Investigating the effect of target of rapamycin kinase inhibition on the Chlamydomonas reinhardtii phosphoproteome: from known homologs to new targets

Probing the global kinome and phosphoproteome in Chlamydomonas reinhardtii via sequential enrichment and quantitative proteomics

(2017) Emily G. Werth et al.   PLANT JOURNAL

LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

(2017) Sungki Hong et al.   eLife

TOR Signaling and Nutrient Sensing

(2016) Thomas Dobrenel et al.   Annual Review of Plant Biology

Recent advances in targeting mTOR signaling pathway using small molecule inhibitors

(2016) Azam Roohi et al.   JOURNAL OF DRUG TARGETING

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Synergism between Inositol Polyphosphates and TOR Kinase Signaling in Nutrient Sensing, Growth Control, and Lipid Metabolism in Chlamydomonas

(2016) Inmaculada Couso et al.   PLANT CELL

The Arabidopsis TOR Kinase Specifically Regulates the Expression of Nuclear Genes Coding for Plastidic Ribosomal Proteins and the Phosphorylation of the Cytosolic Ribosomal Protein S6

(2016) Thomas Dobrenel et al.   Frontiers in Plant Science

Multiplexing strategy for simultaneous detection of redox-, phospho- and total proteome – understanding TOR regulating pathways in Chlamydomonas reinhardtii

(2015) Silas P. Rodrigues et al.   Analytical Methods

Evolutionary history exposes radical diversification among classes of interaction partners of the MLLE domain of plant poly(A)-binding proteins

(2015) Domingo Jiménez-López et al.   BMC EVOLUTIONARY BIOLOGY

La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)

(2015) Bruno D. Fonseca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantifying Reversible Oxidation of Protein Thiols in Photosynthetic Organisms

(2015) William O. Slade et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Target of rapamycin (TOR) plays a critical role in triacylglycerol accumulation in microalgae

(2015) Sousuke Imamura et al.   PLANT MOLECULAR BIOLOGY

Characterization of early autophagy signaling by quantitative phosphoproteomics

(2014) Kristoffer TG Rigbolt et al.   Autophagy

Inducing autophagy

(2014) Lea M Harder et al.   Autophagy

System-level network analysis of nitrogen starvation and recovery in Chlamydomonas reinhardtii reveals potential new targets for increased lipid accumulation

(2014) Luis Valledor et al.   Biotechnology for Biofuels

Overexpression of the PP2A regulatory subunit Tap46 leads to enhanced plant growth through stimulation of the TOR signalling pathway

(2014) Chang Sook Ahn et al.   JOURNAL OF EXPERIMENTAL BOTANY

Integrative Network Analysis of the Signaling Cascades in Seedling Leaves of Bread Wheat by Large-Scale Phosphoproteomic Profiling

(2014) Dong-Wen Lv et al.   JOURNAL OF PROTEOME RESEARCH

The Global Phosphoproteome ofChlamydomonas reinhardtiiReveals Complex Organellar Phosphorylation in the Flagella and Thylakoid Membrane

(2014) Hongxia Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

The Role of Target of Rapamycin Signaling Networks in Plant Growth and Metabolism

(2014) Y. Xiong et al.   PLANT PHYSIOLOGY

Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

(2013) Q. Liu et al.   CANCER RESEARCH

ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change

(2013) Marie-Hélène Montané et al.   JOURNAL OF EXPERIMENTAL BOTANY

Differential Regulation of Carbon Partitioning by the Central Growth Regulator Target of Rapamycin (TOR)

(2013) Yi Zhang et al.   Molecular Plant

Glucose–TOR signalling reprograms the transcriptome and activates meristems

(2013) Yan Xiong et al.   NATURE

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

(2013) Christian C. Dibble et al.   NATURE CELL BIOLOGY

pLogo: a probabilistic approach to visualizing sequence motifs

(2013) Joseph P O'Shea et al.   NATURE METHODS

Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis

(2013) A. M. Robitaille et al.   SCIENCE

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

(2013) S. A. Kang et al.   SCIENCE

1D and 2D annotation enrichment: a statistical method integrating quantitative proteomics with complementary high-throughput data

(2012) Juergen Cox et al.   BMC BIOINFORMATICS

Isolation and Characterization of a Lycopene ε-Cyclase Gene of Chlorella (Chromochloris) zofingiensis. Regulation of the Carotenogenic Pathway by Nitrogen and Light

(2012) Baldo F. Cordero et al.   Marine Drugs

Phosphorylation of Eukaryotic Elongation Factor 2 (eEF2) by Cyclin A–Cyclin-Dependent Kinase 2 Regulates Its Inhibition by eEF2 Kinase

(2012) Asli A. Hizli et al.   MOLECULAR AND CELLULAR BIOLOGY

The Proteomics Identifications (PRIDE) database and associated tools: status in 2013

(2012) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Target of Rapamycin Signaling Regulates Metabolism, Growth, and Life Span in Arabidopsis

(2012) M. Ren et al.   PLANT CELL

Regulation of plant growth and metabolism by the TOR kinase

(2011) Thomas Dobrenel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Targeting the mTOR kinase domain: the second generation of mTOR inhibitors

(2011) Yan-Jie Zhang et al.   DRUG DISCOVERY TODAY

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

(2011) Robbie Loewith et al.   GENETICS

Rapamycin and Glucose-Target of Rapamycin (TOR) Protein Signaling in Plants

(2011) Yan Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution of the TOR Pathway

(2011) Teunis J. P. van Dam et al.   JOURNAL OF MOLECULAR EVOLUTION

mTOR Kinase Domain Phosphorylation Promotes mTORC1 Signaling, Cell Growth, and Cell Cycle Progression

(2011) B. Ekim et al.   MOLECULAR AND CELLULAR BIOLOGY

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1)

(2011) Gokhan Demirkan et al.   PLoS One

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

ISOLATION AND CHARACTERIZATION OF A LYCOPENE β-CYCLASE GENE FROM THE ASTAXANTHIN-PRODUCING GREEN ALGA CHLORELLA ZOFINGIENSIS (CHLOROPHYTA)1

(2010) Baldo F. Cordero et al.   JOURNAL OF PHYCOLOGY

Inhibition of Target of Rapamycin Signaling and Stress Activate Autophagy in Chlamydomonas reinhardtii

(2010) M. E. Perez-Perez et al.   PLANT PHYSIOLOGY

AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity

(2009) C. M. Chresta et al.   CANCER RESEARCH

Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser863and Multisite Phosphorylation

(2009) Kathryn G. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutrient control of TORC1, a cell-cycle regulator

(2009) Xuemin Wang et al.   TRENDS IN CELL BIOLOGY

Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation

(2008) Audrey Carrière et al.   CURRENT BIOLOGY