The ruthenium nitric oxide donor, [Ru(HEDTA)NO], inhibits acute nociception in mice by modulating oxidative stress, cytokine production and activating the cGMP/PKG/ATP-sensitive potassium channel signaling pathway

An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice

(2013) D.A.C. Magro et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

IL-33/ST2 signalling contributes to carrageenin-induced innate inflammation and inflammatory pain: role of cytokines, endothelin-1 and prostaglandin E2

(2013) AC Zarpelon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Vitexin Inhibits Inflammatory Pain in Mice by Targeting TRPV1, Oxidative Stress, and Cytokines

(2013) Sergio M. Borghi et al.   JOURNAL OF NATURAL PRODUCTS

The ruthenium NO donor, [Ru(bpy)2(NO)SO3](PF6), inhibits inflammatory pain: Involvement of TRPV1 and cGMP/PKG/ATP-sensitive potassium channel signaling pathway

(2013) Larissa Staurengo-Ferrari et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Sphingosine 1-Phosphate Mediates Hyperalgesia via a Neutrophil-Dependent Mechanism

(2013) Amanda Finley et al.   PLoS One

Kaurenoic Acid from Sphagneticola trilobata Inhibits Inflammatory Pain: Effect on Cytokine Production and Activation of the NO–Cyclic GMP–Protein Kinase G–ATP-Sensitive Potassium Channel Signaling Pathway

(2012) Sandra S. Mizokami et al.   JOURNAL OF NATURAL PRODUCTS

Stimulation of Peripheral Kappa Opioid Receptors Inhibits Inflammatory Hyperalgesia via Activation of the PI3Kγ/AKT/nNOS/NO Signaling Pathway

(2012) Thiago M Cunha et al.   Molecular Pain

Acetic acid- and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI3K and microglia in mice

(2012) Gabriela F. Pavao-de-Souza et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Anti-superoxide and anti-peroxynitrite strategies in pain suppression

(2011) Kali Janes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Experimental Chemotherapy in Paracoccidioidomycosis Using Ruthenium NO Donor

(2011) Wander Rogério Pavanelli et al.   MYCOPATHOLOGIA

Preconditioning with a Novel Metallopharmaceutical NO Donor in Anesthetized Rats Subjected to Brain Ischemia/Reperfusion

(2011) Marcio Wilker Soares Campelo et al.   NEUROCHEMICAL RESEARCH

Pain and analgesia: The dual effect of nitric oxide in the nociceptive system

(2011) Yara Cury et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Biological activity of ruthenium nitrosyl complexes

(2011) Elia Tfouni et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Antileishmanial activity of ruthenium(II)tetraammine nitrosyl complexes☆

(2010) José Clayston Melo Pereira et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Morphine peripheral analgesia depends on activation of the PI3K /AKT/nNOS/NO/KATP signaling pathway

(2010) T. M. Cunha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis

(2010) Hidenori Hattori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Guanylyl Cyclase Restores Neutrophil Migration and Maintains Bactericidal Activity Increasing Survival in Sepsis

(2010) Heitor A. Paula-Neto et al.   SHOCK

Experimental Chemotherapy against Trypanosoma cruzi Infection Using Ruthenium Nitric Oxide Donors

(2009) J. J. N. Silva et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effects of nitric oxide on neutrophil influx depends on the tissue: role of leukotriene B4 and adhesion molecules

(2009) ACRM Leite et al.   BRITISH JOURNAL OF PHARMACOLOGY

Quercetin Reduces Inflammatory Pain: Inhibition of Oxidative Stress and Cytokine Production

(2009) Daniel A. Valério et al.   JOURNAL OF NATURAL PRODUCTS

No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing

(2009) Achim Schmidtko et al.   TRENDS IN NEUROSCIENCES

Pure MnTBAP selectively scavenges peroxynitrite over superoxide: Comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy

(2008) Ines Batinić-Haberle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Crucial role of neutrophils in the development of mechanical inflammatory hypernociception

(2008) T. M. Cunha et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Targeting endothelin ETA and ETB receptors inhibits antigen-induced neutrophil migration and mechanical hypernociception in mice

(2008) Waldiceu A. Verri Jr et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Hydrogen peroxide is a novel mediator of inflammatory hyperalgesia, acting via transient receptor potential vanilloid 1-dependent and independent mechanisms

(2008) Julie Elizabeth Keeble et al.   PAIN