findings could have implications in diagnostics and design of novel therapeutics for this disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Parasitology
Fabrizio Bruschi, Alisa Gruden-Movesijan, Barbara Pinto, Natasa Ilic, Ljiljana Sofronic-Milosavljevic
Summary: This study investigated the effects of products extracted from Trichinella spiralis muscle larvae on the experimental autoimmune encephalomyelitis (EAE) rat model, finding that treatment with ES L1 could alleviate EAE symptoms. Furthermore, lower levels of serum MMP-9 and NGAL/MMP-9 complex were observed in rats treated with ES L1, indicating a potential mechanism for the amelioration of EAE.
EXPERIMENTAL PARASITOLOGY
(2021)
Article
Immunology
Natasa Ilic, Maja Kosanovic, Alisa Gruden-Movsesijan, Sofija Glamoclija, Ljiljana Sofronic-Milosavljevic, Miodrag Colic, Sergej Tomic
Summary: The rise in autoimmune diseases may be linked to improved living conditions and lack of exposure to immune regulatory agents. Research suggests that Trichinella spiralis excretory-secretory products and extracellular vesicles play a crucial role in modulating immune responses in autoimmunity, indicating a potential new strategy for treating autoimmune diseases through nanoparticle delivery systems.
IMMUNOLOGY LETTERS
(2021)
Article
Parasitology
Ivana Mitic, Sasa Vasilev, Milos Korac, Natasa Ilic, Biljana Bojic, Alisa Gruden-Movsesijan, Ljiljana Sofronic-Milosavljevic
Summary: An outbreak of trichinellosis occurred in Stari Banovci, Serbia, due to consumption of uninspected pork sausages. 28 people were exposed and 24 of them were confirmed to have trichinellosis. The outbreak resulted in a high percentage of pulmonary complications. Immediate treatment should be initiated for suspected cases of trichinellosis to prevent complications.
FOLIA PARASITOLOGICA
(2022)
Article
Cell Biology
Tobias Tertel, Sergej Tomic, Jelena Dokic, Dusan Radojevic, Dejan Stevanovic, Natasa Ilic, Bernd Giebel, Maja Kosanovic
Summary: This study aimed to explore the characteristics of serum extracellular vesicles (EVs) in COVID-19 patients and investigate their potential as biomarkers. The study found that severe COVID-19 patients had increased levels of CD13(+) and CD82(+) EVs in their serum, while mild COVID-19 patients had increased levels of HLA-ABC(+) EVs and CD24(+) EVs. The abundance of these EVs was correlated with disease severity, cytokine concentration, and immunopathogenesis.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Gastroenterology & Hepatology
Dusan Radojevic, Marina Bekic, Alisa Gruden-Movsesijan, Natasa Ilic, Miroslav Dinic, Aleksandar Bisenic, Natasa Golic, Dragana Vucevic, Jelena Dokic, Sergej Tomic
Summary: This study shows that activated myeloid-derived suppressor cells (MDSCs), especially those differentiated with prostaglandin E2 (MDSC-PGE2), can effectively ameliorate symptoms in experimental autoimmune encephalomyelitis (EAE) and prevent extensive changes in gut microbiota composition. The findings suggest the therapeutic potential of MDSCs in the acute phases of multiple sclerosis (MS) and the importance of gut microbiota in MS therapy.
Article
Parasitology
S. Vasilev, B. Suvajdzic, I Mitic, Lj Sabljic, N. Karabasil, Lj Sofronic Milosavljevic, D. Vasilev
Summary: This study compared the efficacy of an aerosol-resistant pepsin powder to conventional pepsin powder in detecting Trichinella spp. larvae. The results showed that the aerosol-resistant pepsin was as effective as the conventional pepsin and safer for analysts.
JOURNAL OF HELMINTHOLOGY
(2022)
Article
Biology
Natasa Ilic, Zanka Bojic-Trbojevic, Britta Lundstroem-Stadelmann, Danica Cujic, Ivana Mitic, Alisa Gruden-Movsesijan
Summary: This study demonstrates the immunomodulatory potential of Trichinella spiralis muscle larvae excretory-secretory products and suggests their possible use as a treatment for inflammatory disorders. The isolated proteins possess galectin-1 properties and induce tolerogenic dendritic cells and regulatory T cells.
Article
Parasitology
N. Ilic, S. Vasilev, A. Gruden-Movsesijan, M. Gnjatovic, Lj Sofronic-Milosavljevic, I Mitic
Summary: This study evaluated the immunoserological, biochemical, and symptomatic disease parameters of patients with trichinellosis. The results showed long-lasting humoral immune response and chronic muscular pain, which significantly affected their daily living activities.
JOURNAL OF HELMINTHOLOGY
(2022)