Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes

Organization of Plasmid DNA into Nucleosome-Like Structures after Transfection in Eukaryotic Cells

(2014) V. Mladenova et al.   BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT

Complementation between inactive fragments of SssI DNA methyltransferase

(2012) Krystyna Ślaska-Kiss et al.   BMC MOLECULAR BIOLOGY

DNA Methylation Does Not Stably Lock Gene Expression but Instead Serves as a Molecular Mark for Gene Silencing Memory

(2012) N. J.- M. Raynal et al.   CANCER RESEARCH

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

TALE nucleases: tailored genome engineering made easy

(2012) Claudio Mussolino et al.   CURRENT OPINION IN BIOTECHNOLOGY

Epigenetic reprogramming of cancer cells via targeted DNA methylation

(2012) Ashley G. Rivenbark et al.   Epigenetics

Selective DNA demethylation by fusion of TDG with a sequence-specific DNA-binding domain

(2012) David J. Gregory et al.   Epigenetics

Targeting Serous Epithelial Ovarian Cancer with Designer Zinc Finger Transcription Factors

(2012) Haydee Lara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid disease drug approved

(2012) Ken Garber   NATURE BIOTECHNOLOGY

Risky business

(2012)   Nature Chemical Biology

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Complexities of occupancy and sequence

(2012) Mary Muers   NATURE REVIEWS GENETICS

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer

(2012) Sabine Stolzenburg et al.   NUCLEIC ACIDS RESEARCH

Current progress of siRNA/shRNA therapeutics in clinical trials

(2011) John C. Burnett et al.   Biotechnology Journal

Targeted Methylation of Two Tumor Suppressor Genes Is Sufficient to Transform Mesenchymal Stem Cells into Cancer Stem/Initiating Cells

(2011) I.-W. Teng et al.   CANCER RESEARCH

Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase

(2011) Bin-Zhong Li et al.   CELL RESEARCH

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Rapid Synthesis of New DNMT Inhibitors Derivatives of Procainamide

(2011) Ludovic Halby et al.   CHEMBIOCHEM

Hydroxylation of methylated CpG dinucleotides reverses stabilisation of DNA duplexes by cytosine 5-methylation

(2011) Armin Thalhammer et al.   CHEMICAL COMMUNICATIONS

Recent Advances in Understanding of the Immunological Off-Target Effects of siRNA

(2011) Marta Olejniczak et al.   CURRENT GENE THERAPY

Reactivation ofMASPINin non-small cell lung carcinoma (NSCLC) cells by artificial transcription factors (ATFs)

(2011) Adriana S. Beltran et al.   Epigenetics

Diverse ways to be specific: a novel Zn-binding domain confers substrate specificity to UTX/KDM6A histone H3 Lys 27 demethylase

(2011) E. Kim et al.   GENES & DEVELOPMENT

Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells

(2011) H. Wu et al.   GENES & DEVELOPMENT

Targeted siRNA delivery to diseased microvascular endothelial cells-Cellular and molecular concepts

(2011) Piotr S. Kowalski et al.   IUBMB LIFE

OPERating ON Chromatin, a Colorful Language where Context Matters

(2011) Kathryn E. Gardner et al.   JOURNAL OF MOLECULAR BIOLOGY

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

(2011) Kristine Williams et al.   NATURE

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

(2011) Gabriella Ficz et al.   NATURE

Genomic mapping of 5-hydroxymethylcytosine in the human brain

(2011) Seung-Gi Jin et al.   NUCLEIC ACIDS RESEARCH

Epigenetic cancer therapy: rationales, targets and drugs

(2011) M Rius et al.   ONCOGENE

DNA Methylation of the First Exon Is Tightly Linked to Transcriptional Silencing

(2011) Fabienne Brenet et al.   PLoS One

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

Histone modification: cause or cog?

(2011) Steven Henikoff et al.   TRENDS IN GENETICS

Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms

(2011) Iris JE Stulemeijer et al.   Epigenetics & Chromatin

Modulation of gene-specific epigenetic states and transcription by non-coding RNAs

(2011) Kevin V. Morris   Clinical Epigenetics

Targeted DNA Methylation by a DNA Methyltransferase Coupled to a Triple Helix Forming Oligonucleotide To Down-Regulate the Epithelial Cell Adhesion Molecule

(2010) Bernardina T. F. van der Gun et al.   BIOCONJUGATE CHEMISTRY

Structure and Function of Mammalian DNA Methyltransferases

(2010) Renata Zofia Jurkowska et al.   CHEMBIOCHEM

Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore

(2010) Jan H Bergmann et al.   EMBO JOURNAL

Targeting of EZH2 to a defined genomic site is sufficient for recruitment of Dnmt3a but not de novo DNA methylation

(2010) Margaret Rush et al.   Epigenetics

Nonhistone protein acetylation as cancer therapy targets

(2010) Brahma N Singh et al.   Expert Review of Anticancer Therapy

Epigenetic modifications as therapeutic targets

(2010) Theresa K Kelly et al.   NATURE BIOTECHNOLOGY

Active DNA demethylation: many roads lead to Rome

(2010) Susan C. Wu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail

(2010) Yingying Zhang et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation of SU(VAR)3–9 by the Chromosomal Kinase JIL-1

(2010) Joern Boeke et al.   PLoS One

Epigenetic Drugs Can Stimulate Metastasis through Enhanced Expression of the Pro-Metastatic Ezrin Gene

(2010) Yanlin Yu et al.   PLoS One

Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels

(2010) Maja Klug et al.   GENOME BIOLOGY

Zinc-finger-based artificial transcription factors and their applications

(2009) Takashi Sera   ADVANCED DRUG DELIVERY REVIEWS

Active DNA Demethylation Mediated by DNA Glycosylases

(2009) Jian-Kang Zhu   Annual Review of Genetics

Methyl-CpG targeted recruitment of p300 reactivates tumor suppressor genes in human cancer cells

(2009) Shinichi Fukushige et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

(2009) K. Agger et al.   GENES & DEVELOPMENT

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

Aberrant de novo methylation of the p16INK4A CpG island is initiated post gene silencing in association with chromatin remodelling and mimics nucleosome positioning

(2009) Rebecca A. Hinshelwood et al.   HUMAN MOLECULAR GENETICS

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

(2009) Gijs van Haaften et al.   NATURE GENETICS

Linking DNA methylation and histone modification: patterns and paradigms

(2009) Howard Cedar et al.   NATURE REVIEWS GENETICS

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

CBP/p300 is a cell type-specific modulator of CLOCK/BMAL1-mediated transcription

(2009) Hiroshi Hosoda et al.   Molecular Brain

Methyl-CpG targeted transcriptional activation allows re-expression of tumor suppressor genes in human cancer cells

(2008) Shinichi Fukushige et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An engineered split M.HhaI-zinc finger fusion lacks the intended methyltransferase specificity

(2008) Glenna E. Meister et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Colorful History of Active DNA Demethylation

(2008) Steen K.T. Ooi et al.   CELL

Functional Reassembly of Split Enzymes On-Site: A Novel Approach for Highly Sequence-Specific Targeted DNA Methylation

(2008) Antal Kiss et al.   CHEMBIOCHEM

Inferring causal relationships among different histone modifications and gene expression

(2008) H. Yu et al.   GENOME RESEARCH

Persistent downregulation of the pancarcinoma-associated epithelial cell adhesion molecule via active intranuclear methylation

(2008) Bernardina T.F. van der Gun et al.   INTERNATIONAL JOURNAL OF CANCER

Heritable Gene Repression through the Action of a Directed DNA Methyltransferase at a Chromosomal Locus

(2008) Alexander E. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Interaction between DNA Methyltransferase DIM-2 and HP1 Is Required for DNA Methylation in Neurospora crassa

(2008) S. Honda et al.   MOLECULAR AND CELLULAR BIOLOGY

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

(2008) Mark E. Kleinman et al.   NATURE

Epigenetic transcriptional repression of cellular genes by a viral SET protein

(2008) Shiraz Mujtaba et al.   NATURE CELL BIOLOGY

A model for transmission of the H3K27me3 epigenetic mark

(2008) Klaus H. Hansen et al.   NATURE CELL BIOLOGY

Combinatorial patterns of histone acetylations and methylations in the human genome

(2008) Zhibin Wang et al.   NATURE GENETICS

De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes

(2008) Silvina Epsztejn-Litman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The triple helix: 50 years later, the outcome

(2008) M. Duca et al.   NUCLEIC ACIDS RESEARCH

Nucleosome destabilization in the epigenetic regulation of gene expression

(2007) Steven Henikoff   NATURE REVIEWS GENETICS