ASD v2.0: updated content and novel features focusing on allosteric regulation

The Underappreciated Role of Allostery in the Cellular Network

(2013) Ruth Nussinov et al.   Annual Review of Biophysics

Identification of Regions of Rabbit Muscle Pyruvate Kinase Important for Allosteric Regulation by Phenylalanine, Detected by H/D Exchange Mass Spectrometry

(2013) Charulata B. Prasannan et al.   BIOCHEMISTRY

Allosite: a method for predicting allosteric sites

(2013) Wenkang Huang et al.   BIOINFORMATICS

Allostery in Disease and in Drug Discovery

(2013) Ruth Nussinov et al.   CELL

Impact of Quaternary Structure Dynamics on Allosteric Drug Discovery

(2013) Eileen K. Jaffe   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Toward an understanding of the sequence and structural basis of allosteric proteins

(2013) Xiaobai Li et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Strategies for the Selective Regulation of Kinases with Allosteric Modulators: Exploiting Exclusive Structural Features

(2012) Zhizhou Fang et al.   ACS Chemical Biology

Exploiting protein flexibility to predict the location of allosteric sites

(2012) Alejandro Panjkovich et al.   BMC BIOINFORMATICS

The Different Ways through Which Specificity Works in Orthosteric and Allosteric Drugs

(2012) Ruth Nussinov et al.   CURRENT PHARMACEUTICAL DESIGN

αC helix displacement as a general approach for allosteric modulation of protein kinases

(2012) Lorenzo Palmieri et al.   DRUG DISCOVERY TODAY

Toward understanding the molecular basis for chemical allosteric modulator design

(2012) Qi Wang et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Looking for a sequence based allostery definition: A statistical journey at different resolution scales

(2012) Saritha Namboodiri et al.   JOURNAL OF THEORETICAL BIOLOGY

PKM2 Enters the Morpheein Academy

(2012) Galina Semenova et al.   MOLECULAR CELL

BioLiP: a semi-manually curated database for biologically relevant ligand–protein interactions

(2012) Jianyi Yang et al.   NUCLEIC ACIDS RESEARCH

Allosteric post-translational modification codes

(2012) Ruth Nussinov et al.   TRENDS IN BIOCHEMICAL SCIENCES

Accurate Prediction of the Dynamical Changes within the Second PDZ Domain of PTP1e

(2012) Elisa Cilia et al.   PLoS Computational Biology

Rational Engineering of Enzyme Allosteric Regulation through Sequence Evolution Analysis

(2012) Jae-Seong Yang et al.   PLoS Computational Biology

Allosteric Communication across the Native and Mutated KIT Receptor Tyrosine Kinase

(2012) Elodie Laine et al.   PLoS Computational Biology

Dynamic dissociating homo-oligomers and the control of protein function

(2011) Trevor Selwood et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

State-Dependent cAMP Binding to Functioning HCN Channels Studied by Patch-Clamp Fluorometry

(2011) Shengjun Wu et al.   BIOPHYSICAL JOURNAL

Pocketome: an encyclopedia of small-molecule binding sites in 4D

(2011) Irina Kufareva et al.   NUCLEIC ACIDS RESEARCH

Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery

(2011) F. Zhu et al.   NUCLEIC ACIDS RESEARCH

Allo-network drugs: harnessing allostery in cellular networks

(2011) Ruth Nussinov et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Interaction Energy Based Protein Structure Networks

(2010) M.S. Vijayabaskar et al.   BIOPHYSICAL JOURNAL

Allostery and population shift in drug discovery

(2010) Gozde Kar et al.   CURRENT OPINION IN PHARMACOLOGY

Protein dynamics and allostery: an NMR view

(2010) Shiou-Ru Tzeng et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Effects of the Allosteric Antagonist 1-(4-Chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea (PSNCBAM-1) on CB1 Receptor Modulation in the Cerebellum

(2010) X. Wang et al.   MOLECULAR PHARMACOLOGY

fpocket: online tools for protein ensemble pocket detection and tracking

(2010) P. Schmidtke et al.   NUCLEIC ACIDS RESEARCH

ASD: a comprehensive database of allosteric proteins and modulators

(2010) Z. Huang et al.   NUCLEIC ACIDS RESEARCH

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

(2010) C. Knox et al.   NUCLEIC ACIDS RESEARCH

Induced fit, conformational selection and independent dynamic segments: an extended view of binding events

(2010) Peter Csermely et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mechanisms of transcription factor selectivity

(2010) Yongping Pan et al.   TRENDS IN GENETICS

Assessing the potential of glucokinase activators in diabetes therapy

(2009) Franz M. Matschinsky   NATURE REVIEWS DRUG DISCOVERY

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

(2009) Antoine Taly et al.   NATURE REVIEWS DRUG DISCOVERY

The Origin of Allosteric Functional Modulation: Multiple Pre-existing Pathways

(2009) Antonio del Sol et al.   STRUCTURE

Developing analgesics by enhancing spinal inhibition after injury: GABAA receptor subtypes as novel targets

(2009) Gordon Munro et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

Allosteric regulation and catalysis emerge via a common route

(2008) Nina M Goodey et al.   Nature Chemical Biology

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Allostery and cooperativity revisited

(2008) Qiang Cui et al.   PROTEIN SCIENCE