T-bet in disease

Overlapping and Distinct Roles of STAT4 and T-bet in the Regulation of T Cell Differentiation and Allergic Airway Inflammation

(2014) S. Furuta et al.   JOURNAL OF IMMUNOLOGY

CD8+ Th17 Mediate Costimulation Blockade-Resistant Allograft Rejection in T-bet-Deficient Mice

(2014) B. E. Burrell et al.   JOURNAL OF IMMUNOLOGY

T-bet and Eomesodermin Play Critical Roles in Directing T Cell Differentiation to Th1 versus Th17

(2014) Y. Yang et al.   JOURNAL OF IMMUNOLOGY

T-Bet Plays a Key Role in NK-Mediated Control of Melanoma Metastatic Disease

(2014) M. B. F. Werneck et al.   JOURNAL OF IMMUNOLOGY

Epigenetic Changes at Il12rb2 and Tbx21 in Relation to Plasticity Behavior of Th17 Cells

(2011) D. Bending et al.   JOURNAL OF IMMUNOLOGY

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

Interferons Direct Th2 Cell Reprogramming to Generate a Stable GATA-3+T-bet+ Cell Subset with Combined Th2 and Th1 Cell Functions

(2010) Ahmed N. Hegazy et al.   IMMUNITY

The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

(2010) Rajesh R. Rao et al.   IMMUNITY

Epigenetic Instability of Cytokine and Transcription Factor Gene Loci Underlies Plasticity of the T Helper 17 Cell Lineage

(2010) Ryuta Mukasa et al.   IMMUNITY

STAT1-Activating Cytokines Limit Th17 Responses through Both T-bet-Dependent and -Independent Mechanisms

(2010) A. V. Villarino et al.   JOURNAL OF IMMUNOLOGY

IL-17RC Is Required for IL-17A- and IL-17F-Dependent Signaling and the Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2010) Y. Hu et al.   JOURNAL OF IMMUNOLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

(2010) Vanja Lazarevic et al.   NATURE IMMUNOLOGY

Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes

(2010) P. Veiga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment

(2010) K. Nistala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preferential recruitment of interferon-γ-expressing TH17 cells in multiple sclerosis

(2009) Hania Kebir et al.   ANNALS OF NEUROLOGY

Colitis-Associated Colorectal Cancer Driven by T-bet Deficiency in Dendritic Cells

(2009) Wendy S. Garrett et al.   CANCER CELL

T-bet protects against exacerbation of schistosome egg-induced immunopathology by regulating Th17-mediated inflammation

(2009) Laura I. Rutitzky et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Sequential Polarization and Imprinting of Type 1 T Helper Lymphocytes by Interferon-γ and Interleukin-12

(2009) Edda G. Schulz et al.   IMMUNITY

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

Cross-regulation of Signaling Pathways by Interferon-γ: Implications for Immune Responses and Autoimmune Diseases

(2009) Xiaoyu Hu et al.   IMMUNITY

T-bet is essential for encephalitogenicity of both Th1 and Th17 cells

(2009) Yuhong Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

(2009) Fernando Cruz-Guilloty et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ectopic T-bet Expression Licenses Dendritic Cells for IL-12-Independent Priming of Type 1 T Cells In Vitro

(2009) M. W. Lipscomb et al.   JOURNAL OF IMMUNOLOGY

IFN-  Regulates the Requirement for IL-17 in Proteoglycan-Induced Arthritis

(2009) P. D. Doodes et al.   JOURNAL OF IMMUNOLOGY

T-bet Inhibits the In Vivo Differentiation of Parasite-Specific CD4 + Th17 Cells in a T Cell-Intrinsic Manner

(2009) Siqi Guo et al.   JOURNAL OF IMMUNOLOGY

Development of Allergen-Induced Airway Inflammation in the Absence of T-bet Regulation Is Dependent on IL-17

(2009) D. M. Durrant et al.   JOURNAL OF IMMUNOLOGY

Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes

(2009) A. Jager et al.   JOURNAL OF IMMUNOLOGY

T-bet-Deficient NOD Mice Are Protected from Diabetes Due to Defects in Both T Cell and Innate Immune System Function

(2009) J. H. Esensten et al.   JOURNAL OF IMMUNOLOGY

Encephalitogenic T cells that stably express both T-bet and RORγt consistently produce IFNγ but have a spectrum of IL-17 profiles

(2009) Sara Abromson-Leeman et al.   JOURNAL OF NEUROIMMUNOLOGY

Expression of TH1 and TH17 cytokines and transcription factors in multiple sclerosis patients: Does baseline T-Bet mRNA predict the response to interferon-beta treatment?

(2009) Jelena Drulovic et al.   JOURNAL OF NEUROIMMUNOLOGY

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

(2009) Meghan A Koch et al.   NATURE IMMUNOLOGY

The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

(2009) R. G. Jenner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY

A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy

(2008) Xueli Yuan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of inflammatory responses by IL-17F

(2008) Xuexian O. Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells

(2008) Fuping Zhang et al.   NATURE IMMUNOLOGY

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

(2008) Valérie Dardalhon et al.   NATURE IMMUNOLOGY

Anomalous Type 17 Response to Viral Infection by CD8+ T Cells Lacking T-bet and Eomesodermin

(2008) A. M. Intlekofer et al.   SCIENCE

T cell–specific T-box transcription factor haplotype is associated with allergic asthma in children

(2007) Monica Cheng Munthe-Kaas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY