Article
Plant Sciences
Xiao-Qing Yang, Wei Li, Zhong-Ying Ren, Jun-Jie Zhao, Xin-Yang Li, Xing-Xing Wang, Xiao-Yu Pei, Yan-Gai Liu, Kun-Lun He, Fei Zhang, Xiong-Feng Ma, Dai-Gang Yang
Summary: This study identified GhSINA1 as a negative regulator in cotton fiber development through its interaction with itself and other GhSINA1 proteins, forming homodimers and heterodimers.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Plant Sciences
Pauline Thomelin, Julien Bonneau, Chris Brien, Radoslaw Suchecki, Ute Baumann, Priyanka Kalambettu, Peter Langridge, Penny Tricker, Delphine Fleury
Summary: Research has identified a quantitative trait locus (QTL) qYDH.3BL in wheat chromosome 3B associated with increased yield in hot and dry climates. The study found that this QTL exerts its effects on early vigour, root growth, plant biomass, and yield components, contributing to the development of heat-tolerant wheat varieties.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Orsolya Bilkei-Gorzo, Tiaan Heunis, Jose Luis Marin-Rubio, Francesca Romana Cianfanelli, Benjamin Bernard Armando Raymond, Joseph Inns, Daniela Fabrikova, Julien Peltier, Fiona Oakley, Ralf Schmid, Anetta Hartlova, Matthias Trost
Summary: This study reveals the importance of phagosomal ubiquitylation and the E3 ubiquitin ligase RNF115 in regulating innate immune functions during bacterial infections.
Article
Chemistry, Medicinal
Adam G. Bond, Conner Craigon, Kwok-Ho Chan, Andrea Testa, Athanasios Karapetsas, Rotimi Fasimoye, Thomas Macartney, J. Julian Blow, Dario R. Alessi, Alessio Ciulli
Summary: This study describes the design and development of a new protein degradation system utilizing a variant of the Brd4 bromodomain as a degradation tag. The system effectively degrades BromoTagged proteins in a fast, selective manner, showing favorable pharmacokinetic profile in mice. This system expands the arsenal of chemical genetic degradation tools for manipulating protein levels and exploring therapeutic potential in cells and in vivo.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Martin P. Schwalm, Lena M. Berger, Maximilian N. Meuter, James D. Vasta, Cesear R. Corona, Sandra Roehm, Benedict-Tilman Berger, Frederic Farges, Sebastian M. Beinert, Franziska Preuss, Viktoria Morasch, Vladimir V. Rogov, Sebastian Mathea, Krishna Saxena, Matthew B. Robers, Susanne Mueller, Stefan Knapp
Summary: E3 ligases play a crucial role in regulating protein homeostasis by recruiting substrate proteins to the proteasomal degradation machinery. Recent research has focused on the Baculovirus IAP Repeat (BIR) family of E3 ligases, which contain a structurally conserved but diverse protein interaction domain. The Inhibitors of Apoptosis (IAP) family, which typically have three BIR domains, are promising drug targets. However, there is currently a lack of assay tools to evaluate the selectivity of inhibitors in this target area.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Rui Zhang, Shaoqing Shi
Summary: HECT-type E3 ubiquitin ligases play a vital role in controlling protein function and stability, and members of the NEDD4 family have critical roles in dysregulation of autophagy in cancer cells. This review focuses on the role of NEDD4 E3 ligases in defective autophagy in cancer cells, discussing their function, substrates, and signaling pathways, providing a basis for cancer treatment through modulation of these ligases.
MOLECULAR MEDICINE
(2023)
Review
Immunology
Haoran Cui, Yaxian Zhang, Leiliang Zhang
Summary: Poxviruses have evolved various mechanisms to evade innate immunity, some of which involve poxvirus-encoded E3 ubiquitin ligases and adaptor proteins. These proteins can be categorized into five groups based on their functional domains and ubiquitin transfer mechanisms. Most known substrates of poxvirus E3 ubiquitin ligases are components of the innate immune system. Current research progress provides mechanistic insights into the interaction between these viruses and their hosts.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Jialing Zhang, Chaonan Li, Long Li, Yajun Xi, Jingyi Wang, Xinguo Mao, Ruilian Jing
Summary: TaAIRP2-1B regulates spike length by facilitating TaHIPP3 degradation, and the haplotype Hap-1B-1 of TaAIRP2-1B is a favorable natural variation for increasing spike length in wheat. This study provides insights into the role of E3 ubiquitin ligase genes in wheat development and identifies TaAIRP2-1B as a key regulator of spike length. The findings also offer genetic resources and markers for wheat molecular breeding.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Biochemistry & Molecular Biology
Ishita Tripathi-Giesgen, Christian Behrends, Arno F. Alpi
Summary: The ubiquitin system plays a crucial role in the host cellular defense program against bacterial infection, especially when certain bacteria are exposed to the host cytosol during invasion. Host cell E3 ubiquitin ligases contribute to the formation of a protective ubiquitin coat on invading pathogens, with their divergent ubiquitin conjugation mechanisms influencing the complexity of the anti-bacterial coating. Bacteria have evolved strategies to evade the activities of the host ubiquitin system.
Review
Biochemistry & Molecular Biology
Dong Wang, Yuanming Zou, Xinyue Huang, Zeyu Yin, Mohan Li, Jiaqi Xu, Boquan Wu, Da Li, Ying Zhang, Yingxian Sun, Xingang Zhang, Naijin Zhang
Summary: The ubiquitin-proteasome system is crucial for regulating protein levels in cells, and SMURF1 and SMURF2 are important components that maintain physiological processes by regulating the stability of multiple proteins. The regulatory functions of SMURFs in disease progression are complex, either facilitative or inhibitory, and understanding their mechanisms offers potential therapeutic targets and new avenues for research.
Review
Biochemistry & Molecular Biology
Dong Wang, Yuanming Zou, Xinyue Huang, Zeyu Yin, Mohan Li, Jiaqi Xu, Boquan Wu, Da Li, Ying Zhang, Yingxian Sun, Xingang Zhang, Naijin Zhang
Summary: The ubiquitin-proteasome system plays a crucial role in regulating protein levels in cells. SMURF1 and SMURF2 are key components in this system, responsible for regulating protein stability and maintaining physiological processes such as cell migration, proliferation, and apoptosis. They also play significant roles in disease progression, with complex regulatory functions. This review focuses on the mechanisms by which SMURF1 and SMURF2 regulate disease progression in non-cancerous diseases, providing potential therapeutic targets for various diseases and new research avenues for SMURF proteins.
Article
Biochemistry & Molecular Biology
Yi Zheng, Jian Deng, Lulu Han, Meng-Wei Zhuang, Yanwen Xu, Jing Zhang, Mei-Ling Nan, Yang Xiao, Peng Zhan, Xinyong Liu, Chengjiang Gao, Pei-Hui Wang
Summary: This study reveals the involvement of the stress response pathway and innate antiviral immunity in the pathogenic mechanism of SARS-CoV-2. NSP5 and N protein of SARS-CoV-2 were found to attenuate the formation of antiviral stress granules (avSG). NSP5 suppressed avSG formation and disrupted the RIG-I-MAVS complex to weaken the RIG-I-mediated antiviral response, while N protein specifically targeted cofactors upstream of RIG-I and affected the recognition of dsRNA by RIG-I.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Qian Lv, Liqun Li, Ying Meng, Huimin Sun, Liuping Chen, Bingxin Wang, Xuejun Li
Summary: The study revealed that TaGW2-6A interacts with TaAGPS and degrades TaAGPS through the 26S proteasome pathway, influencing seed size. This mechanism provides new insights into the formation of wheat grain weight.
Article
Multidisciplinary Sciences
Xiaolan Liu, Xufeng Cen, Ronghai Wu, Ziyan Chen, Yanqi Xie, Fengqi Wang, Bing Shan, Linghui Zeng, Jichun Zhou, Bojian Xie, Yangjun Cai, Jinyan Huang, Yingjiqiong Liang, Youqian Wu, Chao Zhang, Dongrui Wang, Hongguang Xia
Summary: This study reveals that cisplatin enhances the anti-tumor effect of PD-L1 blockade and upregulates ARIH1 expression, promoting T cell infiltration and sensitizing tumors to immune checkpoint blockade. ARIH1 mediates activation of the STING pathway by ubiquitination and degradation of DNA-PKcs, which is a mechanism of tumor resistance to ICB. Activating ARIH1 is an effective strategy to improve the efficacy of cancer immunotherapy.
NATURE COMMUNICATIONS
(2023)
Review
Immunology
Yiyang Liu, Lu Jiang, Xuemeng Sun, Yixuan Song, Yihan Liu, Leiliang Zhang
Summary: TRIM7 plays significant roles in host defense against viral infections and immune signaling pathways. However, viruses have developed immune evasion mechanisms to counteract its function. Understanding the interaction between TRIM7 and antiviral immunity is crucial for developing innovative treatments for viral diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Environmental Sciences
Y. M. Wong, R. Li, C. K. F. Lee, H. T. Wan, Chris K. C. Wong
MARINE POLLUTION BULLETIN
(2017)
Article
Biochemistry & Molecular Biology
Celia S. L. Mak, Mingo M. H. Yung, Lynn M. N. Hui, Leanne L. Leung, Rui Liang, Kangmei Chen, Stephanie S. Liu, Yiming Qin, Thomas H. Y. Leung, Kai-Fai Lee, Karen K. L. Chan, Hextan Y. S. Ngan, David W. Chan
Article
Agriculture, Multidisciplinary
Xiao-Xin Chen, Kargo Kar-Ho Lam, Yi-Bin Feng, Kai Xu, Stephen Cho-Wing Sze, Sydney Chi-Wai Tang, George Pak-Hen Leung, Calvin Kai-Fai Lee, Jun Shi, Zhi-Jun Yang, Sheng-Tao Li, Zhang-Jin Zhang, Kalin Yan-Bo Zhang
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2018)
Article
Pharmacology & Pharmacy
Xueyu Wang, Guo-Cai Wang, Jianhui Rong, Shi Wei Wang, Tzi Bun Ng, Yan Bo Zhang, Kai Fai Lee, Lin Zheng, Hei-Kiu Wong, Ken Kin Lam Yung, Stephen Cho Wing Sze
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Medicine, General & Internal
Syed F. Ahmad, Jeremy K. Brown, Lisa L. Campbell, Magda Koscielniak, Catriona Oliver, Nick Wheelhouse, Gary Entrican, Stuart Mcfee, Gillian S. Wills, Myra O. McClure, Patrick J. Horner, Sevasti Gaikoumelou, Kai F. Lee, Hilary O. D. Critchley, W. Colin Duncan, Andrew W. Horne
Article
Neurosciences
Jing-Yi Liu, Xiao-Xin Chen, Hai-Yong Chen, Jun Shi, George Pak-Heng Leung, Sydney Chi-Wai Tang, Li-Xing Lao, Henry Ka-Fun Yip, Kai-Fai Lee, Stephen Cho-Wing Sze, Zhang-Jin Zhang, Kalin Yanbo Zhang
Article
Environmental Sciences
John A. Kubi, Andy C. H. Chen, Sze Wan Fong, Keng Po Lai, Chris K. C. Wong, William S. B. Yeung, Kai Fai Lee, Yin Lau Lee
ENVIRONMENT INTERNATIONAL
(2019)
Article
Oncology
Carmen O. N. Leung, Wen Deng, Tian-Min Ye, Hextan Y. S. Ngan, Sai Wah Tsao, Annie N. Y. Cheung, Niu Ziru, Dominic C. K. Yuen, Ronald T. K. Pang, William S. B. Yeung
Article
Multidisciplinary Sciences
W. M. Liu, R. R. Cheng, Z. R. Niu, A. C. Chen, M. Y. Ma, T. Li, P. C. Chiu, R. T. Pang, Y. L. Lee, J. P. Ou, Y. Q. Yao, W. S. B. Yeung
Article
Environmental Sciences
Ziyi Wang, Kottawattage S. A. Kottawatta, Suranga P. Kodithuwakku, Thevarathanthrige S. Fernando, Yin-Lau Lee, Ernest H. Y. Ng, William S. B. Yeung, Kai-Fai Lee
Summary: Mancozeb and its metabolite ETU have been shown to inhibit embryo attachment, reduce cell viability, and alter gene expression profiles.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Oncology
Sudini R. Fernando, Cheuk-Lun Lee, Benancy P. C. Wong, Kiu-Wai Cheng, Yin-Lau Lee, Ming-Chung Chan, Ernest H. Y. Ng, William S. B. Yeung, Kai-Fai Lee
Summary: Our research indicates that estrogen and progesterone regulate the expression of PDIA1, leading to differential expressions of membrane PDIA1 protein to modulate endometrial receptivity. This suggests that membrane PDIA1 expression could potentially be used as a predictor of endometrial receptivity and embryo implantation in women undergoing assisted reproduction treatment.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Reproductive Biology
Sudini Ranshaya Fernando, Kottawattage Sanda Arunika Kottawatta, Luhan Jiang, Xian Chen, Kiu-Wai Cheng, Benancy Po-Chau Wong, Ernest Hung-Yu Ng, William Shu-Biu Yeung, Kai-Fai Lee
Summary: Estrogen and progesterone influence the expression of the protein disulfide isomerase (PDI) family in the endometrial epithelium, potentially enhancing endometrial receptivity by regulating PDIs.
REPRODUCTIVE BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Ishani Dinisri, Sandarenu Kodikara, Madhusha Prasadani, Indunil Pathirana, Chathura Rathnayake, Basil Alexander, Kai-Fai Lee, Suranga Pradeep Kodithuwakku
Summary: Mancozeb negatively impacts caprine oocytes and granulosa cells, potentially impairing fertilization ability and developmental potential of the oocytes, and suppressing ovulation. It suppresses granulosa cells viability, reduces cumulus expansion, and suppresses metaphase plate formation in oocytes, while also inducing progesterone secretion from granulosa cells.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2021)
Article
Biotechnology & Applied Microbiology
Ye Tian-Min, Lin Suxia, Ding Shufang, Cao Dandan, Luo Long-Dan, Yeung William Shu Biu
Summary: This study investigated the differential expression of miRNAs and metabolites in the follicular fluid of PCOS patients. The results suggest that these differential miRNAs are involved in metabolic pathways and may serve as potential biomarkers for the diagnosis of PCOS. The findings provide insights into the pathogenesis of PCOS and offer potential targets for its diagnosis and treatment.
Article
Biochemistry & Molecular Biology
Luhan Jiang, Dandan Cao, William S. B. Yeung, Kai-Fai Lee
Summary: This study used single-cell transcriptomics to uncover the cellular characteristics of mouse endometrial stromal cells (ESCs) and their role in modulating the microenvironment of a receptive endometrium. The results showed that both decidualized and non-decidualized ESCs are involved in extracellular remodeling and play a role in regulating endometrial receptivity and immune tolerance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)