期刊
NEUROIMAGE
卷 49, 期 1, 页码 977-983出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2009.08.015
关键词
Obsessive-compulsive disorder; QEEG; EEG coherence; LORETA; Delta/ beta coupling; Thalamo-cortical dysrythmia
资金
- Italian Ministry of University and Scientific and Technological Research [9906151218_001]
Background: Morphological and functional studies suggested involvement of several cortical and subcortical circuitries in patients with obsessive-compulsive disorder (OCD). The aim of the present study was to investigate networks involved in OCD pathophysiology, using power (coupling of EEG bands, low-resolution electromagnetic tomography-LORETA) and coherence analysis in drug naive patients. Method: EEG was obtained from 37 drug-naive patients with OCD and 37 age- and sex-matched controls. Resting EEG was recorded from 29 scalp channels. Coupling (ratio and correlation) between low and high frequencies was analyzed on Fz. For each frequency band, LORETA Current density distribution, intra-hemispheric and inter-hemispheric coherence analysis were computed. Results: OCD had increased Current density for delta in the insula and for beta in frontal, parietal and limbic OCD also had decreased inter-hemispheric coherence and reduced coupling between delta and beta lobes. frequencies. Conclusions: in OCD, increased frontal beta is consistent with previous evidence of frontal dysfunction. Hyperactivity of insular delta Sources, together with rhythms decoupling and reduced interhemispheric alpha coherence are consistent with additional involvement of cortico-subcortical functional connections. Combined use of power and coherence analysis may provide functional measures on different levels of involvement of cortico-subcortical circuits in neuropsychiatric disorders. (C) 2009 Elsevier Inc. All rights reserved.
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