The Therapeutic Potential of MicroRNAs in Cancer

Modifications in Small Interfering RNA That Separate Immunostimulation from RNA Interference

(2014) F. Eberle et al.   JOURNAL OF IMMUNOLOGY

miR-221 Silencing Blocks Hepatocellular Carcinoma and Promotes Survival

(2011) J.-K. Park et al.   CANCER RESEARCH

MicroRNA Replacement Therapy for miR-145 and miR-33a Is Efficacious in a Model of Colon Carcinoma

(2011) A. F. Ibrahim et al.   CANCER RESEARCH

Therapeutic Inhibition of miR-208a Improves Cardiac Function and Survival During Heart Failure

(2011) Rusty L. Montgomery et al.   CIRCULATION

MicroRNAs and developmental timing

(2011) Victor Ambros   CURRENT OPINION IN GENETICS & DEVELOPMENT

Silencing of microRNA-21in vivoameliorates autoimmune splenomegaly in lupus mice

(2011) Barry G. Garchow et al.   EMBO Molecular Medicine

Chemical modification and design of anti-miRNA oligonucleotides

(2011) K A Lennox et al.   GENE THERAPY

Developing therapeutic microRNAs for cancer

(2011) A G Bader et al.   GENE THERAPY

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice

(2011) Mirco Castoldi et al.   JOURNAL OF CLINICAL INVESTIGATION

Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis

(2011) Katey J. Rayner et al.   JOURNAL OF CLINICAL INVESTIGATION

Restitution of Tumor Suppressor MicroRNAs Using a Systemic Nanovector Inhibits Pancreatic Cancer Growth in Mice

(2011) D. Pramanik et al.   MOLECULAR CANCER THERAPEUTICS

Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice

(2011) Phong Trang et al.   MOLECULAR THERAPY

Silencing of microRNA families by seed-targeting tiny LNAs

(2011) Susanna Obad et al.   NATURE GENETICS

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

(2011) Can Liu et al.   NATURE MEDICINE

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

(2011) Eric Huntzinger et al.   NATURE REVIEWS GENETICS

Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis

(2011) Thomas Braun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex

(2011) E. S. Machlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo

(2011) T. Eskildsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of anti-oncomirs miR-143 and -145 in human colorectal tumors

(2010) Y Akao et al.   CANCER GENE THERAPY

Development of a Lung Cancer Therapeutic Based on the Tumor Suppressor MicroRNA-34

(2010) J. F. Wiggins et al.   CANCER RESEARCH

let-7 and miR-17-92: Small-sized major players in lung cancer development

(2010) Hirotaka Osada et al.   CANCER SCIENCE

Thelet-7microRNA reduces tumor growth in mouse models of lung cancer

(2010) Aurora Esquela-Kerscher et al.   CELL CYCLE

MicroRNA regulation of core apoptosis pathways in cancer

(2010) Raquel T. Lima et al.   EUROPEAN JOURNAL OF CANCER

MicroRNAs and Their Therapeutic Potential for Human Diseases: MicroRNAs, miR-143 and -145, Function as Anti-oncomirs and the Application of Chemically Modified miR-143 as an Anti-cancer Drug

(2010) Yukio Kitade et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model

(2010) Li Ma et al.   NATURE BIOTECHNOLOGY

miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma

(2010) Alexander Swarbrick et al.   NATURE MEDICINE

MicroRNA-132–mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis

(2010) Sudarshan Anand et al.   NATURE MEDICINE

Targeting microRNAs in cancer: rationale, strategies and challenges

(2010) Ramiro Garzon et al.   NATURE REVIEWS DRUG DISCOVERY

miRBase: integrating microRNA annotation and deep-sequencing data

(2010) A. Kozomara et al.   NUCLEIC ACIDS RESEARCH

Efficient inhibition of miR-155 function in vivo by peptide nucleic acids

(2010) Martin M. Fabani et al.   NUCLEIC ACIDS RESEARCH

A Direct Comparison of Anti-microRNA Oligonucleotide Potency

(2010) Kim A. Lennox et al.   PHARMACEUTICAL RESEARCH

MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis

(2010) S. H. Najafi-Shoushtari et al.   SCIENCE

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

MicroRNAs and Cancer: Short RNAs Go a Long Way

(2009) Andrea Ventura et al.   CELL

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

The miR-34 family in cancer and apoptosis

(2009) H Hermeking   CELL DEATH AND DIFFERENTIATION

Alternating 2′-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist

(2009) Svetlana Hamm et al.   IMMUNOBIOLOGY

Systemic Delivery of Synthetic MicroRNA-16 Inhibits the Growth of Metastatic Prostate Tumors via Downregulation of Multiple Cell-cycle Genes

(2009) Fumitaka Takeshita et al.   MOLECULAR THERAPY

MicroRNA Expression, Survival, and Response to Interferon in Liver Cancer

(2009) Junfang Ji et al.   NEW ENGLAND JOURNAL OF MEDICINE

Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF

(2009) Jesper Worm et al.   NUCLEIC ACIDS RESEARCH

Regression of murine lung tumors by the let-7 microRNA

(2009) P Trang et al.   ONCOGENE

MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction

(2009) J. Kocerha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

MicroRNA-Mediated Down-Regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg Cells: A Potential Pathogenetic Lesion in Hodgkin Lymphomas

(2008) Kui Nie et al.   AMERICAN JOURNAL OF PATHOLOGY

miR-296 Regulates Growth Factor Receptor Overexpression in Angiogenic Endothelial Cells

(2008) Thomas Würdinger et al.   CANCER CELL

The Promyelocytic Leukemia Zinc Finger-MicroRNA-221/-222 Pathway Controls Melanoma Progression through Multiple Oncogenic Mechanisms

(2008) F. Felicetti et al.   CANCER RESEARCH

microRNA-122 stimulates translation of hepatitis C virus RNA

(2008) Jura Inga Henke et al.   EMBO JOURNAL

MicroRNA expression profiling: A molecular tool for defining the phenotype of hepatocellular tumors

(2008) Chiara Braconi et al.   HEPATOLOGY

MicroRNAs miR-186 and miR-150 Down-regulate Expression of the Pro-apoptotic Purinergic P2X7Receptor by Activation of Instability Sites at the 3′-Untranslated Region of the Gene That Decrease Steady-state Levels of the Transcript

(2008) Lingyin Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA involvement in hepatocellular carcinoma

(2008) Laura Gramantieri et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE

The miR-15a–miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities

(2008) Désirée Bonci et al.   NATURE MEDICINE

Potent inhibition of microRNA in vivo without degradation

(2008) Scott Davis et al.   NUCLEIC ACIDS RESEARCH

Chemical Modification of siRNAs for In Vivo Use

(2008) Mark A. Behlke   OLIGONUCLEOTIDES

Antagomir-17-5p Abolishes the Growth of Therapy-Resistant Neuroblastoma through p21 and BIM

(2008) Laura Fontana et al.   PLoS One

MiR-15a and miR-16-1 cluster functions in human leukemia

(2008) George A. Calin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Experimental identification of microRNA-140 targets by silencing and overexpressing miR-140

(2008) F. E. Nicolas et al.   RNA

Inhibition of microRNA with antisense oligonucleotides

(2007) Christine C. Esau   METHODS