Mouse models of BRCA1 and their application to breast cancer research

BRCA1 gene therapy reduces systemic inflammatory response and multiple organ failure and improves survival in experimental sepsis

(2012) H Teoh et al.   GENE THERAPY

BRCA1, Hormone, and Tissue-Specific Tumor Suppression

(2012) Yanfen Hu   International Journal of Biological Sciences

BRCA1 Functions Independently of Homologous Recombination in DNA Interstrand Crosslink Repair

(2012) Samuel F. Bunting et al.   MOLECULAR CELL

Breast cancer statistics, 2011

(2011) Carol DeSantis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance

(2011) Rinske Drost et al.   CANCER CELL

CDDO-Imidazolide Induces DNA Damage, G2/M Arrest and Apoptosis in BRCA1-Mutated Breast Cancer Cells

(2011) E.-H. Kim et al.   Cancer Prevention Research

CDDO-Methyl Ester Delays Breast Cancer Development in Brca1-Mutated Mice

(2011) E.-H. Kim et al.   Cancer Prevention Research

BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity

(2011) R. Shakya et al.   SCIENCE

“Targeting” Triple-Negative Breast Cancer: The Lessons Learned From BRCA1-Associated Breast Cancers

(2011) Rita Nanda   SEMINARS IN ONCOLOGY

Sensitivity and Acquired Resistance of BRCA1;p53-Deficient Mouse Mammary Tumors to the Topoisomerase I Inhibitor Topotecan

(2010) S. A.L. Zander et al.   CANCER RESEARCH

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Estrogen Receptor Mutations and Changes in Downstream Gene Expression and Signaling

(2010) I. Barone et al.   CLINICAL CANCER RESEARCH

Insights into the targeted elimination of BRCA1-defective cancer stem cells

(2010) Veena Somasundaram et al.   MEDICINAL RESEARCH REVIEWS

Preclinical mouse models for BRCA1-associated breast cancer

(2009) R M Drost et al.   BRITISH JOURNAL OF CANCER

Impaired Skin and Mammary Gland Development and Increased  -Irradiation-Induced Tumorigenesis in Mice Carrying a Mutation of S1152-ATM Phosphorylation Site in Brca1

(2009) S. S. Kim et al.   CANCER RESEARCH

Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors

(2009) J. N. Pulvers et al.   DEVELOPMENT

Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations

(2009) Suhwan Chang et al.   JOURNAL OF CLINICAL INVESTIGATION

A Selective Requirement for 53BP1 in the Biological Response to Genomic Instability Induced by Brca1 Deficiency

(2009) Liu Cao et al.   MOLECULAR CELL

BRCA1 Regulates Acetylation and Ubiquitination of Estrogen Receptor-α

(2009) Yongxian Ma et al.   MOLECULAR ENDOCRINOLOGY

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Induction of Ovarian Leiomyosarcomas in Mice by Conditional Inactivation of Brca1 and p53

(2009) Bridget A. Quinn et al.   PLoS One

Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients

(2008) T. Byrski et al.   BREAST CANCER RESEARCH AND TREATMENT

Cancer Stem Cells Contribute to Cisplatin Resistance in Brca1/p53-Mediated Mouse Mammary Tumors

(2008) N. Shafee et al.   CANCER RESEARCH

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated Tumorigenesis

(2008) Rui-Hong Wang et al.   MOLECULAR CELL

The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression

(2008) R. Shakya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

(2008) S. Rottenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA