Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

The Endocannabinoid System and Pain

(2012) Josee Guindon et al.   CNS & Neurological Disorders-Drug Targets

Cannabinoid Receptors and Endocannabinoids: Role in Neuroinflammatory and Neurodegenerative Disorders

(2012) Tiziana Bisogno et al.   CNS & Neurological Disorders-Drug Targets

Vascular COX-2 Modulates Blood Pressure and Thrombosis in Mice

(2012) Y. Yu et al.   Science Translational Medicine

Molecular characterization and identification of surrogate substrates for diacylglycerol lipase α

(2011) Donna L. Pedicord et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fluorinated COX-2 Inhibitors as Agents in PET Imaging of Inflammation and Cancer

(2011) M. J. Uddin et al.   Cancer Prevention Research

(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2

(2011) Kelsey C Duggan et al.   Nature Chemical Biology

Reversible Gating of Endocannabinoid Plasticity in the Amygdala by Chronic Stress: A Potential Role for Monoacylglycerol Lipase Inhibition in the Prevention of Stress-Induced Behavioral Adaptation

(2011) Joshua J Sumislawski et al.   NEUROPSYCHOPHARMACOLOGY

Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats

(2011) Natale R. Sciolino et al.   PHARMACOLOGICAL RESEARCH

Managing the adverse effects of nonsteroidal anti-inflammatory drugs

(2011) Paola Patrignani et al.   Expert Review of Clinical Pharmacology

Effects of COX-2 inhibition on spinal nociception: the role of endocannabinoids

(2010) LE Staniaszek et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cyclooxygenase-2 Mediates Anandamide Metabolism in the Mouse Brain

(2010) S. T. Glaser et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Preservation of Striatal Cannabinoid CB1 Receptor Function Correlates with the Antianxiety Effects of Fatty Acid Amide Hydrolase Inhibition

(2010) S. Rossi et al.   MOLECULAR PHARMACOLOGY

Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay

(2010) Steven G. Kinsey et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

R-Flurbiprofen Reduces Neuropathic Pain in Rodents by Restoring Endogenous Cannabinoids

(2010) Philipp Bishay et al.   PLoS One

Differential Sensitivity and Mechanism of Inhibition of COX-2 Oxygenation of Arachidonic Acid and 2-Arachidonoylglycerol by Ibuprofen and Mefenamic Acid

(2009) Jeffery J. Prusakiewicz et al.   BIOCHEMISTRY

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

(2009) Kay Ahn et al.   CHEMISTRY & BIOLOGY

Endocannabinoid signals in the control of emotion

(2009) Beat Lutz   CURRENT OPINION IN PHARMACOLOGY

Repeated Homotypic Stress Elevates 2-Arachidonoylglycerol Levels and Enhances Short-Term Endocannabinoid Signaling at Inhibitory Synapses in Basolateral Amygdala

(2009) Sachin Patel et al.   NEUROPSYCHOPHARMACOLOGY

The endocannabinoid system: Its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation

(2009) Vincenzo Di Marzo   PHARMACOLOGICAL RESEARCH

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo

(2009) J. Z. Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzymatic Pathways That Regulate Endocannabinoid Signaling in the Nervous System

(2008) Kay Ahn et al.   CHEMICAL REVIEWS

COX-2 Inhibition in Schizophrenia and Major Depression

(2008) Norbert Muller et al.   CURRENT PHARMACEUTICAL DESIGN

Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation

(2008) Sachin Patel et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Non-redundant Functions of Cyclooxygenases: Oxygenation of Endocannabinoids

(2008) Carol A. Rouzer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

D2 Dopamine Receptor Activation Facilitates Endocannabinoid-Mediated Long-Term Synaptic Depression of GABAergic Synaptic Transmission in Midbrain Dopamine Neurons via cAMP-Protein Kinase A Signaling

(2008) B. Pan et al.   JOURNAL OF NEUROSCIENCE

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology

Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors

(2007) S E O'Sullivan   BRITISH JOURNAL OF PHARMACOLOGY

Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors

(2007) Fabricio A. Moreira et al.   NEUROPHARMACOLOGY

Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of the mouse brain

(2007) L. Cristino et al.   NEUROSCIENCE