Article
Neurosciences
Swathi Kesh, Rajaretinam Rajesh Kannan, Kalaiarasi Sivaji, Anandan Balakrishnan
Summary: Parkinson's disease is characterized by the depletion of dopamine and the formation of Lewy bodies, with hesperidin showing neuroprotective effects by downregulating kinases and oxidative stress markers in both in vitro and in vivo models. This suggests that hesperidin could be a promising drug in targeting kinases in a PD model induced by 6-OHDA.
NEUROSCIENCE LETTERS
(2021)
Article
Gastroenterology & Hepatology
Yan-Yan Fan, Yue Zhang, Rui-Fang Fan, Tao Wang, Xiao Yu, Li-Fei Zheng, Jin-Xia Zhu
Summary: This study found that the pyloric sphincters of Parkinson's disease rats exhibited weakened contraction and relaxation, which may be due to reduced nNOS in the pyloric myenteric plexus. However, sodium nitroprusside could improve pyloric relaxation in these rats. These findings have important implications for the diagnosis and treatment of delayed gastric emptying in Parkinson's disease patients.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Food Science & Technology
Veronica Antipova, Carsten Holzmann, Alexander Hawlitschka, Martin Witt, Andreas Wree
Summary: The study found that intrastriatal injection of Botulinum neurotoxin-A (BoNT-A) can reduce depression-like behavior in hemi-Parkinsonian rats, but did not have a significant effect on anxiety-like behavior.
Article
Biochemistry & Molecular Biology
Ana Gomes, Sandra M. Monteiro, Carlos Venacio, Luis Felix
Summary: This study investigated the effects of 24-Epibrassinolide (24-EPI) on 6-hydroxydopamine (6-OHDA)-induced toxicity. The results showed that 6-OHDA caused developmental abnormalities and Parkinson's disease-like symptoms in embryos, which were reversed by 24-EPI. These findings support further investigation of the neuroprotective effects of 24-EPI.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Helena Berlamont, Arnout Bruggeman, Eva Bauwens, Charysse Vandendriessche, Elien Clarebout, Junhua Xie, Sofie De Bruyckere, Griet Van Imschoot, Elien Van Wonterghem, Richard Ducatelle, Patrick Santens, Annemieke Smet, Freddy Haesebrouck, Roosmarijn E. Vandenbroucke
Summary: Research suggests that gastric H. suis infection may have a neuroprotective effect on Parkinson's disease pathology by reducing 6-OHDA-induced cell loss and improving motor function. This effect is potentially mediated through changes in oxidative stress, as indicated by higher expression levels of antioxidant genes in infected mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Teresa Alberts, Veronica Antipova, Carsten Holzmann, Alexander Hawlitschka, Oliver Schmitt, Jens Kurth, Jan Stenzel, Tobias Lindner, Bernd J. Krause, Andreas Wree, Martin Witt
Summary: Olfactory deficits observed in Parkinson's disease cannot be completely explained by the 6-OHDA hemi-PD rat model, but injection of BoNT-A can improve olfactory performance by increasing the availability of D-2/D3R in the olfactory bulb.
Article
Biochemistry & Molecular Biology
Hui-Chen Su, Yuan-Ting Sun, Ming-Yu Yang, Ching-Yuan Wu, Cheng-Ming Hsu
Summary: This study investigated the effect of a compound extracted from Danshen, dihydroisotanshinone I (DT), on Parkinson's disease (PD) using an in vitro-based cell model. The results showed that DT attenuated cell death, suppressed reactive oxygen species (ROS) and caspase-3 levels, and regulated circadian genes in the PD cell model. These findings suggest that DT has potential as a novel therapeutic agent for PD, but further in vivo studies are needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Mohammad Shabani, Monavareh Soti, Hoda Ranjbar, Reyhaneh Naderi
Summary: Parkinson's disease is characterized by motor disabilities and cognitive impairments. Abscisic acid (ABA) has been found in various brain regions of mammals and has neuroprotective properties. A mouse model of PD was used to investigate the effects of ABA on motor and cognitive disorders. The results showed that ABA significantly improved balance and muscle strength deficits caused by 6-OHDA, but did not improve cognitive impairment or rearing in Parkinsonism mice.
Article
Neurosciences
Farideh Iravanpour, Leila Dargahi, Mohsen Rezaei, Masoud Haghani, Reza Heidari, Neda Valian, Abolhassan Ahmadiani
Summary: The study investigated the effects of intranasal insulin treatment in a rat model of Parkinson's disease, showing significant improvements in motor dysfunction and dopaminergic cell death associated with the disease. The findings suggest that intranasal insulin may be a promising therapeutic approach for Parkinson's disease, potentially targeting mitochondrial dysfunction and modulating inflammation in the brain.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Cell Biology
Hao Yu, Xiaojie Liu, Bixuan Chen, Casey R. Vickstrom, Vladislav Friedman, Thomas J. Kelly, Xiaowen Bai, Li Zhao, Cecilia J. Hillard, Qing-Song Liu
Summary: The selective CB2 agonist GW842166x has protective effects against 6-OHDA-induced loss of dopamine neurons and associated motor deficits in mice, potentially through modulation of dopamine neuron firing activity. The neuroprotective effects of GW842166x were prevented by the CB2 receptor antagonist AM630, indicating a CB2-dependent mechanism. Electrophysiological recordings suggest that GW842166x may reduce dopamine neuron vulnerability to 6-OHDA by decreasing action potential firing and associated calcium load.
Article
Biochemistry & Molecular Biology
Hua Gao, Dan Wang, Yu-Ling Wang, Jie-Ping Mao, Sen Jiang, Xin-Ling Yang
Summary: This study demonstrates that PPX improves motor behavior in PD rats by mediating inflammatory response and regulating the Nurr1/NF-αB signaling pathway, rescuing 6-OHDA-induced TH loss.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Multidisciplinary Sciences
Andrea Slezia, Panna Hegedus, Evgeniia Rusina, Katalin Lengyel, Nicola Solari, Attila Kaszas, Diana Balazsfi, Boris Botzanowski, Emma Acerbo, Florian Missey, Adam Williamson, Balazs Hangya
Summary: Studying animal models allows us to better understand the mechanisms of Parkinson's disease. However, current models mainly focus on late-stage symptoms, leaving a gap in our knowledge of early-stage changes. In this study, a graded-dose unilateral 6-OHDA model was established in mice, and the behavioral, neuronal, and ultrastructural features were analyzed within the first two weeks of lesion induction. The results showed that mild degeneration of dopaminergic neurons can lead to motor deficits shortly after striatal lesions, suggesting that this model can be used to study the early stages of Parkinson's disease in mice.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Medicinal
Qiu-Xu Chen, Ling Zhou, Tao Long, Da-Lian Qin, Yi-Ling Wang, Yun Ye, Xiao-Gang Zhou, Jian-Ming Wu, An-Guo Wu
Summary: The study shows that galangin has the potential to treat Parkinson's disease by inhibiting neuronal degeneration through activation of the Nrf2/Keap1 signaling pathway and alleviating oxidative damage.
Article
Cell Biology
Daniel Rees, Amy L. Beynon, Mariah J. Lelos, Gaynor A. Smith, Luke D. Roberts, Lyndsey Phelps, Stephen B. Dunnett, Alwena H. Morgan, Rowan M. Brown, Timothy Wells, Jeffrey S. Davies
Summary: The feeding-related hormone, acyl-ghrelin, has a potential protective effect on dopamine neurons in experimental models of Parkinson's disease. However, its effect on dopaminergic neurons in the 6-OHDA rat medial forebrain bundle lesion model is unknown.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mauricio dos Santos Pereira, Gabriel Henrique Dias Abreu, Jeremy Rocca, Sabah Hamadat, Rita Raisman-Vozari, Patrick Pierre Michel, Elaine Del Bel
Summary: The study aimed to characterize mechanisms regulating neuroinflammation in L-DOPA-induced dyskinesia in mice, finding that astrocytic and microglial responses, as well as increased pro-inflammatory cytokine levels, were associated with LID development. Treatment with cannabidiol and capsazepine reduced LID severity and TNF-alpha levels, suggesting a potential therapeutic approach. Glutamate-induced TNF-alpha release from astrocytes may contribute to LID by modulating corticostriatal glutamatergic inputs, with cannabidiol + capsazepine attenuating this effect.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Behavioral Sciences
Owen Y. Chao, An-Li Wang, Susanne Nikolaus, Maria A. de Souza Silva
BEHAVIOURAL BRAIN RESEARCH
(2015)
Article
Behavioral Sciences
An-Li Wang, Benedetta Fazari, Owen Y. Chao, Susanne Nikolaus, Svenja V. Trossbach, Carsten Korth, Fernando J. Sialana, Gert Lubec, Joseph P. Huston, Claudia Mattern, Maria Angelica de Souza Silva
NEUROBIOLOGY OF LEARNING AND MEMORY
(2017)
Article
Behavioral Sciences
Owen Y. Chao, Susanne Nikolaus, Marcus Lira Brandao, Joseph P. Huston, Maria A. de Souza Silva
NEUROBIOLOGY OF LEARNING AND MEMORY
(2017)
Article
Behavioral Sciences
Owen Y. Chao, Richelle Yunger, Yi-Mei Yang
BEHAVIOURAL BRAIN RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Yi-Mei Yang, Jason Arsenault, Alaji Bah, Mickael Krzeminski, Adam Fekete, Owen Y. Chao, Laura K. Pacey, Alex Wang, Julie Forman-Kay, David R. Hampson, Lu-Yang Wang
MOLECULAR PSYCHIATRY
(2020)
Correction
Behavioral Sciences
Owen Y. Chao, Richelle Yunger, Yi-Mei Yang
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Behavioral Sciences
An-Li Wang, Owen Y. Chao, Yi-Mei Yang, Svenja V. Trossbach, Christian P. Mueller, Carsten Korth, Joseph P. Huston, Maria Angelica de Souza Silva
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2019)
Article
Neurosciences
Owen Y. Chao, Ezequiel Marron Fernandez de Velasco, Salil Saurav Pathak, Swati Maitra, Hao Zhang, Lisa Duvick, Kevin Wickman, Harry T. Orr, Hirokazu Hirai, Yi-Mei Yang
NEUROPSYCHOPHARMACOLOGY
(2020)
Review
Behavioral Sciences
Owen Y. Chao, Maria A. de Souza Silva, Yi-Mei Yang, Joseph P. Huston
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2020)
Article
Neurosciences
Owen Y. Chao, Salil S. Pathak, Hao Zhang, Nathan Dunaway, Jay-Shake Li, Claudia Mattern, Susanne Nikolaus, Joseph P. Huston, Yi-Mei Yang
Article
Neurosciences
Owen Y. Chao, Hao Zhang, Salil Saurav Pathak, Joseph P. Huston, Yi-Mei Yang
Summary: Disruption of activity in the major anterior lobule IV/V in mice impaired motor coordination but not general locomotion or anxiety-related behavior. Lesioned animals showed memory deficits, while chemogenetic excitation of Purkinje cells affected social approach and social memory.
Article
Neurosciences
Jay-Shake Li, Shan-Sung Yang, Joseph P. Huston, Owen Y. Chao, Yi-Mei Yang, Claudia Mattern
Summary: Studies suggest that intranasal dopamine could potentially improve inhibitory control deficits in ADHD animal models, but caution is advised in determining the dosage due to potential negative effects, as seen in control groups.
PSYCHOPHARMACOLOGY
(2021)
Article
Cell Biology
Kun Fang, Dong Liu, Salil S. Pathak, Bowen Yang, Jin Li, Ramanujam Karthikeyan, Owen Y. Chao, Yi-Mei Yang, Victor X. Jin, Ruifeng Cao
Summary: A study using the Short Day (SD) mouse model found that chronic disruption of circadian rhythms during neurodevelopment can lead to molecular, cellular, and behavioral changes resembling autistic-like phenotypes. This highlights a critical role for circadian rhythms in neurodevelopment.
Review
Behavioral Sciences
Owen Y. Chao, Susanne Nikolaus, Yi-Mei Yang, Joseph P. Huston
Summary: This review summarizes current studies on recognition memory in rodents, indicating that neuronal circuits connected to the medial prefrontal cortex and hippocampus play important roles in the recognition memory of objects and places.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Multidisciplinary Sciences
Owen Y. Chao, Yi-Mei Yang
SCIENTIFIC REPORTS
(2019)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.