Bioinspired Nano-Prodrug with Enhanced Tumor Targeting and Increased Therapeutic Efficiency

Probe-Inspired Nano-Prodrug with Dual-Color Fluorogenic Property Reveals Spatiotemporal Drug Release in Living Cells

(2015) Xiangdong Xue et al.   ACS Nano

Overcoming drug-resistant lung cancer by paclitaxel loaded dual-functional liposomes with mitochondria targeting and pH-response

(2015) Lei Jiang et al.   BIOMATERIALS

Sequential Intra-Intercellular Nanoparticle Delivery System for Deep Tumor Penetration

(2014) Caoyun Ju et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Doxorubicin-loaded, charge reversible, folate modified HPMA copolymer conjugates for active cancer cell targeting

(2014) Lian Li et al.   BIOMATERIALS

Intracellular redox-activated anticancer drug delivery by functionalized hollow mesoporous silica nanoreservoirs with tumor specificity

(2014) Zhong Luo et al.   BIOMATERIALS

Combination of Small Molecule Prodrug and Nanodrug Delivery: Amphiphilic Drug–Drug Conjugate for Cancer Therapy

(2014) Ping Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Avidity Mechanism of Dendrimer–Folic Acid Conjugates

(2014) Mallory A. van Dongen et al.   MOLECULAR PHARMACEUTICS

A bio-inspired flexible fiber array with an open radial geometry for highly efficient liquid transfer

(2014) Qingan Meng et al.   NPG Asia Materials

Avidity Modulation of Folate-Targeted Multivalent Dendrimers for Evaluating Biophysical Models of Cancer Targeting Nanoparticles

(2013) Justin E. Silpe et al.   ACS Chemical Biology

Engineering a Hollow Nanocontainer Platform with Multifunctional Molecular Machines for Tumor-Targeted Therapy in Vitro and in Vivo

(2013) Zhong Luo et al.   ACS Nano

Spatiotemporal Drug Release Visualized through a Drug Delivery System with Tunable Aggregation-Induced Emission

(2013) Xiangdong Xue et al.   ADVANCED MATERIALS

Overcoming multidrug resistance of cancer cells by direct intranuclear drug delivery using TAT-conjugated mesoporous silica nanoparticles

(2013) Limin Pan et al.   BIOMATERIALS

Therapeutic nanomedicine based on dual-intelligent functionalized gold nanoparticles for cancer imaging and therapy in vivo

(2013) Wei-Hai Chen et al.   BIOMATERIALS

Supramolecular self-assembly forming a multifunctional synergistic system for targeted co-delivery of gene and drug

(2013) Feng Zhao et al.   BIOMATERIALS

Supramolecular Nanostructures Formed by Anticancer Drug Assembly

(2013) Andrew G. Cheetham et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Octreotide-functionalized and resveratrol-loaded unimolecular micelles for targeted neuroendocrine cancer therapy

(2013) Wenjin Xu et al.   Nanoscale

Diversity in the origins of proteostasis networks — a driver for protein function in evolution

(2013) Evan T. Powers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dual-Targeting Pro-apoptotic Peptide for Programmed Cancer Cell Death via Specific Mitochondria Damage

(2013) Wei-Hai Chen et al.   Scientific Reports

Charge-reversal plug gate nanovalves on peptide-functionalized mesoporous silica nanoparticles for targeted drug delivery

(2013) Guo-Feng Luo et al.   Journal of Materials Chemistry B

Targeting receptor-mediated endocytotic pathways with nanoparticles: Rationale and advances

(2012) Shi Xu et al.   ADVANCED DRUG DELIVERY REVIEWS

Multistage pH-Responsive Liposomes for Mitochondrial-Targeted Anticancer Drug Delivery

(2012) Ran Mo et al.   ADVANCED MATERIALS

The First Generation of β-Galactosidase-Responsive Prodrugs Designed for the Selective Treatment of Solid Tumors in Prodrug Monotherapy

(2012) Thibaut Legigan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The potential of self-assembled, pH-responsive nanoparticles of mPEGylated peptide dendron–doxorubicin conjugates for cancer therapy

(2012) Wenchuan She et al.   BIOMATERIALS

Anti-angiogenesis therapy in cancer: Current challenges and future perspectives

(2012) Farbod Shojaei   CANCER LETTERS

Target-Activated Coumarin Phototriggers Specifically Switch on Fluorescence and Photocleavage upon Bonding to Thiol-Bearing Protein

(2012) Qiuning Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Perylene-3-ylmethanol: Fluorescent Organic Nanoparticles as a Single-Component Photoresponsive Nanocarrier with Real-Time Monitoring of Anticancer Drug Release

(2012) Avijit Jana et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Co-delivery of siRNA and therapeutic agents using nanocarriers to overcome cancer resistance

(2012) Mar Creixell et al.   Nano Today

Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells

(2011) Feng Wang et al.   ACS Nano

Use of Size and a Copolymer Design Feature To Improve the Biodistribution and the Enhanced Permeability and Retention Effect of Doxorubicin-Loaded Mesoporous Silica Nanoparticles in a Murine Xenograft Tumor Model

(2011) Huan Meng et al.   ACS Nano

Design of Multifunctional Micelle for Tumor-Targeted Intracellular Drug Release and Fluorescent Imaging

(2011) Weiwei Wang et al.   ADVANCED MATERIALS

Redox-Responsive Molecular Nanoreservoirs for Controlled Intracellular Anticancer Drug Delivery Based on Magnetic Nanoparticles

(2011) Zhong Luo et al.   ADVANCED MATERIALS

Reactive and Bioactive Cationic α-Helical Polypeptide Template for Nonviral Gene Delivery

(2011) Nathan P. Gabrielson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Endosomal pH-Activatable Poly(ethylene oxide)-graft-Doxorubicin Prodrugs: Synthesis, Drug Release, and Biodistribution in Tumor-Bearing Mice

(2011) Lei Zhou et al.   BIOMACROMOLECULES

Acid-Activatable Prodrug Nanogels for Efficient Intracellular Doxorubicin Release

(2011) Fuxing Zhan et al.   BIOMACROMOLECULES

The cell penetrating ability of the proapoptotic peptide, KLAKLAKKLAKLAK fused to the N-terminal protein transduction domain of translationally controlled tumor protein, MIIYRDLISH

(2011) Hyo Young Kim et al.   BIOMATERIALS

Tailor-Made Dual pH-Sensitive Polymer–Doxorubicin Nanoparticles for Efficient Anticancer Drug Delivery

(2011) Jin-Zhi Du et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma

(2011) L. Agemy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

(2010) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin

(2010) Marina Talelli et al.   BIOMATERIALS

Drug delivery with upconversion nanoparticles for multi-functional targeted cancer cell imaging and therapy

(2010) Chao Wang et al.   BIOMATERIALS

Endosomal escape pathways for delivery of biologicals

(2010) Amir K. Varkouhi et al.   JOURNAL OF CONTROLLED RELEASE

Prodrugs Forming High Drug Loading Multifunctional Nanocapsules for Intracellular Cancer Drug Delivery

(2010) Youqing Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Active targeting schemes for nanoparticle systems in cancer therapeutics

(2008) James D. Byrne et al.   ADVANCED DRUG DELIVERY REVIEWS

Highly Efficient Drug Delivery with Gold Nanoparticle Vectors for in Vivo Photodynamic Therapy of Cancer

(2008) Yu Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prodrugs: design and clinical applications

(2008) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY

Discovery and Development of Folic-Acid-Based Receptor Targeting for Imaging and Therapy of Cancer and Inflammatory Diseases

(2007) Philip S. Low et al.   ACCOUNTS OF CHEMICAL RESEARCH