Article
Transplantation
Ida M. H. Sorensen, Sasha S. Bjergfelt, Henrik O. Hjortkjaer, Klaus F. Kofoed, Theis Lange, Bo Feldt-Rasmussen, Christina Christoffersen, Susanne Bro
Summary: This study found that calcium scores in the coronary, carotid, and thoracic arteries are independent predictors of major adverse cardiovascular events and all-cause mortality in patients with chronic kidney disease. The potential of calcification in these three arterial sites for predicting cardiovascular events and mortality was most pronounced.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Ana P. Silva, Carla S. B. Viegas, Patricia Guilherme, Nelson Tavares, Carolina Dias, Fatima Rato, Nelio Santos, Marilia Faisca, Edgar de Almeida, Pedro L. Neves, Dina C. Simes
Summary: Accelerated and premature cardiovascular calcification is common in chronic kidney disease patients, with valvular calcification being a critical indicator of cardiovascular disease. Low levels of Gla-rich protein (GRP) and magnesium, along with high levels of phosphate, are associated with mitral and aortic valves calcification. The diagnostic value of GRP may be potentially useful in assessing cardiovascular risk in this population.
Review
Biochemistry & Molecular Biology
Yin Tintut, Henry M. Honda, Linda L. Demer
Summary: Vascular calcification is a complex biological process regulated similarly to skeletal bone at the molecular and cellular levels, affected by metabolic, hormonal, and inflammatory stimuli. Calcium deposits in the vessel wall introduce different stress effects at different edges, influencing the risk of plaque rupture.
Article
Public, Environmental & Occupational Health
Lan Wang, Hong Cheng, Xinrong Zou, Jun Yuan, Wenjing Wu, Siping Han, Jinwei Wang, Luxia Zhang, Kevin He, Ming-Hui Zhao, Xiaoqin Wang
Summary: This study aimed to identify the characteristics, risk factors, and prognosis of cardiovascular calcification in patients with CKD stages 1-4. The results showed that demographic and traditional cardiovascular risk factors were associated with cardiovascular calcification, especially AAC. AAC may be associated with an increased risk of death in CKD patients, while CVC may only be a risk factor for cardiovascular disease in patients with mild to moderate CKD.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Genetics & Heredity
Markus Toelle, Cornelia Henkel, Jaqueline Herrmann, Christoph Daniel, Milen Babic, Mengdi Xia, Anna M. Schulz, Kerstin Amann, Markus van der Giet, Mirjam Schuchardt
Summary: This study evaluated an adenine-based uremic mouse model to study medial vessel calcification and senescence-associated secretory phenotype (SASP) changes, providing a basis for understanding molecular pathogenesis and potential therapeutic interventions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Medicine, General & Internal
Helen Erlandsson, Abdul Rashid Qureshi, Jonaz Ripsweden, Ida Haugen Lofman, Magnus Soderberg, Lars Wennberg, Torbjorn Lundgren, Annette Bruchfeld, Torkel B. Brismar, Peter Stenvinkel
Summary: This study investigated the impact of medial calcification on cardiovascular events (CVE) and mortality in patients starting on kidney failure replacement therapy. Moderate to severe medial calcification in the arteria epigastrica was associated with higher mortality and increased risk of CVE. The medial calcification score could be a reliable method to identify patients with high and low risk of CVE and mortality following kidney transplantation.
JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Michael Mah, Mark Febbraio, Sarah Turpin-Nolan
Summary: Biomarkers play crucial roles in describing biological processes and monitoring intervention strategies. Lipid biomarkers are used in clinical settings to predict and monitor metabolic diseases, such as specific circulating ceramides as predictors of cardiovascular disease and type 2 diabetes mellitus.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Gang Wang, Yanan Wang, Qinzhi Yang, Chunrong Xu, Youkun Zheng, Liqun Wang, Jianbo Wu, Min Zeng, Mao Luo
Summary: This study investigates the effects of metformin (MET) on apoptosis induced by methylglyoxal (MGO) in diabetic vascular complications. It is found that MET can prevent cell apoptosis induced by MGO by suppressing oxidative stress and increasing antioxidative capacity through ROS-mediated PI3K/Akt and Nrf2/HO-1 pathways.
CELL DEATH & DISEASE
(2022)
Review
Medicine, General & Internal
Alessia Gambaro, Gianmarco Lombardi, Chiara Caletti, Flavio Luciano Ribichini, Pietro Manuel Ferraro, Giovanni Gambaro
Summary: There is an association between nephrolithiasis and cardiovascular (CV) morbidities. Metabolic syndrome and habits that promote nephrolithiasis also contribute to CV disease. Conditions like oxidative stress, metabolic acidosis, and reduced mineral density are factors that link the two diseases. Episodes of renal stones should be considered a warning sign of ongoing atherosclerosis. Evaluating CV risk factors and metabolic syndrome in renal stone formers is crucial for treatment and prevention of CV complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Peripheral Vascular Disease
Alberto Cereda, Marco Toselli, Anna Palmisano, Davide Vignale, Arif Khokhar, Gianluca Campo, Matteo Bertini, Marco Loffi, Daniele Andreini, Gianluca Pontone, Gianluigi Patelli, Giuseppe Massimo Sangiorgi, Gabriele Tumminello, Mariarosa Elia, Attilio Iacovoni, Stefano Carugo, Claudio Rapezzi, Antonio Colombo, Francesco Giannini, Antonio Esposito
Summary: Hypertension and coronary calcifications play important roles in the prognosis of COVID-19 patients, increasing the risk of cardiovascular complications.
HYPERTENSION RESEARCH
(2022)
Article
Nutrition & Dietetics
Jundi Jia, Jie Zhang, Dan Ma, Zihao Zhang, Lin Zhao, Tongxin Wang, Hao Xu
Summary: This study aimed to evaluate the relationship between the healthy eating index-2015 (HEI-2015) and abdominal aortic calcification (AAC) in US adults. The results showed that higher HEI-2015 scores were associated with lower AAC scores and a decreased risk of having AAC. Specifically, a higher intake of fruits, greens, and beans was linked to lower AAC scores. These findings suggest that greater adherence to the 2015-2020 Dietary Guidelines for Americans, as assessed by HEI-2015, may be beneficial for preventing vascular calcification and cardiovascular disease among US adults.
FRONTIERS IN NUTRITION
(2023)
Article
Medicine, Research & Experimental
Junhao Li, Rui Zuo, U. Joseph Schoepf, Joseph P. Griffith, Shiyao Wu, Changsheng Zhou, Xingzhi Chen, Weixiong Tan, Zhen Zhou, Hong Gao, Longjiang Zhang, Guifen Yang
Summary: The study aimed to develop and validate a nonenhanced CT based radiomics model for detecting brown adipose tissue (BAT) and explore the relationship between CT radiomics derived BAT and cardiovascular calcification. The study found that radiomics features from nonenhanced CT can reliably detect BAT, and patients with BAT have less cardiovascular calcification.
Article
Environmental Sciences
Parna Dutta, Arunima Sengupta, Santanu Chakraborty
Summary: The article explores the harmful effects and signaling pathways of arterial and aortic valve calcification, proposing a new strategy targeting the mechanism of calcification and emphasizing the application of epigenetics in reducing calcification harm. Further clinical trials are needed for a comprehensive understanding and application of this strategy.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Physiology
Jussi T. Koivumaki, Johan Hoffman, Mary M. Maleckar, Gaute T. Einevoll, Joakim Sundnes
Summary: Mathematical models have greatly advanced cardiovascular physiology research, but barriers between experimental and computational approaches remain, calling for closer integration.
Review
Cell Biology
Emmanuelle Canet-Soulas, Laurence Bessueille, Laura Mechtouff, David Magne
Summary: Arteries calcify as they age, with a high vascular calcium score associated with high cardiovascular mortality risk. While the mechanisms of plaque calcification have been well characterized in mice, human plaques appear to calcify through different mechanisms that remain obscure.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dan Zhou, Ryan A. Hlady, Marissa J. Schafer, Thomas A. White, Chen Liu, Jeong-Hyeon Choi, Jordan D. Miller, Lewis R. Roberts, Nathan K. LeBrasseur, Keith D. Robertson
Article
Geriatrics & Gerontology
Michael B. Stout, Frederik J. Steyn, Michael J. Jurczak, Joao-Paulo G. Camporez, Yi Zhu, John R. Hawse, Diana Jurk, Allyson K. Palmer, Ming Xu, Tamar Pirtskhalava, Glenda L. Evans, Roberta de Souza Santos, Aaron P. Frank, Thomas A. White, David G. Monroe, Ravinder J. Singh, Grace Casaclang-Verzosa, Jordan D. Miller, Deborah J. Clegg, Nathan K. LeBrasseur, Thomas von Zglinicki, Gerald I. Shulman, Tamara Tchkonia, James L. Kirkland
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2017)
Article
Geriatrics & Gerontology
Brian R. Kotajarvi, Marissa J. Schafer, Elizabeth J. Atkinson, Megan M. Traynor, Charles J. Bruce, Kevin L. Greason, Rakesh M. Suri, Jordan D. Miller, Nathan K. LeBrasseur
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2017)
Article
Cardiac & Cardiovascular Systems
Bei Liu, Bin Zhang, Shiliang Huang, Lixia Yang, Carolyn M. Roos, Michael A. Thompson, Y. S. Prakash, Jie Zang, Jordan D. Miller, Ruiwei Guo
CANADIAN JOURNAL OF CARDIOLOGY
(2018)
Article
Cell Biology
Mariana G. Tarrago, Claudia C. S. Chini, Karina S. Kanamori, Gina M. Warner, Ariel Caride, Guilherme C. de Oliveira, Micaela Rud, Adrienne Samani, Kyaw Z. Hein, Runqing Huang, Diana Jurk, Dong Seong Cho, James J. Boslett, Jordan D. Miller, Jay L. Zweier, Joao F. Passos, Jason D. Doles, David J. Becherer, Eduardo N. Chini
Article
Biochemistry & Molecular Biology
Bin Zhang, Bei Liu, Carolyn M. Roos, Michael A. Thompson, Y. S. Prakash, Jordan D. Miller, Rui-wei Guo
Article
Biochemistry & Molecular Biology
Ming Xu, Tamar Pirtskhalava, Joshua N. Farr, Bettina M. Weigand, Allyson K. Palmer, Megan M. Weivoda, Christina L. Inman, Mikolaj B. Ogrodnik, Christine M. Hachfeld, Daniel G. Fraser, Jennifer L. Onken, Kurt O. Johnson, Grace C. Verzosa, Larissa G. P. Langhi, Moritz Weigl, Nino Giorgadze, Nathan K. LeBrasseur, Jordan D. Miller, Diana Jurk, Ravinder J. Singh, David B. Allison, Keisuke Ejima, Gene B. Hubbard, Yuji Ikeno, Hajrunisa Cubro, Vesna D. Garovic, Xiaonan Hou, S. John Weroha, Paul D. Robbins, Laura J. Niedernhofer, Sundeep Khosla, Tamara Tchkonia, James L. Kirkland
Article
Cell Biology
Xiaobing Hu, Shuang Zhu, Rong Liu, Jordan D. Miller, Kevin Merkley, Ronald G. Tilton, Hua Liu
Article
Biochemistry & Molecular Biology
Rodney D. Britt, Michael A. Thompson, Sarah A. Wicher, Logan J. Manlove, Anne Roesler, Yun-Hua Fang, Carolyn Roos, Leslie Smith, Jordan D. Miller, Christina M. Pabelick, Y. S. Prakash
Article
Cell Biology
Allyson K. Palmer, Ming Xu, Yi Zhu, Tamar Pirtskhalava, Megan M. Weivoda, Christine M. Hachfeld, Larissa G. Prata, Theo H. van Dijk, Esther Verkade, Grace Casaclang-Verzosa, Kurt O. Johnson, Hajrunisa Cubro, Ewald J. Doornebal, Mikolaj Ogrodnik, Diana Jurk, Michael D. Jensen, Eduardo N. Chini, Jordan D. Miller, Aleksey Matveyenko, Michael B. Stout, Marissa J. Schafer, Thomas A. White, LaTonya J. Hickson, Marco Demaria, Vesna Garovic, Joseph Grande, Edgar A. Arriaga, Folkert Kuipers, Thomas von Zglinicki, Nathan K. LeBrasseur, Judith Campisi, Tamar Tchkonia, James L. Kirkland
Article
Biochemistry & Molecular Biology
Rhys Anderson, Anthony Lagnado, Damien Maggiorani, Anna Walaszczyk, Emily Dookun, James Chapman, Jodie Birch, Hanna Salmonowicz, Mikolaj Ogrodnik, Diana Jurk, Carole Proctor, Clara Correia-Melo, Stella Victorelli, Edward Fielder, Rolando Berlinguer-Palmini, Andrew Owens, Laura C. Greaves, Kathy L. Kolsky, Angelo Parini, Victorine Douin-Echinard, Nathan K. Lebrasseur, Helen M. Arthur, Simon Tual-Chalot, Marissa J. Schafer, Carolyn M. Roos, Jordan D. Miller, Neil Robertson, Jelena Mann, Peter D. Adams, Tamara Tchkonia, James L. Kirkland, Jeanne Mialet-Perez, Gavin D. Richardson, Joao F. Passos
Article
Cardiac & Cardiovascular Systems
Grace Casaclang-Verzosa, Sirish Shrestha, Muhammad Jahanzeb Khalil, Jung Sun Cho, Marton Tokodi, Sudarshan Balla, Mohamad Alkhouli, Vinay Badhwar, Jagat Narula, Jordan D. Miller, Partho P. Sengupta
JACC-CARDIOVASCULAR IMAGING
(2019)
Review
Endocrinology & Metabolism
Bin Zhang, Virginia M. Miller, Jordan D. Miller
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Medicine, General & Internal
Tina M. Hendricks, Claudia N. Gutierrez, John M. Stulak, Joseph A. Dearani, Jordan D. Miller
MAYO CLINIC PROCEEDINGS
(2020)
Article
Cell Biology
Wen Huang, Hua Liu, Shuang Zhu, Michael Woodson, Rong Liu, Ronald G. Tilton, Jordan D. Miller, Wenbo Zhang
