Scaffolding Proteins of the Post-synaptic Density Contribute to Synaptic Plasticity by Regulating Receptor Localization and Distribution: Relevance for Neuropsychiatric Diseases

Differential Changes in Synaptic Proteins in the Alzheimer Frontal Cortex with Marked Increase in PSD-95 Postsynaptic Protein

(2017) Geneviève Leuba et al.   JOURNAL OF ALZHEIMERS DISEASE

Reduction in Post-Synaptic Scaffolding PSD-95 and SAP-102 Protein Levels in the Alzheimer Inferior Temporal Cortex is Correlated with Disease Pathology

(2017) Dustin T. Proctor et al.   JOURNAL OF ALZHEIMERS DISEASE

The Microtubule-Associated Protein 1A (MAP1A) is an Early Molecular Target of Soluble Aβ-Peptide

(2012) C. Clemmensen et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Targeting glutamate system for novel antipsychotic approaches: Relevance for residual psychotic symptoms and treatment resistant schizophrenia

(2012) Andrea de Bartolomeis et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain

(2012) Douglas J. Cook et al.   NATURE

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

(2012) A. Bach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced Aβ and tau pathology in transgenic mouse models of Alzheimer’s disease

(2011) Charles Y. Shao et al.   ACTA NEUROPATHOLOGICA

Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity

(2011) Fouad Lemtiri-Chlieh et al.   BMC NEUROSCIENCE

RETRACTED: Enhanced Polyubiquitination of Shank3 and NMDA Receptor in a Mouse Model of Autism

(2011) M Ali Bangash et al.   CELL

Neuralized1 Activates CPEB3: A Function for Nonproteolytic Ubiquitin in Synaptic Plasticity and Memory Storage

(2011) Elias Pavlopoulos et al.   CELL

Regulation of AMPA receptor surface diffusion by PSD-95 slots

(2011) Patricio Opazo et al.   CURRENT OPINION IN NEUROBIOLOGY

A promoter variant of SHANK1 affects auditory working memory in schizophrenia patients and in subjects clinically at risk for psychosis

(2011) Leonhard Lennertz et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Inherited and de novo SHANK2 variants associated with autism spectrum disorder impair neuronal morphogenesis and physiology

(2011) Simone Berkel et al.   HUMAN MOLECULAR GENETICS

Importance of Shank3 Protein in Regulating Metabotropic Glutamate Receptor 5 (mGluR5) Expression and Signaling at Synapses

(2011) Chiara Verpelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMDA Receptor-Dependent Regulation of Dendritic Spine Morphology by SAP102 Splice Variants

(2011) B.-S. Chen et al.   JOURNAL OF NEUROSCIENCE

Kalirin Binds the NR2B Subunit of the NMDA Receptor, Altering Its Synaptic Localization and Function

(2011) D. D. Kiraly et al.   JOURNAL OF NEUROSCIENCE

Neurexin-Neuroligin Adhesions Capture Surface-Diffusing AMPA Receptors through PSD-95 Scaffolds

(2011) M. Mondin et al.   JOURNAL OF NEUROSCIENCE

SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism

(2011) C M Durand et al.   MOLECULAR PSYCHIATRY

De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

(2011) G Kirov et al.   MOLECULAR PSYCHIATRY

Dendritic spine pathology in neuropsychiatric disorders

(2011) Peter Penzes et al.   NATURE NEUROSCIENCE

Increased expression of Kalirin-9 in the auditory cortex of schizophrenia subjects: Its role in dendritic pathology

(2011) Anthony J. Deo et al.   NEUROBIOLOGY OF DISEASE

Rescue of synaptic plasticity and spatial learning deficits in the hippocampus of Homer1 knockout mice by recombinant Adeno-associated viral gene delivery of Homer1c

(2011) Hilary Gerstein et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

CDK5 Is Essential for Soluble Amyloid β-Induced Degradation of GKAP and Remodeling of the Synaptic Actin Cytoskeleton

(2011) Francesco Roselli et al.   PLoS One

Neuroprotection by Freezing Ischemic Penumbra Evolution Without Cerebral Blood Flow Augmentation With a Postsynaptic Density-95 Protein Inhibitor

(2011) Bernt T. Bråtane et al.   STROKE

Review: Disruption of the Postsynaptic Density in Alzheimer’s Disease and Other Neurodegenerative Dementias

(2010) Yuesong Gong et al.   American Journal of Alzheimers Disease and Other Dementias

Metabotropic Glutamate Receptor 5/Homer Interactions Underlie Stress Effects on Fear

(2010) Natalie C. Tronson et al.   BIOLOGICAL PSYCHIATRY

Dysregulated Postsynaptic Density and Endocytic Zone in the Amygdala of Human Heroin and Cocaine Abusers

(2010) Anna Ökvist et al.   BIOLOGICAL PSYCHIATRY

Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines

(2010) Baris Bingol et al.   CELL

Calcium Binding to PICK1 Is Essential for the Intracellular Retention of AMPA Receptors Underlying Long-Term Depression

(2010) A. Citri et al.   JOURNAL OF NEUROSCIENCE

Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients

(2010) Ilja Spellmann et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Pattern of acute induction of Homer1a gene is preserved after chronic treatment with first- and second-generation antipsychotics: effect of short-term drug discontinuation and comparison with Homer1a-interacting genes

(2010) Felice Iasevoli et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95

(2010) Li Zhou et al.   NATURE MEDICINE

Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95

(2010) Jihoon Jo et al.   NATURE NEUROSCIENCE

Group 1 mGluR-Dependent Synaptic Long-Term Depression: Mechanisms and Implications for Circuitry and Disease

(2010) Christian Lüscher et al.   NEURON

Differential roles of GRIP1a and GRIP1b in AMPA receptor trafficking

(2010) Laura Jane Hanley et al.   NEUROSCIENCE LETTERS

Homer1a-Dependent Crosstalk Between NMDA and Metabotropic Glutamate Receptors in Mouse Neurons

(2010) Federica Bertaso et al.   PLoS One

Genetic and Functional Analysis of the DLG4 Gene Encoding the Post-Synaptic Density Protein 95 in Schizophrenia

(2010) Min-Chih Cheng et al.   PLoS One

The acute and chronic effects of combined antipsychotic–mood stabilizing treatment on the expression of cortical and striatal postsynaptic density genes

(2010) Carmine Tomasetti et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Haloperidol induces higher Homer1a expression than risperidone, olanzapine and sulpiride in striatal sub-regions

(2010) Felice Iasevoli et al.   PSYCHIATRY RESEARCH

Divergent acute and chronic modulation of glutamatergic postsynaptic density genes expression by the antipsychotics haloperidol and sertindole

(2010) Felice Iasevoli et al.   PSYCHOPHARMACOLOGY

Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility

(2010) Itaru Kushima et al.   SCHIZOPHRENIA BULLETIN

Functional and Dysfunctional Synaptic Plasticity in Prefrontal Cortex: Roles in Psychiatric Disorders

(2009) Yukiori Goto et al.   BIOLOGICAL PSYCHIATRY

Disruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer's disease

(2009) Yuesong Gong et al.   BRAIN RESEARCH

Chromosome 22q13.3 deletion syndrome with a de novo interstitial 22q13.3 cryptic deletion disrupting SHANK3

(2009) A. Delahaye et al.   European Journal of Medical Genetics

Regulation of the Proteasome by Neuronal Activity and Calcium/Calmodulin-dependent Protein Kinase II

(2009) Stevan N. Djakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PSD-95 Is Essential for Hallucinogen and Atypical Antipsychotic Drug Actions at Serotonin Receptors

(2009) A. I. Abbas et al.   JOURNAL OF NEUROSCIENCE

Interaction of Postsynaptic Density Protein-95 with NMDA Receptors Influences Excitotoxicity in the Yeast Artificial Chromosome Mouse Model of Huntington's Disease

(2009) J. Fan et al.   JOURNAL OF NEUROSCIENCE

Synaptic SAP97 Isoforms Regulate AMPA Receptor Dynamics and Access to Presynaptic Glutamate

(2009) C. L. Waites et al.   JOURNAL OF NEUROSCIENCE

Regulation of Synaptic Structure by Ubiquitin C-Terminal Hydrolase L1

(2009) A. E. Cartier et al.   JOURNAL OF NEUROSCIENCE

A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors

(2009) Samarjit Bhattacharyya et al.   NATURE NEUROSCIENCE

Stability of surface NMDA receptors controls synaptic and behavioral adaptations to amphetamine

(2009) Li-Min Mao et al.   NATURE NEUROSCIENCE

Ube3a is required for experience-dependent maturation of the neocortex

(2009) Koji Yashiro et al.   NATURE NEUROSCIENCE

Experience-dependent structural synaptic plasticity in the mammalian brain

(2009) Anthony Holtmaat et al.   NATURE REVIEWS NEUROSCIENCE

A novel mutation in the DLG3 gene encoding the synapse-associated protein 102 (SAP102) causes non-syndromic mental retardation

(2009) Ginevra Zanni et al.   NEUROGENETICS

The State of Synapses in Fragile X Syndrome

(2009) Brad E. Pfeiffer et al.   NEUROSCIENTIST

The Ubiquitin Ligase RPM-1 and the p38 MAPK PMK-3 Regulate AMPA Receptor Trafficking

(2009) Eun Chan Park et al.   PLoS One

Disassembly of Shank and Homer Synaptic Clusters Is Driven by Soluble β-Amyloid1-40 through Divergent NMDAR-Dependent Signalling Pathways

(2009) Francesco Roselli et al.   PLoS One

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD

(2009) T. S. Thorsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes

(2009) M. E. Cahill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spine microdomains for postsynaptic signaling and plasticity

(2009) Thomas M. Newpher et al.   TRENDS IN CELL BIOLOGY

Requirement of the immediate early gene vesl-1S/homer-1a for fear memory formation

(2009) Naoko Inoue et al.   Molecular Brain

Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer's Disease

(2008) Natalia Louneva et al.   AMERICAN JOURNAL OF PATHOLOGY

Kalirin-7 Is an Essential Component of both Shaft and Spine Excitatory Synapses in Hippocampal Interneurons

(2008) X.-M. Ma et al.   JOURNAL OF NEUROSCIENCE

Smaller Dendritic Spines, Weaker Synaptic Transmission, but Enhanced Spatial Learning in Mice Lacking Shank1

(2008) A. Y. Hung et al.   JOURNAL OF NEUROSCIENCE

Kalirin-7 Is Required for Synaptic Structure and Function

(2008) X.-M. Ma et al.   JOURNAL OF NEUROSCIENCE

Endogenous Homer Proteins Regulate Metabotropic Glutamate Receptor Signaling in Neurons

(2008) P. J. Kammermeier   JOURNAL OF NEUROSCIENCE

Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome

(2008) Gül Dölen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Proteasome inhibition enhances the induction and impairs the maintenance of late-phase long-term potentiation

(2008) C. Dong et al.   LEARNING & MEMORY

Dynamic Regulation of Glutamatergic Postsynaptic Activity in Rat Prefrontal Cortex by Repeated Administration of Antipsychotic Drugs

(2008) F. Fumagalli et al.   MOLECULAR PHARMACOLOGY

Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function

(2008) Gary J. Bassell et al.   NEURON

Destabilization of the Postsynaptic Density by PSD-95 Serine 73 Phosphorylation Inhibits Spine Growth and Synaptic Plasticity

(2008) Pascal Steiner et al.   NEURON

Augmentation of Fear Extinction by D-Cycloserine is Blocked by Proteasome Inhibitors

(2008) Sheng-Chun Mao et al.   NEUROPSYCHOPHARMACOLOGY

Dendritic Excitability and Synaptic Plasticity

(2008) P. Jesper Sjöström et al.   PHYSIOLOGICAL REVIEWS

Transmembrane and Ubiquitin-Like Domain-Containing Protein 1 (Tmub1/HOPS) Facilitates Surface Expression of GluR2-Containing AMPA Receptors

(2008) Hyunjeong Yang et al.   PLoS One

Structural plasticity with preserved topology in the postsynaptic protein network

(2008) T. A. Blanpied et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pruning and loss of excitatory synapses by the parkin ubiquitin ligase

(2008) T. D. Helton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organization of the core structure of the postsynaptic density

(2008) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surface Mobility of Postsynaptic AMPARs Tunes Synaptic Transmission

(2008) M. Heine et al.   SCIENCE

Synaptic Protein Degradation Underlies Destabilization of Retrieved Fear Memory

(2008) S.-H. Lee et al.   SCIENCE

Effectiveness of PSD95 Inhibitors in Permanent and Transient Focal Ischemia in the Rat

(2008) Hong-Shuo Sun et al.   STROKE

The Effects of NR2 Subunit-Dependent NMDA Receptor Kinetics on Synaptic Transmission and CaMKII Activation

(2008) David M. Santucci et al.   PLoS Computational Biology

Homer 1a Suppresses Neocortex Long-Term Depression in a Cortical Layer-Specific Manner

(2007) Yoshifumi Ueta et al.   JOURNAL OF NEUROPHYSIOLOGY