Article
Psychology, Clinical
Qing Zhao, Tingting Xu, Yuan Wang, Dandan Chen, Qiang Liu, Zhi Yang, Zhen Wang
Summary: This study investigated the differences in brain functional connectivity within the cortico-striato-thalamo-cortical (CSTC) loop between drug-naive and drug-free OCD patients and healthy controls. The results suggest that exposure to antidepressants may affect the function of certain brain regions. Future longitudinal studies could help reveal the pharmacotherapeutic mechanisms in these loops.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychiatry
Mario A. Yacou, Asadur Chowdury, Philip Easter, Gregory L. Hanna, David R. Rosenberg, Vaibhav A. Diwadkar
Summary: The study utilized dynamic causal modeling to evaluate the impact of attention demand on effective connectivity between OCD patients and healthy controls. Results revealed weakened connectivity in the early constituents of the visual pathway and significantly reduced contextual modulation of the ascending relay from the thalamus to the prefrontal cortex in OCD patients during sustained attention.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biology
Leslie D. Claar, Irene Rembado, Jacqulyn R. Kuyat, Simone Russo, Lydia C. Marks, Shawn R. Olsen, Christof Koch
Summary: This study predicts the presence of consciousness in volunteers and patients by stimulating the brain and analyzing the EEG responses. The researchers conducted similar experiments on mice and observed different patterns of cortical and thalamic responses during wakefulness, running, and anesthesia.
Article
Clinical Neurology
Jiayue Cheng, Puyu Li, Yingying Tang, Chen Zhang, Liangjun Lin, Jian Gao, Zhen Wang
Summary: The study showed that high-definition tDCS treatment in OCD patients can significantly improve symptoms, and the treatment can lead to improvements in GABAB receptor function.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Ilya Sysoev, Gilles van Luijtelaar, Annika Luttjohann
Summary: This study investigated changes in functional connectivity between the thalamus and cortex and between different thalamic nuclei during the process of falling asleep and deepening into slow-wave sleep. The findings revealed that higher order nuclei are more inhibited than first-order nuclei during deep slow-wave sleep. These differences are important for the coordination of sleep-related processes.
BRAIN CONNECTIVITY
(2022)
Article
Neurosciences
Fabrizio Vecchio, Francesca Alu, Alessandro Orticoni, Francesca Miraglia, Elda Judica, Maria Cotelli, Paolo Maria Rossini
Summary: The brain state preceding a task can influence motor performance at the single trial level, with specific changes in EEG rhythms power spectral density correlating with faster responses during a visuomotor task. This suggests that EEG markers may be able to predict an individual's performance on a trial-by-trial basis, highlighting the potential clinical relevance of predicting brain states for rehabilitation strategies.
COGNITIVE NEURODYNAMICS
(2022)
Article
Chemistry, Multidisciplinary
Lucero Albarran-Cardenas, Juan Silva-Pereyra, Benito Javier Martinez-Briones, Jorge Bosch-Bayard, Thalia Fernandez
Summary: EEGs of children with reading disorders show higher theta and lower alpha. Neurofeedback may help by reducing the theta/alpha ratio. This study explored the effects of an NFB protocol on functional connectivity among children with RDs. The results suggest that NFB can positively impact reading-related functions in the brain networks of children with RDs.
APPLIED SCIENCES-BASEL
(2023)
Article
Psychology, Clinical
Jianyu Li, Jian Cheng, Lei Yang, Qihui Niu, Yuanchao Zhang, Lena Palaniyappan
Summary: Obsessive-compulsive disorder (OCD) is believed to be caused by dysconnectivity among interconnected brain regions, leading to a wide range of clinical manifestations. This study found that patients with OCD have increased cortical gyrification in certain brain regions and decreased white matter distortion, which are associated with higher anxiety levels. These findings suggest that alterations in cortical folding and white matter geometry may be neural substrates underlying the clinical manifestations of OCD.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Meaghan E. Spedden, Mikkel M. Beck, Timothy O. West, Simon F. Farmer, Jens B. Nielsen, Jesper Lundbye-Jensen
Summary: This study investigates the cortical mechanisms underlying visually guided steps and highlights the role of oscillatory communication in the parieto-frontal and corticomuscular network. The findings suggest that the brain utilizes coherence to flexibly fine-tune inter-regional communication during human stepping, contributing to the precision control of large-scale movements.
Article
Neurosciences
Mo Modarres, David Cochran, David N. Kennedy, Jean A. Frazier
Summary: This study rigorously analyzed the quantitative EEG (qEEG) of typically developing boys and girls during resting state conditions. The results showed significant differences in various qEEG metrics between boys and girls, suggesting the importance of considering sex as a covariate in qEEG analysis. Furthermore, the study highlights the utility of narrow-band frequencies in examining brain activity in children.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Marta Borras, Sergio Romero, Joan F. Alonso, Alejandro Bachiller, Leidy Y. Serna, Carolina Migliorelli, Miguel A. Mananas
Summary: This study assessed the effect of a limited number of trials on motor-related activity during upper limb movements. The findings suggested that 50 trials can be an appropriate number to obtain stable motor-related features.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Neurosciences
Berangere Thirioux, Nicolas Langbour, Prasanth Bokam, Lea Renaudin, Issa Wassouf, Ghina Harika-Germaneau, Nematollah Jaafari
Summary: Using high-density electrical neuroimaging, this study explores the dysfunctional patterns of microstates dynamics in obsessive-compulsive disorder (OCD). The study finds that OCD patients exhibit increased contribution and decreased duration of microstates C and decreased activity in the Salience Network. Additionally, there is increased activity in the Default Mode Network and Executive Control Network, both associated with other microstates. The hyperactivity of the right angular gyrus in the Executive Control Network correlates with symptom severity.
Article
Engineering, Biomedical
Dong Cui, Han Li, Pengxiang Liu, Guanghua Gu, Xiaoli Li, Lei Wang, Shimin Yin
Summary: This study investigates the neurophysiological mechanism of spectra decrease in mild cognitive impairment (MCI). By proposing a new neural mass model and using the unscented Kalman filter algorithm, the key parameters in MCI patients' EEG signals are identified and found to be related to the spectra decrease. The study suggests a possible neural mechanism explaining the spectra decrease in MCI.
JOURNAL OF NEURAL ENGINEERING
(2022)
Review
Psychiatry
Brian A. Zaboski, Elisa F. Stern, Patrick D. Skosnik, Christopher Pittenger
Summary: Despite the cost-effectiveness and convenience of EEG compared to fMRI and PET, studies investigating OCD using EEG are sparse. Most studies focus on event-related potentials, with P300 being reported abnormal in OCD and normalization with treatment, but the literature is heterogeneous and requires further research.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Hai-di Shan, Ya-fei Liu, Qing Zhao, Yi Wang, Yong-ming Wang, Eric F. Cheung, Raymond C. Chan, Zhen Wang
Summary: The study revealed distinct neural correlates in different subgroups of OCD patients based on obsessive beliefs and impulsivity, suggesting potential implications for future research and clinical treatment.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
Marina Cattaneo, Pierre Jesus, Andrea Lizio, Philippe Fayemendy, Nicoletta Guanziroli, Ettore Corradi, Valeria Sansone, Letizia Leocani, Massimo Filippi, Nilo Riva, Philippe Corcia, Philippe Couratier, Christian Lunetta
Summary: The study revealed that 10% of ALS patients have hypometabolic state, while 40% have hypermetabolic state. Hypometabolism is associated with later need for gastrostomy, non-invasive ventilation and tracheostomy, and hypometabolic patients with ALS have significantly longer survival compared to normometabolic and hypermetabolic patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Alberto Averna, Sara Marceglia, Mattia Arlotti, Marco Locatelli, Paolo Rampini, Alberto Priori, Tommaso Bocci
Summary: This study evaluated the spectrum of local field potentials (LFP) obtained from different contacts within the subthalamic nucleus in Parkinson's disease patients, and their correlations with clinical symptoms. The results showed differences in spectral patterns and correlations with motor symptoms between LFP12 and LFP03 before and after levodopa administration, suggesting potential for optimizing adaptive deep brain stimulation protocols for Parkinson's disease.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Biochemical Research Methods
Valerio Castoldi, Elena Rossi, Silvia Marenna, Giancarlo Comi, Letizia Leocani
Summary: This study compared the repeatability and stability of Motor Evoked Potentials (MEPs) induced by different stimulation methods in mice. The results showed that surface stimulation with a surface electrode had reduced inter-session variability and improved measurement stability.
JOURNAL OF NEUROSCIENCE METHODS
(2022)
Article
Neurosciences
Valerio Castoldi, Silvia Marenna, Su-Chun Huang, Raffaele d'Isa, Linda Chaabane, Giancarlo Comi, Letizia Leocani
Summary: In this study, female Dark Agouti rats were immunized with increasing doses of myelin oligodendrocyte glycoprotein (MOG) to develop experimental autoimmune encephalomyelitis (EAE), a preclinical model of multiple sclerosis. The results showed that increasing MOG dosage augmented visual function impairment in EAE, which could be monitored with noninvasive visual evoked potentials (VEPs) to assess demyelination and axonal loss along optic nerves (ONs).
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Meeting Abstract
Clinical Neurology
Eleonora Colombo, Stefano Messina, Federico Verde, Marco Locatelli, Barbara Poletti, Vincenzo Silani, Nicola Ticozzi
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jagadish C. Ghosh, Michela Perego, Ekta Agarwal, Irene Bertolini, Yuan Wang, Aaron R. Goldman, Hsin-Yao Tang, Andrew Kossenkov, Catherine J. Libby, Lucia R. Languino, Edward F. Plow, Annamaria Morotti, Luisa Ottobrini, Marco Locatelli, David W. Speicher, M. Cecilia Caino, Joel Cassel, Joseph M. Salvino, Marie E. Robert, Valentina Vaira, Dario C. Altieri
Summary: The study reveals that many human tumors have reduced levels of Mic60, an essential scaffold of mitochondrial structure, which leads to the disruption of mitochondrial integrity. Surprisingly, these tumors show decreased cell proliferation, resistance to cell death, and activation of a gene expression program related to innate immunity and cytokine/chemokine signaling. This process induces epithelial-mesenchymal transition, tumor cell movement, and promotes metastatic dissemination.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Clinical Neurology
Leonardo Tariciotti, Paolo Palmisciano, Martina Giordano, Giulia Remoli, Eleonora Lacorte, Giulio Bertani, Marco Locatelli, Francesco Dimeco, Valerio M. Caccavella, Francesco Prada
Summary: This review summarizes the applications of artificial intelligence and machine learning in neurosurgical surgeries, including preoperative planning and intraoperative assistance. The review found that ML models can improve surgical team performances by reducing human errors and providing patient-tailored surgical plans.
JOURNAL OF NEUROSURGICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Francesca Mameli, Fabiana Ruggiero, Michelangelo Dini, Sara Marceglia, Marco Prenassi, Linda Borellini, Filippo Cogiamanian, Elena Pirola, Luigi Gianmaria Remore, Giorgio Fiore, Maria Rita Reitano, Natale Maiorana, Barbara Poletti, Marco Locatelli, Sergio Barbieri, Alberto Priori, Roberta Ferrucci
Summary: This study investigates the impact of deep brain stimulation on personality characteristics in Parkinson's disease patients and finds that despite improvements in motor function and quality of life, there is a significant increase in depressive traits.
Article
Computer Science, Artificial Intelligence
Shuo Liu, Jing Han, Estela Laporta Puyal, Spyridon Kontaxis, Shaoxiong Sun, Patrick Locatelli, Judith Dineley, Florian B. Pokorny, Gloria Dalla Costa, Letizia Leocani, Ana Isabel Guerrero, Carlos Nos, Ana Zabalza, Per Soelberg Sorensen, Mathias Buron, Melinda Magyari, Yatharth Ranjan, Zulqarnain Rashid, Pauline Conde, Callum Stewart, Amos A. Folarin, Richard J. B. Dobson, Raquel Bailon, Srinivasan Vairavan, Nicholas Cummins, Vaibhav A. Narayan, Matthew Hotopf, Giancarlo Comi, Bjoern Schuller
Summary: This study introduces a contrastive convolutional auto-encoder (contrastive CAE) to identify potential COVID-19 infection in participants with multiple sclerosis (MS) based on heart-rate data, achieving high classification performance with effective symptom detection and low false alarm rate.
PATTERN RECOGNITION
(2022)
Article
Oncology
Leonardo Tariciotti, Valerio M. Caccavella, Giorgio Fiore, Luigi Schisano, Giorgio Carrabba, Stefano Borsa, Martina Giordano, Paolo Palmisciano, Giulia Remoli, Luigi Gianmaria Remore, Mauro Pluderi, Manuela Caroli, Giorgio Conte, Fabio Triulzi, Marco Locatelli, Giulio Bertani
Summary: This study evaluates the classification performance of a deep learning algorithm trained on T1Gd-MRI scans to differentiate glioblastomas, PCNSLs, and BMs. The algorithm shows promising results in correctly classifying these tumor subgroups, aiding in appropriate treatment decisions.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Giancarlo Comi, Letizia Leocani, Luigi Ferini-Strambi, Marta Radaelli, Gloria D. Costa, Roberta Lanzillo, Giacomo Lus, Valentina Bianchi, Sebastiano Traccis, Fioravante Capone, Luigi M. E. Grimaldi, Giuseppe Salemi, Alessandra Cardillo, Valentina Zipoli
Summary: This multicentre observational study evaluated the effects of treatment with oral dimethyl fumarate on the quality of sleep in patients with relapsing-remitting multiple sclerosis. The results showed significant improvement in the quality of sleep and depression symptoms in patients treated with dimethyl fumarate. However, further randomised clinical trials are needed to confirm the long-term treatment benefits.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2023)
Article
Health Care Sciences & Services
Andrea Tacchino, Michela Ponzio, Paolo Confalonieri, Letizia Leocani, Matilde Inglese, Diego Centonze, Eleonora Cocco, Paolo Gallo, Damiano Paolicelli, Marco Rovaris, Loredana Sabattini, Gioacchino Tedeschi, Luca Prosperini, Francesco Patti, Placido Bramanti, Elisabetta Pedrazzoli, Mario Alberto Battaglia, Giampaolo Brichetto
Summary: This paper describes the design, development, and usability testing of MS Fitness Intervention Training (MS-FIT), a Kinect-based tool implementing customized Pilates exercises for people with MS. The user-centered design approach was used to create an accessible and challenging tool for balance training. The usability testing showed that MS-FIT is a promising system for enhancing the motivation and engagement of people with MS in performing exercises.
JMIR SERIOUS GAMES
(2023)
Article
Ophthalmology
Valerio Castoldi, Gianpaolo Zerbini, Silvia Maestroni, Ilaria Vigano, Paolo Rama, Letizia Leocani
Summary: This study investigates the effects of topical NGF on neuroretina function and shows that NGF can improve retinal functionality and restore retinal structure in Akita mice.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Medicine, Research & Experimental
Cristina Rivellini, Emanuela Porrello, Giorgia Dina, Simona Mrakic-Sposta, Alessandra Vezzoli, Marco Bacigaluppi, Giorgia Serena Gullotta, Linda Chaabane, Letizia Leocani, Silvia Marenna, Emanuela Colombo, Cinthia Farina, Jia Newcombe, Klaus-Armin Nave, Ruggero Pardi, Angelo Quattrini, Stefano C. Previtali
Summary: Oligodendrocytes are the primary target of demyelinating disorders. Lack of CSN5 (JAB1) expression leads to cellular senescence, chronic inflammation, and oxidative stress, resulting in CNS demyelination, neuroinflammation, and neurodegeneration.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Clinical Neurology
Dario Ricciardi, Silvia Casagrande, Francesco Iodice, Bianca Orlando, Francesca Trojsi, Giovanni Cirillo, Marinella Clerico, Marco Bozzali, Letizia Leocani, Gianmarco Abbadessa, Giuseppina Miele, Gioacchino Tedeschi, Simona Bonavita, Luigi Lavorgna
Summary: The COVID-19 pandemic has necessitated urgent changes in the healthcare system to ensure continued care for patients with chronic neurological diseases like myasthenia gravis. This analysis explores unresolved issues in managing myasthenic patients, the potential of digital technologies, and proposes an online evaluation protocol based on 4 simple tests to enhance MG management. Telemedicine and digital technology have the potential to aid neurologists in making clinical decisions for MG management, reducing unnecessary in-person consultations and optimizing time and space during the pandemic.
NEUROLOGICAL SCIENCES
(2021)
