Article
Biochemistry & Molecular Biology
Rasheed O. Sule, Brett S. Phinney, Michelle R. Salemi, Aldrin V. Gomes
Summary: Prometryn, a widely used herbicide, has been found to have effects on the cardiac system. Proteomic profiling revealed that prometryn may induce mitochondrial dysfunction and alter signaling pathways related to energy metabolism, protein degradation, and fatty acid metabolism in the heart.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Man Liu, Samuel C. Dudley
Summary: Magnesium is essential for cell functions and its deficiency (HypoMg) can lead to cardiovascular diseases. Magnesium supplementation and TRPM7 kinase inhibition may have therapeutic effects for HypoMg and other diseases.
Review
Biochemistry & Molecular Biology
Armita Mahdavi Gorabi, Saeed Aslani, George E. Barreto, Eliana Baez-Jurado, Nasim Kiaie, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: Neuroglobin, identified in 2000 in neurons of human and mouse nervous systems, is an oxygen-binding globin that provides protective effects against hypoxic/ischemic damage by promoting oxygen availability within the mitochondria. Impaired neuroglobin functioning has been linked to the pathogenesis of multiple neurodegenerative disorders. Studies have shown the potential of neuroglobin upregulation in improving neuroprotection through modulation of mitochondrial functions.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Ligia A. Kiyuna, Darlan S. Candido, Luiz R. G. Bechara, Itamar C. G. Jesus, Lisley S. Ramalho, Barbara Krum, Ruda P. Albuquerque, Juliane C. Campos, Luiz H. M. Bozi, Vanessa O. Zambelli, Ariane N. Alves, Nicolas Campolo, Mauricio Mastrogiovanni, Silvina Bartesaghi, Alejandro Leyva, Rosario Duran, Rafael Radi, Guilherme M. Arantes, Edecio Cunha-Neto, Marcelo A. Mori, Che-Hong Chen, Wenjin Yang, Daria Mochly-Rosen, Ian J. MacRae, Ludmila R. P. Ferreira, Julio C. B. Ferreira
Summary: This study investigates the mechanisms and potential treatment for the deleterious effects of 4-hydroxynonenal (4-HNE) in heart failure. The results show that 4-HNE inhibits Dicer, which impairs miRNA processing. Boosting 4-HNE clearance through pharmacological activation of aldehyde dehydrogenase 2 (ALDH2) restores Dicer activity and miRNA biogenesis, offering a potential treatment for heart failure patients.
EUROPEAN HEART JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Yi-Jen Hsueh, Yen-Ning Chen, Yu-Ting Tsao, Chao-Min Cheng, Wei-Chi Wu, Hung-Chi Chen
Summary: This article summarizes and provides updates on the research and treatment methods of ocular degenerative diseases related to oxidative stress. The article reviews the oxidative damage that occurs in different areas of the eye and introduces the antioxidant mechanisms present in the eye as well as the ocular diseases that occur as a result of antioxidant imbalances and relevant biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Alessandro Luciani, Matthew C. S. Denley, Larissa P. Govers, Vincenzo Sorrentino, D. Sean Froese
Summary: Mitochondria, as the powerhouse of the cell, play a crucial role in sustaining energy metabolism and homeostasis, especially in terminally differentiated cells. Dysregulation of the mitochondrial network can lead to a wide range of hereditary and acquired diseases, highlighting the importance of understanding and potentially reversing the pathophysiology of these disorders.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Neurosciences
Yifan Chen, Tianzheng Yu, Patricia Deuster
Summary: The hypothalamus plays a crucial role in regulating energy and temperature homeostasis and its response to heat stress involving mitochondrial dysfunction and apoptosis is explored in this study. Heat exposure induces mitochondrial fission, damage, apoptosis, and mitophagy in the hypothalamus, but pretreatment with the antioxidant AST can protect against these effects. Overall, heat stress-induced hypothalamic apoptosis is associated with altered mitochondrial dynamics favoring fission and mitophagy, which can be mitigated by AST through preserving redox homeostasis and mitochondrial integrity.
Article
Cell Biology
Khadidja Kessas, Zhor Chouari, Imen Ghzaiel, Amira Zarrouk, Mohamed Ksila, Taoufik Ghrairi, Adil El Midaoui, Gerard Lizard, Omar Kharoubi
Summary: This article discusses the role of mitochondria in metabolic processes and their relationship with oxidative stress, neurodegenerative diseases, and apoptosis. The study reveals the potential neuroprotective effects of bioactive compounds and the development of mitochondrial-targeted drugs to alleviate neurodegenerative diseases and promote healthy aging.
Review
Environmental Sciences
Tingting Wu, Zhigang Li, Yongjie Wei
Summary: Mitochondria are double-membraned organelles in eukaryotic cells that determine cell destiny and serve as energy factories. Inhalation of ozone, a highly oxidizing substance in the atmosphere, leads to mitochondrial oxidative stress overload, resulting in the destruction of mitochondrial structure and function and potentially causing various diseases. The specific molecular mechanisms involved in this process require further investigation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Cardiac & Cardiovascular Systems
Huijing Yu, Fang Zhang, Pengyi Yan, Shasha Zhang, Yingmei Lou, Zilong Geng, Zixuan Li, Yan Zhang, Yuejuan Xu, Yanan Lu, Chen Chen, Daowen Wang, Wei Zhu, Xinyang Hu, Jian'an Wang, Tao Zhuang, Yuzhen Zhang, Gengze Wu, Junling Liu, Chunyu Zeng, William T. Pu, Kun Sun, Bing Zhang
Summary: LARP7 plays a crucial role in mitochondrial biogenesis, energy production, and cardiac function by modulating SIRT1 homeostasis and activity. Reduction of LARP7 in diseased hearts contributes to heart failure pathogenesis, while restoring LARP7 in the injured heart confers myocardial protection, identifying the ATM-LARP7-SIRT1 pathway as a potential therapeutic target in heart failure.
Review
Biochemistry & Molecular Biology
Iveta Fizikova, Jozef Dragasek, Peter Racay
Summary: The complexity of the brain can lead to the development of serious neuropsychiatric disorders, such as schizophrenia. The etiopathogenesis of schizophrenia involves multiple mechanisms, highlighting its complexity and providing a new perspective for studying this disorder. This review focuses on the contribution of mitochondria, particularly oxidative damage, ROS, and energy metabolism. It also discusses the role of redox imbalance and lactate in oxidative stress, lipid peroxidation, and cognitive functions in schizophrenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Eleonora Zilio, Valentina Piano, Brunhilde Wirth
Summary: This review discusses the impact of spinal muscular atrophy (SMA) on mitochondrial functions in the neuronal and muscular systems, highlighting the potential contribution of mitochondrial defects to disease progression and the potential of restoring mitochondrial functionality as a therapeutic approach. The study also provides a list of transcripts encoding mitochondrial proteins affected in various SMA models and speculates that age-related mitochondrial deterioration may play a crucial role in adult SMA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Sun Joo Cha, Kiyoung Kim
Summary: Edaravone, as the first known free radical scavenger, has demonstrated cellular protective properties in animals and humans, particularly in terms of its antioxidant activity and its modulation of oxidative damage. The correlation between mitochondria and edaravone in neurodegenerative diseases remains to be elucidated, but recent studies have highlighted its potential therapeutic perspectives in terms of oxidative stress and mitochondrial function.
Article
Geriatrics & Gerontology
Sirawit Sriwichaiin, Nattayaporn Apaijai, Arintaya Phrommintikul, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Wasana Pratchayasakul, Nisakron Thongmung, Usanee Mahantassanapong, Prin Vathesatogkit, Chagriya Kitiyakara, Piyamitr Sritara, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Mitochondrial dysfunction is potentially associated with aging, although there is limited evidence regarding the relationship between mitochondrial function and aging. In this study, mitochondrial function was found to decline with age, with several parameters related to mitochondrial respiration significantly lower in older adults. However, mitochondrial ATP production and mitochondrial coupling efficiency were slightly increased in older adults. Additionally, mitochondrial mass and oxidative stress were significantly reduced in older individuals.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Cell Biology
Yonghu Chen, Yuqi Zhang, Ning Li, Zhe Jiang, Xuezheng Li
Summary: This review provides insights into the newly discovered mitochondrial regulation of the NLRP3 inflammasome in lung diseases, including the roles of mitochondrial autophagy, long noncoding RNA, micro RNA, altered mitochondrial membrane potential, cell membrane receptors, and ion channels in mitochondrial stress and NLRP3 inflammasome regulation. It also summarizes the effective components of potential drugs for the treatment of lung diseases under this mechanism.
INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Roszkowicz-Ostrowska, Patrycja Mlotkowska, Pawel Kowalczyk, Elzbieta Marciniak, Marcin Barszcz, Tomasz Misztal
Summary: This study found that centrally acting KYNA could positively affect neurotrophic factor signaling and DNA repair enzyme activities in the CA1 field of the hippocampus. Both lower and higher doses of KYNA increased the abundance of BDNF and TrkB mRNA, and stimulated DNA damage repair. However, the stimulatory effect on repair activity was less pronounced with the higher dose compared to the lower dose.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pawel Konieczka, Dominika Szkopek, Misza Kinsner, Pawel Kowalczyk, Monika Michalczuk, Damian Bien, Joanna Banach, Paulius Matusevicius, Joanna Bogucka
Summary: This study demonstrated the potential of CBD and nano-Se in modulating microvascularization and muscle fiber lesions in C. perfringens-challenged chickens. The administration of CBD reduced atrophic fibers, while nano-Se or both substances reduced split fibers and necrotic myofibers in the breast muscle. The CBD+Nano-Se group showed a significantly higher number of capillary vessels compared to the control and positive control groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Magdalena Laskowska, Pawel Kowalczyk, Agnieszka Karczmarska, Karol Kramkowski, Karol Wrzosek, Lukasz Laskowski
Summary: This article discusses a novel class of antimicrobial agents, nanocomposites made of spherical silica and silver ions on the surface, which are in high demand due to the increasing antibiotic resistance of bacterial strains. The focus is on materials that can limit bacterial growth on various tactile surfaces. The study presents a method for preparing a silica-based nanocomposite containing silver ions and analyzes their antimicrobial properties. The research demonstrates that the tested nanocomposite induces high oxidative stress in bacterial cells, leading to DNA damage and modification, resulting in rapid bacterial destruction and cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Dominik Koszelewski, Pawel Kowalczyk, Jan Samsonowicz-Gorski, Anastasiia Hrunyk, Anna Brodzka, Justyna Lecka, Karol Kramkowski, Ryszard Ostaszewski
Summary: A mild and efficient method for synthesizing p-quinols under aqueous conditions was developed. The key role of additives in the copper-catalyzed addition reaction of aryl and heteroaryl boronic acids to benzoquinones was observed, with polyvinylpyrrolidone (PVP) being the most efficient additive. This method offers advantages such as broad substrate scope, high yields, atom economy, and use of readily available starting materials, as well as the reusability of the catalytic system. The obtained p-quinols showed antimicrobial activity similar to commonly used antibiotics and can be further modified for different biological activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mateusz Schabikowski, Pawel Kowalczyk, Agnieszka Karczmarska, Barbara Gawdzik, Aleksandra Wypych, Karol Kramkowski, Karol Wrzosek, Lukasz Laskowski
Summary: This article discusses the antimicrobial properties of pristine anodised aluminium oxide matrices, a material considered biologically inert by many. Matrices without the use of harmful compounds were fabricated and tested, showing potential as antibacterial agents. The results demonstrate stronger antibacterial properties compared to antibiotics, indicating their potential as substitutes in clinical infections.
Review
Biochemistry & Molecular Biology
Malgorzata Zaremba, Pawel Serafin, Patrycja Kleczkowska
Summary: Psychosis refers to symptoms that cause serious disorganization of behavior, thinking, and perception of reality. The antitussive drug dextromethorphan (DXM) has gained attention for its potential to induce psychosis. DXM is commonly abused for its euphoric, hallucinogenic, and dissociative effects. Currently, DXM is a legally marketed cough suppressant that is not classified as a controlled substance. The management of DXM-related psychosis depends on the type of symptoms, and atypical antipsychotic drugs are considered the preferred treatment option due to their efficacy and safety profile.
Review
Chemistry, Medicinal
Katarzyna Kaczynska, Monika Jampolska, Piotr Wojciechowski, Dorota Sulejczak, Kryspin Andrzejewski, Dominika Zajac
Summary: Lactoferrin (LF) is a versatile glycoprotein with various properties that can be used to treat lung diseases. Although in vitro and in vivo studies show significant potency of LF in treating lung diseases, its effectiveness in human studies is only confirmed for respiratory tract infections. For other diseases such as lung cancer, COVID-19, and sepsis, the reports are conflicting, and there is a lack of conclusive human studies on the beneficial effects of LF.
Article
Biochemistry & Molecular Biology
Dominik Koszelewski, Pawel Kowalczyk, Anna Brodzka, Anastasiia Hrunyk, Karol Kramkowski, Ryszard Ostaszewski
Summary: The study aimed to assess the synergistic effect of coumarin and alpha-amino dimethyl phosphonate moieties, two important pharmacophores, on antimicrobial activity against different strains of E. coli with varied lipopolysaccharide (LPS). The antimicrobial agents were prepared through a lipase-promoted Kabachnik-Fields reaction, with excellent yield (up to 92%) achieved under mild, solvent- and metal-free conditions. Preliminary exploration of coumarin alpha-amino dimethyl phosphonate analogs as novel antimicrobial agents revealed that the substituents on the phenyl ring strongly influenced the inhibitory activity. The data collected suggested that coumarin-based alpha-aminophosphonates could serve as potential antimicrobial drug candidates, which is crucial due to the increasing resistance of bacteria to commonly used antibiotics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Karolina Dabrowska, Zuzanna Zaczek, Mariusz Panczyk, Sylwia Osowska, Pawel Kowalczyk, Karol Kramkowski, Jacek Sobocki
Summary: Long-term use of TPN can lead to elevation of liver enzymes ALT and AST, and this study aimed to compare their concentration in patients receiving long-term TPN with healthy volunteers. The study also analyzed the effects of lipid emulsions on molecular oxygen percentage and genomic DNA damage. The findings provide important insights into the potential effects of TPN on liver enzymes and cellular metabolism.
Review
Biochemistry & Molecular Biology
Pawel Serafin, Malgorzata Zaremba, Dorota Sulejczak, Patrycja Kleczkowska
Summary: The Lancet Commission on Dementia Prevention, Intervention, and Care identified air pollution as a potential risk factor for dementia in 2017. In 2018, the Lancet Commission on Pollution concluded that there is encouraging evidence for a causal relationship between fine particulate matter and dementia. However, there are limited interventions available to delay or prevent the onset of dementia. This article reviews recent evidence on the association between air pollution exposure and dementia, with a focus on fine particulate matter.
Review
Biochemistry & Molecular Biology
Iryna Kulkova, Jakub Dobrzynski, Pawel Kowalczyk, Grzegorz Belzecki, Karol Kramkowski
Summary: Plant growth-promoting bacteria (PGPB), such as Bacillus cereus, have shown potential as alternatives to conventional fertilizers and chemical plant protection products. These bacteria can directly promote plant growth through the production of growth hormones and phosphate solubilization, as well as indirectly through biocontrol of phytopathogens. B. cereus strains have also been found to enhance plant growth under abiotic stresses and have the ability to suppress the development of important phytopathogens. However, more research is needed to study the effectiveness of B. cereus under field conditions and its impact on the indigenous microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pawel Serafin, Pawel Kowalczyk, Adriano Mollica, Azzurra Stefanucci, Anna K. Laskowska, Magdalena Zawadzka, Karol Kramkowski, Patrycja Kleczkowska
Summary: Finding the ideal antimicrobial drug remains challenging, but amphibian-derived peptides have shown potential as broad-spectrum antibacterial agents. In this study, dermorphin and ranatensin peptides were combined to create a hybrid compound called LENART01. It exhibited superior antimicrobial activity against certain E. coli strains compared to clinically available antibiotics, but showed dose-dependent hemolytic effects in hemolytic assays.
Review
Pharmacology & Pharmacy
Pawel Serafin, Patrycja Kleczkowska
Summary: Bombesin and its analogs have diverse biological properties, making them potential candidates for anticancer drugs, as well as treatments for rheumatoid arthritis and gastrointestinal diseases. The development of hybrid compounds containing bombesin pharmacophores could offer a solution to the challenges associated with polytherapy.
