From FMRP Function to Potential Therapies for Fragile X Syndrome

High MMP-9 activity levels in fragile X syndrome are lowered by minocycline

(2013) Magdalena Dziembowska et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Behavioural methods used in rodent models of autism spectrum disorders: Current standards and new developments

(2013) Markus Wöhr et al.   BEHAVIOURAL BRAIN RESEARCH

A Randomized Double-Blind, Placebo-Controlled Trial of Minocycline in Children and Adolescents with Fragile X Syndrome

(2013) Mary Jacena S. Leigh et al.   JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS

Modulation of mGluR-Dependent MAP1B Translation and AMPA Receptor Endocytosis by MicroRNA miR-146a-5p

(2013) Y.-L. Chen et al.   JOURNAL OF NEUROSCIENCE

The translation of translational control by FMRP: therapeutic targets for FXS

(2013) Jennifer C Darnell et al.   NATURE NEUROSCIENCE

FMRP Regulates Neurotransmitter Release and Synaptic Information Transmission by Modulating Action Potential Duration via BK Channels

(2013) Pan-Yue Deng et al.   NEURON

Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome

(2013) Emily K. Osterweil et al.   NEURON

Long-lasting effects of minocycline on behavior in young but not adult Fragile X mice

(2013) L.E. Dansie et al.   NEUROSCIENCE

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486

(2013) B. M. Dolan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of acamprosate on behavior and brain-derived neurotrophic factor: an open-label study in youth with fragile X syndrome

(2013) Craig A. Erickson et al.   PSYCHOPHARMACOLOGY

Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome?

(2013) Talakad G Lohith et al.   Molecular Autism

Pharmacological treatment of fragile X syndrome with GABAergic drugs in a knockout mouse model

(2012) Inge Heulens et al.   BEHAVIOURAL BRAIN RESEARCH

Chronic administration of AFQ056/Mavoglurant restores social behaviour in Fmr1 knockout mice

(2012) Ilse Gantois et al.   BEHAVIOURAL BRAIN RESEARCH

Activation of 5-HT7 Serotonin Receptors Reverses Metabotropic Glutamate Receptor-Mediated Synaptic Plasticity in Wild-Type and Fmr1 Knockout Mice, a Model of Fragile X Syndrome

(2012) Lara Costa et al.   BIOLOGICAL PSYCHIATRY

Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of Fragile X Syndrome

(2012) Sarah E. Rotschafer et al.   BRAIN RESEARCH

Multiple Autism-Linked Genes Mediate Synapse Elimination via Proteasomal Degradation of a Synaptic Scaffold PSD-95

(2012) Nien-Pei Tsai et al.   CELL

The effect of an mGluR5 inhibitor on procedural memory and avoidance discrimination impairments inFmr1KO mice

(2012) M. F. Vinueza Veloz et al.   GENES BRAIN AND BEHAVIOR

Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model

(2012) S. M. Goebel-Goody et al.   GENES BRAIN AND BEHAVIOR

Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome

(2012) C. A. Hoeffer et al.   GENES BRAIN AND BEHAVIOR

Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics

(2012) Claudia Bagni et al.   JOURNAL OF CLINICAL INVESTIGATION

Evidence for a Fragile X Mental Retardation Protein-Mediated Translational Switch in Metabotropic Glutamate Receptor-Triggered Arc Translation and Long-Term Depression

(2012) F. Niere et al.   JOURNAL OF NEUROSCIENCE

Dephosphorylation-Induced Ubiquitination and Degradation of FMRP in Dendrites: A Role in Immediate Early mGluR-Stimulated Translation

(2012) V. C. Nalavadi et al.   JOURNAL OF NEUROSCIENCE

FMRP targets distinct mRNA sequence elements to regulate protein expression

(2012) Manuel Ascano et al.   NATURE

Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice

(2012) Aditi Bhattacharya et al.   NEURON

Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice

(2012) Aubin Michalon et al.   NEURON

Comprehensive Analysis of Ultrasonic Vocalizations in a Mouse Model of Fragile X Syndrome Reveals Limited, Call Type Specific Deficits

(2012) Snigdha Roy et al.   PLoS One

Impaired Dendritic Expression and Plasticity of h-Channels in the fmr1−/y Mouse Model of Fragile X Syndrome

(2012) Darrin H. Brager et al.   Cell Reports

Fragile X Syndrome: The FMR1 CGG Repeat Distribution Among World Populations

(2011) Emmanuel Peprah   ANNALS OF HUMAN GENETICS

Molecular Mechanisms of Fragile X Syndrome: A Twenty-Year Perspective

(2011) Michael R. Santoro et al.   Annual Review of Pathology-Mechanisms of Disease

The modulation of fragile X behaviors by the muscarinic M4 antagonist, tropicamide.

(2011) Surabi Veeraragavan et al.   BEHAVIORAL NEUROSCIENCE

Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome

(2011) Alexia M. Thomas et al.   BEHAVIOURAL BRAIN RESEARCH

Genetic reduction of muscarinic M4 receptor modulates analgesic response and acoustic startle response in a mouse model of fragile X syndrome (FXS)

(2011) Surabi Veeraragavan et al.   BEHAVIOURAL BRAIN RESEARCH

Arc/Arg3.1 Regulates an Endosomal Pathway Essential for Activity-Dependent β-Amyloid Generation

(2011) Jing Wu et al.   CELL

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

The GABAA Receptor Agonist THIP Ameliorates Specific Behavioral Deficits in the Mouse Model of Fragile X Syndrome

(2011) Jose Luis Olmos-Serrano et al.   DEVELOPMENTAL NEUROSCIENCE

Inhibition of GSK3  improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome

(2011) W. Guo et al.   HUMAN MOLECULAR GENETICS

Proteomics, Ultrastructure, and Physiology of Hippocampal Synapses in a Fragile X Syndrome Mouse Model Reveal Presynaptic Phenotype

(2011) Patricia Klemmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fragile X Mental Retardation Protein Regulates Protein Expression and mRNA Translation of the Potassium Channel Kv4.2

(2011) C. Gross et al.   JOURNAL OF NEUROSCIENCE

Abnormal Presynaptic Short-Term Plasticity and Information Processing in a Mouse Model of Fragile X Syndrome

(2011) P.-Y. Deng et al.   JOURNAL OF NEUROSCIENCE

Reversible Inhibition of PSD-95 mRNA Translation by miR-125a, FMRP Phosphorylation, and mGluR Signaling

(2011) Ravi S. Muddashetty et al.   MOLECULAR CELL

Mutations causing syndromic autism define an axis of synaptic pathophysiology

(2011) Benjamin D. Auerbach et al.   NATURE

AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome

(2011) Josien Levenga et al.   NEUROBIOLOGY OF DISEASE

Bidirectional Regulation of Dendritic Voltage-Gated Potassium Channels by the Fragile X Mental Retardation Protein

(2011) Hye Young Lee et al.   NEURON

Effects of chronic immobilization stress on anxiety-like behavior and basolateral amygdala morphology in Fmr1 knockout mice

(2011) M. Qin et al.   NEUROSCIENCE

Genetic-Background Modulation of Core and Variable Autistic-Like Symptoms in Fmr1 Knock-Out Mice

(2011) Susanna Pietropaolo et al.   PLoS One

Reversal of Fragile X Phenotypes by Manipulation of AβPP/Aβ Levels in Fmr1KO Mice

(2011) Cara J. Westmark et al.   PLoS One

Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome

(2011) D. D. Krueger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of behavioral phenotypes by a muscarinic M1 antagonist in a mouse model of fragile X syndrome

(2011) Surabi Veeraragavan et al.   PSYCHOPHARMACOLOGY

Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome

(2011) Alexia M. Thomas et al.   PSYCHOPHARMACOLOGY

Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056

(2011) S. Jacquemont et al.   Science Translational Medicine

The role of APP and APLP for synaptic transmission, plasticity, and network function: lessons from genetic mouse models

(2011) Martin Korte et al.   EXPERIMENTAL BRAIN RESEARCH

Identification of novel FMR1 variants by massively parallel sequencing in developmentally delayed males

(2010) Stephen C. Collins et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Open-label add-on treatment trial of minocycline in fragile X syndrome

(2010) Carlo Paribello et al.   BMC Neurology

Fragile X Syndrome and Alzheimers Disease: Another Story About APP and β -Amyloid

(2010) J.S. Malter et al.   Current Alzheimer Research

NMDA receptor hypofunction in the dentate gyrus and impaired context discrimination in adult Fmr1 knockout mice

(2010) Brennan D. Eadie et al.   HIPPOCAMPUS

Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome

(2010) Zhong-Hua Liu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Excess Phosphoinositide 3-Kinase Subunit Synthesis and Activity as a Novel Therapeutic Target in Fragile X Syndrome

(2010) C. Gross et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of mTOR Signaling in Fragile X Syndrome

(2010) A. Sharma et al.   JOURNAL OF NEUROSCIENCE

Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome

(2010) E. K. Osterweil et al.   JOURNAL OF NEUROSCIENCE

Fragile X Mental Retardation Protein Is Required for Rapid Experience-Dependent Regulation of the Potassium Channel Kv3.1b

(2010) J. G. Strumbos et al.   JOURNAL OF NEUROSCIENCE

Fragile X mice: Reduced long-term potentiation and N-Methyl-D-Aspartate receptor-mediated neurotransmission in dentate gyrus

(2010) Sung Hwan Yun et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack

(2010) Maile R Brown et al.   NATURE NEUROSCIENCE

Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132

(2010) Dieter Edbauer et al.   NEURON

GSK3 Influences Social Preference and Anxiety-Related Behaviors during Social Interaction in a Mouse Model of Fragile X Syndrome and Autism

(2010) Marjelo A. Mines et al.   PLoS One

Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model

(2010) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome

(2010) A. Suvrathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered mRNA transport, docking, and protein translation in neurons lacking fragile X mental retardation protein

(2010) D.-I. Kao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of Fragile X syndrome

(2009) Christopher J. Yuskaitis et al.   BIOCHEMICAL PHARMACOLOGY

Glycogen synthase kinase 3: more than a namesake

(2009) Geetha Vani Rayasam et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fragile X Mental Retardation Protein Regulates the Levels of Scaffold Proteins and Glutamate Receptors in Postsynaptic Densities

(2009) Janin Schütt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A pilot open label, single dose trial of fenobam in adults with fragile X syndrome

(2009) E Berry-Kravis et al.   JOURNAL OF MEDICAL GENETICS

Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice

(2009) Yuze Shang et al.   JOURNAL OF NEUROCHEMISTRY

The FXG: A Presynaptic Fragile X Granule Expressed in a Subset of Developing Brain Circuits

(2009) S. B. Christie et al.   JOURNAL OF NEUROSCIENCE

Increased GABAB Receptor-Mediated Signaling Reduces the Susceptibility of Fragile X Knockout Mice to Audiogenic Seizures

(2009) L. K. K. Pacey et al.   MOLECULAR PHARMACOLOGY

Generation and Characterization of Fmr1 Knockout Zebrafish

(2009) Marjo J. den Broeder et al.   PLoS One

Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety

(2009) Alexia Thomas et al.   PSYCHOPHARMACOLOGY

Presynaptic translation: stepping out of the postsynaptic shadow

(2009) Michael Akins   Frontiers in Neural Circuits

A Novel Function for Fragile X Mental Retardation Protein in Translational Activation

(2009) Elias G Bechara et al.   PLOS BIOLOGY

A Mouse Model of the Human Fragile X Syndrome I304N Mutation

(2009) Julie B. Zang et al.   PLoS Genetics

MosaicFMR1 deletion causes fragile X syndrome and can lead to molecular misdiagnosis: A case report and review of the literature

(2008) Bradford Coffee et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Identifying intrinsic and extrinsic determinants that regulate internal initiation of translation mediated by the FMR1 5' leader

(2008) Tara Dobson et al.   BMC MOLECULAR BIOLOGY

The Fragile X Syndrome Protein Represses Activity-Dependent Translation through CYFIP1, a New 4E-BP

(2008) Ilaria Napoli et al.   CELL

Limbic Epileptogenesis in a Mouse Model of Fragile X Syndrome

(2008) L.-F. Qiu et al.   CEREBRAL CORTEX

Downregulation of Tonic GABAergic Inhibition in a Mouse Model of Fragile X Syndrome

(2008) Giulia Curia et al.   CEREBRAL CORTEX

A Direct Role for FMRP in Activity-Dependent Dendritic mRNA Transport Links Filopodial-Spine Morphogenesis to Fragile X Syndrome

(2008) Jason B. Dictenberg et al.   DEVELOPMENTAL CELL

Epigenetic analysis reveals a euchromatic configuration in the FMR1 unmethylated full mutations

(2008) Elisabetta Tabolacci et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Effect of genetic background on acoustic startle response in fragile X knockout mice

(2008) VANESSA ERRIJGERS et al.   Genetics Research

Open-Label Treatment Trial of Lithium to Target the Underlying Defect in Fragile X Syndrome

(2008) Elizabeth Berry-Kravis et al.   JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS

The Tyrosine Phosphatase STEP Mediates AMPA Receptor Endocytosis after Metabotropic Glutamate Receptor Stimulation

(2008) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila

(2008) Shuang Chang et al.   Nature Chemical Biology

Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice

(2008) Femke M.S. de Vrij et al.   NEUROBIOLOGY OF DISEASE

FMRP Acts as a Key Messenger for Dopamine Modulation in the Forebrain

(2008) Hansen Wang et al.   NEURON

Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD

(2008) Sungjin Park et al.   NEURON

Rapid Translation of Arc/Arg3.1 Selectively Mediates mGluR-Dependent LTD through Persistent Increases in AMPAR Endocytosis Rate

(2008) Maggie W. Waung et al.   NEURON

Elevated glycogen synthase kinase-3 activity in Fragile X mice: Key metabolic regulator with evidence for treatment potential

(2008) Wenzhong William Min et al.   NEUROPHARMACOLOGY

Fragile X mental retardation protein interactions with the microtubule associated protein 1B RNA

(2008) L. Menon et al.   RNA

Glycogen synthase kinases 3α and 3β in cardiac myocytes: Regulation and consequences of their inhibition

(2007) Thomais Markou et al.   CELLULAR SIGNALLING