Small molecule control of bacterial biofilms

Indole-3-acetaldehyde from Rhodococcus sp. BFI 332 inhibits Escherichia coli O157:H7 biofilm formation

(2012) Jin-Hyung Lee et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

7-fluoroindole as an antivirulence compound against Pseudomonas aeruginosa

(2012) Jin-Hyung Lee et al.   FEMS MICROBIOLOGY LETTERS

Ellagic Acid Derivatives from Rubus ulmifolius Inhibit Staphylococcus aureus Biofilm Formation and Improve Response to Antibiotics

(2012) Cassandra L. Quave et al.   PLoS One

A High-Throughput Screening Assay for Inhibitors of Bacterial Motility Identifies a Novel Inhibitor of the Na+-Driven Flagellar Motor and Virulence Gene Expression in Vibrio cholerae

(2011) Lynn Rasmussen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development of an Antivirulence Drug againstStreptococcus mutans: Repression of Biofilm Formation, Acid Tolerance, and Competence by a Histidine Kinase Inhibitor, Walkmycin C

(2011) Yoko Eguchi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of a Novel Benzimidazole That Inhibits Bacterial Biofilm Formation in a Broad-Spectrum Manner

(2011) Karthik Sambanthamoorthy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Small-Molecule Modulators of Listeria monocytogenes Biofilm Development

(2011) Uyen T. Nguyen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Structure–activity relationship of 2-hydroxy-2-aryl-2,3-dihydro-imidazo[1,2-a]pyrimidinium salts and 2N-substituted 4(5)-aryl-2-amino-1H-imidazoles as inhibitors of biofilm formation by Salmonella Typhimurium and Pseudomonas aeruginosa

(2011) Hans P.L. Steenackers et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Thiolactone modulators of quorum sensing revealed through library design and screening

(2011) Christine E. McInnis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Palmitoyl-dl-Carnitine is a Multitarget Inhibitor of Pseudomonas aeruginosa Biofilm Development

(2011) Iwona B. Wenderska et al.   CHEMBIOCHEM

Inhibition of Acinetobacter baumannii biofilm formation on a methacrylate polymer containing a 2-aminoimidazole subunit

(2011) Lingling Peng et al.   CHEMICAL COMMUNICATIONS

Evaluation of 4,5-Disubstituted-2-Aminoimidazole-Triazole Conjugates for Antibiofilm/Antibiotic Resensitization Activity Against MRSA and Acinetobacter baumannii

(2011) Zhaoming Su et al.   ChemMedChem

4-epi-Pimaric acid: a phytomolecule as a potent antibacterial and anti-biofilm agent for oral cavity pathogens

(2011) F. Ali et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Apple Flavonoid Phloretin Inhibits Escherichia coli O157:H7 Biofilm Formation and Ameliorates Colon Inflammation in Rats

(2011) Jin-Hyung Lee et al.   INFECTION AND IMMUNITY

The Biofilm Inhibitor Carolacton Disturbs Membrane Integrity and Cell Division of Streptococcus mutans through the Serine/Threonine Protein Kinase PknB

(2011) M. Reck et al.   JOURNAL OF BACTERIOLOGY

Inhibitory Effects of D-Amino Acids on Staphylococcus aureus Biofilm Development

(2011) A. I. Hochbaum et al.   JOURNAL OF BACTERIOLOGY

Antifouling Properties of Simple Indole and Purine Alkaloids from the Mediterranean GorgonianParamuricea clavata

(2011) Nicolas Pénez et al.   JOURNAL OF NATURAL PRODUCTS

Intercepting Bacterial Indole Signaling with Flustramine Derivatives

(2011) Cynthia A. Bunders et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetic analysis of surface motility in Acinetobacter baumannii

(2011) K. M. Clemmer et al.   MICROBIOLOGY-SGM

An image-based 384-well high-throughput screening method for the discovery of biofilm inhibitors in Vibrio cholerae

(2011) Kelly C. Peach et al.   Molecular BioSystems

The novel Pseudomonas aeruginosa two-component regulator BfmR controls bacteriophage-mediated lysis and DNA release during biofilm development through PhdA

(2011) Olga E. Petrova et al.   MOLECULAR MICROBIOLOGY

Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms

(2011) Cynthia Bunders et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and biological activity of 2-aminoimidazole triazoles accessed by Suzuki–Miyaura cross-coupling

(2011) Samuel Reyes et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

2-Aminopyrimidine as a novel scaffold for biofilm modulation

(2011) Erick A. Lindsey et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Modulation of Pseudomonas aeruginosa surface-associated group behaviors by individual amino acids through c-di-GMP signaling

(2011) Steve P. Bernier et al.   RESEARCH IN MICROBIOLOGY

Hacking into bacterial biofilms: a new therapeutic challenge

(2011) Christophe Bordi et al.   Annals of Intensive Care

Concise and Diversity-Oriented Route toward Polysubstituted 2-Aminoimidazole Alkaloids and Their Analogues

(2010) Denis S. Ermolat'ev et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents

(2010) S. A. Rogers et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Modulating the development of E. coli biofilms with 2-aminoimidazoles

(2010) Catherine S. Reed et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria

(2010) Cynthia A. Bunders et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Damage of Streptococcus mutans biofilms by carolacton, a secondary metabolite from the myxobacterium Sorangium cellulosum

(2010) Brigitte Kunze et al.   BMC MICROBIOLOGY

Chemical Synthesis and Biological Screening of 2-Aminoimidazole-Based Bacterial and Fungal Antibiofilm Agents

(2010) Steven A. Rogers et al.   CHEMBIOCHEM

3′,5′-Cyclic diguanylic acid: a small nucleotide that makes big impacts

(2010) Hongbin Yan et al.   CHEMICAL SOCIETY REVIEWS

Two-component signal transduction as potential drug targets in pathogenic bacteria

(2010) Yasuhiro Gotoh et al.   CURRENT OPINION IN MICROBIOLOGY

3-Indolylacetonitrile Decreases Escherichia coli O157:H7 Biofilm Formation and Pseudomonas aeruginosa Virulence

(2010) Jin-Hyung Lee et al.   ENVIRONMENTAL MICROBIOLOGY

An update onPseudomonas aeruginosabiofilm formation, tolerance, and dispersal

(2010) Morten Harmsen et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules

(2010) Herman O Sintim et al.   Future Medicinal Chemistry

The Novel Two-Component Regulatory System BfiSR Regulates Biofilm Development by Controlling the Small RNA rsmZ through CafA

(2010) O. E. Petrova et al.   JOURNAL OF BACTERIOLOGY

Structure−Activity Relationship of 4(5)-Aryl-2-amino-1H-imidazoles,N1-Substituted 2-Aminoimidazoles and Imidazo[1,2-a]pyrimidinium Salts as Inhibitors of Biofilm Formation bySalmonellaTyphimurium andPseudomonas aeruginosa

(2010) Hans P. L. Steenackers et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives

(2010) Steven A. Rogers et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase

(2010) Donald R. Ronning et al.   PROTEIN SCIENCE

D-Amino Acids Trigger Biofilm Disassembly

(2010) I. Kolodkin-Gal et al.   SCIENCE

Furanone at Subinhibitory Concentrations Enhances Staphylococcal Biofilm Formation by luxS Repression

(2009) R. Kuehl et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Computer-Aided Identification of Recognized Drugs as Pseudomonas aeruginosa Quorum-Sensing Inhibitors

(2009) L. Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Monitoring of diguanylate cyclase activity and of cyclic-di-GMP biosynthesis by whole-cell assays suitable for high-throughput screening of biofilm inhibitors

(2009) Davide Antoniani et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

From anti-fouling to biofilm inhibition: New cytotoxic secondary metabolites from two Indonesian Agelas sponges

(2009) Triana Hertiani et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous

(2009) Jacqueline A. I. Smith et al.   CHEMICAL COMMUNICATIONS

Regulation ofAcinetobacter baumanniibiofilm formation

(2009) Jennifer A Gaddy et al.   Future Microbiology

Indole Acts as an Extracellular Cue Regulating Gene Expression in Vibrio cholerae

(2009) R. S. Mueller et al.   JOURNAL OF BACTERIOLOGY

The Staphylococcus aureus LytSR Two-Component Regulatory System Affects Biofilm Formation

(2009) B. K. Sharma-Kuinkel et al.   JOURNAL OF BACTERIOLOGY

A 2-Aminobenzimidazole That Inhibits and Disperses Gram-Positive Biofilms through a Zinc-Dependent Mechanism

(2009) Steven A. Rogers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Covalent Inhibition of Bacterial Quorum Sensing

(2009) Neri Amara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The effect of c-di-GMP (3′–5′-cyclic diguanylic acid) on the biofilm formation and adherence of Streptococcus mutans

(2009) Wenjuan Yan et al.   MICROBIOLOGICAL RESEARCH

AI-2 quorum-sensing inhibitors affect the starvation response and reduce virulence in several Vibrio species, most likely by interfering with LuxPQ

(2009) G. Brackman et al.   MICROBIOLOGY-SGM

Transition state analogs of 5′-methylthioadenosine nucleosidase disrupt quorum sensing

(2009) Jemy A Gutierrez et al.   Nature Chemical Biology

Construction and Screening of a 2‐Aminoimidazole Library Identifies a Small Molecule Capable of Inhibiting and Dispersing Bacterial Biofilms across Order, Class, and Phylum

(2008) Steven A. Rogers et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bacterial Quorum Sensing: Signals, Circuits, and Implications for Biofilms and Disease

(2008) Arul Jayaraman et al.   Annual Review of Biomedical Engineering

Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa

(2008) Zhirui Zeng et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Furanone derivatives as quorum-sensing antagonists of Pseudomonas aeruginosa

(2008) Cheoljin Kim et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Effects of N-pyrrole substitution on the anti-biofilm activities of oroidin derivatives against Acinetobacter baumannii

(2008) Justin J. Richards et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Screening of an Oroidin Library againstPseudomonas aeruginosaBiofilms

(2008) Justin J. Richards et al.   CHEMBIOCHEM

Inhibition and dispersion of proteobacterial biofilms

(2008) Justin J. Richards et al.   CHEMICAL COMMUNICATIONS

Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria

(2008) Grant D. Geske et al.   CHEMICAL SOCIETY REVIEWS

Synthesis and Antibiofilm Activity of a Second-Generation Reverse-Amide Oroidin Library: A Structure-Activity Relationship Study

(2008) T. Eric Ballard et al.   CHEMISTRY-A EUROPEAN JOURNAL

Insights onEscherichia colibiofilm formation and inhibition from whole-transcriptome profiling

(2008) Thomas K. Wood   ENVIRONMENTAL MICROBIOLOGY

Control of plant diseases by natural products: Allicin from garlic as a case study

(2008) Alan J. Slusarenko et al.   EUROPEAN JOURNAL OF PLANT PATHOLOGY

Sources of edaphic cyanobacterial diversity in the Dry Valleys of Eastern Antarctica

(2008) Susanna A Wood et al.   ISME Journal

Chelated iron sources are inhibitors ofPseudomonas aeruginosabiofilms and distribute efficiently in anin vitromodel of drug delivery to the human lung

(2008) D.J. Musk et al.   JOURNAL OF APPLIED MICROBIOLOGY

A Fatty Acid Messenger Is Responsible for Inducing Dispersion in Microbial Biofilms

(2008) D. G. Davies et al.   JOURNAL OF BACTERIOLOGY

A Close-up View of the VraSR Two-component System

(2008) Antoaneta Belcheva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy of common hospital biocides with biofilms of multi-drug resistant clinical isolates

(2008) K. Smith et al.   JOURNAL OF MEDICAL MICROBIOLOGY

An Unexpected Switch in the Modulation of AI-2-Based Quorum Sensing Discovered through Synthetic 4,5-Dihydroxy-2,3-pentanedione Analogues

(2008) Colin A. Lowery et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of a two-component regulatory system from Acinetobacter baumannii that controls biofilm formation and cellular morphology

(2008) A. P. Tomaras et al.   MICROBIOLOGY-SGM

Control of bacterial biofilms with marine alkaloid derivatives

(2008) Robert W. Huigens III et al.   Molecular BioSystems

Establishing bacterial communities by 'word of mouth': LuxS and autoinducer 2 in biofilm development

(2008) Kim Rachael Hardie et al.   NATURE REVIEWS MICROBIOLOGY

Inhibition and dispersion of Pseudomonas aeruginosa biofilms with reverse amide 2-aminoimidazole oroidin analogues

(2008) Justin J. Richards et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Design and Synthesis of Macrocyclic Peptomers as Mimics of a Quorum Sensing Signal fromStaphylococcus aureus

(2008) Sarah A. Fowler et al.   ORGANIC LETTERS

Targeting non-multiplying organisms as a way to develop novel antimicrobials

(2008) Anthony R.M. Coates et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identifying the important structural elements of brominated furanones for inhibiting biofilm formation by Escherichia coli

(2007) Yongbin Han et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A complex role for the γ-butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3(2)

(2003) Eriko Takano et al.   MOLECULAR MICROBIOLOGY