Article
Multidisciplinary Sciences
Stephen Arnovitz, Priya Mathur, Melissa Tracy, Azam Mohsin, Soumi Mondal, Jasmin Quandt, Kyle M. Hernandez, Khashayarsha Khazaie, Marei Dose, Akinola Olumide Emmanuel, Fotini Gounari
Summary: This study reveals that aberrant activation of beta-catenin in thymocytes contributes to leukemias by promoting translocations and transformation. Lymphomas resembling T-ALL are sensitive to PARP inhibitors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Developmental Biology
Bo Wang, Xiaozhi Rong, Yumei Zhou, Yunzhang Liu, Jiqin Sun, Beibei Zhao, Bei Deng, Lei Lu, Ling Lu, Yun Li, Jianfeng Zhou
Summary: This study reveals that EIF4A3 acts as a Wnt inhibitor by interfering with the formation of beta-catenin/Tcf transcription activation complex, playing a crucial role in regulating embryonic development in zebrafish.
Article
Endocrinology & Metabolism
Yasaman Badakhshi, Weijuan Shao, Dinghui Liu, Lili Tian, Juan Pang, Jianqiu Gu, Jim Hu, Tianru Jin
Summary: This study reveals that hepatic FGF21 is downregulated in male LTCFDN mice compared to females, implicating the involvement of estrogen-beta-cat/TCF signaling pathway. In mouse primary hepatocytes, FGF21 transcription is positively regulated by the Wnt pathway effector beta-cat/TCF. Ovariectomized female mice show reduced hepatic FGF21 production, correlated with decreased hepatic TCF expression and beta-catenin phosphorylation.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biotechnology & Applied Microbiology
Yi Liu, Jun Ma, Jiu-Shan Song, Hai-Ying Zhou, Jing-Hui Li, Cheng Luo, Xin Geng, He-Xiang Zhao
Summary: TOP2A plays a critical role in the metastatic characteristics of glioma. High expression of TOP2A is associated with poor survival in glioma patients, while silencing TOP2A impairs glioma cell proliferation and aggressiveness. Mechanistically, TOP2A interacts with beta-catenin and promotes its translocation into the nucleus, affecting glioma cell growth and invasion through the Wnt/beta-catenin pathway.
Article
Oncology
Hung-Wen Tsai, Shu-Wen Cheng, Chou-Cheng Chen, I-Wen Chen, Chung-Liang Ho
Summary: In this study, a combined bioinformatics and experimental approach was used to identify potential target genes of the Wnt/beta-catenin signaling pathway. It was found that RMI2 is a new target gene of this pathway and that it promotes epithelial-mesenchymal transition markers, hepatocellular carcinoma cell invasion, and metastasis. These findings suggest that RMI2 could be a potential target for preventing or mitigating the progression of hepatocellular carcinoma.
Article
Biochemistry & Molecular Biology
Hongzao Ni, Daofei Ji, Jing Li, Zongren Zhao, Jiandong Zuo
Summary: The study revealed that IPO11 knockdown suppressed the malignant phenotypes of glioma cells by inactivating the Wnt/beta-catenin pathway, leading to inhibition of cell proliferation, promotion of apoptosis, and suppression of invasion.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Jing Li, Xiaoling Lyu, Pan Wang, Bao Ting Zhu
Summary: This study found that bilberry anthocyanins have a modulating effect on the pathogenesis of Alzheimer's disease. They reduce amyloid plaque load and beta-amyloid 1-42 levels, improve mitochondrial morphology, and decrease NO and ROS levels. In HT22 cells, bilberry anthocyanins also protect against A beta 42-induced cytotoxicity by reducing ROS levels and restoring mitochondrial homeostasis, partly through the upregulation of Mfn2. These findings suggest that bilberry anthocyanins can protect against the development of Alzheimer's disease by restoring mitochondrial homeostasis.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Chemistry, Medicinal
Zhen Wang, Zilu Li, Haitao Ji
Summary: Aberrant activation of the Wnt/beta-catenin signaling pathway is associated with cancer, and direct targeting of beta-catenin is a promising strategy but challenging. Research has identified potential small-molecule binding sites and summarized bioactive small molecules that target beta-catenin directly.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Cell Biology
Bei Tao, Yi Song, Yao Wu, Xiaobo Yang, Tangming Peng, Lilei Peng, Kaiguo Xia, Xiangguo Xia, Ligang Chen, Chuanhong Zhong
Summary: This study found that a stiffer matrix can promote the stemness of glioma cells by activating the BCL9L/Wnt/beta-catenin signaling pathway. Additionally, gigantol can enhance the effectiveness of traditional chemotherapy and radiotherapy by inhibiting Wnt/beta-catenin signaling, providing a potential strategy for clinical treatment of gliomas.
Article
Neurosciences
Yufu Zhu, Yang Xu, Tianze Chen, Yujian Zhang, Qiang Ma, Sunil Rauniyar, Lei Wang, Hengliang Shi
Summary: The study revealed that TSG101 is upregulated in glioma tissues, and high levels of TSG101 are associated with poor prognosis in glioma patients. Functional studies showed that TSG101 promotes the proliferation, migration, and invasion of glioma cells.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Sanne M. van Neerven, Nina E. de Groot, Lisanne E. Nijman, Brendon P. Scicluna, Milou S. van Driel, Maria C. Lecca, Daniel O. Warmerdam, Vaishali Kakkar, Leandro F. Moreno, Felipe A. Vieira Braga, Delano R. Sanches, Prashanthi Ramesh, Sanne ten Hoorn, Arthur S. Aelvoet, Marouska F. van Boxel, Lianne Koens, Przemek M. Krawczyk, Jan Koster, Evelien Dekker, Jan Paul Medema, Douglas J. Winton, Maarten F. Bijlsma, Edward Morrissey, Nicolas Leveille, Louis Vermeulen
Summary: In the ISC niche, the delicate balance of WNT agonists and antagonists is crucial for maintaining the ISC compartment and preventing unrestrained activation of the WNT pathway. Apc-mutant ISCs function as supercompetitors by secreting WNT antagonists to induce differentiation of neighboring wild-type ISCs. Lithium chloride prevents the expansion of Apc-mutant clones and adenoma formation by rendering wild-type ISCs insensitive to WNT antagonists through downstream activation of WNT by inhibiting GSK3 beta. Boosting the fitness of healthy cells may be a powerful strategy to limit the formation of cancers in high-risk individuals.
Article
Cell Biology
Romina J. Walter, Steffen J. Sonnentag, Leonel Munoz-Sagredo, Melanie Merkel, Ludovic Richert, Felix Bunert, Yvonne M. Heneka, Thomas Loustau, Michael Hodder, Rachel A. Ridgway, Owen J. Sansom, Yves Mely, Ulrich Rothbauer, Mark Schmitt, Veronique Orian-Rousseau
Summary: This study proposes a CD44 positive-feedback loop that enhances Wnt signaling and affects intestinal regeneration. The absence of CD44 leads to increased sensitivity to external stimuli, more severe inflammation, and delayed regeneration.
CELL DEATH & DISEASE
(2022)
Article
Neurosciences
Qingjiu Zhou, Qiang Fu, Mahati Shaya, Yalikun Kugeluke, Shaoshan Li, Yisireyili Dilimulati
Summary: This study found that circ_CAPG (circ_0055412) contributes to cisplatin resistance in glioma cells by stabilizing CAPG mRNA and modulating the Wnt/beta-catenin signaling pathway, providing new information for the treatment of glioma.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Zong-qing Zhao, Xiu-jie Wu, Yan-hao Cheng, Yun-fei Zhou, Xi-meng Ma, Jian Zhang, Xue-yuan Heng, Fan Feng
Summary: The study demonstrated that TROAP plays an oncogenic role in glioma by activating the Wnt/beta-Catenin signaling pathway, leading to cell proliferation, migration, invasion, and poor prognosis. Inhibition of TROAP or downstream targets of Wnt/beta-Catenin pathway could reverse the tumor-promoting effects, suggesting TROAP as a potential novel target for glioma therapy.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
San-Zhong Liu, Kai-Xi Ren, Jing Zhao, Shuang Wu, Juan Li, Jian Zang, Zhou Fei, Jun-Long Zhao
Summary: The study revealed that miR-139 and its host gene PDE2A have anti-tumor effects in glioblastomas by regulating GSC stemness. PDE2A and miR-139 modulate GSC characteristics through the Wnt/beta-catenin signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Cell Biology
Xu Zhou, Xiongjin Chen, Tingting Hong, Miaoping Zhang, Yujie Cai, Lili Cui
Summary: The TTC3 gene is located within the Down's syndrome critical region, and its overexpression can accelerate cognitive decline, though the specific mechanism is unknown. TTC3 participates in protein quality control through assisting correct protein folding, degradation, and potentially inducing autophagy, making it a potential target in the treatment of DS and AD.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell Biology
Junfeng Shi, Donglin Lai, Xiaojia Zuo, Dingsheng Liu, Bing Chen, Yanjun Zheng, Changlian Lu, Xuefeng Gu
Summary: This study identified nine ferroptosis-related lncRNAs and constructed a prognostic model for glioma. The model showed high sensitivity and specificity in predicting overall survival. Pathway analysis revealed the involvement of cell cycle, p53 signaling, apoptosis, and oxidative phosphorylation pathways in glioma pathogenesis. Additionally, a strong correlation between these lncRNAs and immunotherapy was observed, suggesting their potential role in guiding immune checkpoint inhibitor therapy for glioma patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Weina Zhao, Changhao Yin, Fengbo Yu, Lifei Wan, Siyao Che, Lili Cui
Summary: This study explored the value of brain structure MRI combined with APOE-epsilon 4 genotype in the early diagnosis and disease progression of elderly patients with vascular cognitive impairment no dementia (VCIND). The results showed that years of education, hypertension, high levels of homocysteine, elevated WMV, WMH, LI, Fazekas scores, and carrying the APOE-epsilon 4 gene were risk factors for VCIND in stroke patients.
CONTRAST MEDIA & MOLECULAR IMAGING
(2022)
Article
Cell Biology
Yanjun Zheng, Jingrong Lin, Dingsheng Liu, Guoqing Wan, Xuefeng Gu, Jian Ma
Summary: Nogo-B plays a role in promoting angiogenesis during cardiac repair after myocardial infarction by activating the Notch signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Geriatrics & Gerontology
Xuefeng Gu, Donglin Lai, Shuang Liu, Kaijie Chen, Peng Zhang, Bing Chen, Gang Huang, Xiaoqin Cheng, Changlian Lu
Summary: This study identified nine hub genes associated with iron metabolism and Alzheimer's disease (AD) through gene expression profiling and analysis. These genes were mainly involved in autophagy and iron metabolism. A diagnostic model of AD was constructed using four of these genes, which showed good diagnostic performance when validated in blood samples. The study also explored the role of these genes in the immune response to AD and identified several drugs targeting these hub genes that may be useful for the treatment of AD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Yuru Han, Baoyu Duan, Jing Wu, Yanjun Zheng, Yinchen Gu, Xiaomeng Cai, Changlian Lu, Xubo Wu, Yanfei Li, Xuefeng Gu
Summary: This study utilized RNA-seq and MeDIP-seq to analyze the genetic and epigenetic features of myocardial infarction (MI) at the early stages, revealing changes in gene expression and methylation regions associated with immune response, apoptosis, and energy metabolism. The study identified potential drug targets in genes related to apoptosis and inflammation, as well as highlighted the importance of methylation changes in genes affecting processes such as cardiac muscle contraction and angiogenesis during MI progression.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Integrative & Complementary Medicine
Jiamei Le, Houlin Ji, Peixian Pi, Kaijie Chen, Xuefeng Gu, Yujie Ma, Yi Fu, Yongning Sun, Xiaoxiao Zhou, Hailong Wu
Summary: The study suggests that Sennoside A (SA) inhibits the growth and metastasis of chondrosarcoma cells by inhibiting the Wnt/β-catenin pathway and stimulating apoptosis, indicating its therapeutic potential.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Immunology
Xuefeng Gu, Jingyi Li, Xiaojia Zuo, Kaijie Chen, Guoqing Wan, Li-li Deng, Weiming Zhao, Changlian Lu
Summary: This study demonstrates that the long noncoding RNA MEG3 is downregulated in various malignant tumors and positively correlates with SLFN5 expression in breast cancer. MEG3 positively modulates SLFN5 expression by sponging miR-146b-5p and inhibits the development of breast cancer.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Oncology
Xiaojia Zuo, Chaojun Lu, Yanjun Zheng, Donglin Lai, Dingsheng Liu, Guoqing Wan, Changlian Lu, Xuefeng Gu
Summary: The study revealed that CCRK is overexpressed in ccRCC and miR-335-5p can regulate CCRK expression. This finding suggests that CCRK could be a potential therapeutic target for ccRCC.
JOURNAL OF ONCOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Donglin Lai, Wenhao Ma, Jie Wang, Luzhu Zhang, Junfeng Shi, Changlian Lu, Xuefeng Gu
Summary: Using bioinformatics methods, the study analyzed the association between the immune system and periodontitis, and identified key genes involved in the development of periodontitis. A diagnostic model was constructed based on these genes, demonstrating good diagnostic performance in both the training and validation datasets.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Immunology
Kaijie Chen, Shuang Liu, Changlian Lu, Xuefeng Gu
Summary: In this study, a BM-TME classifier was developed for accurate prognostic prediction in lung adenocarcinoma (LUAD) by combining the BM score and TME score. Functional annotation analysis revealed that the potential molecular regulatory mechanisms of the BM-TME classifier were closely related to the cell cycle, mitosis, and DNA replication pathways. The classifier also has guiding value for the treatment strategy of LUAD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Xuefeng Gu, Yuru Han, Yue Shao, Wenhao Ma, Zeguo Shao, Guoqing Wan, Changlian Lu, Shuo Shi, Wenli Lu
Summary: Through bioinformatics analysis, it was found that the space environment affects skin keratinocyte differentiation, leading to skin barrier damage and inflammatory responses, but this effect is decreased after return to Earth. Among 10 International Space Station astronauts studied, 311 genes increased in expression after space entry and decreased after return to Earth. Genes with this expression pattern were associated with skin development, keratinocyte differentiation, and cornification. We found that these hub skin-related genes are involved in skin barrier damage and inflammatory responses.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Jingyi Li, Xuefeng Gu, Guoqing Wan, Yuhan Wang, Kaijie Chen, Qi Chen, Changlian Lu
Summary: In this study, it was found that rocuronium bromide (RB) can inhibit the PI3K/AKT/mTOR signaling pathway and autophagy in cancer associated fibroblasts (CAFs), leading to decreased expression of CXCL12 and hence weakening the CXCL12-mediated progression of esophageal cancer (EC).
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Mathematical & Computational Biology
Yuru Han, Shuo Shi, Shuang Liu, Xuefeng Gu
Summary: During space flight, the immune system function is disrupted leading to increased infectious diseases in astronauts. This study aimed to identify key genes and pathways affected by the space environment on the spleen and thymus using bioinformatics analysis of the GEO dataset.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2023)
Article
Toxicology
Ying Zhang, Wenhao Ma, Hao Lin, Xuefeng Gu, Hong Xie
Summary: This study investigated the impact of esketamine on intestinal flora and microenvironment in mice. The results showed that esketamine significantly altered the abundance of intestinal microbiota and gene expression. The ceRNA and transcription factor networks revealed the regulatory mechanisms involved, while gene ontology enrichment analysis indicated the involvement of immune response and transport processes. These findings suggest that esketamine affects the immune environment and transport modes in the gut.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2023)