Review
Biochemistry & Molecular Biology
Jose Angel Alonso-Pineiro, Almudena Gonzalez-Rovira, Ismael Sanchez-Gomar, Juan Antonio Moreno, Ma Carmen Duran-Ruiz
Summary: Atherosclerosis, the underlying cause of cardiovascular diseases and high mortality rates, progresses with the formation of atherosclerotic plaques due to oxidative stress. Strategies aimed at reducing oxidative damage, including the use of antioxidant molecules such as Nrf2 and HO-1, have been studied to inhibit the progression of atherosclerosis.
Article
Pharmacology & Pharmacy
Wei -Chun Chen, Chung-Hao Huang, Wangta Liu, Jin-Ching Lee
Summary: Dengue virus (DENV) infection is a life-threatening disease with no effective treatment options. However, a study found that sulforaphane (SFN) has significant antiviral activity against DENV by inducing heme oxygenase-1 (HO-1) expression and inhibiting viral protease activity. This suggests that SFN could be a promising candidate for treating DENV.
ANTIVIRAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yen-Chang Chen, Jia-Hong Chen, Cheng-Fang Tsai, Chen-Teng Wu, Miao-Hsiang Wu, Pei-Chun Chang, Wei-Lan Yeh
Summary: The study found that nicardipine can inhibit the migration and colony formation of breast cancer cells, and increase the expression of Nrf2 and HO-1. The reduction of matrix metalloproteinase-9 by nicardipine is regulated by Nrf2/HO-1 axis and its catalytic end products.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Woo Jin Lee, Wan Yi Li, Sang Woo Lee, Sung Keun Jung
Summary: The extract of Soroseris hirsuta demonstrates anti-inflammatory and antioxidant effects on LPS-activated murine macrophages, inhibiting nitric oxide expression and key signaling pathways related to inflammation and oxidative stress.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Kyung-Soo Chun, Pawan Kumar Raut, Do-Hee Kim, Young-Joon Surh
Summary: ROS can cause oxidative stress when produced in excess, and NRF2 plays a vital role in adaptive survival response to ROS-induced oxidative stress. Maintaining NRF2-mediated antioxidant defense capacity is crucial in coping with oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Somayyeh Ghareghomi, Faezeh Moosavi-Movahedi, Luciano Saso, Mehran Habibi-Rezaei, Ali Khatibi, Jun Hong, Ali A. Moosavi-Movahedi
Summary: Oxidative stresses play a pivotal role in various pathophysiological conditions. The Keap1/Nrf2 pathway is a dual-edged sword with beneficial effects on both normal and cancer cells by regulating endogenous antioxidant enzymes. Targeting the Nrf2/HO-1 axis is considered a novel strategy for cancer treatment, especially in lung cancer.
Review
Pharmacology & Pharmacy
Yumin Wang, Luyan Gao, Jichao Chen, Qiang Li, Liang Huo, Yanchao Wang, Hongquan Wang, Jichen Du
Summary: Parkinson's disease is a complex neurodegenerative disorder characterized by the loss of dopaminergic neurons in the brain. Oxidative stress has been implicated in its pathogenesis, with the transcription factor Nrf2 playing a key role in activating protective genes against oxidative stress. Recent studies have shown that bioactive compounds can activate Nrf2 and ameliorate neurotoxins associated with PD, suggesting a potential therapeutic target for the treatment of the disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Juan A. Parga, Ana I. Rodriguez-Perez, Maria Garcia-Garrote, Jannette Rodriguez-Pallares, Jose L. Labandeira-Garcia
Summary: Reactive oxygen species (ROS) can regulate cellular metabolism and homeostasis, but excessive production leads to oxidative stress, a key mechanism in the progression of neurodegenerative diseases such as Parkinson's. NRF2 is a transcription factor that regulates the cellular response to oxidative stress. Modulating the NRF2 signaling pathway shows promise in controlling the neurodegenerative process associated with Parkinson's disease.
Review
Biochemistry & Molecular Biology
Wen-Jiang He, Cheng-Hao Lv, Zhong Chen, Meng Shi, Chao-Xi Zeng, De-Xing Hou, Si Qin
Summary: Redox balance is crucial for maintaining normal metabolism in the body. Disruption of this balance can lead to various chronic diseases. Activation of Nrf2 has been found to help alleviate these diseases by reducing oxidative stress and regulating related pathological processes. Therefore, targeting Nrf2 has great potential for the prevention or treatment of chronic diseases.
Article
Food Science & Technology
Ya-Chu Tang, Yung-Jen Chuang, Hsin-Huei Chang, Shin-Hun Juang, Gow-Chin Yen, Jang-Yang Chang, Ching-Chuan Kuo
Summary: The induction of antioxidant proteins and detoxifying enzymes is crucial for protection against carcinogenesis. Activation of NRF2 can lead to the expression of cytoprotective proteins that play a role in defense against toxic and oxidative damages and therefore have potential in cancer chemoprevention. However, aberrant activation of NRF2 in cancer cells can contribute to tumor progression and drug resistance, making the inhibition of NRF2 signaling a promising approach for cancer therapy.
JOURNAL OF FOOD AND DRUG ANALYSIS
(2023)
Article
Oncology
Rui Li, Xin Zeng, Meihua Yang, Xiaohui Xu, Jinmei Feng, Liming Bao, Bingqian Xue, Xin Wang, Yi Huang
Summary: The study found that DPP-4i may accelerate murine breast cancer metastasis by promoting an oncogenic ROS-NRF2-HO-1 axis, inducing aberrant oxidative stress through ROS overproduction. Therefore, this research not only reveals the oncogenic role of DPP-4i in breast cancer progression but also provides a new strategy to alleviate the adverse effects of DPP-4i by targeting HO-1.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Eniko Balogh, Arpan Chowdhury, Haneen Ababneh, David Mate Csiki, Andrea Toth, Viktoria Jeney
Summary: Calcific aortic valve stenosis (CAVS) is characterized by fibro-calcific remodeling of the aortic valves, and activation of the Nrf2/HO-1 pathway inhibits VIC calcification. This study demonstrates that heme-induced Nrf2/HO-1 expression in VICs inhibits calcification, attributing this effect to the end products generated by HO-1-mediated heme degradation and ferritin.
Article
Endocrinology & Metabolism
Xinfeng Zhou, Yijian Zhang, Mingzhuang Hou, Hao Liu, Huilin Yang, Xi Chen, Tao Liu, Fan He, Xuesong Zhu
Summary: Melatonin enhances NRF2 protein levels by inhibiting miR-146a, improving early-stage osteoarthritis cartilage degradation, and holds therapeutic potential.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Bo Yoon Chang, Hyung Joong Kim, Tae Young Kim, Sung Yeon Kim
Summary: The study indicates that pre-treatment with ETZL can effectively reduce alcohol-induced liver injury, decrease oxidative stress, and enhance antioxidant defense mechanisms.
Review
Pharmacology & Pharmacy
Anyamanee Chaiprasongsuk, Uraiwan Panich
Summary: Ethnopharmacological studies are valuable in the development of botanical products for preventing and treating various skin problems caused by UV radiation. Understanding the role of phytochemicals in skin damage and aging can help develop effective photoprotective agents. Phytochemicals can regulate cell homeostasis and improve skin integrity and function, delaying the aging process.
FRONTIERS IN PHARMACOLOGY
(2022)