Article
Chemistry, Medicinal
Dong-Fang Zhao, Yu-Fan Fan, Hao-Nan Yu, Fan-bin Hou, Yan-Wei Xiang, Ping Wang, Guang-Bo Ge, Ling Yang, Jian-Guang Xu
Summary: The study revealed that the flavonoids in vine tea exhibit strong inhibition against human catechol-Omethyltransferase, with myricetin being the most potent compound. This finding not only has implications for the drug exposure of catechol drugs, but also provides a promising lead compound for developing more effective hCOMT inhibitors.
Article
Biochemistry & Molecular Biology
Yingxin Bi, Xianjun Liu, Yue Liu, Mengyuan Wang, Yaming Shan, Yuhe Yin, Xianglong Meng, Fengjie Sun, Hao Li, Zhandong Li
Summary: This study investigated the therapeutic effects of tea polyphenols (TP) and fruit extracts of Lycium ruthenicum (LR) on exercise-induced fatigue (EIF) in a mouse model. The results showed that both TP and LR had anti-inflammatory effects and reduced oxidative stress. MicroRNAs involved in the molecular response to EIF were identified, and the potential regulatory functions were explored.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Mazlum Sahin, Corc Baytaroglu, Emrah Sevgili
Summary: This study found that cilostazol has beneficial effects on Wistar rats' myocardial cells in terms of reducing inflammatory processes, necrosis, and fibrosis.
BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY
(2022)
Article
Biochemical Research Methods
Kari Kopra, Randa Mahran, Titta Yli-Hollo, Sho Tabata, Emmiliisa Vuorinen, Yuki Fujii, Iida Vuorinen, Aki Ogawa-Iio, Akiyoshi Hirayama, Tomoyoshi Soga, Atsuo T. Sasaki, Harri Haermae
Summary: Guanosine triphosphate (GTP) and adenosine triphosphate (ATP) play essential roles in cellular function and their quantification is crucial. A novel quantitative method for monitoring GTP concentration has been introduced and combined with ATP detection to enable high-throughput monitoring. This approach offers a unique opportunity to explore cellular energy metabolism and develop novel therapeutics.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Wei Lin Lee, Ameya Sinha, Ling Ning Lam, Hooi Linn Loo, Jiaqi Liang, Peiying Ho, Liang Cui, Cheryl Siew Choo Chan, Thomas Begley, Kimberly Ann Kline, Peter Dedon
Summary: A newly discovered RNA modifying enzyme in Enterococcus faecalis regulates translation of stress-response proteins by sensing reactive oxygen species (ROS). The enzyme's activity is inhibited by ROS, leading to reduced levels of N-2-methyladenosine (m(2)A) in ribosomal RNA and transfer RNA. Knockout of the enzyme mimics the oxidative stress response, with increased superoxide dismutase levels and decreased virulence proteins. This study reveals a new mechanism in which RNA modifications directly regulate the proteome in response to oxidative stress.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Natalia Zareba, Lukasz Lewandowski, Dominika Kunachowicz, Rene Kizek, Marta Kepinska
Summary: This study reveals that quantum dots (QDs) can influence the activity of superoxide dismutase (SOD) in a size-dependent manner. Additionally, the migration time of QDs-SOD1 complexes varies depending on the type of QD used, with different effects on fluorescence signals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Candida Lorusso, Antonio Calisi, Gianluca Sara, Francesco Dondero
Summary: Silver is currently popular due to its use in nanomaterials for commercial products. Researchers have developed electrophoretic techniques to measure antioxidant enzyme activity and used these techniques to evaluate the effects of silver nitrate and alkane-coated silver nanoparticles on marine bivalve tissues. The results showed minimal effects for nanosilver exposure and dose-dependent effects for the nitrate form.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Pooja D. Patil, Ana Clara Melo, Brian M. Westwood, E. Ann Tallant, Patricia E. Gallagher
Summary: This study found that a muscadine grape skin/seed extract supplement (MGES) has a protective effect against hypertension-induced cardiac damage and oxidative stress, reducing hypertension-induced diastolic dysfunction. This may be achieved by increasing antioxidant enzyme activity and gene expression in cardiac tissue.
Article
Nutrition & Dietetics
Jennifer R. Bathgate, Diane Rigassio Radler, Mindy Kurzer, Hamed Samavat
Summary: Green tea extract (GTE) did not significantly affect plasma F2-isoprostanes concentrations and COMT genotype did not modify the effect of GTE supplementation on F2-isoprostanes concentrations.
NUTRITION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Anthony Al Khoury, Andre El Khoury, Ophelie Rocher, Pamela Hindieh, Olivier Puel, Richard G. G. Maroun, Ali Atoui, Jean-Denis Bailly
Summary: Plant extracts from mate, rosemary, and green tea exhibit anti-AFB1 activity, which is correlated with their phenolic content and radical scavenging capacity. Rutin may be responsible for the anti-mycotoxin effect.
Article
Chemistry, Multidisciplinary
Soha M. Hamdy, Zakaria El-Khayat, Abdel Razik Farrag, Ola N. Sayed, Mervat M. El-Sayed, Diaa Massoud
Summary: This study confirmed the hepatoprotective effect of White tea and Raspberry Ketone against acrylamide-induced liver toxicity in rats, as evidenced by improved liver function markers. The histopathological and immunohistochemical findings supported the biochemical observations.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Medicine, General & Internal
Masato Koike, Masashi Nagao, Yoshiyuki Iwase, Kazuo Kaneko, Muneaki Ishijima, Hidetoshi Nojiri
Summary: This study found that Melon GliSODin (R), a superoxide dismutase-rich melon extract, may help improve subjective symptoms of knee or lower back pain or discomfort. However, no statistically significant differences were observed between the placebo and Melon GliSODin (R) groups in various outcomes after 6 months of treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Magdalena Kwolek-Mirek, Aleksandra Dubicka-Lisowska, Sabina Bednarska, Renata Zadrag-Tecza, Pawel Kaszycki
Summary: Copper-zinc superoxide dismutase (SOD1) is an antioxidant enzyme that regulates oxidative stress-related alterations in the phenotype of the yeast Saccharomyces cerevisiae. Comparative proteomic analysis of the wild-type strain and Delta sod1 mutant revealed differential expression of proteins related to carbon metabolism, amino acid and protein biosynthesis, nucleotide biosynthesis, and antioxidant processes. The study suggests that protein comparative profiling of the Delta sod1 yeast can provide valuable insights into the systemic alterations in the S. cerevisiae phenotype caused by the SOD1 mutation.
Article
Chemistry, Analytical
Stephane Roudeau, Benjamin G. Trist, Asuncion Carmona, Katherine M. Davies, Glenda M. Halliday, Yann Rufin, Stephane Claverol, Stijn J. M. Van Malderen, Gerald Falkenberg, Kay L. Double, Richard Ortega
Summary: A new methodology was developed to analyze the metal content of copper-zinc superoxide dismutase (SOD1) in tissues from the human central nervous system, demonstrating successful preservation of metal, activity, and enrichment of the protein. Results showed Cu and Zn bound to SOD1 in a ratio very close to the expected value of 1, in tissues from healthy individuals. This approach can be adapted to study other metalloproteins in human tissues and other sources.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Francisco Javier Martinez-Noguera, Cristian Marin-Pagan, Jorge Carlos-Vivas, Pedro E. Alcaraz
Summary: The study showed that chronic ingestion of 2S-hesperidin can increase endogenous antioxidant capacity, decrease oxidative stress, and reduce inflammation in amateur cyclists, providing positive effects on their internal status.
Article
Nutrition & Dietetics
Sarah Maria Barneze Costa, Raghavendra Lakshmana Shetty Hallur, David Rafael Abreu Reyes Postdoc, Juliana Ferreira Floriano Postdoc, Maria Antonieta de Barros Leite Carvalhaes, Helio Rubens de Carvalho Nunes, Luis Sobrevia, Paola Valero, Angelica Mercia Pascon Barbosa, Marilza Cunha Vieira Rudge
Summary: This study aimed to assess maternal dietary intake patterns, anthropometric measures, and biochemical markers in women with gestational diabetes mellitus and pregnancy-specific urinary incontinence. The results showed that pregnant women in the gestational diabetes mellitus pregnancy-specific urinary incontinence group had higher body mass index, arm circumference, and triceps skinfold than the other groups, indicating an obesogenic maternal environment. Significant differences in dietary food intake were also observed. The study emphasizes the need for a comprehensive strategy for pregnant women with gestational diabetes mellitus and pregnancy-specific urinary incontinence to address obesity and micronutrient deficiencies.
Article
Nutrition & Dietetics
Aikaterina Vasileiou, Dominique Searle, Sofus C. Larsen, Faidon Magkos, Graham Horgan, R. James Stubbs, Ines Santos, Antonio L. Palmeira, Berit L. Heitmann
Summary: The study compared self-reported total energy intake with total energy expenditure estimated from Fitbit Charge 2 algorithms. The results showed that self-reported energy intake was generally lower than energy expenditure, and the degree of underestimation varied among different populations.
Article
Nutrition & Dietetics
Ziya Erokay Metin, Ozge Mengi Celik, Nevra Koc
Summary: This study demonstrates a significant relationship between climate change awareness and sustainable and healthy eating behaviors as well as adherence to the Mediterranean diet.
Article
Nutrition & Dietetics
Carolline Santos Miranda, Flavia Maria Silva-Veiga, Daiana Araujo Santana-Oliveira, Isabela Macedo Lopes Vasques-Monteiro, Julio Beltrame Daleprane, Vanessa Souza-Mello
Summary: This study investigates the role of peroxisome proliferator-activated receptor (PPAR) activation on thermogenic pathways and mitochondrial metabolism in mouse adipose tissue. The results show that activation of PPARa and dual PPARa/y can reduce body mass, mitigate insulin resistance, and induce browning in white adipose tissue. Preserved mitochondrial metabolism emerges as a potential target for obesity treatment using PPAR agonists, with possible clinical applications.
Article
Nutrition & Dietetics
Qi Ren, Hao-Fan Wu, Ding-Ye Yu, Feng-Min Zhang, Zi-Le Shen, Guo-Wei Huang, Feng Lin, Wei-Zhe Chen, Zhen Yu
Summary: The study aimed to develop a nomogram incorporating preoperative factors for predicting low skeletal muscle mass index and low skeletal muscle radiodensity. The models were calibrated and assessed for their predictive ability using training and validation cohorts, and the clinical usefulness was evaluated using decision curve analysis.
Article
Nutrition & Dietetics
Ruben Castillo-Ortega, Juan Vega-Vargas, Samuel Duran-Aguero
Summary: This study found that during the COVID-19 pandemic, patients with type 1 diabetes experienced decreased adherence to diabetes care, leading to an increase in HbA1c levels, BMI, impaired linear growth, and more hospitalizations. The shift to telemedicine as the main healthcare service also had significant effects on diabetes management.
Article
Nutrition & Dietetics
Yi-Hsiu Chen, Jung-An Lin, Jiun-Rong Chen, Ya-Ling Chen, Suh-Ching Yang
Summary: Regular nutrition consultations have been shown to have significant effects on reducing cardiovascular disease risk factors, especially for individuals with obesity.
Article
Nutrition & Dietetics
Jacinta Winderlich, Bridget Little, Felix Oberender, Tessa Bollard, Tamara Farrell, Samantha Jenkins, Emma Landorf, Andrea McCall, Jessica Menzies, Katie O. ' Brien, Carla Rowe, Kirsten Sim, Melanie van der Wilk, Jemma Woodgate, Eldho Paul, Andrew A. Udy, Emma J. Ridley
Summary: The study aims to describe nutrition provision in Australian and New Zealand pediatric intensive care units, assess the adequacy of enteral nutrition, and evaluate the methods for estimating energy and protein requirements.
Article
Nutrition & Dietetics
Xi Zhang, Jia-Xin Huang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li, Han-Ping Shi, Ming-Hua Cong
Summary: The study found that the modified Controlling Nutritional Status system, which includes C-reactive protein as an inflammatory parameter, is more accurate than the traditional system in predicting the survival of patients with cancer cachexia. High Controlling Nutritional Status and modified Controlling Nutritional Status are both independent risk factors for survival and have a negative impact on survival in patients with advanced-stage cancers, such as esophagogastric and colorectal cancer.
Article
Nutrition & Dietetics
Karolien Dams, Gregory R. A. De Meyer, Rita Jacobs, Tom Schepens, Stany Perkisas, Greta Moorkens, Philippe Jorens
Summary: The study aimed to investigate the development of muscle atrophy in COVID-19 intensive care unit patients and its relationship with hospital outcomes. The results showed that the difference in muscle thickness was linked to the outcome, with the best survival observed in the group with stable muscle thickness.
Article
Nutrition & Dietetics
Bruna Clemente Cota, Mariana de Santis Filgueiras, Patricia Feliciano Pereira, Leidjaira Lopes Juvanhol, Juliana Farias de Novaes
Summary: This study found that higher consumption of ultra-processed food (UPF) and a diet consisting of high proinflammatory foods were associated with the normal-weight obesity (NWO) phenotype in children.
Article
Nutrition & Dietetics
Victor Nogueira da Cruz Silveira, Cleber Lopes Campelo, Antonio Luis Rodrigues da Costa, Patricia Maria Abreu Machado, Ana Karina Teixeira da Cunha Franca, Alcione Miranda dos Santos
Summary: This psychometric study proposed a scale for estimating the consumption of ultra processed foods using item response theory. The study used data from a representative sample of 2515 adolescents aged 18 and 19 from Brazilian Birth Cohorts Consortium. The findings demonstrated that the proposed scale can accurately estimate the consumption of ultra processed foods and is correlated with latent traits related to food consumption.
Article
Nutrition & Dietetics
Dehao Yang, Jiaqi Huang, Jingyu Hu, Minyue Zhang, Haobo Xie, Yilin Chen, Yining Jin, Zerui Jiang, Yanchu Wang, Jinrong Zhu, Xin Lu, Siqi Chen, Yiyun Weng, Guangyong Chen
Summary: This study investigates the association between malnutrition and 6-month outcomes in acute ischemic stroke patients with or without intravenous thrombolysis. The results show a significant association between malnutrition and poor functional outcome.
Article
Nutrition & Dietetics
Ainoa Cristina de Oliveira Candido, Felipe Silva Neves, Vanessa Sequeira Fontes, Adriana Soares Torres Melo, Eliane Rodrigues de Faria, Michele Pereira Netto, Renata Maria Souza Oliveira, George Luiz Lins Machado-Coelho, Ana Paula Carlos Candido
Summary: This study investigated the frequency of breakfast consumption and its associations with the consumption of food at different degrees of industrial processing and with overweight indicators in Brazilian adolescents. The results showed that 20% of adolescents skipped breakfast and 46% of their caloric intake came from ultra-processed foods. Skipping breakfast was associated with increased consumption of ultra-processed foods, higher BMI-for-age, and higher body fat percentage.