Review
Medicine, Research & Experimental
Ahmed A. Elmarakby, Jennifer C. Sullivan
Summary: Although there have been numerous clinical and experimental studies identifying a sexual dimorphism in blood pressure control, the specific mechanisms underlying these differences remain unclear. Previous research has suggested that differential regulation of adrenergic receptors, the renin-angiotensin system, oxidative stress, nitric oxide bioavailability and immune cells play a role in sex differences in blood pressure control in SHR.
Article
Pharmacology & Pharmacy
Michal Kluknavsky, Andrea Micurova, Martin Skratek, Peter Balis, Monika Okuliarova, Jan Manka, Iveta Bernatova
Summary: This study investigated the differences in biodistribution of superparamagnetic magnetite nanoparticles (IONs) in the heart and liver of normotensive Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats. It also examined the effects of IONs on the expression of selected genes involved in iron metabolism regulation. The results showed that SHR had less ION incorporation in tissues compared to WKY, and hearts had less ION distribution compared to livers.
Article
Biotechnology & Applied Microbiology
Yan Jun Ma, Xin Ping Li, Yue Wang, Jian Wen Wang
Summary: The results illustrate that the use of sodium nitroprusside (SNP) can significantly enhance the biosynthesis of fungal secondary metabolite hypocrellin and regulate oxidative reactions and membrane lipid expression by releasing nitric oxide, thereby increasing production yield.
MICROBIAL CELL FACTORIES
(2021)
Article
Engineering, Biomedical
Jiaxin Chen, Bingbing Zhao, Junhui Zou, Jiachen Yang, Lifen Yang, Junmei Zhang, Wei Chen, Dechun Huang, Yinan Zhong
Summary: A bombesin-installed nanoplatform combining mitoxantrone (MTO) and nitric oxide (NO) is developed for targeted chemotherapy against prostate cancer. The nanoplatform actively targets and accumulates in tumor sites, and releases NO to induce DNA damage and reactive oxygen species (ROS) generation, enhancing the cytotoxicity of MTO through inhibition of DNA repair and anti-oxidation pathways.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Zhengbing Zhuge, Sarah McCann Haworth, Carina Nihlen, Lucas Rannier R. A. Carvalho, Sophia K. Heuser, Andrei L. Kleschyov, Josefine Nasiell, Miriam M. Cortese-Krott, Eddie Weitzberg, Jon O. Lundberg, Mattias Carlstroem
Summary: This study aimed to investigate the effects of a lack of endothelial nitric oxide synthase (eNOS) in red blood cells (RBCs) on vascular endothelial function. Results showed that RBCs lacking eNOS induced endothelial dysfunction and vascular oxidative stress, similar to RBCs from patients with preeclampsia. This suggests that RBC-derived nitric oxide (NO) bioactivity plays a crucial role in protecting the endothelium from oxidative stress.
Article
Pharmacology & Pharmacy
Gustavo H. Oliveira-Paula, Daniela A. Pereira, Lucas C. Pinheiro, Graziele C. Ferreira, Waynice N. Paula-Garcia, Luis Garcia, Riccardo Lacchini, Marcelo R. Luizon, Jose E. Tanus-Santos
Summary: This study found that PRKCA genotypes and haplotypes may impact the hypotensive responses to propofol, possibly by modifying NO bioavailability, and that PRKCA-NOS3 interactions modify the blood pressure-lowering effects of propofol.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Isabela Borges de Melo, Gustavo H. Oliveira-Paula, Leticia Perticarrara Ferezin, Graziele C. Ferreira, Lucas C. Pinheiro, Jose E. Tanus-Santos, Luis V. Garcia, Riccardo Lacchini, Waynice N. Paula-Garcia
Summary: The polymorphisms or haplotypes of the TRPA1 gene may influence the hypotensive responses to propofol, and the mechanisms involved may be different from those related to NO bioavailability.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Gustavo H. Oliveira-Paula, Fernanda Borchers Coeli-Lacchini, Leticia Perticarrara Ferezin, Graziele C. Ferreira, Lucas C. Pinheiro, Waynice N. Paula-Garcia, Luis V. Garcia, Jose E. Tanus-Santos, Riccardo Lacchini
Summary: The study suggests that genetic variations in the ARG2 gene may affect patients' hypotensive responses and NO availability in response to propofol anesthesia.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Lei Wen, Xinyu Ma, Jing Yang, Minmin Jiang, Chao Peng, Zhongyun Ma, Huan Yu, Yinhui Li
Summary: This study proposed a new design strategy based on pi-conjugation modulation for fluorescent probes, which can generate different emission bands in the presence and absence of the target. The newly designed fluorescence probe, Rhod-DCM-B, exhibited outstanding sensitivity and excellent selectivity towards ONOO-. It was successfully employed to determine endogenous and exogenous ONOO- in living cells, and effectively monitored the ONOO- in vivo.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Wenwei Lu, Yusheng Wang, Zhifeng Fang, Hongchao Wang, Jinlin Zhu, Qixiao Zhai, Jianxin Zhao, Hao Zhang, Wei Chen
Summary: This study evaluated the preventive effect of Bifidobacterium longum CCFM752 on hypertension and found that it can prevent hypertension by inhibiting oxidative stress and restoring gut microbiota balance.
Article
Food Science & Technology
Francineide Fernandes-Costa, Rayanelle Tissiane Gomes da Silva, Atalia Ferreira de Lima Flor, Maria Claudia R. Brandao, Petronio F. Athayde-Filho, Maria do Socorro Franca-Falcao, Valdir de Andrade Braga, Gustavo Jorge dos Santos, Mattias Carlstrom, Josiane de Campos Cruz
Summary: Our study investigated the cardiometabolic effect of NDBP treatment in a mouse model of type 1 diabetes (T1DM). The results showed that NDBP treatment reduced hyperglycemia, improved glucose tolerance, and decreased oxidative stress in the liver and pancreas. Additionally, NDBP treatment improved vascular function but had no effect on hypertension.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biology
Jana Radosinska, Marta Kollarova, Tomas Jasenovec, Dominika Radosinska, Norbert Vrbjar, Peter Balis, Angelika Puzserova
Summary: This study investigated the changes in erythrocyte parameters and nitric oxide (NO) production in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) and their relationship with age. The researchers found that erythrocyte deformability was inversely proportional to systolic blood pressure in WKY rats but not in SHR. There was a significant negative correlation between erythrocyte size and blood pressure in SHR but not in WKY rats. Erythrocyte deformability was directly related to NO production in both normotensive and hypertensive animals. Age-related changes in deformability were partially associated with changes in NO production in both WKY and SHR. However, caution is needed when interpreting the data obtained in erythrocyte parameters observed in SHR in relation to human hypertension.
Article
Biochemistry & Molecular Biology
Stanislava Vrankova, Zuzana Galandakova, Jakub Benko, Martina Cebova, Igor Riecansky, Olga Pechanova
Summary: The results of the study indicate that 10 weeks of social isolation led to a significant decrease in PPI, accompanied by a decrease in NOS activity in the cerebral cortex and the cerebellum, an increase in iNOS in the hippocampus, and an increase in CD concentration in cortex homogenate. On the other hand, 29 weeks of social isolation had an opposite effect on NOS activity, with an increase in the cerebral cortex and the cerebellum in animals reared in a social environment, accompanied by a decrease in CD concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Marijke Grau, Lennart Kuck, Thomas Dietz, Wilhelm Bloch, Michael J. Simmonds
Summary: Red blood cell (RBC) deformability is crucial for microcirculatory function and is enhanced by physiological shear stress while negatively affected by supraphysiological shears and/or free radical exposure. Older RBCs demonstrate lower deformability compared to younger RBCs, and both sub-populations experience decreased deformability due to free radicals. Shear exposure does not impact reactive species in the sub-populations, but it reduces nitric oxide synthase (NOS) activation and increases RBC deformability in older RBCs. These findings reveal the complex interplay between mechanical stress, free radicals, and RBC mechanics in different sub-populations.
Article
Medicine, Research & Experimental
Jessica A. Troiano, Simone R. Potje, Murilo E. Graton, Daniela S. Silva, Rafael M. da Costa, Rita C. Tostes, Cristina Antoniali
Summary: Pregnancy decreases the content of vascular O-GlcNAc-modified proteins. Increased OGA activity and decreased O-GlcNAc modification of eNOS boost eNOS activity in arteries of P-Wistar rats. In P-SHR, altered OGA activity may lower the content of O-GlcNAc-modified proteins, but decreased OGT activity seems a potential mechanism to reduce glycosylation.
Article
Dentistry, Oral Surgery & Medicine
Matheus Lima Cypriano, Guilherme Henrique Alves dos Santos Ramos, Ana Carolina Fujimori de Oliveira, Damaris Raissa dos Santos, Gabriela Alice Fiais, Arthur Passos de Oliveira, Cristina Antoniali, Rita Cassia Menegati Dornelles, Ana Claudia de Melo Stevanato Nakamune, Antonio Hernandes Chaves-Neto
Summary: Orchiectomy increased salivary flow rate, buffering capacity, ion concentrations, etc. TRT restored these parameters to normal levels, while MT showed better reduction in oxidative damage in saliva.
ARCHIVES OF ORAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marta T. Gomes, Yang Bai, Simone R. Potje, Lu Zhang, Angelia D. Lockett, Roberto F. Machado
Summary: This review discusses the role of bioenergetic and inflammatory impairments in the development of pulmonary arterial hypertension (PAH).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Tiago J. Costa, Simone R. Potje, Thais F. C. Fraga-Silva, Julio A. Da Silva-Neto, Paula R. Barros, Daniel Rodrigues, Mirele R. Machado, Ronaldo B. Martins, Rosangela A. Santos-Eichler, Maira N. Benatti, Keyla S. G. de Sa, Carlos Eduardo L. Almado, Italo A. Castro, Marjorie C. Pontelli, Leonardo La Serra, Fernando S. Carneiro, Christiane Becari, Paulo Louzada-Junior, Rene D. R. Oliveira, Dario S. Zamboni, Eurico Arruda, Maria Auxiliadora-Martins, Fernanda R. C. Giachini, Vania L. D. Bonato, Natasha E. Zachara, Gisele F. Bomfim, Rita C. Tostes
Summary: This study demonstrates that SARS-CoV-2 infection impairs mitochondrial function and activates TLR9 signaling in endothelial cells, leading to inflammatory responses and endothelial dysfunction. Targeting mitochondrial metabolic pathways may offer new therapeutic strategies for COVID-19.
VASCULAR PHARMACOLOGY
(2022)
Article
Physiology
Jessica A. Troiano, Simone R. Potje, Murilo E. Graton, Emily T. Goncalves, Rita C. Tostes, Cristina Antoniali
Summary: Pregnancy increases nitric oxide (NO) generation in arteries without affecting the number of caveolae or the expression of main eNOS regulatory proteins, but decreases Cav-1/eNOS interaction. This decrease seems to be an important mechanism to increase eNOS activity and nitric oxide production in pregnant normotensive and hypertensive rats.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Damaris Raissa dos Santos, Gabriela Alice Fiais, Arthur de Oliveira Passos, Luis Fernando Gadioli dos Santos, Giseli Mitsuy Kayahara, Marcelo Macedo Crivelini, Doris Hissako Matsushita, Cristina Antoniali, Ana Claudia de Melo Stevanato Nakamune, Rita Cassia Menegati Dornelles, Antonio Hernandes Chaves-Neto
Summary: Orchiectomy affects the redox balance and function of salivary glands, while testosterone replacement therapy can reverse the oxidative damage, morphological alterations, and salivary gland dysfunction induced by orchiectomy.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Luiz Henrique Natali, Jessica Antonini Troiano, Simone Regina Potje, Daniel Penteado Martins Dias, Cristina Antoniali
Summary: Pregnancy can reduce blood pressure in spontaneously hypertensive rats and improve vascular regulation, but does not enhance BRS, it does normalize altered sympathetic vasomotor modulation in SHR.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Multidisciplinary Sciences
Helena C. Barroso, Murilo E. Graton, Simone R. Potje, Jessica A. Troiano, Lilian X. Silva, Ana Claudia M. S. Nakamune, Cristina Antoniali
Summary: Oxidative stress is a key feature in hypertension, and saliva can be used to evaluate oxidative stress biomarkers and antioxidant systems in hypertensive patients. Nebivolol, as an anti-hypertensive drug, has shown effectiveness in reducing oxidative stress.
Article
Dentistry, Oral Surgery & Medicine
Jordana Resende Martins, Beatriz Diaz-Fabregat, Wilmer Ramirez-Carmona, Douglas Roberto Monteiro, Juliano Pelim Pessan, Cristina Antoniali
Summary: There is a relationship between salivary biomarkers of oxidative stress and dental caries in children. The levels of oxidative stress biomarkers and salivary parameters are altered in the saliva of children with dental caries.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Marco Aurelio Gomes, Carolina Manzano, Thayane Miranda Alves, Gabriela Alice Fiais, Rayara Nogueira Freitas, Maria Sara de Lima Coutinho Mattera, Rita Cassia Menegati Dornelles, Doris Hissako Matsushita, Ana Claudia de Melo Stevanato Nakamune, Antonio Hernandes Chaves-Neto
Summary: Mate tea was found to increase tissue protein synthesis and improve antioxidant defenses in the salivary glands of diabetic rats.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Physiology
Murilo E. Graton, Bruno H. S. H. Ferreira, Jessica A. Troiano, Simone. R. R. Potje, Gabriel. T. T. Vale, Ana Claudia M. S. Nakamune, Carlos R. Tirapelli, Francis. J. J. Miller, Valdecir. F. F. Ximenes, Cristina Antoniali
Summary: This study compared the effects of apocynin and protocatechuic acid on hypertensive rats and vascular cells. Both compounds showed antioxidant and free radical scavenging abilities, and were able to decrease oxidative stress damage. Additionally, they increased nitric oxide levels and reduced vascular constriction. Therefore, these compounds have potential therapeutic importance in the treatment of vascular diseases.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bruna Kaori Namba Inoue, Laura Vidoto Paludetto, Naara Gabriela Monteiro, Fabio Roberto de Souza Batista, Igor Lebedenco Kitagawa, Roberto Santana da Silva, Cristina Antoniali, Paulo Noronha Lisboa Filho, Roberta Okamoto
Summary: Postmenopausal osteoporosis and poor dietary habits can lead to overweightness and obesity. This study found that nitric oxide has the potential to improve peri-implant conditions, especially at low concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Damaris Raissa dos Santos, Gabriela Alice Fiais, Henrique Arnaldo Oliveira, Tayna Buffulin Ribas, Rayne Oliveira Souza, Thais Veronica Saori Tsosura, Doris Hissako Matsushita, Edilson Ervolino, Rita Cassia Menegati Dornelles, Ana Claudia de Melo Stevanato Nakamune, Antonio Hernandes Chaves-Neto
Summary: The anti-obesity drug sibutramine hydrochloride has negative effects on the redox state and biochemical parameters in the salivary glands of rats, impairing enzymatic and non-enzymatic antioxidant defenses.
CLINICAL ORAL INVESTIGATIONS
(2022)