Review
Endocrinology & Metabolism
Mageswary Sivalingam, Ishwar S. Parhar
Summary: Kisspeptin, encoded by the KISS1 gene, is a potential metastasis suppressor gene. Multiple types of Kiss and KissR genes have been discovered in mammalian and non-mammalian vertebrate species, but are notably absent in birds. Kiss neuronal populations are mainly found in the hypothalamus, while KissRs are widely distributed in the brain and play a role in puberty, gonadal maturation, and the reproductive axis. Recent gene deletion studies in zebrafish and medaka have raised controversy regarding the reproductive role of kiss.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Cell Biology
Georgia S. Kavanagh, Jason Tadi, Sydney M. Balkenhol, Alexander S. Kauffman, Shane K. Maloney, Jeremy T. Smith
Summary: Kisspeptin signaling depletion leads to increased adiposity and reduced energy expenditure in mice, as well as alterations in the regulation of core body temperature as well as circadian and ultradian rhythms.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Review
Cell Biology
Xuehan Li, Chunyu Liang, Yi Yan
Summary: The Kiss1/GPR54 system plays a crucial role in regulating energy balance and metabolic homeostasis by controlling energy intake and expenditure balance, affecting insulin secretion, and influencing skeletal muscle function.
Article
Oncology
Marek Gowkielewicz, Aleksandra Lipka, Aleksandra Piotrowska, Marta Szadurska-Noga, Jacek J. Nowakowski, Ewa Lepiarczyk, Marta Wiszpolska, Tomasz Wasniewski, Piotr Dziegiel, Jerzy Kaleczyc, Mariusz Krzysztof Majewski, Marta Majewska
Summary: The study aims to analyze the expression of KISS and its receptor GPR54 in cells of various histological types of endometrial cancer (EC) and correlate it with concomitant diseases and biometric characteristics. The study found that the expression of KISS and GPR54 is correlated with concomitant diseases and demographic characteristics, but not with histological type of cancer or hormonal contraception. The results suggest that the expression levels of KISS and GPR54 are associated with the development and prognosis of endometrial cancer.
Article
Biochemistry & Molecular Biology
Mahdi Golshan, Azadeh Hatef, Negar Kazori, Magdalena Socha, Miroslawa Sokolowska-Mikolajczyk, Hamid R. Habibi, Otomar Linhart, Sayyed Mohammad Hadi Alavi
Summary: This study reveals that exposure to bisphenol A (BPA) reduces sperm quality in goldfish and increases the levels of circulating LH and mRNA transcripts of upstream neuroendocrine regulators of reproduction.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Su Zhang, Fangfei Yu, Anran Che, Binghe Tan, Chenshen Huang, Yuxue Chen, Xiaohong Liu, Qi Huang, Wenying Zhang, Chengbin Ma, Min Qian, Mingyao Liu, Juliang Qin, Bing Du
Summary: Emerging evidence suggests that physiological distress is closely correlated with cancer incidence and mortality. This study demonstrates that acute restraint increases the levels of kisspeptin and the expression of its receptor, Gpr54, in the hypothalamus and T cells within the spleen and tumor microenvironment. The administration of kisspeptin-10 impairs T cell function, while knockout of Gpr54 inhibits lung tumor progression. These findings indicate that kisspeptin/GPR54 signaling plays a nonredundant role in stress-induced tumor immune evasion.
Article
Endocrinology & Metabolism
Md. Mahiuddin Zahangir, Md. Shahjahan, Hironori Ando
Summary: Kisspeptin plays an important role in reproductive regulation in animals. In grass puffer, kisspeptin has different effects depending on the reproductive stage, and it mainly acts by regulating the expression of genes in the hypothalamic-pituitary-gonadal axis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Veronica Sobrino, Maria Soledad Avendano, Cecilia Perdices-Lopez, Manuel Jimenez-Puyer, Manuel Tena-Sempere
Summary: In late 2003, the identification of the reproductive roles of kisspeptins and Gpr54 led to a surge in research interest and established fundamental concepts in physiological roles of kisspeptins. This early knowledge set the stage for more recent in-depth studies on neuronal networks involving Kiss1 neurons and their regulation mechanisms.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Christopher Simon, Tomoko Soga, Ishwar Parhar
Summary: This study found that the hypothalamic neurohormone kisspeptin-10 (KP-10) plays an important role in cholinergic neurodegenerative diseases. KP-10 interacts with α-synuclein (α-syn) through its cognate G-protein-coupled receptor GPR54 and protects cholinergic-like neurons from damage. These findings have important implications for the affinity mechanism and neuroprotective effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Dongsheng Wang, Zhixiang Wu, Chenglong Zhao, Xinghai Yang, Haifeng Wei, Mingyao Liu, Jian Zhao, Ming Qian, Zhenxi Li, Jianru Xiao
Summary: The upregulation of GPR54 in RA patient tissue is associated with disease severity, while KP-10/GPR54 may have therapeutic effects and can serve as a novel treatment target for RA.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Anne Duittoz, Xavier Cayla, Renaud Fleurot, Jonas Lehnert, Anmar Khadra
Summary: Kisspeptin (Kp), acting through the GPR54 receptor, controls reproduction by influencing GnRH neuronal activity, with potential complex mechanisms involved. Mutual regulation between GnRH and Kp neurons has been suggested, with Kp-dependent volume transmission playing a crucial role in this process. Mathematical modeling highlights the synergy between GnRH-R and GPR54 in defining GnRH neuronal activity and release.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ikram Ilahi, Taqweem Ul Haq
Summary: Kisspeptin is a peptide hormone that regulates reproductive functions and puberty onset in humans and mammals by acting on various levels of the reproductive axis. Mutations in the kisspeptin gene or receptor gene can lead to conditions like idiopathic hypogonadotropic hypogonadism and central precocious puberty. Elevated levels of kisspeptin in the serum or plasma have been identified as a potential marker for diagnosing central precocious puberty.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Khatereh Nourmohammadi, Farrin Babaei-Balderlou, Seyyed Meysam Abtahi-Foroushani
Summary: Acute food restriction reduces testosterone levels, increases kisspeptin/GPR54 signaling, and dopamine D-2 receptor plays a key role in these effects.
IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A-SCIENCE
(2021)
Article
Endocrinology & Metabolism
Cecilia Perdices-Lopez, Maria S. Avendano, Alexia Barroso, Francisco Gaytan, Francisco Ruiz-Pino, Maria J. Vazquez, Silvia Leon, Yong Bhum Song, Veronica Sobrino, Violeta Heras, Antonio Romero-Ruiz, Juan Roa, Federico Mayor Jr, Cristina Murga, Leonor Pinilla, Ursula B. Kaiser, Manuel Tena-Sempere
Summary: The study reveals the significant role of G protein-coupled receptor kinase-2 (GRK2) in regulating the timing of puberty. GRK2 negatively regulates kisspeptin actions in GnRH neurons, thus influencing the onset of puberty, particularly under conditions of nutritional deficiency. Pharmacological studies and conditional ablation experiments provide evidence for the expression and regulatory role of GRK2 in GnRH neurons.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Review
Biochemistry & Molecular Biology
Nisha Zhu, Mengxiang Zhao, Yuxian Song, Liang Ding, Yanhong Ni
Summary: KiSS-1 is an anti-metastasis gene encoding peptide products that act as endogenous ligands for G proteincoupled receptor 54, regulating various physiological activities such as puberty initiation, fertility, and feedback in the HPG axis. It plays a crucial role in cancer biology, serving as a promising biomarker for diagnosis, therapeutic target identification, and prognosis.
Article
Oncology
Ulrike Wokoun, Martin Hellriegel, Guenter Emons, Carsten Gruendker
Review
Endocrinology & Metabolism
Carsten Gruendker, Guenter Emons
FRONTIERS IN ENDOCRINOLOGY
(2017)
Article
Oncology
Rainer Girgert, Guenter Emons, Carsten Gruendker
Review
Endocrinology & Metabolism
Rainer Girgert, Guenter Emons, Carsten Gruendker
FRONTIERS IN ENDOCRINOLOGY
(2019)
Review
Obstetrics & Gynecology
Carsten Gruendker, Matthias Laesche, JohannaW. Hellinger, Guenter Emons
GEBURTSHILFE UND FRAUENHEILKUNDE
(2019)
Article
Obstetrics & Gynecology
Carsten Gruendker, Ulrike Wokoun, Martin Hellriegel, Guenter Emons
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2019)
Article
Oncology
Johanna W. Hellinger, Silke Huechel, Lena Goetz, Gerd Bauerschmitz, Guenter Emons, Carsten Gruendker
FRONTIERS IN ONCOLOGY
(2019)
Review
Oncology
Matthias Laesche, Guenter Emons, Carsten Gruendker
FRONTIERS IN ONCOLOGY
(2020)
Article
Multidisciplinary Sciences
Johanna W. Hellinger, Franziska Schoemel, Judith Buse, Christof Lenz, Gerd Bauerschmitz, Guenter Emons, Carsten Gruendker
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Katharina Kolb, Johanna Hellinger, Maike Kansy, Florian Wegwitz, Gerd Bauerschmitz, Guenter Emons, Carsten Gruendker
Review
Cell Biology
Carsten Gruendker, Guenter Emons
Summary: The HPG axis regulates the female menstrual cycle through GnRH, which can impact ovarian cancer either indirectly through the HPG axis or directly through receptors on the surface of tumor cells.
Review
Cell Biology
Gunter Emons, Carsten Gruendker
Summary: Endometrial cancer expresses GnRH and its receptor, which can regulate proliferation, the cell cycle, and apoptosis. GnRH agonists are used in fertility preserving therapy for early EC, but show limited activity in advanced or recurrent EC. Further clinical trials exploring the GnRH-system in EC may be beneficial.
Review
Cell Biology
Matthias Laesche, Horst Urban, Julia Gallwas, Carsten Gruendker
Summary: Cervical cancer is mainly caused by long-term infection of HPV virus, with weakened immune system and damaged cervical mucosa being crucial factors for carcinogenesis. Aberrant microbial microenvironment, immune and metabolic signalling are pathological mechanisms of cervical cancer.
Article
Cell Biology
Friederike Steifensand, Julia Gallwas, Gerd Bauerschmitz, Carsten Gruendker
Summary: Increased glucose requirement and upregulated glutaminolysis play crucial roles in cancer cell survival, making combined metabolic treatments a potentially effective strategy for improving therapy outcomes in estrogen receptor alpha-positive breast cancer.
Review
Biochemistry & Molecular Biology
Matthias Laesche, Julia Gallwas, Carsten Gruendker
Summary: Despite precautionary measures and vaccinations, HPV-related cancers still remain a significant concern. Research and therapy efforts are needed to address the challenges posed by this disease. HPV infection has the ability to evade immune recognition and utilize host cells for replication. Understanding the effects of HPV infection on metabolic, hormonal, and immune signaling pathways can provide insights into the development of cervical cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)