Article
Pharmacology & Pharmacy
Nathan Hayes, Mark Fogarty, Laura Sadofsky, Huw Simon Jones
Summary: Age-related frailty is a significant health and social care burden, and there is a lack of suitable cell culture model for screening compounds to promote healthy skeletal muscle function. This study used C2C12 cells to characterize the changes in reactive oxygen and nitrogen species (RONS) signaling in young and aged myoblasts and myotubes, and assessed the effect of dietary polyphenols on RONS signaling in aged cultures. The findings showed increased RONS levels in aged cells and identified kaempferol and resveratrol as compounds that can modulate RONS signaling in skeletal muscle cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Carlos Rodrigo Castro-Castaneda, Francisco Altamirano-Lamarque, Alan Gabriel Ortega-Macias, Francisco J. Santa Cruz-Pavlovich, Alejandro Gonzalez-De la Rosa, Juan Armendariz-Borunda, Arturo Santos, Jose Navarro-Partida
Summary: This article reviews the positive impact of nutraceuticals on various ophthalmic conditions and highlights the results of clinical trials.
Review
Immunology
Sanni Kumar, Juhi Saxena, Vijay Kumar Srivastava, Sanket Kaushik, Himadri Singh, Khaled Abo-El-Sooud, Mohamed M. Abdel-Daim, Anupam Jyoti, Rohit Saluja
Summary: The antioxidant defense system plays a crucial role in reducing oxidative stress by limiting the amount of reactive oxygen species in sepsis. Despite a strong relationship between scavengers of ROS and antioxidants, the comprehensive understanding of ROS scavenging in cellular antioxidant signaling remains lacking in sepsis research.
Review
Biochemistry & Molecular Biology
Hirofumi Kiyokawa, Yuma Hoshino, Kazuhiro Sakaguchi, Shigeo Muro, Junji Yodoi
Summary: Epithelial cells in the respiratory system are directly exposed to exogenous ROS, increasing the risk of oxidative stress; Dysfunction of redox regulation due to cellular aging accelerates COPD pathogenesis; Drugs targeting oxidative stress pathways can help precisely regulate the redox system.
Article
Biochemistry & Molecular Biology
Dongwei Wang, Yani Deng, Lei Zhao, Kai Wang, Dongmei Wu, Zhuoyan Hu, Xuwei Liu
Summary: This study aimed to explore the potential of GABA and fermented litchi juice enriched with GABA (FLJ) in protecting against obesity in a high-fat diet mouse model. Supplementation of GABA and FLJ showed an anti-obesogenic effect by reducing body weight gain, fat accumulation, and oxidative damage, and improving serum lipid profile and hepatic function. Sequencing of fecal samples indicated that GABA and FLJ intervention had different regulatory effects on gut microbiota dysbiosis induced by the high-fat diet.
Review
Biochemistry & Molecular Biology
Pawel Kowalczyk, Dorota Sulejczak, Patrycja Kleczkowska, Iwona Bukowska-Osko, Marzena Kucia, Marta Popiel, Ewa Wietrak, Karol Kramkowski, Karol Wrzosek, Katarzyna Kaczynska
Summary: Oxidative stress arises from excessive production of ROS and impairment of antioxidant defense systems, leading to damage to cellular biomolecules such as DNA and contributing to cellular damage and disease development. Research has highlighted the significant role of mitochondrial oxidative stress in a variety of pathological processes, from Alzheimer's disease to autoimmune type 1 diabetes, and explored therapeutic approaches targeting oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Wenlong Hao, Minghao Li, Qingmin Cai, Shiying Wu, Xiangyao Li, Quanyu He, Yongbin Hu
Summary: This review discusses the KEAP1/NRF2 signaling mechanisms and recent advances in understanding the role of NRF2 in primary fibrotic lesions. It also explores the therapeutic potential of antioxidant substances and drugs and summarizes the prospects of NRF2 in fibrosis treatment.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Cell Biology
Ming-Ming Chen, Yan Li, Shou-Long Deng, Yue Zhao, Zheng-Xing Lian, Kun Yu
Summary: Mitochondria in skeletal muscle play an important role in producing ATP for muscle contraction, but also produce reactive species as byproducts. Traditionally, an increase in reactive oxygen/nitrogen species (RONS) is associated with oxidative stress and muscle dysfunction, but recent studies have highlighted the physiological significance of an optimal RONS level in skeletal muscle under the influence of antioxidants.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Genaro Gabriel Ortiz, Ana Laura Briones-Torres, Gloria Benitez-King, Luis Javier Gonzalez-Ortiz, Claudia Veronica Palacios-Magana, Fermin Paul Pacheco-Moises
Summary: Melatonin has therapeutic properties in experimental autoimmune encephalomyelitis (EAE), inhibiting inflammation, reducing oxidative stress, and preserving membrane fluidity. It could be an adjuvant treatment for multiple sclerosis (MS) based on preclinical evidence.
Review
Biochemistry & Molecular Biology
Shima Taherkhani, Katsuhiko Suzuki, Ruheea Taskin Ruhee
Summary: The excessive consumption of nutrients, especially fast-foods, and a sedentary lifestyle are leading causes of obesity associated with oxidative stress (OS). Antioxidant supplements are highly regarded for their ability to neutralize reactive oxygen species (ROS) in improving obesity. However, inconsistent results from studies on animal response to antioxidant supplements suggest a need for further research, especially in humans.
Review
Biochemistry & Molecular Biology
Lital Argaev-Frenkel, Tovit Rosenzweig
Summary: Oxidative stress is a crucial factor in the development of type 2 diabetes (T2D) and its associated complications. However, there is insufficient evidence to support the effectiveness of antioxidants (AOXs) in treating this disease. Inappropriate dosing of AOXs and the individual variation in the presence and severity of oxidative stress may explain the lack of benefits from AOX therapy.
Article
Oncology
Valentina Rossi, Marzia Govoni, Giuseppina Di Stefano
Summary: Cancer cells consume large amounts of glucose and produce increased lactate, which was recently found to play a role in gene expression regulation and drug resistance. This study aimed to investigate whether increased lactate levels can affect the anticancer efficacy of doxorubicin. Lactate was found to offer protection against oxidative damage caused by the drug, which is important in mediating its cardiotoxic effects.
Article
Environmental Sciences
Yu Wang, Hongjing Zhao, Yachen Liu, Jingyan Li, Xiaopan Nie, Puyi Huang, Mingwei Xing
Summary: This study revealed the therapeutic effect of Lycopene (LYC) on sulfamethoxazole (SMZ)-induced intestinal injury in grass carp, showing that LYC can suppress intestinal damage, oxidative stress, inflammation, and apoptosis, as well as reduce autophagy activation caused by SMZ.
ENVIRONMENTAL POLLUTION
(2021)
Review
Neurosciences
Jiahao Zhang, Zeyu Zhang, Xiaoyu Wang, Yibo Liu, Qian Yu, Kaikai Wang, Yuanjian Fang, Cameron Lenahan, Maohua Chen, Sheng Chen
Summary: Spontaneous subarachnoid hemorrhage (SAH) is a devastating form of stroke with limited treatment options and poor patient outcomes. Early brain injury (EBI) occurring within 72 hours after SAH has been suggested to contribute to its poor clinical outcomes. Oxidative stress, which damages subcellular organelles, such as mitochondria and endoplasmic reticulum (ER), is recognized as a main mechanism of EBI. This review discusses the connection between oxidative stress and subcellular organelles after SAH and summarizes promising therapeutic options based on these mechanisms.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Virology
Neda Yaghoubi, Masoud Youssefi, Farahzad Jabbari Azad, Faramarz Farzad, Zahra Yavari, Farnaz Zahedi Avval
Summary: The study found that COVID-19 patients may be more susceptible to reduced antioxidant capacity, and such variations in blood samples could be considered as a predictive marker of COVID-19 severity.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Raquel G. Bardallo, Garoa Santocildes, Joan Ramon Torrella, Teresa Carbonell, Gines Viscor
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Raquel G. Bardallo, Rui Teixeira da Silva, Teresa Carbonell, Emma Folch-Puy, Carlos Palmeira, Joan Rosello-Catafau, Jacques Pirenne, Rene Adam, Arnau Panisello-Rosello
Summary: This study investigates the effects of PEG35 in different liver preservation solutions, showing that PEG35 promotes the activity of mitochondrial enzyme ALDH2 and, when combined with glutathione, prevents the formation of toxic aldehyde adducts, reducing damage in a fatty liver rat model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Debora Coimbra-Costa, Fernando Garzon, Norma Alva, Tiago C. C. Pinto, Fernando Aguado, Joan Ramon Torrella, Teresa Carbonell, Ramon Rama
Summary: Intermittent hypobaric hypoxia (IHH) exerted neuroprotection against acute severe hypoxia (ASH)-induced oxidative injury by preventing oxidative stress, inhibiting the apoptotic cascade, and modulating NF-kappa B and EPO levels in the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Raquel G. Bardallo, Arnau Panisello-Rosello, Sergio Sanchez-Nuno, Norma Alva, Joan Rosello-Catafau, Teresa Carbonell
Summary: In response to stress signal, Nrf2 regulates the expression of genes involved in antioxidant defense and detoxification, maintaining cellular homeostasis. During ischemia-reperfusion injury, Nrf2 activation can enhance cellular defense and promote hepatic recovery by mitigating oxidative stress and inflammation.
Article
Immunology
Rui Teixeira Da Silva, Raquel G. Bardallo, Emma Folch-Puy, Teresa Carbonell, Carlos M. Palmeira, Constantino Fondevila, Rene Adam, Joan Rosello-Catafau, Arnau Panisello-Rosello
Summary: Hypothermic static cold storage and machine perfusion are current clinical standards for liver graft preservation. Preservation of mitochondrial function and energy levels has emerged as a key aspect, but the relationship between liver mitochondrial protection and perfusate/solution use needs further investigation. The use of alternative solutions like IGL-2 shows promise in maintaining mitochondrial integrity and simplifying logistics, with potential for better transplantation outcomes.
TRANSPLANTATION PROCEEDINGS
(2022)
Article
Biochemistry & Molecular Biology
Raquel G. Bardallo, Idoia Company-Marin, Emma Folch-Puy, Joan Rosello-Catafau, Arnau Panisello-Rosello, Teresa Carbonell
Summary: The use of steatotic livers for transplantation poses a challenge due to increased vulnerability to ischemia-reperfusion injury. This study explores the benefits of adding PEG35 and glutathione (GSH) to preservation solutions for protecting against energy depletion and oxidative stress. The results show that the addition of PEG35 and GSH helps to maintain energy metabolism and prevent oxidative stress, making it a valuable option for organ preservation in clinical transplantation.
Review
Biochemistry & Molecular Biology
Raquel G. Bardallo, Rui T. da Silva, Teresa Carbonell, Carlos Palmeira, Emma Folch-Puy, Joan Rosello-Catafau, Rene Adam, Arnau Panisello-Rosello
Summary: This review examines the effects of preservation methods on mitochondrial functions in marginal liver grafts and discusses various preservation solutions and additives to protect mitochondrial machinery. The goal is to increase the pool of suitable organs and improve transplant outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Immunology
Arnau Panisello-Rosello, Rui T. da Silva, Emma Folch-Puy, Teresa Carbonell, Carlos M. Palmeira, Constantino Fondevila, Joan Rosello-Catafau, Rene Adam
Article
Biology
Alessandra Moreira-Reis, Jose Luis Mate-Munoz, Juan Hernandez-Lougedo, Sergio Vilches-Saez, Marta Benet, Pablo Garcia-Fernandez, Eulogio Pleguezuelos, Teresa Carbonell, Norma Alva, Manuel Vicente Garnacho-Castano
Summary: This study evaluated the effects of aerobic dance on obese and overweight elderly people in terms of body composition, oxidative stress, and muscular and cardiorespiratory fitness. The results showed that aerobic dance can be an effective alternative to lose weight, prevent oxidative stress, and improve cardiorespiratory fitness in this population.
Article
Multidisciplinary Sciences
Manuel Vicente Garnacho-Castano, Sergio Sanchez-Nuno, Lorena Molina-Raya, Teresa Carbonell, Jose Luis Mate-Munoz, Eulogio Pleguezuelos-Cobo, Noemi Serra-Paya
Summary: This study aimed to investigate the effects of circulating nitrate plus nitrite concentrations on resistance exercise performance, VO2 and biomarkers of muscle damage. The results showed that intake of beetroot juice can increase repetitions and reduce VO2, which is beneficial for improving exercise performance.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Alessandra Moreira-Reis, Jose Luis Mate-Munoz, Juan Hernandez-Lougedo, Pablo Garcia-Fernandez, Juan Ramon Heredia-Elvar, Eulogio Pleguezuelos, Teresa Carbonell, Norma Alva, Manuel Vicente Garnacho-Castano
Summary: This study compared the oxygen consumption, ventilatory efficiency, and blood lactate concentration between aerobic dance on an air dissipation platform and treadmill constant-load test. The results showed no significant differences in oxygen consumption and ventilatory efficiency between the two exercise modes, but higher blood lactate concentrations were observed during aerobic dance on an air dissipation platform at 10 and 20 minutes.
Article
Biochemistry & Molecular Biology
Iliana Lopez-Soldado, Adrian Gabriel Torres, Raul Ventura, Inma Martinez-Ruiz, Angels Diaz-Ramos, Evarist Planet, Diane J. Cooper, Agnieszka Pazderska, Krzysztof Wanic, Declan O'Hanlon, Donal J. O'Gorman, Teresa Carbonell, Lluis Ribas de Pouplana, John J. Nolan, Antonio Zorzano, Maria Isabel Hernandez-Alvareza
Summary: Type 2 diabetes mellitus (T2D) is a major contributor to morbidity and mortality, affecting millions of people worldwide. In this study, alterations in the expression of mitochondrial aminoacyl-tRNA synthetases (mt-aaRSs) in skeletal muscle of T2D patients were observed. The repression of mt-aaRSs expression was independent of age and could contribute to reduced protein synthesis in mitochondria. Additionally, an increased iNOS abundance in diabetic mice may inhibit the aminoacylation of mt-aaRSs, suggesting a regulatory role in diabetes.