Reactive nitroxidative species and nociceptive processing: determining the roles for nitric oxide, superoxide, and peroxynitrite in pain

NMDA-receptor activation and nitroxidative regulation of the glutamatergic pathway during nociceptive processing

(2010) Zhoumou Chen et al.   PAIN

Reactive oxygen species in rats with chronic post-ischemia pain

(2009) K. H. KWAK et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

(2009) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

Involvement of NMDA receptor in nociceptive effects elicited by intrathecal [Tyr6] γ2-MSH(6-12), and the interaction with nociceptin/orphanin FQ in pain modulation in mice

(2009) Min Chang et al.   BRAIN RESEARCH

Opposing actions of neuronal nitric oxide synthase isoforms in formalin-induced pain in mice

(2009) Yuri A. Kolesnikov et al.   BRAIN RESEARCH

Glial activation in the rostroventromedial medulla promotes descending facilitation to mediate inflammatory hypersensitivity

(2009) Jill Roberts et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cell-type specific activation of p38 and ERK mediates calcitonin gene-related peptide involvement in tolerance to morphine-induced analgesia

(2009) Zhiyong Wang et al.   FASEB JOURNAL

Does the Unfavorable Pharmacokinetic and Pharmacodynamic Profile of the iNOS Inhibitor GW273629 Lead to Inefficacy in Acute Migraine?

(2009) B. J. Van der Schueren et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Impaired Priming and Activation of the Neutrophil NADPH Oxidase in Patients with IRAK4 or NEMO Deficiency

(2009) Anjali Singh et al.   JOURNAL OF IMMUNOLOGY

NMDA Receptor Activation Increases Free Radical Production through Nitric Oxide and NOX2

(2009) H. Girouard et al.   JOURNAL OF NEUROSCIENCE

Persistent Inflammation Induces GluR2 Internalization via NMDA Receptor-Triggered PKC Activation in Dorsal Horn Neurons

(2009) J.-S. Park et al.   JOURNAL OF NEUROSCIENCE

Persistent Pain Is Dependent on Spinal Mitochondrial Antioxidant Levels

(2009) E. S. Schwartz et al.   JOURNAL OF NEUROSCIENCE

Targeting peroxynitrite driven nitroxidative stress with synzymes: A novel therapeutic approach in chronic pain management

(2009) Daniela Salvemini et al.   LIFE SCIENCES

Reactive Oxygen Species Mediate TNFR1 Increase after TRPV1 Activation in Mouse DRG Neurons

(2009) Fei Ma et al.   Molecular Pain

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

(2009) Angela M Brennan et al.   NATURE NEUROSCIENCE

Superoxide signaling in pain is independent of nitric oxide signaling

(2009) Hee Young Kim et al.   NEUROREPORT

Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance

(2009) T. Doyle et al.   NEUROSCIENCE

Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1β

(2009) S.S. Lewis et al.   NEUROSCIENCE

Spinal ceramide and neuronal apoptosis in morphine antinociceptive tolerance

(2009) Leesa Bryant et al.   NEUROSCIENCE LETTERS

Peripheral inflammation increased the synaptic expression of NMDA receptors in spinal dorsal horn

(2009) Xian Yang et al.   PAIN

The NALP1 inflammasome controls cytokine production and nociception in a rat fracture model of complex regional pain syndrome

(2009) Wen-Wu Li et al.   PAIN

Models and Mechanisms of Hyperalgesia and Allodynia

(2009) Jürgen Sandkühler   PHYSIOLOGICAL REVIEWS

Oxidative challenges sensitize the capsaicin receptor by covalent cysteine modification

(2009) H.-h. Chuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms involved in inflammasome activation

(2009) Clare Bryant et al.   TRENDS IN CELL BIOLOGY

Peroxynitrite: a strategic linchpin of opioid analgesic tolerance

(2009) Daniela Salvemini et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The “Toll” of Opioid-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia

(2009) Linda R. Watkins et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Peroxynitrite and opiate antinociceptive tolerance: A painful reality

(2008) Daniela Salvemini   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

NMDAR-nNOS generated zinc recruits PKCγ to the HINT1–RGS17 complex bound to the C terminus of Mu-opioid receptors

(2008) María Rodríguez-Muñoz et al.   CELLULAR SIGNALLING

Involvement of neuronal, inducible and endothelial nitric oxide synthases in capsaicin-induced muscle hypersensitivity

(2008) Jong-Seok Lee et al.   EUROPEAN JOURNAL OF PAIN

Amelioration of neurological and biochemical deficits by peroxynitrite decomposition catalysts in experimental diabetic neuropathy

(2008) Manish Arora et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Peripheral antinociceptive effects of µ- and δ-opioid receptor agonists in NOS2 and NOS1 knockout mice during chronic inflammatory pain

(2008) Sergi Leánez et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity

(2008) Michael M. Ndengele et al.   FASEB JOURNAL

Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways

(2008) Ines Batinić-Haberle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glial TLR4 receptor as new target to treat neuropathic pain: Efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice

(2008) Isabella Bettoni et al.   GLIA

Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidases

(2008) Timothy J. Harrigan et al.   JOURNAL OF NEUROCHEMISTRY

Translocation of GluR1-Containing AMPA Receptors to a Spinal Nociceptive Synapse during Acute Noxious Stimulation

(2008) M. Larsson et al.   JOURNAL OF NEUROSCIENCE

Reactive Oxygen Species Derived from NOX1/NADPH Oxidase Enhance Inflammatory Pain

(2008) M. Ibi et al.   JOURNAL OF NEUROSCIENCE

Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase

(2008) C. Cheret et al.   JOURNAL OF NEUROSCIENCE

Supraspinal Glial-Neuronal Interactions Contribute to Descending Pain Facilitation

(2008) F. Wei et al.   JOURNAL OF NEUROSCIENCE

Spinal Ceramide Modulates the Development of Morphine Antinociceptive Tolerance via Peroxynitrite-Mediated Nitroxidative Stress and Neuroimmune Activation

(2008) M. M. Ndengele et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pathological and protective roles of glia in chronic pain

(2008) Erin D. Milligan et al.   NATURE REVIEWS NEUROSCIENCE

Fluorocitrate, an Inhibitor of Glial Metabolism, Inhibits the Up-Regulation of NOS Expression, Activity and NO Production in the Spinal Cord Induced by Formalin Test in Rats

(2008) Xiao-Cai Sun et al.   NEUROCHEMICAL RESEARCH

Pharmacological assessments of nitric oxide synthase isoforms and downstream diversity of NO signaling in the maintenance of thermal and mechanical hypersensitivity after peripheral nerve injury in mice

(2008) Mitsuo Tanabe et al.   NEUROPHARMACOLOGY

The contributing role of CD14 in toll-like receptor 4 dependent neuropathic pain

(2008) L. Cao et al.   NEUROSCIENCE

Phenyl N-t-butylnitrone, a reactive oxygen species scavenger, reduces zymosan-induced visceral pain in rats

(2008) Jigong Wang et al.   NEUROSCIENCE LETTERS

Oxidative stress in the spinal cord is an important contributor in capsaicin-induced mechanical secondary hyperalgesia in mice

(2008) Erica S. Schwartz et al.   PAIN

Hydrogen peroxide is a novel mediator of inflammatory hyperalgesia, acting via transient receptor potential vanilloid 1-dependent and independent mechanisms

(2008) Julie Elizabeth Keeble et al.   PAIN

The purinergic antagonist PPADS reduces pain related behaviours and interleukin-1β, interleukin-6, iNOS and nNOS overproduction in central and peripheral nervous system after peripheral neuropathy in mice

(2007) Cataldo Martucci et al.   PAIN