Novel vaccine vectors for HIV-1

Ending AIDS — Is an HIV Vaccine Necessary?

(2014) Anthony S. Fauci et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protective Efficacy of a Global HIV-1 Mosaic Vaccine against Heterologous SHIV Challenges in Rhesus Monkeys

(2013) Dan H. Barouch et al.   CELL

Comparative Analysis of the Magnitude, Quality, Phenotype, and Protective Capacity of Simian Immunodeficiency Virus Gag-Specific CD8+ T Cells following Human-, Simian-, and Chimpanzee-Derived Recombinant Adenoviral Vector Immunization

(2013) K. M. Quinn et al.   JOURNAL OF IMMUNOLOGY

Heterogeneity in Neutralization Sensitivities of Viruses Comprising the Simian Immunodeficiency Virus SIVsmE660 Isolate and Vaccine Challenge Stock

(2013) M. Lopker et al.   JOURNAL OF VIROLOGY

Clinical Assessment of a Novel Recombinant Simian Adenovirus ChAdOx1 as a Vectored Vaccine Expressing Conserved Influenza A Antigens

(2013) Richard D Antrobus et al.   MOLECULAR THERAPY

Immune clearance of highly pathogenic SIV infection

(2013) Scott G. Hansen et al.   NATURE

The Quest for an HIV-1 Vaccine — Moving Forward

(2013) Dan H. Barouch   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy Trial of a DNA/rAd5 HIV-1 Preventive Vaccine

(2013) Scott M. Hammer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cytomegalovirus Vectors Violate CD8+ T Cell Epitope Recognition Paradigms

(2013) S. G. Hansen et al.   SCIENCE

Randomized, placebo-controlled trial to assess the safety and immunogenicity of an adenovirus type 35-based circumsporozoite malaria vaccine in healthy adults

(2013) C Buddy Creech et al.   Human Vaccines & Immunotherapeutics

First-in-Human Evaluation of the Safety and Immunogenicity of a Recombinant Adenovirus Serotype 26 HIV-1 Env Vaccine (IPCAVD 001)

(2012) Lindsey R. Baden et al.   JOURNAL OF INFECTIOUS DISEASES

Characterization of Humoral and Cellular Immune Responses Elicited by a Recombinant Adenovirus Serotype 26 HIV-1 Env Vaccine in Healthy Adults (IPCAVD 001)

(2012) Dan H. Barouch et al.   JOURNAL OF INFECTIOUS DISEASES

Clinical Assessment of a Recombinant Simian Adenovirus ChAd63: A Potent New Vaccine Vector

(2012) Geraldine A. O’Hara et al.   JOURNAL OF INFECTIOUS DISEASES

The Number of Toll-Like Receptor 9-Agonist Motifs in the Adenovirus Genome Correlates with Induction of Dendritic Cell Maturation by Adenovirus Immune Complexes

(2012) M. Perreau et al.   JOURNAL OF VIROLOGY

Alternative Serotype Adenovirus Vaccine Vectors Elicit Memory T Cells with Enhanced Anamnestic Capacity Compared to Ad5 Vectors

(2012) Pablo Penaloza-MacMaster et al.   JOURNAL OF VIROLOGY

Comparative Analysis of Simian Immunodeficiency Virus Gag-Specific Effector and Memory CD8+T Cells Induced by Different Adenovirus Vectors

(2012) Wendy G. Tan et al.   JOURNAL OF VIROLOGY

Adenovirus Serotype 26 Utilizes CD46 as a Primary Cellular Receptor and Only Transiently Activates T Lymphocytes following Vaccination of Rhesus Monkeys

(2012) H. Li et al.   JOURNAL OF VIROLOGY

Vaccination with Adenovirus Serotypes 35, 26, and 48 Elicits Higher Levels of Innate Cytokine Responses than Adenovirus Serotype 5 in Rhesus Monkeys

(2012) Jeffrey E. Teigler et al.   JOURNAL OF VIROLOGY

Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys

(2012) Dan H. Barouch et al.   NATURE

A Phase I Double Blind, Placebo-Controlled, Randomized Study of a Multigenic HIV-1 Adenovirus Subtype 35 Vector Vaccine in Healthy Uninfected Adults

(2012) Michael C. Keefer et al.   PLoS One

Vaccine Vectors Derived from a Large Collection of Simian Adenoviruses Induce Potent Cellular Immunity Across Multiple Species

(2012) S. Colloca et al.   Science Translational Medicine

Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man

(2012) E. Barnes et al.   Science Translational Medicine

New Paradigms for HIV/AIDS Vaccine Development

(2011) Louis J. Picker et al.   Annual Review of Medicine

Safety and efficacy of the HVTN 503/Phambili Study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study

(2011) Glenda E Gray et al.   LANCET INFECTIOUS DISEASES

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys

(2011) N. L. Letvin et al.   Science Translational Medicine

International seroepidemiology of adenovirus serotypes 5, 26, 35, and 48 in pediatric and adult populations

(2011) Dan H. Barouch et al.   VACCINE

Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys

(2010) Dan H Barouch et al.   NATURE MEDICINE

Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys

(2010) Sampa Santra et al.   NATURE MEDICINE

Evasion of CD8+ T Cells Is Critical for Superinfection by Cytomegalovirus

(2010) S. G. Hansen et al.   SCIENCE

Pathways of memory CD8+ T-cell development

(2009) Oliver Bannard et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Adenovirus-specific immunity after immunization with an Ad5 HIV-1 vaccine candidate in humans

(2009) Kara L O'Brien et al.   NATURE MEDICINE

Baseline Ad5 serostatus does not predict Ad5 HIV vaccine–induced expansion of adenovirus-specific CD4+ T cells

(2009) Natalie A Hutnick et al.   NATURE MEDICINE

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

(2009) Scott G Hansen et al.   NATURE MEDICINE

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1

(2009) A. Benlahrech et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

International epidemiology of human pre-existing adenovirus (Ad) type-5, type-6, type-26 and type-36 neutralizing antibodies: Correlates of high Ad5 titers and implications for potential HIV vaccine trials

(2009) T. Christopher Mast et al.   VACCINE

Adenovirus Serotype 5 Hexon Mediates Liver Gene Transfer

(2008) Simon N. Waddington et al.   CELL

Antiviral CD8+T cells in the genital tract control viral replication and delay progression to AIDS after vaginal SIV challenge in rhesus macaques immunized with virulence attenuated SHIV 89.6

(2008) M. Genescà et al.   JOURNAL OF INTERNAL MEDICINE

Magnitude and Phenotype of Cellular Immune Responses Elicited by Recombinant Adenovirus Vectors and Heterologous Prime-Boost Regimens in Rhesus Monkeys

(2008) J. Liu et al.   JOURNAL OF VIROLOGY

HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case–cohort analysis

(2008) M Juliana McElrath et al.   LANCET

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET