NLRP3 Inflammasome Formation and Activation in Nonalcoholic Steatohepatitis: Therapeutic Target for Antimetabolic Syndrome Remedy FTZ

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

NLRP3 inflammasome as a novel target for docosahexaenoic acid metabolites to abrogate glomerular injury

(2017) Guangbi Li et al.   JOURNAL OF LIPID RESEARCH

A critical role for the NLRP3 inflammasome in NASH

(2017) Hugh Thomas   Nature Reviews Gastroenterology & Hepatology

Conophylline inhibits non-alcoholic steatohepatitis in mice

(2017) Yukiomi Nakade et al.   PLoS One

Contribution of redox-dependent activation of endothelial Nlrp3 inflammasomes to hyperglycemia-induced endothelial dysfunction

(2016) Yang Chen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Activation of NLRP3 inflammasomes in mouse hepatic stellate cells during Schistosoma J. infection

(2016) Nan Meng et al.   Oncotarget

Coronary Endothelial Dysfunction Induced by Nucleotide Oligomerization Domain-Like Receptor Protein with Pyrin Domain Containing 3 Inflammasome Activation During Hypercholesterolemia: Beyond Inflammation

(2015) Yang Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Cardiovascular Pathobiology of Inflammasomes: Inflammatory Machinery and Beyond

(2015) Pin-Lan Li   ANTIOXIDANTS & REDOX SIGNALING

Endothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritis

(2015) Yang Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1

(2015) Yang Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Anti-HMGB1 antibody reduces weight gain in mice fed a high-fat diet

(2015) V N Montes et al.   Nutrition & Diabetes

Endothelial NLRP3 Inflammasome Activation and Enhanced Neointima Formation in Mice by Adipokine Visfatin

(2014) Min Xia et al.   AMERICAN JOURNAL OF PATHOLOGY

Activation of inflammasomes in podocyte injury of mice on the high fat diet: Effects of ASC gene deletion and silencing

(2014) Krishna M. Boini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

High Mobility Group Box-1 (HMGB1) Participates in the Pathogenesis of Alcoholic Liver Disease (ALD)

(2014) Xiaodong Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nod-like Receptor Protein 3 (NLRP3) Inflammasome Activation and Podocyte Injury via Thioredoxin-Interacting Protein (TXNIP) during Hyperhomocysteinemia

(2014) Justine M. Abais et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chinese herbal medicine FTZ attenuates insulin resistance via IRS1 and PI3K in vitro and in rats with metabolic syndrome

(2014) Xuguang Hu et al.   Journal of Translational Medicine

Tumor Necrosis Factor-Alpha Induced by Hepatitis B Virus Core Mediating the Immune Response for Hepatitis B Viral Clearance in Mice Model

(2014) Horng-Tay Tzeng et al.   PLoS One

Inflammation triggers high mobility group box 1 (HMGB1) secretion in adipose tissue, a potential link to obesity

(2013) Manoj Kumar Gunasekaran et al.   CYTOKINE

In VitroScreening for Antihepatic Steatosis Active Components within Coptidis Rhizoma Alkaloids Extract Using Liver Cell Extraction with HPLC Analysis and a Free Fatty Acid-Induced Hepatic Steatosis HepG2 Cell Assay

(2013) Hui Fan et al.   Evidence-based Complementary and Alternative Medicine

Contribution of endogenously produced reactive oxygen species to the activation of podocyte NLRP3 inflammasomes in hyperhomocysteinemia

(2013) Justine M. Abais et al.   FREE RADICAL BIOLOGY AND MEDICINE

Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice

(2013) Kengo Tomita et al.   HEPATOLOGY

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

Contribution of NADPH Oxidase to Membrane CD38 Internalization and Activation in Coronary Arterial Myocytes

(2013) Ming Xu et al.   PLoS One

NADPH Oxidase-Mediated Triggering of Inflammasome Activation in Mouse Podocytes and Glomeruli During Hyperhomocysteinemia

(2012) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Activation of Nod-Like Receptor Protein 3 Inflammasomes Turns on Podocyte Injury and Glomerular Sclerosis in Hyperhomocysteinemia

(2012) Chun Zhang et al.   HYPERTENSION

TRAIL death receptor 4 signaling via lysosome fusion and membrane raft clustering in coronary arterial endothelial cells: evidence from ASM knockout mice

(2012) Xiang Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Effects of Fufang Zhenzhu Tiaozhi Prescription (复方贞术调脂方), A Chinese herbal preparation, on atherosclerosis in ApoE-/- mice and related mechanisms

(2011) Fu-tian Tang et al.   Chinese Journal of Integrative Medicine

A new TCM formula FTZ lowers serum cholesterol by regulating HMG-CoA reductase and CYP7A1 in hyperlipidemic rats

(2011) Jiao Guo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Visfatin-induced lipid raft redox signaling platforms and dysfunction in glomerular endothelial cells

(2010) Krishna M. Boini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Evaluation of foam cell formation in cultured macrophages: an improved method with Oil Red O staining and DiI-oxLDL uptake

(2010) Suowen Xu et al.   CYTOTECHNOLOGY

Intracellular reactive oxygen species are required for directional migration of resident and bone marrow-derived hepatic pro-fibrogenic cells

(2010) Erica Novo et al.   JOURNAL OF HEPATOLOGY