The role of transcription factor Nrf2 in skin cells metabolism

Role of nuclear factor E2-related factor 2 (Nrf2) in epidermal differentiation

(2014) Young Lee et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Curcumin does not switch melanin synthesis towards pheomelanin in B16F10 cells

(2014) Agnieszka Wolnicka-Glubisz et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Piper betle induces phase I & II genes through Nrf2/ARE signaling pathway in mouse embryonic fibroblasts derived from wild type and Nrf2 knockout cells

(2014) Wan Nuraini Wan Hasan et al.   BMC Complementary and Alternative Medicine

Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice

(2014) M. Schafer et al.   EMBO Molecular Medicine

Effect of 7, 8-dihydroxyflavone on the up-regulation of Nrf2-mediated heme oxygenase-1 expression in hamster lung fibroblasts

(2014) Min Ju Ryu et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Impaired Activation of the Nrf2-ARE Signaling Pathway Undermines H 2 O 2 -Induced Oxidative Stress Response: A Possible Mechanism for Melanocyte Degeneration in Vitiligo

(2014) Zhe Jian et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Nrf2 Negatively Regulates Melanogenesis by Modulating PI3K/Akt Signaling

(2014) Jung-Min Shin et al.   PLoS One

Targeting Nrf2-Keap1 signaling for chemoprevention of skin carcinogenesis with bioactive phytochemicals

(2014) Kyung-Soo Chun et al.   TOXICOLOGY LETTERS

Topical application of the synthetic triterpenoid RTA 408 activates Nrf2 and induces cytoprotective genes in rat skin

(2013) Scott A. Reisman et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Peroxiredoxin-2 Represses Melanoma Metastasis by Increasing E-Cadherin/ -Catenin Complexes in Adherens Junctions

(2013) D. J. Lee et al.   CANCER RESEARCH

Redox activation of Nrf2 & NF-κB: A double end sword?

(2013) Mabel Buelna-Chontal et al.   CELLULAR SIGNALLING

Disruption of Thioredoxin Reductase 1 Protects Mice from Acute Acetaminophen-Induced Hepatotoxicity through Enhanced NRF2 Activity

(2013) Andrew D. Patterson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Efficacy of the melanocortin analogue Nle4-D-Phe7-α-melanocyte-stimulating hormone in the treatment of patients with Hailey-Hailey disease

(2013) G. Biolcati et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis

(2013) Richard J. Mead et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of fibroblast-derived factors on the proliferation and differentiation of human melanocytes in culture

(2013) Tomohisa Hirobe et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Inhibition of nuclear factor-erythroid 2–related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence

(2013) Daniela Volonte et al.   MOLECULAR BIOLOGY OF THE CELL

The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells

(2013) William R Heath et al.   NATURE IMMUNOLOGY

Allergic Skin Inflammation Induced by Chemical Sensitizers Is Controlled by the Transcription Factor Nrf2

(2013) Zeina El Ali et al.   TOXICOLOGICAL SCIENCES

Reactivity of Chemical Sensitizers Toward Amino Acids In Cellulo Plays a Role in the Activation of the Nrf2-ARE Pathway in Human Monocyte Dendritic Cells and the THP-1 Cell Line

(2013) Camille Migdal et al.   TOXICOLOGICAL SCIENCES

Nrf2-dependent and Nrf2-independent induction of phase 2 detoxifying and antioxidant enzymes during keratinocyte differentiation

(2012) Mei Shan Piao et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

The high Nrf2 expression in human acute myeloid leukemia is driven by NF- B and underlies its chemo-resistance

(2012) S. A. Rushworth et al.   BLOOD

Oxidation Levels Differentially Impact Melanocytes: Low versus High Concentration of Hydrogen Peroxide Promotes Melanin Synthesis and Melanosome Transfer

(2012) Luyan Tang et al.   DERMATOLOGY

Ellagic acid protects human keratinocyte (HaCaT) cells against UVA-induced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes

(2012) You-Cheng Hseu et al.   FOOD AND CHEMICAL TOXICOLOGY

TGF-beta 1 induced fibroblast proliferation is mediated by the FGF-2/ERK pathway

(2012) Li Xiao   Frontiers in Bioscience-Landmark

Identification of UV-protective Activators of Nuclear Factor Erythroid-derived 2-Related Factor 2 (Nrf2) by Combining a Chemical Library Screen with Computer-based Virtual Screening

(2012) Franziska Lieder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf2 Protein Up-regulates Antiapoptotic Protein Bcl-2 and Prevents Cellular Apoptosis

(2012) Suryakant K. Niture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caveolin-1 Inhibits Expression of Antioxidant Enzymes through Direct Interaction with Nuclear Erythroid 2 p45-related Factor-2 (Nrf2)

(2012) Wen Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vitiligo-Inducing Phenols Activate the Unfolded Protein Response in Melanocytes Resulting in Upregulation of IL6 and IL8

(2012) Siavash Toosi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Absence of Nrf2 Enhances NF-B-Dependent Inflammation following Scratch Injury in Mouse Primary Cultured Astrocytes

(2012) Hao Pan et al.   MEDIATORS OF INFLAMMATION

Ethanol Extract of Peanut Sprout Induces Nrf2 Activation and Expression of Antioxidant and Detoxifying Enzymes in Human Dermal Fibroblasts: Implication for its Protection Against UVB-irradiated Oxidative Stress

(2012) Jee-Young Choi et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene

(2012) Jimmy Fourtounis et al.   RESPIRATORY RESEARCH

Human Skin Model Containing Melanocytes: Essential Role of Keratinocyte Growth Factor for Constitutive Pigmentation—Functional Response to α-Melanocyte Stimulating Hormone and Forskolin

(2012) Christine Duval et al.   TISSUE ENGINEERING PART C-METHODS

UV-B exposure, ROS, and stress: inseparable companions or loosely linked associates?

(2012) Éva Hideg et al.   TRENDS IN PLANT SCIENCE

Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment

(2012) Frances P. Noonan et al.   Nature Communications

Mechanisms of chemical-induced innate immunity in allergic contact dermatitis

(2011) S. F. Martin et al.   ALLERGY

Curcumin suppresses TGF-β signaling by inhibition of TGIF degradation in scleroderma fibroblasts

(2011) Kemin Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer

(2011) P. A. Konstantinopoulos et al.   CANCER RESEARCH

Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway

(2011) Miao Yu et al.   CELLULAR SIGNALLING

Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids

(2011) Emilia Kansanen et al.   FREE RADICAL BIOLOGY AND MEDICINE

3,3′-Diindolylmethane but not indole-3-carbinol activates Nrf2 and induces Nrf2 target gene expression in cultured murine fibroblasts

(2011) I. M. A. Ernst et al.   FREE RADICAL RESEARCH

Evaluation of the skin sensitization potential of chemicals in THP-1/keratinocyte co-cultures

(2011) Yu-ping Cao et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Differentiation-dependent expression of NADP(H):quinone oxidoreductase-1 via NF-E2 related factor-2 activation in human epidermal keratinocytes

(2011) Mei Shan Piao et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Heme Oxygenase-1 Protects Human Melanocytes from H2O2-Induced Oxidative Stress via the Nrf2-ARE Pathway

(2011) Zhe Jian et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Identification of Ketoconazole as an AhR-Nrf2 Activator in Cultured Human Keratinocytes: The Basis of Its Anti-Inflammatory Effect

(2011) Gaku Tsuji et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells

(2010) Atsushi Ishikado et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ionizing Radiation Activates the Nrf2 Antioxidant Response

(2010) J. T. McDonald et al.   CANCER RESEARCH

INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis

(2010) S K Niture et al.   CELL DEATH AND DIFFERENTIATION

Bcl-2 sustains hormetic response by inducing Nrf-2 nuclear translocation in L929 mouse fibroblasts

(2010) Armando Luna-López et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis

(2010) M. Schafer et al.   GENES & DEVELOPMENT

Transcriptional Upregulation of Nrf2-Dependent Phase II Detoxification Genes in the Involved Epidermis of Vitiligo Vulgaris

(2010) Vivek T. Natarajan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Skin Barrier Function in Healthy Subjects and Patients with Atopic Dermatitis in Relation to Filaggrin Loss-of-Function Mutations

(2010) Ivone Jakasa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Genetic Deletion of Nrf2 Promotes Immortalization and Decreases Life Span of Murine Embryonic Fibroblasts

(2010) L. Jodar et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane

(2010) Constance L. Saw et al.   MOLECULAR CARCINOGENESIS

Allyl-, butyl- and phenylethyl-isothiocyanate activate Nrf2 in cultured fibroblasts

(2010) Insa M.A. Ernst et al.   PHARMACOLOGICAL RESEARCH

Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro

(2010) Roger Emter et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems

(2009) Kosuke Okada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Essential role of Nrf2 in keratinocyte protection from UVA by quercetin

(2009) Shintarou Kimura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of Activator Protein-1 by Sulforaphane Involves Interaction with Cysteine in the cFos DNA-Binding Domain: Implications for Chemoprevention of UVB-Induced Skin Cancer

(2009) S. E. Dickinson et al.   CANCER RESEARCH

Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1–NRF2 pathway, and not the BACH1–NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds

(2009) A.Kenneth MacLeod et al.   CARCINOGENESIS

α-Melanocyte-Stimulating Hormone Counteracts the Suppressive Effect of UVB on Nrf2 and Nrf-Dependent Gene Expression in Human Skin

(2009) Agatha Kokot et al.   ENDOCRINOLOGY

Sulforaphane but not ascorbigen, indole-3-carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture

(2009) Anika E. Wagner et al.   EXPERIMENTAL DERMATOLOGY

A role for Bach1 and HO-2 in suppression of basal and UVA-induced HO-1 expression in human keratinocytes

(2009) Julia Li Zhong et al.   FREE RADICAL BIOLOGY AND MEDICINE

The molecular pathology of rosacea

(2009) Kenshi Yamasaki et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

(2009) Yoo Ri Kim et al.   JOURNAL OF PATHOLOGY

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

(2009) Dung-Fang Lee et al.   MOLECULAR CELL

A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders

(2009) Jiyoung Kim et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The Nrf2-Keap1-ARE Toxicity Pathway as a Cellular Sensor for Skin Sensitizers—Functional Relevance and a Hypothesis on Innate Reactions to Skin Sensitizers

(2009) Andreas Natsch   TOXICOLOGICAL SCIENCES

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

(2009) Larry G. Higgins et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

15d-PGJ2 Upregulates Synthesis of IL-8 in Endothelial Cells Through Induction of Oxidative Stress

(2008) Alicja Jozkowicz et al.   ANTIOXIDANTS & REDOX SIGNALING

Prostaglandin D2 induces heme oxygenase-1 in human retinal pigment epithelial cells

(2008) Jiraporn Kuesap et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Transcriptional profiling in human HaCaT keratinocytes in response to kaempferol and identification of potential transcription factors for regulating differential gene expression

(2008) Byung Young Kang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Antioxidants and Phase 2 Enzymes in Macrophages: Regulation by Nrf2 Signaling and Protection Against Oxidative and Electrophilic Stress

(2008) Hong Zhu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The susceptibility to vitiligo is associated with NF-E2-related factor2 (Nrf2) gene polymorphisms: a study on Chinese Han population

(2008) Cui-Ping Guan et al.   EXPERIMENTAL DERMATOLOGY

Arsenic-induced malignant transformation of human keratinocytes: Involvement of Nrf2

(2008) Jingbo Pi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HMOX1 and NQO1 Genes are Upregulated in Response to Contact Sensitizers in Dendritic Cells and THP-1 Cell Line: Role of the Keap1/Nrf2 Pathway

(2008) Nadège Ade et al.   TOXICOLOGICAL SCIENCES