Imaging Brain Effects of APOE4 in Cognitively Normal Individuals Across the Lifespan

APOE-epsilon4 and aging of medial temporal lobe gray matter in healthy adults older than 50 years

(2014) Joy L. Taylor et al.   NEUROBIOLOGY OF AGING

18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons

(2014) David S. Knopman et al.   NEUROBIOLOGY OF AGING

APOE  4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory

(2014) G. A. Kerchner et al.   NEUROLOGY

Amyloid and APOE  4 interact to influence short-term decline in preclinical Alzheimer disease

(2014) E. C. Mormino et al.   NEUROLOGY

Association of hypometabolism and amyloid levels in aging, normal subjects

(2014) V. J. Lowe et al.   NEUROLOGY

Functional Brain Connectivity Using fMRI in Aging and Alzheimer’s Disease

(2014) Emily L. Dennis et al.   NEUROPSYCHOLOGY REVIEW

Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer’s disease

(2013) Yen Ying Lim et al.   BRAIN

Common Variants in Psychiatric Risk Genes Predict Brain Structure at Birth

(2013) R. C. Knickmeyer et al.   CEREBRAL CORTEX

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

The apolipoprotein E epsilon 4 allele is associated with ventricular expansion rate and surface morphology in dementia and normal aging

(2013) Florence F. Roussotte et al.   NEUROBIOLOGY OF AGING

Mapping the effects of ApoE4, age and cognitive status on 18F-florbetapir PET measured regional cortical patterns of beta-amyloid density and growth

(2013) Kelly R. Murphy et al.   NEUROIMAGE

Differential effects of the ApoE4 genotype on brain structure and function

(2013) Silke Matura et al.   NEUROIMAGE

Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later

(2013) C. M. Roe et al.   NEUROLOGY

Dissecting the Gene Dose-Effects of the APOE ε4 and ε2 Alleles on Hippocampal Volumes in Aging and Alzheimer’s Disease

(2013) Christopher A. Hostage et al.   PLoS One

Neuroimaging biomarkers for Alzheimer's disease in asymptomatic APOE4 carriers

(2013) G. Chételat et al.   REVUE NEUROLOGIQUE

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

Brain Differences in Infants at Differential Genetic Risk for Late-Onset Alzheimer Disease

(2013) Douglas C. Dean et al.   JAMA Neurology

Aβ amyloid, cognition, and APOE genotype in healthy older adults

(2012) Yen Ying Lim et al.   Alzheimers & Dementia

In vivo assessment of amyloid-β deposition in nondemented very elderly subjects

(2012) Chester A. Mathis et al.   ANNALS OF NEUROLOGY

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Accelerating Cortical Thinning: Unique to Dementia or Universal in Aging?

(2012) Anders M. Fjell et al.   CEREBRAL CORTEX

Apolipoprotein E, Not Fibrillar  -Amyloid, Reduces Cerebral Glucose Metabolism in Normal Aging

(2012) W. J. Jagust et al.   JOURNAL OF NEUROSCIENCE

Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-β plaques: a prospective cohort study

(2012) Christopher M Clark et al.   LANCET NEUROLOGY

Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease

(2012) Adam S. Fleisher et al.   NEUROBIOLOGY OF AGING

Correlations between FDG PET glucose uptake-MRI gray matter volume scores and apolipoprotein E ε4 gene dose in cognitively normal adults: A cross-validation study using voxel-based multi-modal partial least squares

(2012) Kewei Chen et al.   NEUROIMAGE

Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults

(2012) Y. Y. Lim et al.   NEUROLOGY

Indicators of amyloid burden in a population-based study of cognitively normal elderly

(2012) M. M. Mielke et al.   NEUROLOGY

 -Amyloid burden in healthy aging: Regional distribution and cognitive consequences

(2012) K. M. Rodrigue et al.   NEUROLOGY

Family History and APOE-4 Genetic Risk in Alzheimer’s Disease

(2012) Markus Donix et al.   NEUROPSYCHOLOGY REVIEW

Reduced Hippocampal Volume in Healthy Young ApoE4 Carriers: An MRI Study

(2012) Laurence O'Dwyer et al.   PLoS One

Posterior Cingulate Glucose Metabolism, Hippocampal Glucose Metabolism, and Hippocampal Volume in Cognitively Normal, Late-Middle-Aged Persons at 3 Levels of Genetic Risk for Alzheimer Disease

(2012) Hillary D. Protas et al.   JAMA Neurology

Impact of apolipoprotein ɛ4–cerebrospinal fluid beta-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment

(2011) Gloria C. Chiang et al.   Alzheimers & Dementia

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Design Considerations for Characterizing Psychiatric Trajectories Across the Lifespan: Application to Effects of APOE-ε4 on Cerebral Cortical Thickness in Alzheimer's Disease

(2011) Wesley K. Thompson et al.   AMERICAN JOURNAL OF PSYCHIATRY

Amyloid-beta plaque growth in cognitively normal adults: Longitudinal [11C]Pittsburgh compound B data

(2011) Andrei G. Vlassenko et al.   ANNALS OF NEUROLOGY

Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease

(2011) Victor L. Villemagne et al.   ANNALS OF NEUROLOGY

White matter integrity and vulnerability to Alzheimer's disease: Preliminary findings and future directions

(2011) Brian T. Gold et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Episodic memory on the path to Alzheimer's disease

(2011) Michela Gallagher et al.   CURRENT OPINION IN NEUROBIOLOGY

Use of Florbetapir-PET for Imaging β-Amyloid Pathology

(2011) Christopher M. Clark   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Increased Hippocampal Default Mode Synchronization during Rest in Middle-Aged and Elderly APOE  4 Carriers: Relationships with Memory Performance

(2011) E. T. Westlye et al.   JOURNAL OF NEUROSCIENCE

APOE and Alzheimer disease: a major gene with semi-dominant inheritance

(2011) E Genin et al.   MOLECULAR PSYCHIATRY

Glucose metabolism and gray-matter concentration in apolipoprotein E ε4 positive normal subjects

(2011) Miharu Samuraki et al.   NEUROBIOLOGY OF AGING

APOE modifies the association between A  load and cognition in cognitively normal older adults

(2011) K. Kantarci et al.   NEUROLOGY

Progressive regional atrophy in normal adults with a maternal history of Alzheimer disease

(2011) R. A. Honea et al.   NEUROLOGY

Interaction effects of subjective memory impairment and ApoE4 genotype on episodic memory and hippocampal volume

(2011) N. Striepens et al.   PSYCHOLOGICAL MEDICINE

Family History of Alzheimer's Disease and Hippocampal Structure in Healthy People

(2010) Markus Donix et al.   AMERICAN JOURNAL OF PSYCHIATRY

Apolipoprotein E4allele in the normal elderly: neuropsychologic and brain MRI correlates

(2010) H. Schmidt et al.   CLINICAL GENETICS

Revising the definition of Alzheimer's disease: a new lexicon

(2010) Bruno Dubois et al.   LANCET NEUROLOGY

Longitudinal MRI atrophy biomarkers: Relationship to conversion in the ADNI cohort

(2010) Shannon L. Risacher et al.   NEUROBIOLOGY OF AGING

Sex and age differences in atrophic rates: an ADNI study with n=1368 MRI scans

(2010) Xue Hua et al.   NEUROBIOLOGY OF AGING

Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging

(2010) Christopher C. Rowe et al.   NEUROBIOLOGY OF AGING

The effects of APOE-ε4 on the BOLD response

(2010) Aaron J. Trachtenberg et al.   NEUROBIOLOGY OF AGING

Longitudinal changes in medial temporal cortical thickness in normal subjects with the APOE-4 polymorphism

(2010) Markus Donix et al.   NEUROIMAGE

Differential effects of the APOE genotype on brain function across the lifespan

(2010) N. Filippini et al.   NEUROIMAGE

Hippocampal atrophy rates and CSF biomarkers in elderly APOE2 normal subjects

(2010) G. C. Chiang et al.   NEUROLOGY

Reduced gray matter volume in normal adults with a maternal family history of Alzheimer disease

(2010) R. A. Honea et al.   NEUROLOGY

Medial temporal lobe dysfunction during encoding and retrieval of episodic memory in non-demented APOE ε4 carriers

(2010) J. Kukolja et al.   NEUROSCIENCE

Cortical thickness is associated with different apolipoprotein E genotypes in healthy elderly adults

(2010) Ming Fan et al.   NEUROSCIENCE LETTERS

Aβ-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease

(2010) Yadong Huang   TRENDS IN MOLECULAR MEDICINE

Temporal lobe functional activity and connectivity in young adult APOE ɛ4 carriers

(2009) Nancy A. Dennis et al.   Alzheimers & Dementia

Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age

(2009) Eloise Kok et al.   ANNALS OF NEUROLOGY

APOEpredicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

(2009) John C. Morris et al.   ANNALS OF NEUROLOGY

Cortical Binding of Pittsburgh Compound B, an Endophenotype for Genetic Studies of Alzheimer's Disease

(2009) Anthony L. Hinrichs et al.   BIOLOGICAL PSYCHIATRY

Selective effect of age, Apo e4, and Alzheimer's disease on hippocampal subfields

(2009) Susanne G. Mueller et al.   HIPPOCAMPUS

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Reduced hippocampal CA2, CA3, and dentate gyrus activity in asymptomatic people at genetic risk for Alzheimer's disease

(2009) Nanthia A. Suthana et al.   NEUROIMAGE

APOE  2 is associated with intact cognition but increased Alzheimer pathology in the oldest old

(2009) D. J. Berlau et al.   NEUROLOGY

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Fibrillar amyloid-  burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

(2009) E. M. Reiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct patterns of brain activity in young carriers of the APOE- 4 allele

(2009) N. Filippini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of β-Amyloid in a Frontal Cortical Brain Biopsy Specimen and by Positron Emission Tomography With Carbon 11–Labeled Pittsburgh Compound B

(2008) Ville Leinonen   ARCHIVES OF NEUROLOGY

Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

(2008) Milos D. Ikonomovic et al.   BRAIN

Selective effect of Apo e4 on CA3 and dentate in normal aging and Alzheimer's disease using high resolution MRI at 4 T

(2008) S.G. Mueller et al.   NEUROIMAGE

Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriers

(2008) A.C. Burggren et al.   NEUROIMAGE

Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls

(2008) Jonathan H. Morra et al.   NEUROIMAGE

Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease

(2008) L. Mosconi et al.   NEUROLOGY

Accelerated age-related cortical thinning in healthy carriers of apolipoprotein E ɛ4

(2006) Thomas Espeseth et al.   NEUROBIOLOGY OF AGING