Non-erythroid alpha spectrin prevents telomere dysfunction after DNA interstrand cross-link damage

DNA interstrand crosslinks induce a potent replication block followed by formation and repair of double strand breaks in intact mammalian cells

(2012) Daniel Vare et al.   DNA REPAIR

CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion

(2012) Peili Gu et al.   EMBO JOURNAL

Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

(2012) Anitha Suram et al.   EMBO JOURNAL

Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway

(2012) H. Kim et al.   GENES & DEVELOPMENT

Removal of Shelterin Reveals the Telomere End-Protection Problem

(2012) A. Sfeir et al.   SCIENCE

Spectrin-based skeleton as an actor in cell signaling

(2011) B. Machnicka et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Physiological consequences of defects in ERCC1–XPF DNA repair endonuclease

(2011) Siobhán Q. Gregg et al.   DNA REPAIR

Telomere dysfunction and chromosome instability

(2011) John P. Murnane   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Shelterin complex and associated factors at human telomeres

(2011) Raffaella Diotti et al.   Nucleus

Knockdown of μ-Calpain in Fanconi Anemia, FA-A, Cells by siRNA Restores αII Spectrin Levels and Corrects Chromosomal Instability and Defective DNA Interstrand Cross-Link Repair

(2010) Pan Zhang et al.   BIOCHEMISTRY

Telomere Loss as a Mechanism for Chromosome Instability in Human Cancer

(2010) John P. Murnane   CANCER RESEARCH

FEN1 Ensures Telomere Stability by Facilitating Replication Fork Re-initiation

(2010) Abhishek Saharia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping

(2010) Sophie Badie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Knockdown of αII spectrin in normal human cells by siRNA leads to chromosomal instability and decreased DNA interstrand cross-link repair

(2009) Laura W. McMahon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

(2009) P. Martinez et al.   GENES & DEVELOPMENT

BRCA1 Localization to the Telomere and Its Loss from the Telomere in Response to DNA Damage

(2009) Rahul D. Ballal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fanconi anemia proteins and endogenous stresses

(2009) Qishen Pang et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs

(2009) Hyeung Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A role for monoubiquitinated FANCD2 at telomeres in ALT cells

(2009) Qiang Fan et al.   NUCLEIC ACIDS RESEARCH

The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links

(2009) A. Z. Al-Minawi et al.   NUCLEIC ACIDS RESEARCH

The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

(2009) P. Knipscheer et al.   SCIENCE

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

The SH3 Domain of αII Spectrin Is a Target for the Fanconi Anemia Protein, FANCG†

(2008) Joel A. Lefferts et al.   BIOCHEMISTRY

Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2

(2008) A. Konishi et al.   GENES & DEVELOPMENT

Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms

(2008) Yili Wu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The genetic and molecular basis of Fanconi anemia

(2008) Johan P. de Winter et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH