Targeting of the Hydrophobic Metabolome by Pathogens

The Anti-Inflammatory Effects of Prostaglandins

(2016) Jose U. Scher et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Lipidomics: Analysis of the Lipid Composition of Cells and Subcellular Organelles by Electrospray Ionization Mass Spectrometry

(2014) Britta Brügger   Annual Review of Biochemistry

Rhinovirus Uses a Phosphatidylinositol 4-Phosphate/Cholesterol Counter-Current for the Formation of Replication Compartments at the ER-Golgi Interface

(2014) Pascal S. Roulin et al.   Cell Host & Microbe

Lipid interactions during virus entry and infection

(2014) Michela Mazzon et al.   CELLULAR MICROBIOLOGY

Interaction of pathogens with host cholesterol metabolism

(2014) Dmitri Sviridov et al.   CURRENT OPINION IN LIPIDOLOGY

Oxysterol-Binding Protein Is a Phosphatidylinositol 4-Kinase Effector Required for HCV Replication Membrane Integrity and Cholesterol Trafficking

(2014) Hongliang Wang et al.   GASTROENTEROLOGY

The Critical Role of Membrane Cholesterol in Salmonella-Induced Autophagy in Intestinal Epithelial Cells

(2014) Fu-Chen Huang   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lipidomics identifies a requirement for peroxisomal function during influenza virus replication

(2014) Lukas Bahati Tanner et al.   JOURNAL OF LIPID RESEARCH

Importance of Sphingosine Kinase (SphK) as a Target in Developing Cancer Therapeutics and Recent Developments in the Synthesis of Novel SphK Inhibitors

(2014) Daniel Plano et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Composition of West Nile Virus Lipid Envelope Unveils a Role of Sphingolipid Metabolism in Flavivirus Biogenesis

(2014) M. A. Martin-Acebes et al.   JOURNAL OF VIROLOGY

Phosphatidylinositol-4 kinase III beta and oxysterol-binding protein accumulate unesterified cholesterol on poliovirus-induced membrane structure

(2014) Minetaro Arita   MICROBIOLOGY AND IMMUNOLOGY

Oxidized Fatty Acids as Inter-Kingdom Signaling Molecules

(2014) Carolina Pohl et al.   MOLECULES

RAB11-mediated trafficking in host–pathogen interactions

(2014) Annabel Guichard et al.   NATURE REVIEWS MICROBIOLOGY

Lipid requirements for entry of protein toxins into cells

(2014) Kirsten Sandvig et al.   PROGRESS IN LIPID RESEARCH

Membranous Replication Factories Induced by Plus-Strand RNA Viruses

(2014) Inés Romero-Brey et al.   Viruses-Basel

Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranes

(2014) Rodney K. Lyn et al.   Scientific Reports

De novo Fatty Acid Biosynthesis Contributes Significantly to Establishment of a Bioenergetically Favorable Environment for Vaccinia Virus Infection

(2014) Matthew D. Greseth et al.   PLoS Pathogens

Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal PhenotypeIn Vivo

(2013) Catherine Spickler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Novel, Broad-Spectrum Inhibitor of Enterovirus Replication That Targets Host Cell Factor Phosphatidylinositol 4-Kinase IIIβ

(2013) Hilde M. van der Schaar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP

(2013) Bruno Mesmin et al.   CELL

Enteroviruses Harness the Cellular Endocytic Machinery to Remodel the Host Cell Cholesterol Landscape for Effective Viral Replication

(2013) Olha Ilnytska et al.   Cell Host & Microbe

The Antiviral Effector IFITM3 Disrupts Intracellular Cholesterol Homeostasis to Block Viral Entry

(2013) Samad Amini-Bavil-Olyaee et al.   Cell Host & Microbe

Exploitation of host lipids by bacteria

(2013) François Vromman et al.   CURRENT OPINION IN MICROBIOLOGY

Retrograde transport of protein toxins through the Golgi apparatus

(2013) Kirsten Sandvig et al.   HISTOCHEMISTRY AND CELL BIOLOGY

LtpD Is a Novel Legionella pneumophila Effector That Binds Phosphatidylinositol 3-Phosphate and Inositol Monophosphatase IMPA1

(2013) Clare R. Harding et al.   INFECTION AND IMMUNITY

Morphological and Biochemical Characterization of the Membranous Hepatitis C Virus Replication Compartment

(2013) D. Paul et al.   JOURNAL OF VIROLOGY

Host-lipidome as a potential target of protozoan parasites

(2013) Abdur Rub et al.   MICROBES AND INFECTION

Toxoplasma gondii salvages sphingolipids from the host Golgi through the rerouting of selected Rab vesicles to the parasitophorous vacuole

(2013) Julia D. Romano et al.   MOLECULAR BIOLOGY OF THE CELL

Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids

(2013) C. J. Cambier et al.   NATURE

The non-canonical roles of clathrin and actin in pathogen internalization, egress and spread

(2013) Ashley C. Humphries et al.   NATURE REVIEWS MICROBIOLOGY

Targeting lipid biosynthesis and salvage in apicomplexan parasites for improved chemotherapies

(2013) Isabelle Coppens   NATURE REVIEWS MICROBIOLOGY

Oxysterol-binding proteins: Sterol and phosphoinositide sensors coordinating transport, signaling and metabolism

(2013) Vesa M. Olkkonen et al.   PROGRESS IN LIPID RESEARCH

Lipid synthesis in protozoan parasites: A comparison between kinetoplastids and apicomplexans

(2013) Srinivasan Ramakrishnan et al.   PROGRESS IN LIPID RESEARCH

Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans

(2013) Jean-Marie Galano et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections

(2013) Vincent C. Tam   SEMINARS IN IMMUNOLOGY

The Lipid Kinase Phosphatidylinositol-4 Kinase III Alpha Regulates the Phosphorylation Status of Hepatitis C Virus NS5A

(2013) Simon Reiss et al.   PLoS Pathogens

Increased Long Chain acyl-Coa Synthetase Activity and Fatty Acid Import Is Linked to Membrane Synthesis for Development of Picornavirus Replication Organelles

(2013) Jules A. Nchoutmboube et al.   PLoS Pathogens

Bacterial Colonization of Host Cells in the Absence of Cholesterol

(2013) Stacey D. Gilk et al.   PLoS Pathogens

PGE2 suppression of innate immunity during mucosal bacterial infection

(2013) Mallory Agard et al.   Frontiers in Cellular and Infection Microbiology

Cell signalling by reactive lipid species: new concepts and molecular mechanisms

(2012) Ashlee Higdon et al.   BIOCHEMICAL JOURNAL

Lipid acquisition by intracellular Chlamydiae

(2012) Cherilyn A. Elwell et al.   CELLULAR MICROBIOLOGY

Lipids at the interface of virus–host interactions

(2012) Vineela Chukkapalli et al.   CURRENT OPINION IN MICROBIOLOGY

Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol

(2012) Su-Yang Liu et al.   IMMUNITY

The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response

(2012) Mathieu Blanc et al.   IMMUNITY

ASalmonella typhimurium-translocated Glycerophospholipid:Cholesterol Acyltransferase Promotes Virulence by Binding to the RhoA Protein Switch Regions

(2012) Doris L. LaRock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leishmania-Induced Biphasic Ceramide Generation in Macrophages Is Crucial for Uptake and Survival of the Parasite

(2012) Saikat Majumder et al.   JOURNAL OF INFECTIOUS DISEASES

Lipid Metabolite Profiling Identifies Desmosterol Metabolism as a New Antiviral Target for Hepatitis C Virus

(2012) Mary A. Rodgers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Arenavirus Infection Induces Discrete Cytosolic Structures for RNA Replication

(2012) N. L. Baird et al.   JOURNAL OF VIROLOGY

Cytosolic lipid inclusions formed during infection by viral and bacterial pathogens

(2012) Matthias Stehr et al.   MICROBES AND INFECTION

Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain

(2012) F.-Xabier Contreras et al.   NATURE

An accelerated workflow for untargeted metabolomics using the METLIN database

(2012) Ralf Tautenhahn et al.   NATURE BIOTECHNOLOGY

Metabolomics: the apogee of the omics trilogy

(2012) Gary J. Patti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HMDB 3.0—The Human Metabolome Database in 2013

(2012) David S. Wishart et al.   NUCLEIC ACIDS RESEARCH

ARF1 and GBF1 Generate a PI4P-Enriched Environment Supportive of Hepatitis C Virus Replication

(2012) Leiliang Zhang et al.   PLoS One

Metabolic Responses of Primary and Transformed Cells to Intracellular Listeria monocytogenes

(2012) Nadine Gillmaier et al.   PLoS One

The Host Endocytic Pathway is Essential for Plasmodium berghei Late Liver Stage Development

(2012) Mafalda Lopes da Silva et al.   TRAFFIC

Secretive Bacterial Pathogens and the Secretory Pathway

(2012) Hubert Hilbi et al.   TRAFFIC

Bacterial Pathogens Commandeer Rab GTPases to Establish Intracellular Niches

(2012) Mary-Pat Stein et al.   TRAFFIC

Dengue Virus Infection Perturbs Lipid Homeostasis in Infected Mosquito Cells

(2012) Rushika Perera et al.   PLoS Pathogens

Self-Enhancement of Hepatitis C Virus Replication by Promotion of Specific Sphingolipid Biosynthesis

(2012) Yuichi Hirata et al.   PLoS Pathogens

AMP-Activated Kinase Restricts Rift Valley Fever Virus Infection by Inhibiting Fatty Acid Synthesis

(2012) Theresa S. Moser et al.   PLoS Pathogens

Applications of Mass Spectrometry to Lipids and Membranes

(2011) Richard Harkewicz et al.   Annual Review of Biochemistry

Liquid chromatographic–mass spectrometric analysis of phospholipids. Chromatography, ionization and quantification

(2011) Jos F. Brouwers   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Manipulation of vascular function by blood flukes?

(2011) Akram Da'dara et al.   BLOOD REVIEWS

Recruitment and Activation of a Lipid Kinase by Hepatitis C Virus NS5A Is Essential for Integrity of the Membranous Replication Compartment

(2011) Simon Reiss et al.   Cell Host & Microbe

ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites

(2011) Jun Sasaki et al.   EMBO JOURNAL

The Deubiquitinase Activity of the Salmonella Pathogenicity Island 2 Effector, SseL, Prevents Accumulation of Cellular Lipid Droplets

(2011) Ellen T. Arena et al.   INFECTION AND IMMUNITY

Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses

(2011) Xianlin Han et al.   MASS SPECTROMETRY REVIEWS

Production of prostaglandins, isoprostanes and thromboxane by Aspergillus fumigatus: Identification by gas chromatography–tandem mass spectrometry and quantification by enzyme immunoassay

(2011) Claudio Kupfahl et al.   MOLECULAR IMMUNOLOGY

RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42

(2011) B. Misselwitz et al.   Molecular Systems Biology

Manipulation of host membranes by bacterial effectors

(2011) Hyeilin Ham et al.   NATURE REVIEWS MICROBIOLOGY

GLAMM: Genome-Linked Application for Metabolic Maps

(2011) J. T. Bates et al.   NUCLEIC ACIDS RESEARCH

West Nile Virus Replication Requires Fatty Acid Synthesis but Is Independent on Phosphatidylinositol-4-Phosphate Lipids

(2011) Miguel A. Martín-Acebes et al.   PLoS One

The Role of the Phosphatidylinositol 4-Kinase PI4KA in Hepatitis C Virus-Induced Host Membrane Rearrangement

(2011) Andrew W. Tai et al.   PLoS One

Biochemistry and cell signaling taught by bacterial effectors

(2011) Jixin Cui et al.   TRENDS IN BIOCHEMICAL SCIENCES

Role of Lipids in Virus Replication

(2011) M. Lorizate et al.   Cold Spring Harbor Perspectives in Biology

Mycobacterium tuberculosis Uses Host Triacylglycerol to Accumulate Lipid Droplets and Acquires a Dormancy-Like Phenotype in Lipid-Loaded Macrophages

(2011) Jaiyanth Daniel et al.   PLoS Pathogens

Virus Entry by Endocytosis

(2010) Jason Mercer et al.   Annual Review of Biochemistry

Lipidomics: New Tools and Applications

(2010) Markus R. Wenk   CELL

Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication

(2010) Nai-Yun Hsu et al.   CELL

The Phosphoinositide Phosphatase SopB Manipulates Membrane Surface Charge and Trafficking of the Salmonella-Containing Vacuole

(2010) Malina A. Bakowski et al.   Cell Host & Microbe

Cytoplasmic Viral Replication Complexes

(2010) Johan A. den Boon et al.   Cell Host & Microbe

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

Revitalizing membrane rafts: new tools and insights

(2010) Kai Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipidomics: coming to grips with lipid diversity

(2010) Andrej Shevchenko et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase

(2010) J. Mankouri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis

(2010) N. S. Heaton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Functional Genomic Screen Identifies Cellular Cofactors of Hepatitis C Virus Replication

(2009) Andrew W. Tai et al.   Cell Host & Microbe

Mass spectrometry: from proteomics to metabolomics and lipidomics

(2009) William J. Griffiths et al.   CHEMICAL SOCIETY REVIEWS

Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening

(2009) Maud Trotard et al.   FASEB JOURNAL

Thematic Review Series: Proteomics.An integrated omics analysis of eicosanoid biology,

(2009) Matthew W. Buczynski et al.   JOURNAL OF LIPID RESEARCH

Identification of an Overabundant Cholesterol Precursor in Hepatitis B Virus Replicating Cells by Untargeted Lipid Metabolite Profiling

(2009) Mary A. Rodgers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication

(2009) J. Borawski et al.   JOURNAL OF VIROLOGY

Role of Oxysterol Binding Protein in Hepatitis C Virus infection

(2009) Y. Amako et al.   JOURNAL OF VIROLOGY

Role of Cholesterol Pathways in Norovirus Replication

(2009) K.-O. Chang   JOURNAL OF VIROLOGY

Pathogen trafficking pathways and host phosphoinositide metabolism

(2009) Stefan S. Weber et al.   MOLECULAR MICROBIOLOGY

Lipidomics joins the omics evolution

(2009) E. A. Dennis   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication

(2009) K. L. Berger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis of oxylipins in non-mammals

(2009) Alexandra Andreou et al.   PROGRESS IN LIPID RESEARCH

Lipids in host–pathogen interactions: Pathogens exploit the complexity of the host cell lipidome

(2009) Ynske P.M. van der Meer-Janssen et al.   PROGRESS IN LIPID RESEARCH

Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication

(2009) Frédéric H. Vaillancourt et al.   VIROLOGY

Cholesterol biosynthesis modulation regulates dengue viral replication

(2009) Christopher Rothwell et al.   VIROLOGY

Host-bacteria interactions in the intestine: homeostasis to chronic inflammation

(2009) Theolis Barbosa et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production

(2008) Wei Yang et al.   HEPATOLOGY

The Gregarious Lipid Droplet

(2008) Joel M. Goodman   JOURNAL OF BIOLOGICAL CHEMISTRY

SopB promotes phosphatidylinositol 3-phosphate formation onSalmonellavacuoles by recruiting Rab5 and Vps34

(2008) Gustavo V. Mallo et al.   JOURNAL OF CELL BIOLOGY

Esterification of cholesterol by a type III secretion effector during intracellular Salmonella infection

(2008) Parwez Nawabi et al.   MOLECULAR MICROBIOLOGY

Modification of intracellular membrane structures for virus replication

(2008) Sven Miller et al.   NATURE REVIEWS MICROBIOLOGY

Cytoplasmic lipid droplets are translocated into the lumen of the Chlamydia trachomatis parasitophorous vacuole

(2008) J. L. Cocchiaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycobacterial persistence requires the utilization of host cholesterol

(2008) A. K. Pandey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fungi and inflammatory bowel diseases: Alterations of composition and diversity

(2008) Stephan J. Ott et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Vaccinia Virus Uses Macropinocytosis and Apoptotic Mimicry to Enter Host Cells

(2008) J. Mercer et al.   SCIENCE

The Chlamydial Inclusion Preferentially Intercepts Basolaterally Directed Sphingomyelin-Containing Exocytic Vacuoles

(2008) Elizabeth R. Moore et al.   TRAFFIC

Sphingomyelin Functions as a Novel Receptor for Helicobacter pylori VacA

(2008) Vijay R. Gupta et al.   PLoS Pathogens

Informatics and computational strategies for the study of lipids

(2007) Laxman Yetukuri et al.   Molecular BioSystems