Article
Pharmacology & Pharmacy
Majid Reza Farokhi, Erfan Taherifard, Roksana SoukhakLari, Leila Moezi, Fatema Pirsalami, Amir Savardashtaki, Maryam Moosavi
Summary: This study found that Agmatine has a dose-dependent effect on passive avoidance memory in mice. Low doses impaired memory, while high doses improved memory. Agmatine had no effect on nociception. Additionally, the modulation of CaMKII-alpha and ERK signaling pathways by Agmatine may be related to its dose-dependent effect on memory.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Yosef Avchalumov, Robert J. Oliver, Wulfran Trenet, Rocio Erandi Heyer Osorno, Britta D. Sibley, Dvijen C. Purohit, Candice Contet, Marisa Roberto, John J. Woodward, Chitra D. Mandyam
Summary: Chronic ethanol exposure was found to enhance neuronal excitability in the medial PFC (mPFC) and dentate gyms (DG), while re-exposure during protracted abstinence did not have the same effect, indicating resistance to vapor-induced effects. Molecular adaptations, including altered afterhyperpolarization and changes in the kinetics of action potentials, were identified under different conditions. Furthermore, Western blotting demonstrated alterations in phosphorylation levels of Ca2+/calmodulin-dependent protein kinase II (CaMKII) and glutamate receptor GluN2A/2B subunits, suggesting a novel relationship between these proteins and neuronal excitability in the context of moderate to severe AUD.
Article
Integrative & Complementary Medicine
Dongdong Qian, Jing Tian, Sining Wang, Xiaoli Shan, Pei Zhao, Huihua Chen, Ming Xu, Wei Guo, Chen Zhang, Rong Lu
Summary: This study found that TCA can inhibit cardiac hypertrophy and block the CaMKII/ERK pathway, regulating calcium handling and thus protecting the heart.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Biochemistry & Molecular Biology
Wei Dai, Mingxu Zhao, Caiyun Chen, Chang Zhou, Peng Wang, Zhilai Yang, Shan Gao, Yao Lu, Jiqian Zhang, Xuesheng Liu
Summary: The study highlights the importance of synaptic-activated CaMKII in Alzheimer's disease (AD) treatment and provides a new therapeutic strategy for AD treatment.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Environmental Sciences
Kyeong Hwa Sim, Youn Ju Lee
Summary: PFHxS may induce developmental neurotoxicity and downregulate neural proteins GAP-43 and CaMKII via the NMDA receptor-mediated PKCs (alpha and delta)-ERK/AMPK pathways, resulting in memory impairment in adult mice.
Article
Immunology
Xiao-Min Zhang, Ming-Hui Lun, Wei Du, Fang Ma, Ze-Qing Huang
Summary: This study observed the ameliorative effect of a kappa opioid receptor (KOR) agonist on rats with neuropathic pain (NP) and investigated the mechanism of action involving the calcium ion (Ca2+)/calcium/calmodulin-dependent protein kinase II (CaMKII)/cyclic AMP response element binding protein (CREB) pathway. The KOR agonist improved the pain thresholds of the NP rats, inhibited inflammatory responses, and relieved oxidative stress injury. It achieved its effects by suppressing the activity of the Ca2+/CaMKII/CREB pathway.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Finn T. Roberts-Craig, Luke P. Worthington, Samuel P. O'Hara, Jeffrey R. Erickson, Alison K. Heather, Zoe Ashley
Summary: This review evaluates the role of different CaMKII splice variants in vascular pathological and physiological mechanisms, emphasizing the need for further research to understand their importance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ping Liu, Xiaoji Cong, Shengjie Liao, Xinglong Jia, Xiaomin Wang, Wei Dai, Linhui Zhai, Lei Zhao, Jing Ji, Duan Ni, Zhiwei Liu, Yulu Chen, Lulu Pan, Wei Liu, Jian Zhang, Min Huang, Bin Liu, Minjia Tan
Summary: This study identified phosphorylation-dependent SCF substrates using a quantitative phosphoproteome approach, demonstrating the mechanism by which SCFFBXO22 recognizes a phosphodegron. FBXO22 was shown to mediate BAG3 ubiquitination and degradation, impacting tumor growth, apoptosis, and cell cycle progression.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Anesthesiology
Attila Keresztes, Keith Olson, Paul Nguyen, Marissa A. Lopez-Pier, Ryan Hecksel, Natalie K. Barker, Zekun Liu, Victor Hruby, John Konhilas, Paul R. Langlais, John M. Streicher
Summary: This study reveals a new function of opioid receptors as a negative feedback brake on opioid-induced analgesia. By using a selective antagonist for the mu and delta opioid receptors (MDOR), the researchers found that the antagonist could enhance the analgesic effect of oxymorphone in mice, suggesting a role for MDOR in regulating pain. Additionally, the study found that the enhancement effect was selective to MDOR and occurred through the repression of Src and CaMKII signal transduction. These findings suggest that MDOR antagonism could be a potential approach to improve clinical opioid therapy.
Article
Biochemistry & Molecular Biology
Cristiane Ribeiro de Carvalho, Mark William Lopes, Leandra C. Constantino, Alexandre Ademar Hoeller, Hiago Murilo de Melo, Ricardo Guarnieri, Marcelo Neves Linhares, Zuner Assis Bortolotto, Rui Daniel Prediger, Alexandra Latini, Katia Lin, Julio Licinio, Rodrigo Bainy Leal, Roger Walz
Summary: The phosphorylation rate of extracellular signal-related kinase in the amygdala is associated with anxiety symptoms in humans and innate anxiety- and conditioned freezing behaviors in rats. However, ERK1/2 in the amygdala is only required for the expression of defensive-learned behavior.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Ju Yeong Kim, Hun Hee Park, Tai-Soon Yong, Soung-Hoo Jeon
Summary: The study showed that LiCl and EGF treatments have different effects on osteosarcoma cells, with LiCl reducing cell migration and proliferation, while EGF promoting cell migration and proliferation. Additionally, it was found that LiCl can interfere with the translocation of pERK from the cytoplasm to the nucleus.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Qiaofeng Liu, Ting Min, Jun Dong, Xin Wang
Summary: Minocycline alleviates morphine withdrawal symptoms by inhibiting the activation of microglia and downregulating the expression of CaMKII, Ras, and p-ERK.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Multidisciplinary Sciences
Yusuke Sakai, Haiyan Li, Hiromichi Inaba, Yuki Funayama, Erina Ishimori, Ayako Kawatake-Kuno, Hirotaka Yamagata, Tomoe Seki, Teruyuki Hobara, Shin Nakagawa, Yoshifumi Watanabe, Susumu Tomita, Toshiya Murai, Shusaku Uchida
Summary: The study explores the role of CaMKII beta in the ventral hippocampus in depression susceptibility and resilience, revealing that its modulation of TARP gamma-8 phosphorylation enhances stress resilience by increasing the expression of AMPA receptor subunit GluA1. These findings provide new insights into the molecular mechanisms underlying chronic stress-induced behavioral changes and offer strategies for preventing and treating stress-related psychiatric disorders.
Article
Neurosciences
G. Elliott Wimmer, Christian Buechel
Summary: This study examined the influence of aversive experiences on behavior and brain activity. Findings showed that participants avoided pain-associated objects and exhibited pain value memory in tests. The hippocampus played a critical role in modulating these memories and behaviors.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Sasuk Kim, Juhee Lim, Yeojin Bang, Jisook Moon, Min-Soo Kwon, Jin Tae Hong, Jeha Jeon, Hyemyung Seo, Hyun Jin Choi
MOLECULAR NEUROBIOLOGY
(2018)
Article
Neurosciences
Juhee Lim, Yeojin Bang, Jong-Hyun Choi, Arum Han, Min-Soo Kwon, Kwang Hyeon Liu, Hyun Jin Choi
JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Min-Jung Park, Hyun-Sun Park, Min-Jung You, Jongman Yoo, Seung Hyun Kim, Min-Soo Kwon
MOLECULAR NEUROBIOLOGY
(2019)
Article
Psychiatry
Hoyoung Sohn, Min-Soo Kwon, Sun-Woo Lee, Jongsoo Oh, Min-Kyoung Kim, Sang-Hyuk Lee, Kang Soo Lee, Borah Kim
PSYCHIATRY INVESTIGATION
(2018)
Article
Orthopedics
Dhong Won Lee, In Keun Park, Min Jeong Kim, Woo Jong Kim, Min Soo Kwon, Sung Jin Kang, Jin Goo Kim, Young Yi
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2019)
Article
Chemistry, Medicinal
Joong-Won Ha, Min-Jung You, Hyun-Sun Park, Jong Wan Kim, Min-Soo Kwon
ARCHIVES OF PHARMACAL RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
JooHyun Jee, Sang Yun Jeong, Han Kyung Kim, Seon Young Choi, Sukin Jeong, Joongwoon Lee, Ji Su Ko, Mi Sun Kim, Min-Soo Kwon, Jongman Yoo
Article
Cell & Tissue Engineering
Joo Hyun Jee, Dong Hyeon Lee, Jisu Ko, Soojung Hahn, Sang Yun Jeong, Han Kyung Kim, Enoch Park, Seon Young Choi, Sukin Jeong, Joong Woon Lee, Han-Jun Cho, Min-Soo Kwon, Jongman Yoo
STEM CELLS INTERNATIONAL
(2019)
Article
Neurosciences
Jaehwa Lim, Hoyoung Sohn, Min-Soo Kwon, Borah Kim
Summary: This study found significantly elevated levels of TNF-alpha and IL-8 in patients with MDD compared to healthy controls, along with lower FA and higher MD and RD values in specific WM regions. Voxel-wise correlation analysis showed a significant relationship between TNF-alpha levels and changes in white matter microstructure in specific brain regions.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2021)
Article
Chemistry, Medicinal
Bohyun Yang, Jae-Sang Ryu, Chan Rim, Jung U. Shin, Min-Soo Kwon
Summary: This study aimed to identify the mechanisms underlying anxiety/depressive-like behaviors in atopic dermatitis (AD). The findings suggest that reduced Arg1 positive microglia may contribute to these behaviors through pCREB/BDNF reduction in AD.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Immunology
Min-Jung You, Chan Rim, Youn-Jung Kang, Min-Soo Kwon
Summary: This study developed a new method to obtain mature microglia from mouse NEL at E13.5, which exhibited microglial functions and maintained characteristics in passage culture. Transcriptome analysis showed NEL-MG had better conservation of microglia signature genes compared to neonatal microglia.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Kyu-Beom Jang, Min-Jung You, Bohyun Yang, Chan Rim, Hui-Ju Kim, Min-Soo Kwon
Summary: The acidic environment caused by stroke, traumatic brain injury, and Alzheimer's disease can alter the functioning of microglia. However, the mechanisms underlying these functional changes are unclear. This study found that acidic stimuli increased the levels of certain molecules and reduced others in BV2 cells, leading to impaired phagocytic function. Short-term exposure to acidity affected specific signaling pathways, while prolonged exposure normalized some levels and increased others. Inhibiting the ERK pathway restored the functional changes induced by acidic environment in microglia. These findings suggest that targeting the ERK pathway may be a potential strategy for treating microglial dysfunction in neurological disorders.
NEUROCHEMICAL RESEARCH
(2022)
Review
Chemistry, Medicinal
Min-Soo Kwon
Summary: Microglia have long been considered the main culprits in neuroinflammatory responses due to their role as primary phagocytes in the central nervous system (CNS). However, recent research has shown that advanced and precise approaches targeting microglia are more effective in managing neurological disorders. Microglia derived from the yolk sac have a heterogeneous composition and play a crucial role in maintaining CNS homeostasis and phagocytosis. Disruptions in microglia development can lead to neurodevelopmental disorders, and microglia can aggravate or alleviate neuroinflammation depending on the microenvironment.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Psychiatry
Min-Jung You, Chan Rim, Minji Bang, Soyoung Sung, Hui-Ju Kim, Sang-Hyuk Lee, Min-Soo Kwon
Summary: This study found that microglia in patients with panic disorder have unique characteristics, including dysregulation of the cholesterol biosynthesis pathway and impaired phagocytosis, which reflect their clinical phenotype.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Chan Rim, Hyun-Sun Park, Min-Jung You, Bohyun Yang, Hui-Ju Kim, Soyoung Sung, Min-Soo Kwon
Summary: Fetal microglia, being sensitive to changes in the utero environment, may play a role in the sex-biased onset of psychiatric disorders. In this study, prenatal exposure to dexamethasone induced schizophrenia-relevant behaviors in male mice and depressive-like behavior in female mice. The altered microglial function and dopaine system proteins were observed in the affected brain regions. These findings suggest that altered microglial function and increased synaptic pruning may be involved in the occurrence of psychiatric disorders in the prenatal dexamethasone-exposed offspring.
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
