Article
Nutrition & Dietetics
Camila D. S. Barros, Jomenica B. Livramento, Margaret G. Mouro, Elisa Mieko Suemitsu Higa, Carlos T. Moraes, Celia Harumi Tengan
Summary: Supplementation of L-arginine may improve symptoms in MELAS patients by reducing protein nitration.
Article
Chemistry, Analytical
Lei Wen, Xinyu Ma, Jing Yang, Minmin Jiang, Chao Peng, Zhongyun Ma, Huan Yu, Yinhui Li
Summary: This study proposed a new design strategy based on pi-conjugation modulation for fluorescent probes, which can generate different emission bands in the presence and absence of the target. The newly designed fluorescence probe, Rhod-DCM-B, exhibited outstanding sensitivity and excellent selectivity towards ONOO-. It was successfully employed to determine endogenous and exogenous ONOO- in living cells, and effectively monitored the ONOO- in vivo.
ANALYTICAL CHEMISTRY
(2022)
Article
Plant Sciences
Neha Gupta, Arun Kumar Mishra
Summary: NOS-derived NO plays a critical role in protecting cyanobacteria from oxidative burst and maintaining their physiological balance. Addition of L-NAME inhibitor reduces NO accumulation, while addition of L-arginine increases NO synthesis. Inhibition of NOS leads to decreased growth and metabolic activity of cyanobacteria, as well as decline in photopigments, PSII efficiency, loss in membrane integrity and DNA damage, ultimately resulting in cell death.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Stanislava Vrankova, Zuzana Galandakova, Jakub Benko, Martina Cebova, Igor Riecansky, Olga Pechanova
Summary: The results of the study indicate that 10 weeks of social isolation led to a significant decrease in PPI, accompanied by a decrease in NOS activity in the cerebral cortex and the cerebellum, an increase in iNOS in the hippocampus, and an increase in CD concentration in cortex homogenate. On the other hand, 29 weeks of social isolation had an opposite effect on NOS activity, with an increase in the cerebral cortex and the cerebellum in animals reared in a social environment, accompanied by a decrease in CD concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Xiaoxiao Liu, Di Gong, Qingbo Ke, Lina Yin, Shiwen Wang, Tianpeng Gao
Summary: A meta-analysis of 86 studies has shown that nitric oxide (NO) can significantly improve plant biomass, alleviate oxidative damage, and increase the content of Ca, Fe, and Mg in heavy metal-stressed plants. The optimal concentration of SNP (an NO donor) for hydroponic culture is in the range of 75-150 μM. These findings provide valuable insights for the future application of NO as a plant growth regulator for enhancing heavy metal stress tolerance in agriculture and breeding.
Review
Food Science & Technology
Joseph Festa, Mariasole Da Boit, Aamir Hussain, Harprit Singh
Summary: Cardiovascular disease is the leading cause of global death, with endothelial dysfunction being a predictor for most CVD. Polyphenols from sources like wine and grape extracts can help prevent endothelial dysfunction, while anthocyanin flavonoids found in berries also improve vascular function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Ophthalmology
Tadanobu Yoshikawa, Kenji Obayashi, Kimie Miyata, Keigo Saeki, Nahoko Ogata
Summary: The study revealed a significant association between higher serum ADMA levels and severe glaucoma, which remained significant after adjusting for potential confounders.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Engineering, Environmental
Xin Huang, Ke Ren, Zhiyong Chang, Youqing Ye, Dechun Huang, Wei Zhao, Lixin Yang, Yuqin Dong, Zhiting Cao, Haishi Qiao
Summary: A novel GBM treatment strategy combining photothermal therapy, tumor starvation, and nitric oxide therapy is developed using functionalized black phosphorus nanosheets. The mild chemical modification empowers BP with superior stability and induces release of H2O2 and NO. Membrane-coated BPAG shows improved penetration and GBM targeting ability.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Multidisciplinary Sciences
Hossam G. Tohamy, Mahmoud S. El-Neweshy, Mohamed Mohamed Soliman, Samy Sayed, Mustafa Shukry, Heba I. Ghamry, Hoda Abd-Ellatieff
Summary: The study found that royal jelly has a protective effect against HDU-induced hepatic injury by maintaining the hepatic oxidative/antioxidative status, reducing inflammation, and inhibiting cell apoptosis. This suggests that royal jelly could be used as an adjuvant therapy in patients on long-term HDU medication.
Review
Biochemistry & Molecular Biology
Yuting Meng, Huaikang Jing, Jing Huang, Renfang Shen, Xiaofang Zhu
Summary: Nitric oxide (NO) is a crucial signaling molecule in plants, playing roles in regulating plant growth and development, and responding to stress. Cadmium (Cd) pollution is a widespread environmental hazard that inhibits plant growth and threatens human health. Plants have evolved mechanisms to cope with Cd stress, and NO is known to be involved in these responses. However, the mechanisms by which Cd stress affects the accumulation of endogenous NO in plants and the role of exogenous NO in plant responses to Cd stress remain unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Xilei Xie, Yawen Liu, Guangzhao Liu, Yuying Zhao, Jinyan Liu, Yong Li, Jian Zhang, Xiaoyun Jiao, Xu Wang, Bo Tang
Summary: In this study, a novel fluorescent probe was designed and synthesized, allowing the visualization of the crucial role of peroxynitrite in Alzheimer's disease through in vivo experiments in mice.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Renato C. Nogueira, Magdalena Minnion, Anna D. Clark, Alex Dyson, Jose E. Tanus-Santos, Martin Feelisch
Summary: Nitrite concentrations in blood play a crucial role in assessing intracellular nitric oxide (NO) activity and endothelial function. However, using nitrosylhemoglobin (HbNO) as an early marker of COVID-19 patient risk may be premature.
Review
Biochemistry & Molecular Biology
Juan A. Godoy, Juvenal A. Rios, Pol Picon-Pages, Victor Herrera-Fernandez, Bronte Swaby, Giulia Crepin, Ruben Vicente, Jose M. Fernandez-Fernandez, Francisco J. Munoz
Summary: Mitochondria play critical roles in neurons by regulating neurotransmission and synaptic plasticity through ATP supply, calcium homeostasis, redox balance control, and apoptosis. Their functional integrity is mainly maintained by mitostasis, involving processes like mitochondrial transport, anchoring, fusion, and fission, regulated by various signaling pathways. The communication between mitochondria and the endoplasmic reticulum (ER) via mitochondria-associated membranes (MAMs) is crucial for Ca2+ buffering. Alterations in mitochondrial activity can lead to increased production of reactive oxygen species, disturbance in physiological metabolism, and mitochondrial dysfunction resulting in cell death through apoptosis.
Article
Plant Sciences
Cheng Qin, Jie Shen, Mohammad Abass Ahanger
Summary: Experiments were conducted to evaluate the role of exogenously applied nitric oxide (NO) and spermidine (Spd) in alleviating the damaging effects of nickel toxicity on tomato. It was found that the application of NO and Spd effectively reduced the harmful effects of nickel, improving the growth and physiological parameters of tomato plants.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Elena Grossini, Divya Garhwal, Sakthipriyan Venkatesan, Daniela Ferrante, Angelica Mele, Massimo Saraceno, Ada Scognamiglio, Jessica Mandrioli, Amedeo Amedei, Fabiola De Marchi, Letizia Mazzini
Summary: This study analyzed the plasma redox system and nitric oxide levels in ALS patients and investigated the effects of plasma on mitochondrial function in endothelial vascular cells and astrocytes. The results showed that oxidative stress and neurovascular unit changes play a central role in ALS, and unknown plasma factors may be involved in the disease pathogenesis.
Article
Chemistry, Multidisciplinary
Zhaoxu Tu, Haishi Qiao, Yuting Yan, Guy Guday, Wei Chen, Mohsen Adeli, Rainer Haag
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2018)
Article
Biochemistry & Molecular Biology
Xingmei Chen, Hongliang Qian, Haishi Qiao, Bin Dong, Enping Chen, Dechun Huang, Ting Wang, Wei Chen
Review
Biochemistry & Molecular Biology
Raut Bholakant, Hongliang Qian, Junmei Zhang, Xin Huang, Dechun Huang, Jan Feijen, Yinan Zhong, Wei Chen
Article
Chemistry, Multidisciplinary
Jing Liu, Youqiao Xu, Haojie Lu, Rong Wang, Zhuolu Xia, Changshun Zhao, Dechun Huang, Feng Jiang, Wei Chen
Summary: Three self-assembled nanoaggregates were constructed using different molecules, and their properties were characterized through various experiments. The results showed that nanoaggregates with disulfide groups exhibited better stability and improved cytotoxicity against cancer cells. Additionally, the nanoaggregates showed targeting ability to specific cellular components, leading to enhanced antitumor efficacy.
Article
Nanoscience & Nanotechnology
Changshun Zhao, Suchen Wen, Jingfang Pan, Ke Wang, Yicheng Ji, Dechun Huang, Bingbing Zhao, Wei Chen
Summary: Cross-linked supersmall zwitterionic micelles (X-CBMs) based on zwitterionic hyperbranched polycarbonates are synthesized for efficient targeted drug delivery. X-CBMs exhibit prolonged blood circulation and high tumor accumulation due to their cross-linked structure and zwitterion decoration. The X-CBMs-mediated delivery of paclitaxel (PTX) formulation shows a significantly enhanced targeted antitumor outcome against the 4T1 tumor model.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Biomaterials
Yuhong Ma, Qihang Li, Jingru Yang, Yuan Cheng, Caihua Li, Changshun Zhao, Wei Chen, Dechun Huang, Hongliang Qian
Summary: This study developed crosslinked zwitterionic microcapsules for improved oral insulin delivery, which showed superior insulin transport and hypoglycemic effect compared to non-modified microcapsules. These findings highlight the great potential of crosslinked zwitterionic microcapsules as an oral insulin delivery platform for diabetes therapy.
BIOMATERIALS SCIENCE
(2023)
Article
Engineering, Biomedical
Junmei Zhang, Bo Wang, Hui Wang, Zheng Wang, Pan Zhang, Xin Huang, Hongliang Qian, Dechun Huang, Wei Chen, Yinan Zhong
Summary: In this study, a reversibly double-locked hydroxycamptothecin (HCPT) prodrug nanoparticle was developed for safe and efficient chemotherapy of orthotopic lung cancer. The nanoparticle demonstrated high stability against dilution and acid-triggered drug release, leading to targeted tumor treatment.
ACTA BIOMATERIALIA
(2023)
Article
Nanoscience & Nanotechnology
Bingbing Zhao, Yuqing Wan, Xiang Zhou, Junmei Zhang, Jiaxin Chen, Jiachen Yang, Yunzhu Liu, Wei Chen, Yinan Zhong, Hongliang Qian
Summary: By incorporating a bombesin (BBN)-decorated two-in-one prodrug (T-NO/E-2-PMs) into the body, the expression of androgen receptor (AR) can be inhibited, the tumor microenvironment of castration-resistant prostate cancer (CRPC) can be reprogrammed, and the therapeutic effect of estradiol on hypoxic CRPC can be enhanced.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Materials Science, Biomaterials
Raut Bholakant, Bin Dong, Xiang Zhou, Xin Huang, Changshun Zhao, Dechun Huang, Yinan Zhong, Hongliang Qian, Wei Chen, Jan Feijen
Summary: Combination therapy based on multifunctional polymeric micelles (PMs) plays a crucial role in cancer treatment by synergistically optimizing therapeutic outcomes and minimizing adverse effects. Strategies such as combining multiple anticancer drugs and chemo-gene therapy are emerging as key research focuses in this field.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Materials Science, Biomaterials
Xin Huang, Yanfei Li, Dengyu Li, Xiang Zhou, Haishi Qiao, Lifen Yang, Yicheng Ji, Xuejiao Zhang, Dechun Huang, Wei Chen
Summary: A PD-M@BP/PTX nanosystem has been developed to achieve remote controlled release for multi-drug resistant cervical tumors, while also reducing potential systemic toxicity.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Ievgen S. Donskyi, Ying Chen, Philip Nickl, Guy Guday, Haishi Qiao, Katharina Achazi, Andreas Lippitz, Wolfgang E. S. Unger, Christoph Boettcher, Wei Chen, Mohsen Adeli, Rainer Haag
Article
Materials Science, Biomaterials
Haishi Qiao, Xingmei Chen, Qiming Wang, Junmei Zhang, Dechun Huang, Enping Chen, Hongliang Qian, Yinan Zhong, Qi Tang, Wei Chen
BIOMATERIALS SCIENCE
(2020)
Article
Materials Science, Biomaterials
Haishi Qiao, Xingmei Chen, Enping Chen, Junmei Zhang, Dechun Huang, Danqi Yang, Youchao Ding, Hongliang Qian, Jan Feijen, Wei Chen
BIOMATERIALS SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Xiaobin Huang, Yong Hou, LeiLei Zhong, Dechun Huang, Hongliang Qian, Marcel Karperien, Wei Chen