Article
Cell Biology
Chenchen Pan, Frank Winkler
Summary: This article reviews recent advances in understanding the interactions between cancer and the nervous system, and how this knowledge can be applied to improve cancer therapies. It highlights the importance of cancer neuroscience research and provides a roadmap for future studies.
NATURE CELL BIOLOGY
(2022)
Review
Oncology
Dalia Fleifel, Jeanette Gowen Cook
Summary: The G1 phase of the cell cycle is regulated by multiple cell cycle regulators, and both stem cells and cancer cells show similarities and differences in their regulatory mechanisms and functional outcomes during this phase. Pluripotency factors play important roles in G1 phase dynamics, which have implications for stem cell pluripotency and tumor formation.
Editorial Material
Oncology
Lili Tang, Javid Moslehi, Yamei Tang
Summary: Comorbid conditions are common among cancer survivors, and as cancer therapy techniques evolve, new interdisciplinary fields such as psycho-oncology, cardio-oncology, and neurology are recognized as crucial. Collaborations across these fields are essential to better understand and address the complex needs of cancer patients at a crossroads.
News Item
Biochemistry & Molecular Biology
Nicolas Rouhier
Summary: Ferredoxins are found to be universal electron donors, and a study on human mitochondrial ferredoxins reveals the presence of unique cellular functions and partners for each protein.
NATURE CHEMICAL BIOLOGY
(2023)
Review
Oncology
Rui Wang, Aashiq Hussain, Quanquan Guo, Meimei Ma
Summary: DNA is highly immunogenic and can activate the cGAS-STING pathway, which plays a crucial role in the pathogenesis and progression of neoplastic diseases. The modulation of cGAS-STING signaling holds great promise for cancer therapy, although there are disagreements on whether to activate or inhibit this pathway.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Miao Huang, Heyang Wang, Cole Mackey, Michael C. C. Chung, Juan Guan, Guangrong Zheng, Arkaprava Roy, Mingyi Xie, Christopher Vulpe, Xin Tang
Summary: Biomechanical forces play a fundamental role in biology, diseases, and medicine. Mechanobiology is an emerging field that investigates how biological mechanisms are regulated by these forces and how physical principles can be used to develop new therapeutic strategies. This article reviews the latest knowledge on the mechanosensitive protein YAP and its involvement in drug resistance in human cancer. It discusses the mechanical regulation of YAP in living cells, the molecular mechanisms by which YAP influences drug resistance, and the reciprocal relationship between mechanical regulation and drug resistance. By integrating these topics, the article proposes a unified framework for the design of novel mechanomedicines and advancements in cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Paul Robin, Lyderic Bocquet
Summary: Nanofluidics, the study of flows at the smallest scales, has developed rapidly, allowing for fine control of fluidic and ionic transport at the molecular level. Artificial ionic machines can be created by harnessing the phenomena at the nanoscales and taking advantage of techniques from various fields of physics. These machines, based on solid-state nanopores, should exploit their specific properties, such as electronic structure and interaction with light. New methods for probing nanofluidic systems are needed to advance the field and build complex ionic machines inspired by nature.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Multidisciplinary Sciences
Jennifer Cable, Jeffrey C. Rathmell, Erika L. Pearce, Ping-Chih Ho, Marcia C. Haigis, Murad R. Mamedov, Meng-Ju Wu, Susan M. Kaech, Lydia Lynch, Mark A. Febbraio, Sagar P. Bapat, Hanna S. Hong, Weiping Zou, Yasmine Belkaid, Zuri A. Sullivan, Andrea Keller, Stefanie K. Wculek, Douglas R. Green, Catherine Postic, Ido Amit, Salvador Aznar Benitah, Russell G. Jones, Miguel Reina-Campos, Santiago Valle Torres, Semir Beyaz, Donal Brennan, Luke A. J. O'Neill, Rachel J. Perry, Dirk Brenner
Summary: Immunometabolism studies the relationship between metabolism and immunity, with a focus on the metabolic pathways within immune cells and the impact of immune cells on systemic metabolism. In the Keystone symposium on Immunometabolism at the Crossroads of Obesity and Cancer, experts presented recent research on the complex interplay between metabolism, immunity, and cancer, highlighting metabolic links between tumor cells and immune cells, the effects of diet, the microbiome, and obesity on immune system function and cancer, and new technologies to study the immune system and uncover novel metabolic pathways.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Oncology
Marina Chiara Garassino, Antoni Ribas
Summary: The immunomodulatory effects of immune-checkpoint blockade therapy for cancer may affect the immune response to COVID-19, particularly in severe cases. Current evidence does not support the idea that this therapy worsens COVID-19 complications, allowing for its continued use during the pandemic while collecting data on its effects on COVID-19 vaccination.
CANCER IMMUNOLOGY RESEARCH
(2021)
Review
Medicine, Research & Experimental
Nirali Shukla, Ankit Naik, Kamlesh Moryani, Molisha Soni, Jigna Shah, Heena Dave
Summary: This review focuses on the signaling pathways and biological activities of the TGF-beta family in breast cancer pathogenesis and highlights its potential as a biomarker and drug target. It is beneficial for early detection, disease monitoring, and treatment selection in breast cancer.
Article
Biochemistry & Molecular Biology
Fabrizio Fontana, Patrizia Limonta
Summary: Mitochondria in cancer cells undergo unique functional and structural dynamics, contributing to the balance between cell survival and death through metabolic rewiring, gene mutations, oxidative stress, and regulation of apoptotic proteins. The dynamic alterations in mitochondrial dynamics serve as effective biomarkers of tumor progression and potential targets for anticancer strategies.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Subodh Verma, C. David Mazer, Kim A. Connelly
Summary: Although the link between inflammation and atherosclerosis is already known, the importance of this relationship after reducing LDL-C levels is uncertain. A recent study in The Lancet shows that residual inflammatory risk is a more reliable predictor of fatal and non-fatal events compared to residual cholesterol risk, suggesting the use of inflammation testing to guide vascular risk reduction.
Editorial Material
Public, Environmental & Occupational Health
Konstantin Chumakov, Ellie Ehrenfeld, Vadim Agol, Eckard Wimmer
Summary: The initiative to eradicate polio needs a reassessment of its strategy and proposes a new strategic goal of eradicating the disease rather than the virus. This can be achieved by implementing global immunisation programmes with improved vaccines to create and maintain high rates of population immunity indefinitely.
LANCET GLOBAL HEALTH
(2021)
Review
Oncology
Goran Micevic, Marcus W. Bosenberg, Qin Yan
Summary: Immune checkpoint inhibitors (ICI) have shown significant improvements in treating various cancers, but there are still challenges to overcome. Some cold tumor types, like pancreatic cancer, have low response rates to ICI due to low immunogenicity. Additionally, patients who initially respond to ICI may experience T-cell exhaustion, leading to a lack of sustained response. Recent studies have highlighted the role of epigenetic modifiers in regulating tumor cell immunity and T-cell exhaustion, suggesting that targeting the intersection of epigenetics and immune checkpoint therapy could enhance antitumor immune responses.
CLINICAL CANCER RESEARCH
(2023)
Review
Plant Sciences
Vera Inacio, Raquel Santos, Rafael Prazeres, Jose Graca, Celia M. Miguel, Leonor Morais-Cecilio
Summary: The development of plant tissues and organs during post-embryonic growth is controlled by both primary and secondary meristems. Epigenetic mechanisms play important roles in the activity and differentiation of primary meristem cells, and may also regulate secondary meristems. Understanding the epigenetic regulation of secondary meristems is essential for addressing climate change issues and implementing innovative breeding programs.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Cheng Xu, Yunfei Wang, Qiu Tu, Zhiye Zhang, Mengrou Chen, James Mwangi, Yaxiong Li, Yang Jin, Xudong Zhao, Ren Lai
Article
Multidisciplinary Sciences
Xia Sheng, Hatice Zeynep Nenseth, Su Qu, Omer F. Kuzu, Turid Frahnow, Lukas Simon, Stephanie Greene, Qingping Zeng, Ladan Fazli, Paul S. Rennie, Ian G. Mills, Havard Danielsen, Fabian Theis, John B. Patterson, Yang Jin, Fahri Saatcioglu
NATURE COMMUNICATIONS
(2019)
Article
Oncology
Ji-Hua Shi, Wen-Zhi Guo, Yang Jin, Hua-Peng Zhang, Chun Pang, Jie Li, Pal-Dag Line, Shui-Jun Zhang
Review
Oncology
Yu Wang, Kai Wang, Yang Jin, Xia Sheng
Review
Medicine, Research & Experimental
Tingting Zhang, Ningning Li, Chaoyang Sun, Yang Jin, Xia Sheng
EMBO MOLECULAR MEDICINE
(2020)
Article
Oncology
Nicklas Pihlstrom, Yang Jin, Zeynep Nenseth, Omer F. Kuzu, Fahri Saatcioglu
Summary: Prostate cancer is one of the most common non-skin cancers among men, with no curative treatment currently available. STAMP2, an important factor for prostate cancer growth and survival, is regulated by inflammatory signaling which may affect disease progression. Inflammatory events and dysregulated cytokine expression are implicated in prostate cancer, and STAMP2 knockdown increases the sensitivity of prostate cancer cells to cytokine treatment.
Article
Oncology
Nora Pallmann, Ke Deng, Marte Livgard, Martina Tesikova, Yixin Jin, Nicolai Sebastian Frengen, Nermin Kahraman, Hamada M. Mokhlis, Bulent Ozpolat, Wanja Kildal, Havard Emil Danielsen, Ladan Fazli, Paul S. Rennie, Partha P. Banerjee, Aykut Uren, Yang Jin, Omer F. Kuzu, Fahri Saatcioglu
Summary: In prostate cancer cells, activating transcription factor 4 (ATF4) exclusively activates gene expression involved in the mitochondrial (m1C) one-carbon cycle, not the cytoplasmic (c1C) cycle; knockdown of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibits prostate cancer cell growth significantly. This suggests that the m1C cycle plays a key role in prostate cancer progression and may serve as a potential biomarker and therapeutic target.
Article
Chemistry, Multidisciplinary
Fengzhen Cui, Qingfei Pan, Siyi Wang, Faming Zhao, Runxin Wang, Tingting Zhang, Yaying Song, Jun He, Haolin Zhang, Qiang Weng, Yang Jin, Wei Xia, Yuanyuan Li, Guo-Yuan Yang, Winnok H. De Vos, Jean-Pierre Timmermans, Shunqing Xu, Yaohui Tang, Xia Sheng
Summary: The study reveals the neurodevelopmental toxicity of benzophenones during pregnancy, which impairs hippocampal development and causes cognitive dysfunction in offspring mice by activating specific signaling pathways that lead to inflammation and cell apoptosis.
Article
Pharmacology & Pharmacy
Gan Wang, Min Zhang, Ping Meng, Chengbo Long, Xiaodong Luo, Xingwei Yang, Yunfei Wang, Zhiye Zhang, James Mwangi, Peter Muiruri Kamau, Zhi Dai, Zunfu Ke, Yi Zhang, Wenlin Chen, Xudong Zhao, Fei Ge, Qiumin Lv, Mingqiang Rong, Dongsheng Li, Yang Jin, Xia Sheng, Ren Lai
Summary: Unlike healthy cells, cancer cells heavily rely on the molecular chaperone protein TRiC, particularly its subunit CCT4, for protein folding and maintenance of proteostasis. In this study, we demonstrate that targeting CCT4 with the compound anticarin-beta can effectively inhibit osteosarcoma cell survival and impede STAT3 maturation. Anticarin-beta shows high selectivity for cancer cells and exhibits remarkable antitumor efficacy in orthotopic and patient-derived xenograft models of osteosarcoma.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Multidisciplinary
Rourou Xiao, Lixin You, Li Zhang, Xichen Guo, Ensong Guo, Faming Zhao, Bin Yang, Xi Li, Yu Fu, Funian Lu, Zizhuo Wang, Chen Liu, Wenju Peng, Wenting Li, Xiaohang Yang, Yingyu Dou, Jingbo Liu, Wei Wang, Tianyu Qin, Yaoyuan Cui, Xiaoxiao Zhang, Fuxia Li, Yang Jin, Qingping Zeng, Beibei Wang, Gordon B. Mills, Gang Chen, Xia Sheng, Chaoyang Sun
Summary: The WEE1 inhibitor AZD1775 induces endoplasmic reticulum stress and activates the PERK and IRE1 alpha branches of the unfolded protein response in TP53 mutant ovarian cancer models. Inhibition of the IRE1 alpha-XBP1s pathway may enhance the efficacy of AZD1775.
Article
Oncology
Chengcheng Shi, Faming Zhao, Tingting Zhang, Denghui Xu, Zhuangyu Hao, Fengzhen Cui, Ji-Hua Shi, Yang Jin, Ningning Li, Caihong Yang, Yi Zhang, Xia Sheng
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Yixin Jin, Kristina Berg Lorvik, Yang Jin, Carole Beck, Adam Sike, Irene Persiconi, Emilie Kvaloy, Fahri Saatcioglu, Claire Dunn, Jon Amund Kyte
Summary: This study describes a CAR T cell targeting STEAP1 and demonstrates its potential clinical application in prostate cancer. The CAR T cells showed specific response against STEAP1 and effectively inhibited tumor growth and prolonged survival in vivo.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Oncology
Jorgen Sikkeland, Matthew Yoke Wui Ng, Hatice Zeynep Nenseth, Bilal Unal, Su Qu, Yang Jin, Anne Simonsen, Fahri Saatcioglu
Summary: STAMP2 suppresses autophagy through modulation of the integrated stress response axis and regulates mitochondrial respiration, both of which have significant metabolic effects and support PCa growth.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Andrology
Ming-Sheng Liu, Hui Zhao, Chen-Xiang Xu, Ping-Bo Xie, Wei Wang, Ying-Yu Yang, Wen-Hui Lee, Yang Jin, Hong-Qing Zhou
Summary: The EPHX2 gene, frequently deleted in prostate cancer, shows significantly decreased expression levels in tumors compared to normal tissues, and is inversely correlated with Gleason grade and disease-free survival time. Its deregulation is significantly correlated with the clinical characteristics of PCa progression and may serve as a prognostic marker for PCa.
ASIAN JOURNAL OF ANDROLOGY
(2021)
Review
Oncology
Yang Jin, Fahri Saatcioglu
