Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

RNA-Seq versus oligonucleotide array assessment of dose-dependent TCDD-elicited hepatic gene expression in mice

(2015) Rance Nault et al.   BMC GENOMICS

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality

(2015) Shaimaa Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute Activation of Oxidative Pentose Phosphate Pathway as First-Line Response to Oxidative Stress in Human Skin Cells

(2015) Andreas Kuehne et al.   MOLECULAR CELL

Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation

(2015) Sophia Y. Lunt et al.   MOLECULAR CELL

l-Cysteine metabolism and its nutritional implications

(2015) Jie Yin et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway

(2014) Anna Stincone et al.   BIOLOGICAL REVIEWS

Regulation of G6PD acetylation by KAT9/SIRT2 modulates NADPH homeostasis and cell survival during oxidative stress

(2014) Y.-P. Wang et al.   EMBO JOURNAL

Mitochondrial Targeting of Cytochrome P450 (CYP) 1B1 and Its Role in Polycyclic Aromatic Hydrocarbon-induced Mitochondrial Dysfunction

(2014) Seema Bansal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

Development of a Computational High-Throughput Tool for the Quantitative Examination of Dose-Dependent Histological Features

(2014) Rance Nault et al.   TOXICOLOGIC PATHOLOGY

Serine and glycine metabolism in cancer

(2014) Ivano Amelio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of the pentose phosphate pathway in cancer

(2014) Peng Jiang et al.   Protein & Cell

Evaluation of the Association between Persistent Organic Pollutants (POPs) and Diabetes in Epidemiological Studies: A National Toxicology Program Workshop Review

(2013) Kyla W. Taylor et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Aryl Hydrocarbon Receptor–Dependent Induction of Liver Fibrosis by Dioxin

(2013) Stéphane Pierre et al.   TOXICOLOGICAL SCIENCES

Analysis of glutamine dependency in non-small cell lung cancer

(2012) A. Pieter J. van den Heuvel et al.   CANCER BIOLOGY & THERAPY

Metabolomics Identifies an Inflammatory Cascade Involved in Dioxin- and Diet-Induced Steatohepatitis

(2012) Tsutomu Matsubara et al.   Cell Metabolism

The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression

(2012) Timothy V. Beischlag et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner

(2012) Rachel Tanos et al.   HEPATOLOGY

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Role of the Ah Receptor in Homeostatic Control of Fatty Acid Synthesis in the Liver

(2012) Rachel Tanos et al.   TOXICOLOGICAL SCIENCES

High-Resolution Genome-wide Mapping of AHR and ARNT Binding Sites by ChIP-Seq

(2012) Raymond Lo et al.   TOXICOLOGICAL SCIENCES

TCDD-Elicited Effects on Liver, Serum, and Adipose Lipid Composition in C57BL/6 Mice

(2012) Michelle Manente Angrish et al.   TOXICOLOGICAL SCIENCES

PPARγ contributes to PKM2 and HK2 expression in fatty liver

(2012) Ganna Panasyuk et al.   Nature Communications

The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond

(2011) Marcus Conrad et al.   AMINO ACIDS

Integration of Genome-Wide Computation DRE Search, AhR ChIP-chip and Gene Expression Analyses of TCDD-Elicited Responses in the Mouse Liver

(2011) Edward Dere et al.   BMC GENOMICS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

PKM2: A gatekeeper between growth and survival

(2011) Isaac Harris et al.   CELL RESEARCH

Genome-Wide Computational Analysis of Dioxin Response Element Location and Distribution in the Human, Mouse, and Rat Genomes

(2011) Edward Dere et al.   CHEMICAL RESEARCH IN TOXICOLOGY

TCDD and cancer: A critical review of epidemiologic studies

(2011) Paolo Boffetta et al.   CRITICAL REVIEWS IN TOXICOLOGY

Aryl Hydrocarbon Receptor Deficiency Enhances Insulin Sensitivity and Reduces PPAR-α Pathway Activity in Mice

(2011) Chun Wang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Metabolomic analysis of liver and skeletal muscle tissues in C57BL/6J and DBA/2J mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

(2011) Shuhai Lin et al.   Molecular BioSystems

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

Comparative Metabolomic and Genomic Analyses of TCDD-Elicited Metabolic Disruption in Mouse and Rat Liver

(2011) Agnes L. Forgacs et al.   TOXICOLOGICAL SCIENCES

Exactly the Same but Different: Promiscuity and Diversity in the Molecular Mechanisms of Action of the Aryl Hydrocarbon (Dioxin) Receptor

(2011) Michael S. Denison et al.   TOXICOLOGICAL SCIENCES

Nrf2 protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis

(2011) Hong Lu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Metabolomic Analysis and Visualization Engine for LC−MS Data

(2010) Eugene Melamud et al.   ANALYTICAL CHEMISTRY

MetPA: a web-based metabolomics tool for pathway analysis and visualization

(2010) J. Xia et al.   BIOINFORMATICS

ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair

(2010) Claudia Cosentino et al.   EMBO JOURNAL

A Novel Role for the Dioxin Receptor in Fatty Acid Metabolism and Hepatic Steatosis

(2010) Jung Hoon Lee et al.   GASTROENTEROLOGY

Identification of the Aryl Hydrocarbon Receptor Target GeneTiPARPas a Mediator of Suppression of Hepatic Gluconeogenesis by 2,3,7,8-Tetrachlorodibenzo-p-dioxin and of Nicotinamide as a Corrective Agent for This Effect

(2010) Silvia Diani-Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Automated Dose-Response Analysis and Comparative Toxicogenomic Evaluation of the Hepatic Effects Elicited by TCDD, TCDF, and PCB126 in C57BL/6 Mice

(2010) Anna K. Kopec et al.   TOXICOLOGICAL SCIENCES

Introducing the “TCDD-Inducible AhR-Nrf2 Gene Battery”

(2009) Ronnie L. Yeager et al.   TOXICOLOGICAL SCIENCES

PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: Comparative toxicogenomic effects of dioxin and non-dioxin-like ligands

(2009) Anna K. Kopec et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

ProteoWizard: open source software for rapid proteomics tools development

(2008) Darren Kessner et al.   BIOINFORMATICS

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low-dose dioxins alter gene expression related to cholesterol biosynthesis, lipogenesis, and glucose metabolism through the aryl hydrocarbon receptor-mediated pathway in mouse liver

(2008) Shoko Sato et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY