Depolarization Controls TRAIL-Sensitization and Tumor-Selective Killing of Cancer Cells: Crosstalk with ROS

The Four Faces of Autophagy: Implications for Cancer Therapy

(2014) D. A. Gewirtz   CANCER RESEARCH

Mitochondrial Permeability Transition as Target of Anticancer Drugs

(2014) Lisa Via et al.   CURRENT PHARMACEUTICAL DESIGN

Cytoprotective and nonprotective autophagy in cancer therapy

(2013) David A. Gewirtz   Autophagy

Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: Differences between primary and cancer cells

(2013) Jaganmohan Reddy Jangamreddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dimethylfumarate induces apoptosis in human mast cells

(2013) Anja Förster et al.   EXPERIMENTAL DERMATOLOGY

Mitochondrial superoxide mediates mitochondrial and endoplasmic reticulum dysfunctions in TRAIL-induced apoptosis in Jurkat cells

(2013) Toshio Inoue et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hydrogen peroxide induces cell death in human TRAIL-resistant melanoma through intracellular superoxide generation

(2013) MIZUKI TOCHIGI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Crosstalk between mitochondrial ROS and depolarization in the potentiation of TRAIL-induced apoptosis in human tumor cells

(2013) MIKI SUZUKI-KARASAKI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Hepatocyte expression of TRAIL pathway regulators correlates with histopathological and clinical parameters in chronic HCV infection

(2013) Sylvia Brost et al.   PATHOLOGY RESEARCH AND PRACTICE

bis-Dehydroxy-Curcumin Triggers Mitochondrial-Associated Cell Death in Human Colon Cancer Cells through ER-Stress Induced Autophagy

(2013) Valentina Basile et al.   PLoS One

Autophagy, Apoptosis, Mitoptosis and Necrosis: Interdependence Between Those Pathways and Effects on Cancer

(2012) Wiem Chaabane et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

(2012) Yuqing Wang et al.   Autophagy

Targeting NADPH oxidases for the treatment of cancer and inflammation

(2012) Michael Y. Bonner et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting Mitochondria in Fighting Cancer

(2012) Vladimir Gogvadze   CURRENT PHARMACEUTICAL DESIGN

The three Rs along the TRAIL: Resistance, re-sensitization and reactive oxygen species (ROS)

(2012) Gregory Mellier et al.   FREE RADICAL RESEARCH

Wogonin Induces Reactive Oxygen Species Production and Cell Apoptosis in Human Glioma Cancer Cells

(2012) Cheng-Fang Tsai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Depolarization potentiates TRAIL-induced apoptosis in human melanoma cells: Role for ATP-sensitive K+ channels and endoplasmic reticulum stress

(2012) YOSHIHIRO SUZUKI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Diallyl trisulfide sensitizes human melanoma cells to TRAIL-induced cell death by promoting endoplasmic reticulum-mediated apoptosis

(2012) MAYUMI MURAI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics

(2012) L Y Dimberg et al.   ONCOGENE

Bezielle Selectively Targets Mitochondria of Cancer Cells to Inhibit Glycolysis and OXPHOS

(2012) Vivian Chen et al.   PLoS One

TRAIL enhances paracetamol-induced liver sinusoidal endothelial cell death in a Bim- and Bid-dependent manner

(2012) A Badmann et al.   Cell Death & Disease

Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS

(2011) Shampa Chatterjee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Activation of ER stress and apoptosis by hydrogen peroxide in HeLa cells: Protective role of mild heat preconditioning at 40°C

(2011) Pragathi Pallepati et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting the extrinsic apoptosis signaling pathway for cancer therapy

(2011) Thomas J. Sayers   CANCER IMMUNOLOGY IMMUNOTHERAPY

Pancratistatin induces apoptosis and autophagy in metastatic prostate cancer cells

(2011) Siyaram Pandey   INTERNATIONAL JOURNAL OF ONCOLOGY

Death Receptor 5 Signaling Promotes Hepatocyte Lipoapoptosis

(2011) Sophie C. Cazanave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigallocatechin-3-gallate induces cell apoptosis of human chondrosarcoma cells through apoptosis signal-regulating kinase 1 pathway

(2011) Wei-Hung Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pancratistatin Selectively Targets Cancer Cell Mitochondria and Reduces Growth of Human Colon Tumor Xenografts

(2011) C. Griffin et al.   MOLECULAR CANCER THERAPEUTICS

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells

(2011) Kartick C. Pramanik et al.   PLoS One

The Slow-Releasing Hydrogen Sulfide Donor, GYY4137, Exhibits Novel Anti-Cancer Effects In Vitro and In Vivo

(2011) Zheng Wei Lee et al.   PLoS One

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Different apoptotic effects of wogonin via induction of H2O2 generation and Ca2+ overload in malignant hepatoma and normal hepatic cells

(2010) Libin Wei et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Targeting GRP78 to enhance melanoma cell death

(2010) Shaun Martin et al.   Pigment Cell & Melanoma Research

Plasma membrane depolarization and Na,K-ATPase impairment induced by mitochondrial toxins augment leukemia cell apoptosis via a novel mitochondrial amplification mechanism

(2009) Wu Yin et al.   BIOCHEMICAL PHARMACOLOGY

Mitochondrial calcium and the permeability transition in cell death

(2009) John J. Lemasters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Reactive oxygen species up-regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin

(2009) Dae-Hee Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

LY303511 Enhances TRAIL Sensitivity of SHEP-1 Neuroblastoma Cells via Hydrogen Peroxide-Mediated Mitogen-Activated Protein Kinase Activation and Up-regulation of Death Receptors

(2009) K. Shenoy et al.   CANCER RESEARCH

Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery

(2009) B Zhivotovsky et al.   CELL DEATH AND DIFFERENTIATION

Superoxide is the major reactive oxygen species regulating autophagy

(2009) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway

(2009) R Naughton et al.   LEUKEMIA

Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

(2009) Stephen J. Ralph et al.   MOLECULAR ASPECTS OF MEDICINE

2-Deoxy-D-glucose enhances TRAIL-induced apoptosis in human melanoma cells through XBP-1-mediated up-regulation of TRAIL-R2

(2009) Hao Liu et al.   Molecular Cancer

Discrete generations of intracellular hydrogen peroxide and superoxide in antigen-stimulated mast cells: Reciprocal regulation of store-operated Ca2+ channel activity

(2009) Yoshihiro Suzuki et al.   MOLECULAR IMMUNOLOGY

Increased levels of superoxide and H2O2mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation

(2008) Nùkhet Aykin-Burns et al.   BIOCHEMICAL JOURNAL

Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds

(2008) Anna A. Powolny et al.   CANCER LETTERS

Pure MnTBAP selectively scavenges peroxynitrite over superoxide: Comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy

(2008) Ines Batinić-Haberle et al.   FREE RADICAL BIOLOGY AND MEDICINE

The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway

(2008) S Wang   ONCOGENE