Article
Multidisciplinary Sciences
Tatsuya Shioda, Ittetsu Takahashi, Kensuke Ikenaka, Naonobu Fujita, Tomotake Kanki, Toshihiko Oka, Hideki Mochizuki, Adam Antebi, Tamotsu Yoshimori, Shuhei Nakamura
Summary: Accumulating evidence suggests that the molecular network involving neuronal MML-1 function is crucial for regulating systemic aging. This study demonstrates that MML-1 and its heterodimer partners play a primary role in neurons to extend longevity in germlineless animals, acting via downstream cascades that are distinct from HLH-30. The MML-1-GLT-5 axis in neurons is critical for maintaining proteostasis and reducing oxidative stress in long-lived animals through autophagy and peroxidase MLT-7, respectively.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Elisa Enriquez-Hesles, Daniel L. Smith, Nazif Maqani, Margaret B. Wierman, Matthew D. Sutcliffe, Ryan D. Fine, Agata Kalita, Sean M. Santos, Michael J. Muehlbauer, James R. Bain, Kevin A. Janes, John L. Hartman, Matthew D. Hirschey, Jeffrey S. Smith
Summary: Caloric restriction has been shown to improve the health span and life span of various organisms by influencing the metabolism of specific amino acids, such as L-serine, through the one-carbon metabolism pathway. This mechanism suggests a potential non-cell-autonomous regulation of life span, providing insights into interventions for aging-associated diseases.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Barbel Rohrer, Manas R. Biswal, Elisabeth Obert, Yujing Dang, Yanhui Su, Xiaofeng Zuo, Ben Fogelgren, Altaf A. Kondkar, Glenn P. Lobo, Joshua H. Lipschutz
Summary: The study focused on the mechanisms of the highly conserved exocyst trafficking complex in regulating eye physiology in zebrafish and mice, particularly the role of Exoc5. Exoc5 was found to be crucial for eye development, with mutants showing smaller eyes and abnormal RPE pigmentation, leading to compromised visual function. The research also demonstrated that loss of Exoc5 resulted in retinal thinning, degeneration of photoreceptors, and progressive visual impairment, highlighting the importance of exocyst-mediated signaling in maintaining RPE structure and function for overall eye health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Juncai He, Yan Fu, Lingling Ge, Jiaman Dai, Yajie Fang, Yijian Li, Xianliang Gu, Zui Tao, Ting Zou, Minghui Li, Yong Liu, Haiwei Xu, Zheng Qin Yin
Summary: This study investigated the activation of microglia and its contribution to photoreceptor degeneration in retinitis pigmentosa (RP). The results showed that disease-associated microglia activation can suppress the degeneration of rods and cones, reducing secondary damage caused by the accumulation of dead cells and infiltrated neutrophils.
Review
Immunology
Kai Yang
Summary: Regulatory T cells (Tregs) play important roles in immune regulation, and cellular metabolism is crucial for their function. Tregs reprogram cellular metabolic programs to sustain their suppressive function, and altered metabolism also influences Treg activation and function. Manipulation of systemic metabolites has emerged as an attractive strategy to modulate tissue Treg metabolism and improve treatment of immune-related diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Yuming Zhang, Fengyu Yuan, Pei Li, Jihai Gu, Junjun Han, Zhihua Ni, Fengsong Liu
Summary: This study found that Resveratrol (RES) inhibits the proliferation of HeLa cells by perturbing mitochondrial structure and function, and ROS-induced autophagy plays a critical role in this process.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Prashant Kumar, Fahad Zadjali, Ying Yao, Daniel Johnson, Brian Siroky, Aristotelis Astrinidis, Peter Vogel, Kenneth W. Gross, John J. Bissler
Summary: The pathogenesis of TSC renal cystic disease is not well understood, but a new mouse model reveals changes in cystic epithelial cells and the important role of extracellular vesicles (EVs) in the disease process.
Article
Medicine, Research & Experimental
Daijin Li, Jing Xu, Jie Chang, Yujue Wang, Xiaoye Du, Hanhan Wu, Jingang Cui, Peiwei Wang, Teng Zhang, Yu Chen
Summary: Through in vitro and in vivo experiments, this study demonstrates for the first time that hyperoside can protect photoreceptors from oxidative stress-induced mitochondrial dysfunction and cell death, thereby reducing the degeneration of retinal projection cells and maintaining retinal homeostasis. These findings suggest that hyperoside has the potential to be a protective agent for the treatment of related photoreceptor degenerative diseases.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Nuria Puig, Jose Rives, Montserrat Estruch, Ana Aguilera-Simon, Noemi Rotllan, Mercedes Camacho, Nuria Colome, Francesc Canals, Jose Luis Sanchez-Quesada, Sonia Benitez
Summary: Electronegative low-density lipoprotein (LDL(-)) is a modified fraction of human plasma LDL with atherogenic properties, including increased bioactive lipid mediator content. The present study suggests the presence of ceramidase (CDase)-like activity in LDL(-), which is associated with the increased sphingosine (Sph) content. However, the exact origin of this activity remains unknown and requires further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Nikki Naim, Francis R. G. Amrit, Ramesh Ratnappan, Nicholas DelBuono, Julia A. Loose, Arjumand Ghazi
Summary: The Caenorhabditis elegans pro-longevity factor NHR-49 promotes resistance against Pseudomonas aeruginosa but modulates immunity and longevity distinctly. NHR-49 is differentially regulated by interventions that bring about long-term changes (life span extension) versus short-term stress (pathogen exposure) and orchestrates discrete outputs, including pathogen-specific transcriptional programs.
Article
Biochemistry & Molecular Biology
Yiyi Chen, Yujie Dong, Jie Yan, Lan Wang, Shirley Yu, Kangwei Jiao, Francois Paquet-Durand
Summary: This study systematically mapped the transcriptional changes that occur in the degenerating mouse retina at the single cell level using single-cell RNA-sequencing. The results highlight the relevance of Ca2+-signaling and metabolic pathways to hereditary photoreceptor degeneration, and suggest that metabolic changes in rd1 mutation may be regulated through the MAPK pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Cyntanna C. Hawkins, Amber B. Jones, Emily R. Gordon, Sarah E. Williford, Yuvika Harsh, Julia K. Ziebro, Catherine J. Landis, G. C. Sajina, David K. Crossman, Sara J. Cooper, Sasanka Ramanadham, Ninh Doan, Anita B. Hjelmeland
Summary: In this study, the researchers found that acid ceramidase (ASAH1) is highly expressed in GBM and is associated with migration-related genes. Through shRNA knockdown and carmofur inhibition, they demonstrated the role of ASAH1 in GBM migration. Inhibition of ASAH1 using carmofur may be a potential clinically relevant treatment for GBM.
Review
Plant Sciences
Stephan Clemens
Summary: Nearly 10% of plant proteins belong to the zinc proteome and require zinc as a catalyst or structural element, with the majority of protein-bound zinc in eukaryotic cells found in the cytosol. Various metabolites and peptides serve as zinc buffers to supply zinc to enzymes, transporters, or sensor proteins, with zinc acquisition mediated by specific proteins and zinc transportation controlled by different mechanisms. Recent studies in mammalian cells have revealed the regulatory roles of zinc in modulating cellular zinc pools and influencing protein interactions and signaling cascade activities.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Oncology
Miguel Cosenza-Contreras, Agnes Schafer, Justin Sing, Lena Cook, Maren N. Stillger, Chia-Yi Chen, Jose Villacorta Hidalgo, Niko Pinter, Larissa Meyer, Tilman Werner, Darleen Bug, Zeno Haberl, Oliver Kuebeck, Kai Zhao, Susanne Stei, Anca Violeta Gafencu, Radu Ionita, Felix M. Brehar, Jaime Ferrer-Lozano, Gloria Ribas, Leo Cerda-Alberich, Luis Marti-Bonmati, Christopher Nimsky, Alexis Van Straaten, Martin L. Biniossek, Melanie Foll, Nina Cabezas-Wallscheid, Jorg Buscher, Hannes Rost, Armelle Arnoux, Jorg W. Bartsch, Oliver Schilling
Summary: This study utilized proteomics and lipidomics to analyze patient-matched initial and recurrent glioblastoma specimens, revealing increased immune cell infiltration and extracellular matrix reorganization in recurrent glioblastoma. ASAH1 and SYNM were identified as potential plasma markers for the progression of recurrent glioblastoma.
Article
Agriculture, Multidisciplinary
Shinji Yamashita, Michiru Soga, Ephantus Nguma, Mikio Kinoshita, Teruo Miyazawa
Summary: The ethanol extract from polished rice containing GlcCer suppresses inflammation and protects intestinal cells. GlcCer-related substances reversed the reduction in cell numbers induced by LPS, while GlcCer-metabolic inhibitors suppressed the beneficial effects of GlcCer-related substances.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Cell Biology
Govind Kunduri, Changqing Yuan, Velayoudame Parthibane, Katherine M. Nyswaner, Ritu Kanwar, Kunio Nagashima, Steven G. Britt, Nickita Mehta, Varshika Kotu, Mindy Porterfield, Michael Tiemeyer, Patrick J. Dolph, Usha Acharya, Jairaj K. Acharya
JOURNAL OF CELL BIOLOGY
(2014)
Article
Cell Biology
Motiur Rahman, Niraj K. Nirala, Alka Singh, Lihua Julie Zhu, Kaori Taguchi, Takeshi Bamba, Eiichiro Fukusaki, Leslie M. Shaw, David G. Lambright, Jairaj K. Acharya, Usha R. Acharya
JOURNAL OF CELL BIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
M. Athar Masood, Raghavendra P. Rao, Jairaj K. Acharya, Josip Blonder, Timothy D. Veenstra
Article
Multidisciplinary Sciences
Raghavendra Pralhada Rao, Luana Scheffer, Sargur M. Srideshikan, Velayoudame Parthibane, Teresa Kosakowska-Cholody, M. Athar Masood, Kunio Nagashima, Prabhakar Gudla, Stephen Lockett, Usha Acharya, Jairaj K. Acharya
Article
Multidisciplinary Sciences
Govind Kunduri, Daniel Turner-Evans, Yutaka Konya, Yoshihiro Izumi, Kunio Nagashima, Stephen Lockett, Joost Holthuis, Takeshi Bamba, Usha Acharya, Jairaj K. Acharya
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Cell Biology
T. Kosakowska-Cholody, J. Lin, S. M. Srideshikan, L. Scheffer, N. I. Tarasova, J. K. Acharya
CELL DEATH & DISEASE
(2014)
Article
Materials Science, Biomaterials
Sandeep Kumar, Jyoti Thakur, Kavita Yadav, Madhurima Mitra, Sanjay Pal, Arjun Ray, Siddhi Gupta, Nihal Medatwal, Ragini Gupta, Deepakkumar Mishra, Parul Rani, Siladitya Padhi, Priyanka Sharma, Arti Kapil, Aasheesh Srivastava, U. Deva Priyakumar, Ujjaini Dasgupta, Lipi Thukral, Avinash Bajaj
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Article
Chemistry, Multidisciplinary
Sanjay Pal, Nihal Medatwal, Sandeep Kumar, Animesh Kar, Varsha Komalla, Prabhu Srinivas Yavvari, Deepak Kumar Mishra, Zaigham Abbas Rizvi, Shiv Nandan, Dipankar Malakar, Manoj Pillai, Amit Awasthi, Prasenjit Das, Ravi Datta Sharma, Aasheesh Srivastava, Sagar Sengupta, Ujjaini Dasgupta, Avinash Bajaj
ACS CENTRAL SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Velayoudame Parthibane, Jing Lin, Diwash Acharya, Thiruvaimozhi Abimannan, Sargur Madabushi Srideshikan, Kimberly Klarmann, Acong Yang, Ferri Soheilian, Kunio Nagashima, Stephen D. Fox, Thorkell Andresson, Lino Tessarollo, Jonathan R. Keller, Usha Acharya, Jairaj K. Acharya
Summary: The Serine palmitoyltransferase complex (SPT) is crucial for sphingolipid biosynthesis in mammals, with the smaller subunit SSSPTA essential for embryogenesis and hematopoietic function, while the smaller subunit SSSPTB has no significant impact on the adult hematopoietic compartment. This highlights the importance of SSSPTA in the SPT complex for mammalian development and hematopoiesis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Parijat Sarkar, Kaleeckal G. Harikumar, Satinder S. Rawat, Sanjib Das, Tushar K. Chakraborty, Amitabha Chattopadhyay
Summary: Serotonin is a crucial neurotransmitter that regulates various functions by binding to different serotonin receptors. Novel fluorescent analogs of serotonin have been synthesized and characterized, showing high environmental sensitivity and specific binding to serotonin receptors, providing a new fluorescent approach for studying the molecular environment of serotonin receptors.
Article
Biochemistry & Molecular Biology
Beatriz Sanchez-Solana, Dunrui Wang, Xiaolan Qian, Parthibane Velayoudame, Dhirendra K. Simanshu, Jairaj K. Acharya, Douglas R. Lowy
Summary: We have identified phosphatidylserine (PS) as the lipid ligand for DLC1-START, and found that in addition to binding Caveolin-1, DLC1-START also binds PLCD1 protein. The importance of PS binding for the interactions of DLC1 with Caveolin-1 and PLCD1 was demonstrated, indicating a crucial role in tumorigenesis. Analysis of cancer-associated DLC1-START mutants revealed diverse deficiencies in binding properties, highlighting the versatile role of DLC1-START in promoting protein interactions and tumor suppression beyond its RhoGAP activity.
Article
Biochemistry & Molecular Biology
Govind Kunduri, Si-Hung Le, Valentina Baena, Nagampalli Vijaykrishna, Adam Harned, Kunio Nagashima, Daniel Blankenberg, Izumi Yoshihiro, Kedar Narayan, Takeshi Bamba, Usha Acharya, Jairaj K. Acharya
Summary: In this study, researchers discovered that CPE is a key lipid molecule in Drosophila spermatocyte division, and its deficiency leads to meiotic cytokinesis defects. They also found that CPE is enriched in Rab7-labeled multivesicular bodies, which localize to the cleavage furrow. Additional experiments demonstrated the requirement of Rab11 for the localization of CPE-enriched endosomes to the cleavage furrow.
Review
Cell Biology
Govind Kunduri, Usha Acharya, Jairaj K. Acharya
Summary: This review discusses the characteristics and mechanisms of various lipid species associated with cytokinesis, including forward trafficking, endocytic recycling, local synthesis, and cortical flow models. It focuses on the roles of sphingolipids and phosphatidylinositols in cytokinesis and discusses the differences in lipid species requirements and distribution between mitotic and male meiotic cells.
Article
Chemistry, Multidisciplinary
Nihal Medatwal, Mohammad Nafees Ansari, Sandeep Kumar, Sanjay Pal, Somesh Kumar Jha, Priyanka Verma, Kajal Rana, Ujjaini Dasgupta, Avinash Bajaj
Article
Hematology
Velayoudame Parthibane, Diwash Acharya, Sargur Madabushi Srideshikan, Jing Lin, Dru G. Myerscough, Thiruvaimozhi Abimannan, Nagampalli Vijaykrishna, Daniel Blankenberg, Lavanya Bondada, Kimberly D. Klarmann, Stephen D. Fox, Thorkell Andresson, Lino Tessarollo, Usha Acharya, Jonathan R. Keller, Jairaj K. Acharya