Article
Biochemistry & Molecular Biology
Shan Cao, Lan Xiao, Junyao Wang, Guodong Chen, Yulan Liu
Summary: The study demonstrates that HuR regulates cell migration and rapid epithelial repair by posttranscriptionally regulating Cav-1, highlighting the critical role of posttranscriptional regulation in the process.
BIOCHEMICAL JOURNAL
(2021)
Article
Plant Sciences
Wei Kong, Shutang Tan, Qing Zhao, De-Li Lin, Zhi-Hong Xu, Jiri Friml, Hong-Wei Xue
Summary: The study revealed the important regulatory role of the PELOTA-HBS1 complex in plants, confirming its functionality in degrading T-DNA disrupted PDK1 transcripts to rescue growth and developmental defects.
Article
Multidisciplinary Sciences
Wei Wang, Fei Shao, Xueying Yang, Juhong Wang, Rongxuan Zhu, Yannan Yang, Gaoxiang Zhao, Dong Guo, Yingli Sun, Jie Wang, Qi Xue, Shugeng Gao, Yibo Gao, Jie He, Zhimin Lu
Summary: This study demonstrates that METTL3 downregulates APC by upregulating its m(6)A modification and recruiting YTHDF2 for APC mRNA degradation, leading to enhanced glycolysis and tumor growth in esophageal cancer.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Hsiao-Chin Chou, Chun-Mei Cheng, Chi-Hwa Yang, Tzu-Yin Lin, Ya-Wen Liu, Tse-Hua Tan, Yi-Rong Chen
Summary: This study revealed the importance of DUSP3 as a regulator of epithelial TJ and its decrease may be implicated in the progression of epithelial cancers.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Food Science & Technology
Lucas Heils, Martina Schneemann, Ralf Gerhard, Joerg-Dieter Schulzke, Roland Buecker
Summary: The study investigated the impact of Clostridioides difficile binary toxin (CDT) on the intestinal epithelial barrier and found that sublethal concentrations of CDT induced barrier dysfunction with increased permeability and redistribution of tight junction proteins. This suggests that CDT may contribute to diarrhea by compromising the intestinal barrier function.
Article
Biochemistry & Molecular Biology
Tianzhuo Zhang, Zhe Wang, Minghui Liu, Lu Liu, Xin Yang, Yu Zhang, Juntao Bie, Yutong Li, Mengmeng Ren, Chen Song, Wengong Wang, Hongyu Tan, Jianyuan Luo
Summary: This study uncovers acetylation as a novel regulatory modification of EWSR1, which is essential for its function in DNA damage response. UV-induced EWSR1 acetylation represses its interaction with spliceosomal component U1C, leading to the suppression of CHK2 activity.
Article
Biochemistry & Molecular Biology
Kimiyoshi Yano, Ryou-U Takahashi, Bunsyo Shiotani, Junko Abe, Tomoki Shidooka, Yuki Sudo, Yusuke Yamamoto, Shisei Kan, Hiroki Sakagami, Hidetoshi Tahara
Summary: PRPF19 is identified as a critical regulator of cellular senescence in normal human fibroblasts by modulating MDM4 splicing and p53 activity, leading to induction of p53-dependent cellular senescence.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yuyao Chu, Yanrong Zhu, Yajing Zhang, Xiaojing Liu, Yilei Guo, Lan Chang, Xinming Yun, Zhifeng Wei, Yufeng Xia, Yue Dai
Summary: Tetrandrine can protect against intestinal epithelial barrier defects in colitis by promoting Occludin expression through the AhR/miR-429 pathway, suggesting its potential use as a barrier protector in the treatment of colitis.
Article
Biochemistry & Molecular Biology
Martyna Nowacka, Przemyslaw Latoch, Matylda A. Izert, Natalia K. Karolak, Rafal Tomecki, Michal Koper, Agnieszka Tudek, Agata L. Starosta, Maria W. Gorna
Summary: This study proposes an mRNA enrichment strategy based on the RNA-binding properties of human IFIT1, which effectively depletes rRNA while maintaining high quality RNA-seq data with coverage of the protein coding transcriptome. It is a cost-effective and versatile tool for preparing mRNA libraries for various organisms.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ravi Kumar, Dipak Kumar Poria, Partho Sarothi Ray
Summary: Posttranscriptional regulation of gene expression is crucial in controlling the inflammatory response and preventing tumorigenesis. The interactions between HuR and La proteins play a cooperative role in regulating PDCD4 mRNA translation and mitigating the oncogenic function of miR-21. This interplay demonstrates a synergistic effect on PDCD4 expression, helping maintain balance between inflammation and tumorigenesis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Neurosciences
Silvia Torices, Timea Teglas, Oandy Naranjo, Nikolai Fattakhov, Kristyna Frydlova, Rosalba Cabrera, Olivia M. Osborne, Enze Sun, Allan Kluttz, Michal Toborek
Summary: HIV-1 infection commonly leads to blood brain barrier (BBB) alterations and neurocognitive disorders in patients. The BBB, formed by cells of the neurovascular unit (NVU) sealed together by occludin, can be infected by HIV-1 through the presence of pericytes. This study investigates the role of OAS genes and occludin in the regulation of HIV-1 infection in human brain pericytes.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Julien Champagne, Abhijeet Pataskar, Naomi Blommaert, Remco Nagel, Demi Wernaart, Sofia Ramalho, Juliana Kenski, Onno B. Bleijerveld, Esther A. Zaal, Celia R. Berkers, Maarten Altelaar, Daniel S. Peeper, William J. Faller, Reuven Agami
Summary: This study reveals that ribosomal frameshifting induced by tryptophan depletion is a common phenomenon in cancer, associated with hyperactivation of the MAPK pathway. It shows that sloppiness results in aberrant peptide presentation at the cell surface, allowing specific killing of drug-resistant cancer cells by T lymphocytes.
Article
Immunology
Zijie Xia, Jihao Xu, Eugene Lu, Wei He, Silu Deng, Ai-Yu Gong, Juliane Strass-Soukup, Gislaine A. Martins, Guoqing Lu, Xian-Ming Chen
Summary: The study shows significant alterations in the topology of m(6)A mRNA methylome in intestinal epithelial cells following Cryptosporidium parvum infection, affecting innate defense and expression of immune-related genes. This suggests a key role of m(6)A mRNA modification in regulating immune responses in intestinal epithelial cells during microbial infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ashley G. Boice, Karla E. Lopez, Raj K. Pandita, Melissa J. Parsons, Chloe Charendoff, Vijay Charaka, Alexandre F. Carisey, Tej K. Pandita, Lisa Bouchier-Hayes
Summary: The study demonstrates that caspase-2 is activated in dividing cells in G1 phase of the cell cycle and plays a crucial role in maintaining genomic stability by protecting cells from replication stress and promoting replication fork protection. These functions are independent of its pro-apoptotic role and involve regulating cell cycle and DNA repair events to prevent the accumulation of DNA damage.
Article
Medicine, Research & Experimental
Sujata Jana, Rucha Deo, Rowan P. Hough, Yuzhen Liu, Jessie L. Horn, Jonathan L. Wright, Hung-Ming Lam, Kevin R. Webster, Gary G. Chiang, Nahum Sonenberg, Andrew C. Hsieh
Summary: This study showed that protein synthesis is essential for urothelial cancer formation and growth but not necessary for bladder homeostasis. Phosphorylation of eIF4E at serine 209 plays a critical role in bladder cancer initiation and progression, with tumors having high levels of eIF4E phosphorylation showing sensitivity to specific inhibitors.