Epigallocatechin-3-Gallate as a Potential Therapeutic Drug for TTR-Related Amyloidosis: “In Vivo” Evidence from FAP Mice Models

Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation

(2011) Nelson Ferreira et al.   FEBS LETTERS

Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises?

(2011) Derliz Mereles et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Crystal Structure of the Green Tea Polyphenol (−)-Epigallocatechin Gallate−Transthyretin Complex Reveals a Novel Binding Site Distinct from the Thyroxine Binding Site,

(2010) Masanori Miyata et al.   BIOCHEMISTRY

Effects of the main green tea polyphenol epigallocatechin-3-gallate on cardiac involvement in patients with AL amyloidosis

(2010) Derliz Mereles et al.   Clinical Research in Cardiology

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses

(2010) Stephen Connelly et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Synergy of combined Doxycycline/TUDCA treatment in lowering Transthyretin deposition and associated biomarkers: studies in FAP mouse models

(2010) Isabel Cardoso et al.   Journal of Translational Medicine

Bioavailability and catabolism of green tea flavan-3-ols in humans

(2010) Daniele Del Rio et al.   NUTRITION

Carvedilol treatment reduces transthyretin deposition in a familial amyloidotic polyneuropathy mouse model

(2010) Bárbara Macedo et al.   PHARMACOLOGICAL RESEARCH

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity

(2009) Nelson Ferreira et al.   FEBS LETTERS

Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy

(2008) Bárbara Macedo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A new Thr49Pro transthyretin gene mutation associated with leptomeningeal amyloidosis

(2008) Kazuma Nakagawa et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The heat shock response modulates transthyretin deposition in the peripheral and autonomic nervous systems

(2008) Sofia Duque Santos et al.   NEUROBIOLOGY OF AGING