Natural zinc ribbon HNH endonucleases and engineered zinc finger nicking endonuclease

Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme

(2012) J. Wang et al.   GENOME RESEARCH

Precision genome engineering with programmable DNA-nicking enzymes

(2012) E. Kim et al.   GENOME RESEARCH

Exploring the DNA-recognition potential of homeodomains

(2012) S. W. Chu et al.   GENOME RESEARCH

FLASH assembly of TALENs for high-throughput genome editing

(2012) Deepak Reyon et al.   NATURE BIOTECHNOLOGY

A transcription activator-like effector toolbox for genome engineering

(2012) Neville E Sanjana et al.   Nature Protocols

Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects

(2012) Cherie L. Ramirez et al.   NUCLEIC ACIDS RESEARCH

Structural, functional and evolutionary relationships between homing endonucleases and proteins from their host organisms

(2012) G. K. Taylor et al.   NUCLEIC ACIDS RESEARCH

Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers

(2012) Adrian W. Briggs et al.   NUCLEIC ACIDS RESEARCH

The protein gp74 from the bacteriophage HK97 functions as a HNH endonuclease

(2012) Serisha Moodley et al.   PROTEIN SCIENCE

Tyrosine partners coordinate DNA nicking by theSalmonella typhimuriumplasmid pCU1 relaxase enzyme

(2011) Rebekah P. Nash et al.   FEBS LETTERS

Genome Engineering With Zinc-Finger Nucleases

(2011) Dana Carroll   GENETICS

Characterization of Type II and III Restriction-Modification Systems from Bacillus cereus Strains ATCC 10987 and ATCC 14579

(2011) S.-y. Xu et al.   JOURNAL OF BACTERIOLOGY

Zinc-finger recombinase activities in vitro

(2011) Marko M. Prorocic et al.   NUCLEIC ACIDS RESEARCH

Degenerate sequence recognition by the monomeric restriction enzyme: single mutation converts BcnI into a strand-specific nicking endonuclease

(2011) Georgij Kostiuk et al.   NUCLEIC ACIDS RESEARCH

Activity, specificity and structure of I-Bth0305I: a representative of a new homing endonuclease family

(2011) Gregory K. Taylor et al.   NUCLEIC ACIDS RESEARCH

Structural and functional analysis of the archaeal endonuclease Nob1

(2011) Thomas Veith et al.   NUCLEIC ACIDS RESEARCH

Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase

(2011) C. A. Gersbach et al.   NUCLEIC ACIDS RESEARCH

Assembly of custom TALE-type DNA binding domains by modular cloning

(2011) Robert Morbitzer et al.   NUCLEIC ACIDS RESEARCH

De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks

(2011) M. M. Mahfouz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

(2010) M. Christian et al.   GENETICS

Frequent Endonuclease Cleavage at Off-target Locations In Vivo

(2010) Lisa M Petek et al.   MOLECULAR THERAPY

A TALE nuclease architecture for efficient genome editing

(2010) Jeffrey C Miller et al.   NATURE BIOTECHNOLOGY

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template

(2010) Michael J. Metzger et al.   NUCLEIC ACIDS RESEARCH

Natural and engineered nicking endonucleases--from cleavage mechanism to engineering of strand-specificity

(2010) S.-H. Chan et al.   NUCLEIC ACIDS RESEARCH

TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain

(2010) Ting Li et al.   NUCLEIC ACIDS RESEARCH

Cofactor Requirement of HpyAV Restriction Endonuclease

(2010) Siu-Hong Chan et al.   PLoS One

Unusual Target Site Disruption by the Rare-Cutting HNH Restriction Endonuclease PacI

(2010) Betty W. Shen et al.   STRUCTURE

Cleavage of Phosphorothioated DNA and Methylated DNA by the Type IV Restriction Endonuclease ScoMcrA

(2010) Guang Liu et al.   PLoS Genetics

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

Targeting individual subunits of the FokI restriction endonuclease to specific DNA strands

(2009) K. L. Sanders et al.   NUCLEIC ACIDS RESEARCH

Phage T4 mobE promotes trans homing of the defunct homing endonuclease I-TevIII

(2009) Gavin W. Wilson et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of the ββα-Me type II restriction endonuclease Hpy99I with target DNA

(2009) Monika Sokolowska et al.   NUCLEIC ACIDS RESEARCH

REBASE—a database for DNA restriction and modification: enzymes, genes and genomes

(2009) Richard J. Roberts et al.   NUCLEIC ACIDS RESEARCH

Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease

(2009) A. McConnell Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering BspQI nicking enzymes and application of N.BspQI in DNA labeling and production of single-strand DNA

(2009) Penghua Zhang et al.   PROTEIN EXPRESSION AND PURIFICATION

Targeting DNA 5mCpG sites with chimeric endonucleases

(2008) Alexey Fomenkov et al.   ANALYTICAL BIOCHEMISTRY

Genome Sequence and Characteristics of Lrm1, a Prophage from Industrial Lactobacillus rhamnosus Strain M1

(2008) E. Durmaz et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Interaction of the TFIIB zinc ribbon with RNA polymerase II

(2008) Laura M. Elsby et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Characterization of a novel portal protein from deep-sea thermophilic bacteriophage GVE2

(2008) Yiqian Wang et al.   GENE

Structural Analysis of the Heterodimeric Type IIS Restriction Endonuclease R.BspD6I Acting as a Complex between a Monomeric Site-specific Nickase and a Catalytic Subunit

(2008) Galina S. Kachalova et al.   JOURNAL OF MOLECULAR BIOLOGY

Engineering Variants of the I-SceI Homing Endonuclease with Strand-specific and Site-specific DNA-nicking Activity

(2008) Yan Niu et al.   JOURNAL OF MOLECULAR BIOLOGY

Expanding or Restricting the Target Site Repertoire of Zinc-finger Nucleases: The Inter-domain Linker as a Major Determinant of Target Site Selectivity

(2008) Eva-Maria Händel et al.   MOLECULAR THERAPY

An affinity-based scoring scheme for predicting DNA-binding activities of modularly assembled zinc-finger proteins

(2008) Jeffry D. Sander et al.   NUCLEIC ACIDS RESEARCH

Zinc Finger Database (ZiFDB): a repository for information on C2H2 zinc fingers and engineered zinc-finger arrays

(2008) F. Fu et al.   NUCLEIC ACIDS RESEARCH