Review
Biochemistry & Molecular Biology
Richard Kwamla Amewu, Patrick Opare Sakyi, Dorcas Osei-Safo, Ivan Addae-Mensah
Summary: Cancer is a complex disease with drugs targeting potential multiple targets being proposed as cutting-edge treatments. However, drug resistance, systemic toxicity, and ineffectiveness in various cancer treatments remain widespread issues. Therefore, efficient therapeutic agents targeting multiple targets in different cancer cells are suggested.
Review
Pharmacology & Pharmacy
Seyed Abdulmajid Ayatollahi, Javad Sharifi-Rad, Patrick Valere Tsouh Fokou, Gail B. Mahady, Hafiz Ansar Rasul Suleria, Shivani Krishna Kapuganti, Kundlik Gadhave, Rajanish Giri, Neha Garg, Rohit Sharma, Daniel Ribeiro, Celia F. Rodrigues, Zeljko Reiner, Yasaman Taheri, Natalia Cruz-Martins
Summary: The current COVID-19 pandemic is a significant threat to human health and the global economy, with over 107 million infections and approximately 2.4 million deaths worldwide. While the development of vaccines has been a major step forward, new anti-viral and anti-inflammatory drug therapies are still needed for effective treatment of the disease. Researchers are exploring natural products as potential treatments for COVID-19, with some showing promise in fighting viral infections.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Applied
Xianan Zhang, Mingshen Su, Jihong Du, Huijuan Zhou, Xiongwei Li, Minghao Zhang, Yang Hu, Zhengwen Ye
Summary: Peach fruits are rich in phenolic compounds, including 19 proanthocyanidins and 37 other phenolic compounds. The quantities of these compounds vary among different peach accessions and are influenced by fruit ripening period, breeding background, and fruit type. This study provides a comprehensive profile of phenolic compounds in peach germplasms, which can be useful in breeding peach plants with specific phenolics.
Article
Chemistry, Multidisciplinary
Usama Ramadan Abdelmohsen, Soad A. L. Bayoumi, Nesma M. Mohamed, Yaser A. Mostafa, Che J. Ngwa, Gabriele Pradel, Salwa F. Farag
Summary: Malaria is a dangerous parasitic disease, and new antimalarial drugs are urgently needed. Natural products, particularly phenylpropanoids, have shown potential as antimalarial agents. In this study, in silico analysis and in vitro assays were conducted to assess the antimalarial activity of naturally-occurring phenylpropanoids.
Article
Chemistry, Applied
R. Heras-Mozos, R. Gavara, P. Hernandez-Munoz
Summary: Reversible imine bonds were used to develop pH-dependent antifungal systems by grafting benzaldehyde and citral onto chitosan films. The formation of imine bonds was confirmed, and the incorporation of aldehyde units into the chitosan polymer was estimated. The study found that acidic media favored the release of aldehydes, with imine bonds from benzaldehyde being more prone to hydrolysis.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Kwadwo Gyapong Agyenim-Boateng, Shengrui Zhang, Md Shariful Islam, Yongzhe Gu, Bin Li, Muhammad Azam, Ahmed M. Abdelghany, Jie Qi, Suprio Ghosh, Abdulwahab S. Shaibu, Berhane Sibhatu Gebregziabher, Yue Feng, Jing Li, Yinghui Li, Chunyi Zhang, Lijuan Qiu, Zhangxiong Liu, Qiuju Liang, Junming Sun
Summary: Soybean is a rich source of folates, with 5-CHO-H(4)folate as the main component. Seed-coat colour, seed weight, ecoregion, and accession type significantly affect soybean folate content, with higher folate content found in accessions from Northeast China.
Review
Food Science & Technology
Omar S. Ahmed, Charles Tardif, Caroline Rouger, Vessela Atanasova, Florence Richard-Forget, Pierre Waffo-Teguo
Summary: This article introduces a promising strategy of using phenolic compounds obtained from botanical extracts as bioagents to inhibit fungal growth and limit mycotoxin production. The mechanism, regulations, and safety of these botanical agents are discussed, along with recent strategies to overcome stability and solubility constraints of phenolic compounds in food and feed stuffs.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2022)
Article
Chemistry, Multidisciplinary
Deng Wang, Chaping Cheng, Xinyu Chen, Jinming Wang, Kaiyuan Liu, Na Jing, Penghui Xu, Xialian Xi, Yujiao Sun, Zhongzhong Ji, Huifang Zhao, Yuman He, Kai Zhang, Xinxing Du, Baijun Dong, Yuxiang Fang, Pengcheng Zhang, Xueming Qian, Wei Xue, Wei-Qiang Gao, Helen He Zhu
Summary: The activation of androgen receptor (AR) signaling pathway in tumor-associated macrophages (TAMs) promotes the overexpression and secretion of IL-1 beta, inhibiting cytotoxic T cells activation and leading to an immune suppressive microenvironment in advanced prostate cancer (PCa). Combined treatment of androgen deprivation therapy (ADT) with anti-IL-1 beta antibody and immune checkpoint inhibitor anti-PD-1 antibody shows a stronger anticancer effect on castration-resistant PCa.
Article
Biochemistry & Molecular Biology
Jong-Kwang Kim, Jae-Hun Jung, Dong-Hoon Shin, Hye-Jin You, Seho Cha, Bo-Seul Song, Jae-Young Joung, Weon-Seo Park, Kwang-Pyo Kim, Jae-Kyung Myung
Summary: This study characterized the rapid proteomic changes in VCaP cells after androgen treatment, identifying five protein clusters involved in different stages of androgen-initiated signal transmission and processing. The study revealed significant regulation of AR-regulated proteins in CRPC patients and provided a comprehensive perspective on the molecular mechanisms underlying CRPC progression.
Article
Environmental Sciences
Yanfei Wang, Kathryn J. J. Coyne
Summary: Transcriptomic analysis revealed differential impacts of IRI-160AA and ammonium on Karlodinium veneficum, identifying cellular mechanisms behind the algicidal effect. This research provided insights on algal response to bacterial derivatives in nature.
FRONTIERS IN MARINE SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Amandeep Singh, Asif Raza, Shantu Amin, Chendil Damodaran, Arun K. Sharma
Summary: This article reviews the medicinal implications, particularly the anticancer properties, of natural withanolides and their synthetic analogs. The analysis of relevant literature demonstrates the translational potential of these promising compounds.
Review
Biochemistry & Molecular Biology
Roshanak Hariri, Mina Saeedi, Tahmineh Akbarzadeh
Summary: Tyrosinase is a crucial enzyme in the biosynthesis of melanin pigment, and its inhibitors have been extensively studied as effective skin whitening agents. Peptides have attracted attention due to their high potency and safety in inhibiting tyrosinase activity.
JOURNAL OF PEPTIDE SCIENCE
(2021)
Article
Biology
Zhe Kong, Yali Lu, Xuechao Wan, Jun Luo, Dujian Li, Yan Huang, Chenji Wang, Yao Li, Yaoting Xu
Summary: The androgen receptor (AR) signaling pathway is crucial in prostate cancer development. We identified numerous androgen-responsive circRNAs and mRNAs, suggesting a potential regulatory role of AR in circRNA expression. Furthermore, the dysregulated circRNAs circNFIA and circZNF561 may serve as diagnostic biomarkers for prostate cancer.
Article
Biochemistry & Molecular Biology
Wenhua Huang, Qin Chen, Yali Lu, Zhe Kong, Xuechao Wan, Yan Huang, Minyan Qiu, Yao Li
Summary: Long noncoding RNA RP11-1023L17.1 is highly expressed in prostate cancer and acts as an oncogene by enhancing c-Myc protein stability through repression of FBXO32 mRNA expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tiziano De Ventura, Mariasole Perrone, Sonia Missiroli, Paolo Pinton, Paolo Marchetti, Giovanni Strazzabosco, Giulia Turrin, Davide Illuminati, Virginia Cristofori, Anna Fantinati, Martina Fabbri, Carlotta Giorgi, Claudio Trapella, Vinicio Zanirato
Summary: A new chalconoid, velutone F, from the Millettia velutina plant, has shown potent effects as an NLRP3-inflammasome inhibitor; the search for new NLRP3 inhibitors is a current topic of interest in medicinal chemistry. Researchers have reported the synthesis of velutone F and unknown non-natural regioisomers using different synthetic strategies, providing a useful pathway for further studies on NLRP3-inhibitors in the flavonoid class.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Christopher J. Robinson, Carol L. Wagner, Bruce W. Hollis, John E. Baatz, Donna D. Johnson
AMERICAN JOURNAL OF PERINATOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Stephan W. Glasser, Melissa D. Maxfield, Teah L. Ruetschilling, Henry T. Akinbi, John E. Baatz, Joseph A. Kitzmiller, Kristen Page, Yan Xu, Erik L. Bao, Thomas R. Korfhagen
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2013)
Article
Biotechnology & Applied Microbiology
Annalaura Mancia, John T. Elliott, Michael Halter, Kiran Bhadriraju, Alessandro Tona, Tighe A. Spurlin, Bobby L. Middlebrooks, John E. Baatz, Gregory W. Warr, Anne L. Plant
BIOTECHNOLOGY PROGRESS
(2012)
Meeting Abstract
Oncology
Demetri D. Spyropoulos, Chadrick E. Denlinger, Ellen C. Riemer, Danforth A. Newton, E. Ellen Jones, Richard R. Drake, John E. Baatz
Article
Biochemistry & Molecular Biology
Annalaura Mancia, Demetri D. Spyropoulos, Wayne E. McFee, Danforth A. Newton, John E. Baatz
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2012)
Article
Obstetrics & Gynecology
E. R. Unal, T. Lynn, J. Neidich, D. Salazar, L. Goetzl, J. E. Baatz, T. C. Hulsey, R. Van Dolah, L. J. Guillette, R. Newman
JOURNAL OF PERINATOLOGY
(2012)
Article
Respiratory System
Stephan W. Glasser, Albert P. Senft, Melissa D. Maxfield, Teah L. Ruetschilling, John E. Baatz, Kristen Page, Thomas R. Korfhagen
RESPIRATORY RESEARCH
(2013)
Review
Pediatrics
Hilal Yildiz Atar, John E. Baatz, Rita M. Ryan
Summary: The association between infants of diabetic mothers (IDMs) and respiratory distress syndrome (RDS) has been well recognized, with increased obesity and diabetes prevalence leading to more pregnant women being overweight and diabetic. Challenges in glycemic control during pregnancy may impact surfactant synthesis and contribute to respiratory distress in newborns.
Article
Nutrition & Dietetics
Katherine E. Chetta, Joseph L. Alcorn, John E. Baatz, Carol L. Wagner
Summary: Frozen storage is crucial for preserving human milk for critically ill and very preterm infants, while milk pasteurization is essential for donor milk given to this population. Nutrient changes occur in milk due to storage and processing conditions, potentially leading to the presence of bioactive complexes like HAMLET, which may have unknown clinical implications. HAMLET, a protein-lipid complex found in human milk, has specific toxicity to certain cells and can trigger inflammatory pathways with unclear consequences, particularly in immature intestinal tissues. Addressing HAMLET's presence and bioactive role in human milk is important in neonatal research.
Article
Pediatrics
Siamak M. Yazdi, Ekta U. Patel, Colby D. Richardson, K. Thomas Hardy, John E. Baatz, Jennifer K. Mulligan, Rita M. Ryan
Summary: This study demonstrates that dexamethasone treatment significantly reduces the severity of bronchopulmonary dysplasia (BPD) in preterm infants by decreasing respiratory severity score (RSS), CD4+IL-6+ cells, CD8+IL-6+ cells, CXCR3+IL-6+ cells, and CXCR3+IL-2+ cells, as well as total IFN-gamma in TA. Additionally, the study found a significant correlation between RSS and CD4+IL-6+ cells in TA.
Article
Nutrition & Dietetics
Danforth A. Newton, John E. Baatz, Katherine E. Chetta, Preston W. Walker, Renee O. Washington, Judy R. Shary, Carol L. Wagner
Summary: The sufficiency of vitamin D in breastfeeding mothers may have different physiological effects compared to the sufficiency of vitamin D in infants. Maternal vitamin D status showed an inverse correlation with infant plasma TNF concentration. The immune response of infants seemed to be more closely related to maternal vitamin D sufficiency, while IL-10 and IL-12 responses were more correlated to infant vitamin D status.
Article
Biochemistry & Molecular Biology
Melinda A. Engevik, Leah K. Stripe, John E. Baatz, Carol L. Wagner, Katherine E. Chetta
Summary: The intestinal microbiota plays a crucial role in the health of preterm neonates. This study aimed to analyze the growth patterns of different bacterial strains in the human intestine in response to formula and human milk. The findings suggest that formula supports the growth of specific pathogenic strains, while both formula and human milk support the growth of commensal bacteria.
Article
Respiratory System
Danforth A. Newton, Robyn G. Lottes, Rita M. Ryan, Demetri D. Spyropoulos, John E. Baatz
Summary: Studies suggest that altered lactate metabolism in AEC2 may play a key role in the development and progression of IPF, making it a potential novel therapeutic target.
RESPIRATORY RESEARCH
(2021)
Meeting Abstract
Critical Care Medicine
A. P. Senft, D. Mitzel, J. T. Hunzeker, T. Witt, M. G. Wathelet, K. S. Harrod, J. E. Baatz
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2011)
Meeting Abstract
Critical Care Medicine
D. A. Newton, D. D. Spyropoulos, J. E. Baatz
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2011)