Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality

Increased activity of both CDK1 and CDK2 is necessary for the combinatorial activity of WEE1 inhibition and cytarabine

(2018) Tamara B. Garcia et al.   LEUKEMIA RESEARCH

Control of Mus81 nuclease during the cell cycle

(2017) Boris Pfander et al.   FEBS LETTERS

Inhibitory phosphorylation of Cdk1 mediates prolonged prophase I arrest in female germ cells and is essential for female reproductive lifespan

(2016) Deepak Adhikari et al.   CELL RESEARCH

A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis

(2016) Heike Duda et al.   DEVELOPMENTAL CELL

Targeting WEE1 Kinase in Cancer

(2016) Christopher J. Matheson et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation

(2015) Sophia X. Pfister et al.   CANCER CELL

Regulated eukaryotic DNA replication origin firing with purified proteins

(2015) Joseph T. P. Yeeles et al.   NATURE

A haploid genetic screen identifies the G1/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity

(2015) Anne Margriet Heijink et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Kinomics Identifies Candidate Therapeutic Targets in Head and Neck Cancer

(2014) R. Moser et al.   CLINICAL CANCER RESEARCH

Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe

(2014) S. Sarbajna et al.   GENES & DEVELOPMENT

A Cascade of Histone Modifications Induces Chromatin Condensation in Mitosis

(2014) Bryan J. Wilkins et al.   SCIENCE

Coordinated Actions of SLX1-SLX4 and MUS81-EME1 for Holliday Junction Resolution in Human Cells

(2013) Haley D.M. Wyatt et al.   MOLECULAR CELL

Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation

(2013) B. T. Hughes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase Functions in Cell Death and Disease

(2013) D. R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

Genomic Instability in Cancer

(2013) T. Abbas et al.   Cold Spring Harbor Perspectives in Biology

Human GEN1 and the SLX4-Associated Nucleases MUS81 and SLX1 Are Essential for the Resolution of Replication-Induced Holliday Junctions

(2013) Elizabeth Garner et al.   Cell Reports

Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation

(2012) K. Klotz-Noack et al.   JOURNAL OF CELL SCIENCE

Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption

(2012) H. Beck et al.   MOLECULAR AND CELLULAR BIOLOGY

Loss of Cyclin-Dependent Kinase 2 (CDK2) Inhibitory Phosphorylation in a CDK2AF Knock-In Mouse Causes Misregulation of DNA Replication and Centrosome Duplication

(2012) H. Zhao et al.   MOLECULAR AND CELLULAR BIOLOGY

The CDK1 inhibitory kinase MYT1 in DNA damage checkpoint recovery

(2012) J P H Chow et al.   ONCOGENE

Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination

(2012) M Krajewska et al.   ONCOGENE

Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration

(2012) M. K. Diril et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Forced Mitotic Entry of S-Phase Cells as a Therapeutic Strategy Induced by Inhibition of WEE1

(2012) Marieke Aarts et al.   Cancer Discovery

Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis

(2011) Joao Matos et al.   CELL

Targeting the S and G2 checkpoint to treat cancer

(2011) Tao Chen et al.   DRUG DISCOVERY TODAY

Analysis of protein dynamics at active, stalled, and collapsed replication forks

(2011) B. M. Sirbu et al.   GENES & DEVELOPMENT

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease

(2011) Raquel Domínguez-Kelly et al.   JOURNAL OF CELL BIOLOGY

Coupling of T161 and T14 phosphorylations protects cyclin B–CDK1 from premature activation

(2011) Katia Coulonval et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of the initiation step of DNA replication by cyclin-dependent kinases

(2010) Seiji Tanaka et al.   CHROMOSOMA

Mechanism of Holliday junction resolution by the human GEN1 protein

(2010) U. Rass et al.   GENES & DEVELOPMENT

Maintaining genome stability at the replication fork

(2010) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

High cyclin B1 expression is associated with poor survival in breast cancer

(2009) K Aaltonen et al.   BRITISH JOURNAL OF CANCER

Cdk2 and Cdk4 Activities Are Dispensable for Tumorigenesis Caused by the Loss of p53

(2009) V. C. Padmakumar et al.   MOLECULAR AND CELLULAR BIOLOGY

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

(2009) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

Cdk1 Participates in BRCA1-Dependent S Phase Checkpoint Control in Response to DNA Damage

(2009) Neil Johnson et al.   MOLECULAR CELL

G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer

(2008) N Bucher et al.   BRITISH JOURNAL OF CANCER

Rapid Cycling and Precocious Termination of G1 Phase in Cells Expressing CDK1AF

(2008) Joseph R. Pomerening et al.   MOLECULAR BIOLOGY OF THE CELL

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

(2008) Nadya Dimitrova et al.   NATURE

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

(2008) Paola Scaffidi et al.   NATURE CELL BIOLOGY