Article
Cell Biology
Yuan Zhao, Bruce Zhang, Ioan Marcu, Faria Athar, Hongyuan Wang, Evgeniy R. Galimov, Hannah Chapman, David Gems
Summary: Reduction of insulin/IGF-1 signaling can extend the lifespan of Caenorhabditis elegans, affecting different forms of death. Pharyngeal expression of the DAF-16 FOXO transcription factor plays a significant role in promoting lifespan extension and reducing certain types of death.
Article
Biochemistry & Molecular Biology
Huimin Liu, Ying Wang, Weiping Zhang, Weichao Sun, Xiaoxue Ji, Shouan Zhang, Kang Qiao
Summary: This study demonstrated that lentinan from Lentinus edodes could effectively increase the lifespan and enhance oxidative stress resistance in Caenorhabditis elegans through the activation of DAF-16 and SKN-1.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Lei Zhou, Jin Liu, Lan-Lan Bu, Duan-Fang Liao, Shao-Wu Cheng, Xi-Long Zheng
Summary: The novel compound curcumin acetylsalicylate (CA) was found to extend the lifespan of Caenorhabditis elegans in a dose-dependent manner, decrease oxidative stress, and increase the expression of antioxidative genes. Activation of the DAF-16 transcription factor by CA may contribute to delaying aging in C. elegans.
Article
Pharmacology & Pharmacy
Ganlan Zhang, Hui Liu, Ting Xue, Xiangming Kong, Dongmei Tian, Libo Luo, Yanhua Yang, Keqing Xu, Youheng Wei, Ziheng Zhuang
Summary: Aging is a process of degenerative changes that cause diseases and disabilities. Research aims to find drugs that can extend lifespan and treat age-related diseases. Ribavirin has been discovered as a potential drug for aging intervention by inhibiting TOR signaling and activating AMPK. Its anti-aging effect is mediated via AMPK-TOR signaling.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ying-Zi Wang, Song-Yu Guo, Rui-Li Kong, Ao-Ran Sui, Zhen-Hua Wang, Rong-Xiao Guan, Kundu Supratik, Jie Zhao, Shao Li
Summary: This study found that scorpion venom heat-resistant synthesized peptide (SVHRSP) could prolong the lifespan of Caenorhabditis elegans (C. elegans) and improve its age-related physiological functions. The antiaging mechanism of SVHRSP in nematodes might be mediated by the insulin/insulin-like growth factor-1 signaling pathway. This research has important implications for promoting healthy aging and developing drugs to treat age-related diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Mercedes M. Perez-Jimenez, Jose M. Monje-Moreno, Ana Maria Brokate-Llanos, Monica Venegas-Caleron, Alicia Sanchez-Garcia, Paula Sansigre, Amador Valladares, Sara Esteban-Garcia, Irene Suarez-Pereira, Javier Vitorica, Jose Julian Rios, Marta Artal-Sanz, Angel M. Carrion, Manuel J. Munoz
Summary: The study demonstrates that loss of function of the steroid sulfatase sul-2 in Caenorhabditis elegans increases lifespan and ameliorates protein aggregation diseases, through mechanisms involving factors related to germline-mediated longevity. Sul-2 is predominantly expressed in sensory neurons, suggesting regulation by environmental cues.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Shu Jiang, Cui-Ping Jiang, Pei Cao, Yong-Hong Liu, Cheng-Hai Gao, Xiang-Xi Yi
Summary: In this study, the antiaging effect of Sonneradon A (SDA), a compound extracted from the fruits of mangrove Sonneratia apetala, was investigated using the animal model Caenorhabditis elegans. It was found that SDA inhibited reactive oxygen species (ROS) production, reduced the accumulation of aging markers, and enhanced the innate immune response to infection. Furthermore, SDA extended the lifespan of specific mutants and this effect may be related to the enhancement of resistance to oxidative stress through mitochondrial and insulin/insulin-like growth factor-1 signaling pathways.
Article
Biochemistry & Molecular Biology
Shiling Feng, Chunyan Zhang, Tao Chen, Lijun Zhou, Yan Huang, Ming Yuan, Tian Li, Chunbang Ding
Summary: The study found that OLE significantly prolongs the lifespan of Caenorhabditis elegans and increases their resistance to lethal heat shock and oxidative stress. OLE regulates stress resistance and lifespan extension in nematodes through the activation of the IIS and SKN-1/Nrf2 signaling pathways.
Article
Chemistry, Medicinal
Jing-Shan Wu, Chun-Guo Lin, Chang-Long Jin, Yan-Xia Zhou, Ying-Xiu Li
Summary: The marine bacterium Planococcus maritimu ML1206 was found to have antioxidant properties and could enhance the ability of nematodes to resist oxidative stress and extend their lifespan. These findings suggest that ML1206 has potential anti-aging and antioxidant functions and could be used in aquaculture and as a dietary supplement.
Article
Cell Biology
David Knupp, Brian G. Jorgensen, Hussam Z. Alshareef, Jaffar M. Bhat, Jeremy J. Grubbs, Pedro Miura, Alexander M. van Der Linden
Summary: Accumulation of circRNAs is regulated by ADR-1 and plays a role in the aging process, as demonstrated in Caenorhabditis elegans. Deletion of circ-crh-1 leads to a longer lifespan, and transcriptome alterations were identified in the circ-crh-1 mutants using RNA-Seq.
Article
Food Science & Technology
Chenxuan Wu, Jun Liu, Junwen Ma, Qiaojuan Yan, Zhengqiang Jiang
Summary: NAT has been shown to extend the lifespan of C. elegans and improve resistance to heat and oxidation stress. The mechanism involves insulin/insulin-like signaling and activation of AMPK, leading to enhanced activity of DAF-16 and induction of autophagy. These findings suggest that NAT could be used as a dietary restriction mimic centered on AMPK and has potential anti-aging effects in higher organisms.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Cell Biology
Takafumi Ogawa, Koji Masumura, Yuki Kohara, Muneyoshi Kanai, Tomoyoshi Soga, Yoshikazu Ohya, T. Keith Blackwell, Masaki Mizunuma
Summary: Methionine restriction can extend lifespan and delay aging-associated pathologies. Supplementation with S-adenosyl-L-homocysteine (SAH) can mimic the effects of methionine restriction by reducing methionine levels and activating AMP-activated protein kinase (AMPK), thereby extending lifespan.
Article
Multidisciplinary Sciences
Shengjie Fan, Yingxuan Yan, Ying Xia, Zhenyu Zhou, Lingling Luo, Mengnan Zhu, Yongli Han, Deqiang Yao, Lijun Zhang, Minglv Fang, Lina Peng, Jing Yu, Ying Liu, Xiaoyan Gao, Huida Guan, Hongli Li, Changhong Wang, Xiaojun Wu, Huanhu Zhu, Yu Cao, Cheng Huang
Summary: Using C. elegans as a model, researchers found that nomilin, a compound found in citrus fruit, significantly extended the lifespan, healthspan, and toxin resistance of the nematodes. This anti-aging effect was dependent on specific pathways and nuclear hormone receptors. Additionally, nomilin was identified to directly bind with the human pregnane X receptor (hPXR). In animal studies, dietary supplementation of nomilin improved healthspan and lifespan, and induced a gene signature associated with longevity.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Shiyao Wang, Dongfa Lin, Jiaofei Cao, Liping Wang
Summary: Animal studies have shown that 1-acetyl-5-phenyl-1H-pyrrol-3-yl acetate (APPA) is a powerful antioxidant and can increase the lifespan of Caenorhabditis elegans through regulating oxidative stress and the insulin/insulin-like growth factor (IGF) signaling pathway. The mitochondrial pathway is also involved in APPA's lifespan extension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hui Li, Xiaoxuan Yu, Fanwei Meng, Zhenyu Zhao, Shuwen Guan, Liping Wang
Summary: Ferulic acid can extend the lifespan of Caenorhabditis elegans by improving locomotion, reducing fat accumulation, and lowering polyQ aggregation. It enhances resistance to heat and oxidative stress by reducing ROS levels and upregulating the expression of hlh-30, skn-1, and hsf-1. The insulin/IGF-1 signaling pathway and multiple longevity mechanisms are associated with the longevity effects of ferulic acid in C. elegans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)